Manipulation of adenovirus interactions with host factors for gene therapy applications (Q37984486)

26 August 2017

title

Manipulation of adenovirus interactions with host factors for gene therapy applications (English)

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26 August 2017

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2

Alan L Parker

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26 August 2017

Margaret R Duffy

1

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26 August 2017

Angela C Bradshaw

series ordinal

3

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26 August 2017

Andrew H Baker

series ordinal

4

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26 August 2017

publication date

1 February 2012

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26 August 2017

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26 August 2017

volume

7

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26 August 2017

issue

2

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26 August 2017

page(s)

271-288

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Initial sequencing and analysis of the human genome

26 August 2017

cites work

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

T lymphocyte-directed gene therapy for ADA- SCID: initial trial results after 4 years.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

System for efficient helper-dependent minimal adenovirus construction and rescue

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Toxicity of a first-generation adenoviral vector in rhesus macaques

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

INGN 201 (Advexin): adenoviral p53 gene therapy for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Phase I trial of replication-competent adenovirus-mediated suicide gene therapy combined with IMRT for prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Feasibility of adenovirus-mediated hNIS gene transfer and 131I radioiodine therapy as a definitive treatment for localized prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

The Junctional Adhesion Molecule JAML Is a Costimulatory Receptor for Epithelial γδ T Cell Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

The Molecular Interaction of CAR and JAML Recruits the Central Cell Signal Transducer PI3K

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Identification of contact residues and definition of the CAR-binding site of adenovirus type 5 fiber protein

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Identification of a conserved receptor-binding site on the fiber proteins of CAR-recognizing adenoviridae

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Coxsackie adenovirus receptor (CAR) regulates integrin function through activation of p44/42 MAPK.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Drifting motions of the adenovirus receptor CAR and immobile integrins initiate virus uncoating and membrane lytic protein exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

A capsid-encoded PPxY-motif facilitates adenovirus entry

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Activation of p38 and ERK signaling during adenovirus vector cell entry lead to expression of the C-X-C chemokine IP-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Adenovirus protein VI mediates membrane disruption following capsid disassembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Cytoplasmic dynein mediates adenovirus binding to microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Microtubule-dependent plus- and minus end-directed motilities are competing processes for nuclear targeting of adenovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

The role of the nuclear pore complex in adenovirus DNA entry

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

The influence of adenovirus fiber structure and function on vector development for gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Adenovirus type 5 interactions with human blood cells may compromise systemic delivery.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Human erythrocytes bind and inactivate type 5 adenovirus by presenting Coxsackie virus-adenovirus receptor and complement receptor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Effect of adenovirus serotype 5 fiber and penton modifications on in vivo tropism in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

The Cell Adhesion Molecule “CAR” and Sialic Acid on Human Erythrocytes Influence Adenovirus In Vivo Biodistribution

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Recombinant adenovirus vectors activate the alternative complement pathway, leading to the binding of human complement protein C3 independent of anti-ad antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Bioluminescence imaging reveals a significant role for complement in liver transduction following intravenous delivery of adenovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Multiple innate inflammatory responses induced after systemic adenovirus vector delivery depend on a functional complement system.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector-triggered immune responses in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Use of DAF-displaying adenovirus vectors reduces induction of transgene- and vector-specific adaptive immune responses in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Adenoviruses use lactoferrin as a bridge for CAR-independent binding to and infection of epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Adenovirus serotype 5 infects human dendritic cells via a coxsackievirus-adenovirus receptor-independent receptor pathway mediated by lactoferrin and DC-SIGN.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Adenovirus-platelet interaction in blood causes virus sequestration to the reticuloendothelial system of the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Clearance of adenovirus by Kupffer cells is mediated by scavenger receptors, natural antibodies, and complement

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Adenovirus Binding to Blood Factors Results in Liver Cell Infection and Hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Targeting of adenovirus serotype 5 (Ad5) and 5/47 pseudotyped vectors in vivo: fundamental involvement of coagulation factors and redundancy of CAR binding by Ad5.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Adenovirus serotype 5 hexon mediates liver gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Processing and trafficking of clotting factor X in the secretory pathway. Effects of warfarin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Substitution of hexon hypervariable region 5 of adenovirus serotype 5 abrogates blood factor binding and limits gene transfer to liver

