Harnessing genomics and genome biology to understand malaria biology (Q38001919)

26 August 2017

Harnessing genomics and genome biology to understand malaria biology (English)

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26 August 2017

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5

Dyann F Wirth

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26 August 2017

Daniel E Neafsey

2

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Stephen F Schaffner

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3

object named as

Stephen F Schaffner

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26 August 2017

1

Sarah K Volkman

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26 August 2017

Daniel J Park

4

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PubMed ID

22495435

26 August 2017

language of work or name

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12 April 2012

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26 August 2017

Nature Reviews Genetics

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26 August 2017

13

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26 August 2017

5

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26 August 2017

315-328

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https://scigraph.springernature.com/pub.10.1038/nrg3187

26 August 2017

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cites work

Malaria morbidity and pyrethroid resistance after the introduction of insecticide-treated bednets and artemisinin-based combination therapies: a longitudinal study

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Genome sequence of the human malaria parasite Plasmodium falciparum

21 January 2018

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Comparative genomics of the neglected human malaria parasite Plasmodium vivax

21 January 2018

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Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii

21 January 2018

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A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses

21 January 2018

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Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes

21 January 2018

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How can we identify parasite genes that underlie antimalarial drug resistance?

21 January 2018

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Assessing the effect of natural selection in malaria parasites.

21 January 2018

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Detecting signatures of balancing selection to identify targets of anti-parasite immunity

21 January 2018

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Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution

21 January 2018

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Genome variation and evolution of the malaria parasite Plasmodium falciparum

21 January 2018

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Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome.

21 January 2018

1 reference

A genome-wide map of diversity in Plasmodium falciparum

21 January 2018

1 reference

Gene copy number variation throughout the Plasmodium falciparum genome

21 January 2018

1 reference

Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum

21 January 2018

1 reference

Detection of genome-wide polymorphisms in the AT-rich Plasmodium falciparum genome using a high-density microarray

21 January 2018

1 reference

A systematic map of genetic variation in Plasmodium falciparum

21 January 2018

1 reference

Optimizing comparative genomic hybridization probes for genotyping and SNP detection in Plasmodium falciparum

21 January 2018

1 reference

A systems-based analysis of Plasmodium vivax lifecycle transcription from human to mosquito

21 January 2018

1 reference

Initial sequencing and analysis of the human genome

21 January 2018

1 reference

Origin of the human malaria parasite Plasmodium falciparum in gorillas

21 January 2018

1 reference

Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs

21 January 2018

1 reference

Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum

21 January 2018

1 reference

Recombination hotspots and population structure in Plasmodium falciparum

21 January 2018

1 reference

Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum

21 January 2018

1 reference

Genetic diversity and population structure of Plasmodium falciparum in Thailand, a low transmission country

21 January 2018

1 reference

Extreme geographical fixation of variation in the Plasmodium falciparum gamete surface protein gene Pfs48/45 compared with microsatellite loci

21 January 2018

1 reference

Dynamics of polymorphism in a malaria vaccine antigen at a vaccine-testing site in Mali

21 January 2018

1 reference

A field trial to assess a blood-stage malaria vaccine

21 January 2018

1 reference

The hitch-hiking effect of a favourable gene

21 January 2018

2 references

https://pubmed.ncbi.nlm.nih.gov/22495435

21 January 2018

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

High recombination rate in natural populations of Plasmodium falciparum

1 reference

High recombination rates and hotspots in a Plasmodium falciparum genetic cross

21 January 2018

1 reference

Detecting recent positive selection in the human genome from haplotype structure

21 January 2018

1 reference

Return of chloroquine-susceptible falciparum malaria in Malawi was a reexpansion of diverse susceptible parasites

21 January 2018

1 reference

Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum

21 January 2018

1 reference

A selective sweep driven by pyrimethamine treatment in southeast asian malaria parasites

21 January 2018

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Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum

21 January 2018

1 reference

Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum.

21 January 2018

1 reference

Adaptive copy number evolution in malaria parasites

21 January 2018

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Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets

21 January 2018

1 reference

Deciphering the ubiquitin-mediated pathway in apicomplexan parasites: a potential strategy to interfere with parasite virulence.

