Evidence for FGF23 involvement in a bone-kidney axis regulating bone mineralization and systemic phosphate and vitamin D homeostasis. (Q37991256)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22396162%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

title

Evidence for FGF23 involvement in a bone-kidney axis regulating bone mineralization and systemic phosphate and vitamin D homeostasis (English)

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25 January 2020

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25 January 2020

author name string

Aline Martin

series ordinal

1

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language of work or name

English

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publication date

1 January 2012

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Advances in Experimental Medicine and Biology

25 January 2020

published in

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volume

728

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25 January 2020

page(s)

65-83

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An interpretation of acute changes in plasma 45Ca following parathyroid hormone administration to thyroparathyroidectomized rats.

25 January 2020

cites work

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12 December 2020

Thrombospondin-4 binds specifically to both collagenous and non-collagenous extracellular matrix proteins via its C-terminal domains

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12 December 2020

Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain

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Transcriptional regulation of alpha 2(I) collagen gene expression by fibroblast growth factor-2 in MC3T3-E1 osteoblast-like cells.

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Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia

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12 December 2020

FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate

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12 December 2020

Catabolic effects of continuous human PTH (1--38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation

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Analysis of recombinant Phex: an endopeptidase in search of a substrate

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Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype.

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Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene

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Ontogeny of Phex/PHEX protein expression in mouse embryo and subcellular localization in osteoblasts

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12 December 2020

Inhibition of MEPE cleavage by Phex.

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12 December 2020

Human fibroblast growth factor-23 mutants suppress Na+-dependent phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3 production

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12 December 2020

Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression

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12 December 2020

The autosomal dominant hypophosphatemic rickets R176Q mutation in fibroblast growth factor 23 resists proteolytic cleavage and enhances in vivo biological potency

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Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store

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Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein

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Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia

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12 December 2020

Serum FGF23 levels in normal and disordered phosphorus homeostasis.

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12 December 2020

Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX.

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12 December 2020

FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting

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12 December 2020

Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent

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12 December 2020

bFGF Administration Lowers the Phosphate Threshold for Mineralization in Bone Marrow Stromal Cells

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12 December 2020

Dentin matrix protein 1 immobilized on type I collagen fibrils facilitates apatite deposition in vitro.

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12 December 2020

MEPE has the properties of an osteoblastic phosphatonin and minhibin.

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12 December 2020

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

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12 December 2020

Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis

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12 December 2020

FGF23 is processed by proprotein convertases but not by PHEX.

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12 December 2020

Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders

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12 December 2020

Mineral metabolism, mortality, and morbidity in maintenance hemodialysis.

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12 December 2020

Expression of SIBLINGs and their partner MMPs in salivary glands

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12 December 2020

Evolution of the Fgf and Fgfr gene families

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12 December 2020

Fibroblast growth factor 7: an inhibitor of phosphate transport derived from oncogenic osteomalacia-causing tumors

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12 December 2020

Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice

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12 December 2020

An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia.

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12 December 2020

Fibroblast growth factor 23, parathyroid hormone, and 1alpha,25-dihydroxyvitamin D in surgically treated primary hyperparathyroidism

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12 December 2020

Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men.

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12 December 2020

Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation

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12 December 2020

Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for impaired mineralization in X-linked rickets (HYP)

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12 December 2020

Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice.

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12 December 2020

Role of matrix extracellular phosphoglycoprotein in the pathogenesis of X-linked hypophosphatemia

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12 December 2020

Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates

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12 December 2020

Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease

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12 December 2020

Overexpression of human PHEX under the human beta-actin promoter does not fully rescue the Hyp mouse phenotype.

1 reference

12 December 2020

Fibroblast growth factor-23 mutants causing familial tumoral calcinosis are differentially processed.

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12 December 2020

Mice with a disruption of the thrombospondin 3 gene differ in geometric and biomechanical properties of bone and have accelerated development of the femoral head

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12 December 2020

Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism

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12 December 2020

Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23

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12 December 2020

Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice

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12 December 2020

DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis

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12 December 2020

Regulation of fibroblast growth factor-23 signaling by klotho

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12 December 2020

Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process

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12 December 2020

Pathogenic role of Fgf23 in Hyp mice.

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12 December 2020

Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D.

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12 December 2020

Role of matrix Gla protein in parathyroid hormone inhibition of osteoblast mineralization

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12 December 2020

Correction of the mineralization defect in hyp mice treated with protease inhibitors CA074 and pepstatin

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12 December 2020

Constitutive expression of thrombospondin 1 in MC3T3-E1 osteoblastic cells inhibits mineralization

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12 December 2020

Hypophosphatemia: an evidence-based approach to its clinical consequences and management

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12 December 2020

A deleterious mutation in SAMD9 causes normophosphatemic familial tumoral calcinosis

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12 December 2020

Correlation between hyperphosphatemia and type II Na-Pi cotransporter activity in klotho mice

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12 December 2020

Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism.

