How phosphoinositide 3-phosphate controls growth downstream of amino acids and autophagy downstream of amino acid withdrawal (Q37977162)

26 August 2017

How phosphoinositide 3-phosphate controls growth downstream of amino acids and autophagy downstream of amino acid withdrawal (English)

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26 August 2017

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Nicholas T Ktistakis

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26 August 2017

Maria Manifava

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PubMed ID

22260663

26 August 2017

Priya Schoenfelder

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3

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PubMed ID

22260663

26 August 2017

Sergio Rotondo

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4

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26 August 2017

1 February 2012

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Biochemical Society Transactions

26 August 2017

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26 August 2017

40

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26 August 2017

1

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26 August 2017

37-43

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Amino acid signaling in TOR activation

26 August 2017

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https://api.crossref.org/works/10.1042%2FBST20110684

TOR signaling in growth and metabolism

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Biogenesis and cargo selectivity of autophagosomes

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Autophagy: process and function

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Regulation of autophagy by phosphatidylinositol 3-phosphate

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

The regulation and function of Class III PI3Ks: novel roles for Vps34.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Role of class II phosphoinositide 3-kinase in cell signalling

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

The Sir Hans Krebs Lecture. How a lipid mediates tumour suppression. Delivered on 29 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Regulation of membrane traffic by phosphoinositide 3-kinases

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Induction of autophagy and inhibition of tumorigenesis by beclin 1

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

The PX domains of p47phox and p40phox bind to lipid products of PI(3)K

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

FYVE fingers bind PtdIns(3)P

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Beclin 1 or not Beclin 1...

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Control of autophagy initiation by phosphoinositide 3-phosphatase Jumpy

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Identification of PTPsigma as an autophagic phosphatase.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

The Atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential function

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20110684

Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

The double-edged effect of autophagy in pancreatic beta cells and diabetes

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

3D tomography reveals connections between the phagophore and endoplasmic reticulum

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L).

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Membrane curvature response in autophagy

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Mitochondria supply membranes for autophagosome biogenesis during starvation

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Plasma membrane contributes to the formation of pre-autophagosomal structures

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Rheb fills a GAP between TSC and TOR.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Regulation of TORC1 by Rag GTPases in nutrient response

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20110684

hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20110684

hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

The late endosome is essential for mTORC1 signaling

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Regulation of mTORC1 by the Rab and Arf GTPases

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Phosphatidylinositol-3-OH kinases are Rab5 effectors.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Human VPS34 and p150 are Rab7 Interacting Partners

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Lysosomal positioning coordinates cellular nutrient responses.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

Termination of autophagy and reformation of lysosomes regulated by mTOR

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110684

PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20110684

Transport of phosphatidylinositol 3-phosphate into the vacuole via autophagic membranes in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20110684

21 January 2018

Identifiers

DOI

10.1042/BST20110684

1 reference

26 August 2017

1 reference

PubMed ID

22260663