21 January 2018

1 reference

Malaria parasite clag3 genes determine channel-mediated nutrient uptake by infected red blood cells

21 January 2018

1 reference

The "Malaria's Eve" hypothesis and the debate concerning the origin of the human malaria parasite Plasmodium falciparum.

21 January 2018

1 reference

Positive natural selection in the human lineage

21 January 2018

1 reference

The origin of malaria: mixed messages from genetic diversity

21 January 2018

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The paradoxical population genetics of Plasmodium falciparum

21 January 2018

1 reference

Inferring the joint demographic history of multiple populations from multidimensional SNP frequency data

21 January 2018

1 reference

Joint analysis of demography and selection in population genetics: where do we stand and where could we go?

21 January 2018

1 reference

Human malaria parasites in continuous culture

21 January 2018

1 reference

Dissecting the loci of low-level quinine resistance in malaria parasites

21 January 2018

1 reference

Drug resistance and genetic mapping in Plasmodium falciparum.

21 January 2018

1 reference

Probing the multifactorial basis of Plasmodium falciparum quinine resistance: Evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE

21 January 2018

1 reference

Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine

21 January 2018

1 reference

Genetic linkage analyses redefine the roles of PfCRT and PfMDR1 in drug accumulation and susceptibility in Plasmodium falciparum

21 January 2018

1 reference

Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7.

21 January 2018

1 reference

Erythrocyte binding protein PfRH5 polymorphisms determine species-specific pathways of Plasmodium falciparum invasion

21 January 2018

1 reference

A genetic locus on Plasmodium falciparum chromosome 12 linked to a defect in mosquito-infectivity and male gametogenesis

21 January 2018

1 reference

A genetic map and recombination parameters of the human malaria parasite Plasmodium falciparum

21 January 2018

1 reference

Genome scanning of Amazonian Plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasites

21 January 2018

1 reference

South American Plasmodium falciparum after the malaria eradication era: clonal population expansion and survival of the fittest hybrids

21 January 2018

1 reference

High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western Cambodia

21 January 2018

1 reference

21 January 2018

1 reference

Efficiency and power in genetic association studies

21 January 2018

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Multiethnic genetic association studies improve power for locus discovery

21 January 2018

1 reference

Genetic mapping in human disease

21 January 2018

1 reference

Genomic control for association studies

21 January 2018

1 reference

Principal components analysis corrects for stratification in genome-wide association studies

21 January 2018

1 reference

Association mapping in structured populations

21 January 2018

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Variance component model to account for sample structure in genome-wide association studies

21 January 2018

1 reference

Efficient control of population structure in model organism association mapping

21 January 2018

1 reference

New approaches to population stratification in genome-wide association studies

21 January 2018

1 reference

ROADTRIPS: case-control association testing with partially or completely unknown population and pedigree structure

21 January 2018

1 reference

Allele frequency-based and polymorphism-versus-divergence indices of balancing selection in a new filtered set of polymorphic genes in Plasmodium falciparum

21 January 2018

1 reference

A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes

21 January 2018

1 reference

Validation of isoleucine utilization targets in Plasmodium falciparum

21 January 2018

1 reference

Target identification and validation of novel antimalarials

21 January 2018

1 reference

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

21 January 2018

1 reference

A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor

21 January 2018

1 reference

Spiroindolones, a potent compound class for the treatment of malaria

21 January 2018

1 reference

A Research Agenda to Underpin Malaria Eradication

21 January 2018

1 reference

Genotyping of Plasmodium falciparum infections by PCR: a comparative multicentre study

21 January 2018

1 reference

Exposing malaria in-host diversity and estimating population diversity by capture-recapture using massively parallel pyrosequencing

21 January 2018

1 reference

Biased distribution of msp1 and msp2 allelic variants in Plasmodium falciparum populations in Thailand.