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Expanded anticancer therapeutic window of hexon-modified oncolytic adenovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Coagulation factor X mediates adenovirus type 5 liver gene transfer in non-human primates (Microcebus murinus)

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

A cluster of basic amino acids in the factor X serine protease mediates surface attachment of adenovirus/FX complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Differential effects of murine and human factor X on adenovirus transduction via cell-surface heparan sulfate

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Molecular diversity of heparan sulfate

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Humoral immune response to the capsid components of recombinant adenoviruses: routes of immunization modulate virus-induced Ig subclass shifts

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Evaluation of toxicity from high-dose systemic administration of recombinant adenovirus vector in vector-naive and pre-immunized mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Effect of neutralizing sera on factor x-mediated adenovirus serotype 5 gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Comparative seroprevalence and immunogenicity of six rare serotype recombinant adenovirus vaccine vectors from subgroups B and D

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Rapid Kupffer cell death after intravenous injection of adenovirus vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Antiviral antibodies target adenovirus to phagolysosomes and amplify the innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Sequestration of adenoviral vector by Kupffer cells leads to a nonlinear dose response of transduction in liver

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Polyinosinic acid enhances delivery of adenovirus vectors in vivo by preventing sequestration in liver macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Tropism-modification strategies for targeted gene delivery using adenoviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

In vitro and in vivo properties of adenovirus vectors with increased affinity to CD46

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Substitution of adenovirus serotype 3 hexon onto a serotype 5 oncolytic adenovirus reduces factor X binding, decreases liver tropism, and improves antitumor efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Neutralizing antibodies to adenovirus serotype 5 vaccine vectors are directed primarily against the adenovirus hexon protein

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Hexon gene switch strategy for the generation of chimeric recombinant adenovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Generation of a Kupffer cell-evading adenovirus for systemic and liver-directed gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

PEGylation of adenovirus with retention of infectivity and protection from neutralizing antibody in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Effective tumor targeted gene transfer using PEGylated adenovirus vector via systemic administration

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Tumor vascular targeted delivery of polymer-conjugated adenovirus vector for cancer gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Chemical modification with high molecular weight polyethylene glycol reduces transduction of hepatocytes and increases efficacy of intravenously delivered oncolytic adenovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Modification of adenoviral vectors with polyethylene glycol modulates in vivo tissue tropism and gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Modifications of adenovirus hexon allow for either hepatocyte detargeting or targeting with potential evasion from Kupffer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

A targetable, injectable adenoviral vector for selective gene delivery to pulmonary endothelium in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Targeting adenoviruses with factor x-single-chain antibody fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

A Potent Trivalent Sialic Acid Inhibitor of Adenovirus Type 37 Infection of Human Corneal Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Crystal Structure of Human Adenovirus at 3.5 Å Resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Identification of low-molecular weight inhibitors of HIV-1 reverse transcriptase using a cell-based high-throughput screening system.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Tumor cells as cellular vehicles to deliver gene therapies to metastatic tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Approaches to utilize mesenchymal progenitor cells as cellular vehicles

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Human bone marrow-derived mesenchymal stem cells for intravascular delivery of oncolytic adenovirus Delta24-RGD to human gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Mesenchymal progenitor cells as cellular vehicles for delivery of oncolytic adenoviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Mesenchymal stem cells as a vehicle for targeted delivery of CRAds to lung metastases of breast carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Chimeric PSA enhancers exhibit augmented activity in prostate cancer gene therapy vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Use of tissue-specific microRNA to control pathology of wild-type adenovirus without attenuation of its ability to kill cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

MicroRNA controlled adenovirus mediates anti-cancer efficacy without affecting endogenous microRNA activity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific MicroRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

miR-122a-Regulated Expression of a Suicide Gene Prevents Hepatotoxicity Without Altering Antitumor Effects in Suicide Gene Therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

An iron-binding protein common to many external secretions

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.11.186

21 January 2018

Identifiers

DOI

10.2217/NNM.11.186

1 reference

26 August 2017

1 reference