1 reference

12 December 2020

DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis.

1 reference

12 December 2020

Acute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men

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12 December 2020

Klotho converts canonical FGF receptor into a specific receptor for FGF23

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12 December 2020

Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts

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12 December 2020

Ablation of vitamin D signaling rescues bone, mineral, and glucose homeostasis in Fgf-23 deficient mice.

1 reference

12 December 2020

Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals

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12 December 2020

Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo

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12 December 2020

Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity

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12 December 2020

Association between KLOTHO gene and hand osteoarthritis in a female Caucasian population.

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12 December 2020

A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis

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12 December 2020

Distinct roles for intrinsic osteocyte abnormalities and systemic factors in regulation of FGF23 and bone mineralization in Hyp mice.

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12 December 2020

Parathyroid hormone regulates fibroblast growth factor-23 in a mouse model of primary hyperparathyroidism

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12 December 2020

The parathyroid is a target organ for FGF23 in rats

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12 December 2020

Functional evolutionary history of the mouse Fgf gene family

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12 December 2020

Degradation of MEPE, DMP1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP

1 reference

12 December 2020

Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia

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12 December 2020

betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c

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12 December 2020

FGF23 is elevated in Gambian children with rickets

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12 December 2020

Overexpression of fibroblast growth factor 23 suppresses osteoblast differentiation and matrix mineralization in vitro

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12 December 2020

Tumor producing fibroblast growth factor 23 localized by two-staged venous sampling

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12 December 2020

A translocation causing increased alpha-klotho level results in hypophosphatemic rickets and hyperparathyroidism

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12 December 2020

Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling

1 reference

12 December 2020

Anti-FGF23 neutralizing antibodies show the physiological role and structural features of FGF23.

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12 December 2020

Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen

1 reference

12 December 2020

Pathogenic role of Fgf23 in Dmp1-null mice.

1 reference

12 December 2020

MEPE-ASARM peptides control extracellular matrix mineralization by binding to hydroxyapatite: an inhibition regulated by PHEX cleavage of ASARM

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12 December 2020

Genetic evidence of serum phosphate-independent functions of FGF-23 on bone

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12 December 2020

Studies of the DMP1 57-kDa functional domain both in vivo and in vitro

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12 December 2020

Endocrine functions of bone in mineral metabolism regulation.

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12 December 2020

Normal FGF23 levels in adult idiopathic phosphate diabetes.

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12 December 2020

FGF23 is a putative marker for bone healing and regeneration.

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12 December 2020

Carbonic anhydrase II deficiency syndrome in a Belgian family is caused by a point mutation at an invariant histidine residue (107 His----Tyr): complete structure of the normal human CA II gene

1 reference

12 December 2020

Regulation of fibroblast growth factor 23 production in bone in uremic rats.

1 reference

12 December 2020

A paradigm of integrative physiology, the crosstalk between bone and energy metabolisms

1 reference

12 December 2020

Oral phosphate supplementation corrects hypophosphatemia and normalizes plasma FGF23 and 25-hydroxyvitamin D3 levels in women with chronic metabolic acidosis.

1 reference

12 December 2020

RT-PCR analysis for FGF23 using paraffin sections in the diagnosis of phosphaturic mesenchymal tumors with and without known tumor induced osteomalacia

1 reference

12 December 2020

Bone formation regulates circulating concentrations of fibroblast growth factor 23.

1 reference

12 December 2020

Bone modeling and remodeling

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12 December 2020

Parathyroid hormone stimulates phosphate efflux through an apparently adenosine 3',5'-monophosphate-independent process in rat parotid cell aggregates

1 reference

12 December 2020

Genetic transmission of tumoral calcinosis: autosomal dominant with variable clinical expressivity

1 reference

12 December 2020

Bone response to phosphate and vitamin D metabolites in the hypophosphatemic male mouse

1 reference

12 December 2020

A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. The HYP Consortium

1 reference

12 December 2020

cDNA cloning and expression of a novel human UDP-N-acetyl-alpha-D-galactosamine. Polypeptide N-acetylgalactosaminyltransferase, GalNAc-t3

1 reference

12 December 2020

Role of 1,25-dihydroxyvitamin D3 on intestinal phosphate absorption in rats with a normal vitamin D supply

1 reference

12 December 2020

Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein

1 reference

12 December 2020

Cloning and sequencing of human PEX from a bone cDNA library: evidence for its developmental stage-specific regulation in osteoblasts

1 reference

12 December 2020

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

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12 December 2020

Intrinsic mineralization defect in Hyp mouse osteoblasts

1 reference

12 December 2020

10.1007/978-1-4614-0887-1_4

Identifiers

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