21 January 2018

1 reference

A general SNP-based molecular barcode for Plasmodium falciparum identification and tracking

21 January 2018

1 reference

First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children

21 January 2018

1 reference

Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in The Gambia: a randomised trial

21 January 2018

1 reference

RTS,S/AS02A malaria vaccine does not induce parasite CSP T cell epitope selection and reduces multiplicity of infection

21 January 2018

1 reference

Impact of RTS,S/AS02(A) and RTS,S/AS01(B) on genotypes of P. falciparum in adults participating in a malaria vaccine clinical trial

21 January 2018

1 reference

The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum

21 January 2018

1 reference

Discovery of gene function by expression profiling of the malaria parasite life cycle

21 January 2018

1 reference

Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum

21 January 2018

1 reference

Quantitative protein expression profiling reveals extensive post-transcriptional regulation and post-translational modifications in schizont-stage malaria parasites

21 January 2018

1 reference

Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites

21 January 2018

1 reference

New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq

21 January 2018

1 reference

A global view of the nonprotein-coding transcriptome in Plasmodium falciparum

21 January 2018

1 reference

Distinct physiological states of Plasmodium falciparum in malaria-infected patients

21 January 2018

1 reference

Statistical estimation of cell-cycle progression and lineage commitment in Plasmodium falciparum reveals a homogeneous pattern of transcription in ex vivo culture.

21 January 2018

1 reference

Comparative transcriptional and genomic analysis of Plasmodium falciparum field isolates

21 January 2018

1 reference

Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription

21 January 2018

1 reference

Specific DNA-binding by apicomplexan AP2 transcription factors

21 January 2018

1 reference

Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains

21 January 2018

1 reference

Plasmodium biology: genomic gleanings

21 January 2018

1 reference

Transcriptional control and gene silencing in Plasmodium falciparum

21 January 2018

1 reference

Epigenetics in Apicomplexa: control of gene expression during cell cycle progression, differentiation and antigenic variation

21 January 2018

1 reference

Control of gene expression in Plasmodium falciparum - ten years on.

21 January 2018

1 reference

Comparative genomics of transcription factors and chromatin proteins in parasitic protists and other eukaryotes

21 January 2018

1 reference

Chromatin-mediated epigenetic regulation in the malaria parasite Plasmodium falciparum

21 January 2018

1 reference

A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs

21 January 2018

1 reference

Noncoding RNA, antigenic variation, and the virulence genes of Plasmodium falciparum

21 January 2018

1 reference

Genetic linkage and association analyses for trait mapping in Plasmodium falciparum

21 January 2018

1 reference

A proteomic view of the Plasmodium falciparum life cycle

21 January 2018

1 reference

Proteome analysis of separated male and female gametocytes reveals novel sex-specific Plasmodium biology

21 January 2018

1 reference

Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry.

21 January 2018

1 reference

Proteomic profiling of Plasmodium sporozoite maturation identifies new proteins essential for parasite development and infectivity

21 January 2018

1 reference

Proteomic analysis of zygote and ookinete stages of the avian malaria parasite Plasmodium gallinaceum delineates the homologous proteomes of the lethal human malaria parasite Plasmodium falciparum

21 January 2018

1 reference

Reality check for malaria proteomics

21 January 2018

1 reference

A comprehensive Plasmodium falciparum protein interaction map reveals a distinct architecture of a core interactome

21 January 2018

1 reference

Exploring metabolomic approaches to analyse phospholipid biosynthetic pathways in Plasmodium

21 January 2018

1 reference

Retracted: Branched tricarboxylic acid metabolism in Plasmodium falciparum

21 January 2018

1 reference

Host-parasite interactions revealed by Plasmodium falciparum metabolomics

21 January 2018

1 reference

Metabolite profiling of the intraerythrocytic malaria parasite Plasmodium falciparum by (1)H NMR spectroscopy

21 January 2018

1 reference

Complexity of Plasmodium falciparum clinical samples from Uganda during short-term culture

21 January 2018

1 reference

Large deletions result from breakage and healing of P. falciparum chromosomes.

21 January 2018

1 reference

Using CF11 cellulose columns to inexpensively and effectively remove human DNA from Plasmodium falciparum-infected whole blood samples

21 January 2018

1 reference

Hybrid selection for sequencing pathogen genomes from clinical samples

21 January 2018

1 reference

Close kinship within multiple-genotype malaria parasite infections

21 January 2018

1 reference

Protective efficacy of the RTS,S/AS02 Plasmodium falciparum malaria vaccine is not strain specific

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22495435

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22495435

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRG3187

1 reference

PubMed ID

22495435

Dimensions Publication ID

26 August 2017

0 references

1 reference

PubMed ID

22495435