Lead-oriented synthesis: a new opportunity for synthetic chemistry (Q37978254)

26 August 2017

Lead-oriented synthesis: a new opportunity for synthetic chemistry (English)

1 reference

26 August 2017

1 reference

Alan Nadin

1

1 reference

26 August 2017

Channa Hattotuwagama

series ordinal

2

1 reference

26 August 2017

Ian Churcher

series ordinal

3

1 reference

26 August 2017

language of work or name

English

0 references

publication date

3 January 2012

1 reference

Angewandte Chemie International Edition

26 August 2017

0 references

volume

51

1 reference

26 August 2017

5

1 reference

26 August 2017

1114-1122

1 reference

Can the pharmaceutical industry reduce attrition rates?

26 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

The influence of drug-like concepts on decision-making in medicinal chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

ADMET rules of thumb II: A comparison of the effects of common substituents on a range of ADMET parameters

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Physiochemical drug properties associated with in vivo toxicological outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Lipophilicity in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

A quantitative assessment of hERG liability as a function of lipophilicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Defining optimum lipophilicity and molecular weight ranges for drug candidates-Molecular weight dependent lower logD limits based on permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Getting physical in drug discovery: a contemporary perspective on solubility and hydrophobicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

A comparison of physiochemical property profiles of development and marketed oral drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

The evolution of synthetic oral drug properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Transporter-mediated uptake into cellular compartments

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Implications of the dominant role of transporters in drug uptake by cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Pursuing the leadlikeness concept in pharmaceutical research.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Molecular complexity and its impact on the probability of finding leads for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

970 Million Druglike Small Molecules for Virtual Screening in the Chemical Universe Database GDB-13

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Fragment-based lead discovery: leads by design

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

A ‘Rule of Three’ for fragment-based lead discovery?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Escape from flatland: increasing saturation as an approach to improving clinical success.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

The impact of aromatic ring count on compound developability--are too many aromatic rings a liability in drug design?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Covalent modifiers: an orthogonal approach to drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

ALARM NMR: a rapid and robust experimental method to detect reactive false positives in biochemical screens

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Solid-phase synthesis of 2-pyridones, 1,4-diazepines, and 1,4-oxazepines from resin-bound 3-amino-2-seleno ester

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Polymer-supported alpha-acylamino ketones: preparation and application in syntheses of 1,2,4-trisubstituted-1H-imidazoles

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Efficient and convenient synthesis of indazol-3(2H)-ones and 2-aminobenzonitriles

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Multiplicity of diverse heterocycles from polymer-supported alpha-acylamino ketones

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Rapid access to N-substituted diketopiperazines by one-pot Ugi-4CR/deprotection+activation/cyclization (UDAC).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Parallel microwave synthesis of 2-styrylquinazolin-4(3H)-ones in a high-throughput platform using HPLC/GC vials as reaction vessels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

The medicinal chemist's toolbox: an analysis of reactions used in the pursuit of drug candidates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Factors determining the selection of organic reactions by medicinal chemists and the use of these reactions in arrays (small focused libraries).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Molecular shape diversity of combinatorial libraries: a prerequisite for broad bioactivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Target-oriented and diversity-oriented organic synthesis in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Natural products as sources of new drugs over the last 25 years

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Iridium-Catalyzed Asymmetric Allylic Amination with Polar Amines: Access to Building Blocks with Lead-Like Molecular Properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Protecting-group-free synthesis as an opportunity for invention

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

Diversity-oriented synthesis and solid-phase organic synthesis under controlled microwave heating

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201105840

21 January 2018

Identifiers

DOI

10.1002/ANIE.201105840

1 reference

26 August 2017

1 reference