How much do antiretroviral drugs penetrate into the central nervous system? (Q38003612)

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29 January 2020

2 references

26 April 2020

18 December 2020

How much do antiretroviral drugs penetrate into the central nervous system? (English)

1 reference

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29 January 2020

main subject

anti-retroviral agent

0 references

1 reference

12 September 2019

1 reference

18 December 2020

3

1 reference

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29 January 2020

author name string

L Ene

series ordinal

1

1 reference

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29 January 2020

D Duiculescu

series ordinal

2

1 reference

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publication date

24 November 2011

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Journal of medicine and life

29 January 2020

14 November 2011

2 references

26 April 2020

18 December 2020

5 references

22 June 2019

12 September 2019

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29 January 2020

26 April 2020

18 December 2020

4

1 reference

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29 January 2020

issue

4

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29 January 2020

page(s)

432-439

1 reference

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Creative Commons Attribution 2.0 Generic

29 January 2020

copyright license

4 references

22 June 2019

12 September 2019

26 April 2020

Mode of coreceptor use by R5 HIV type 1 correlates with disease stage: a study of paired plasma and cerebrospinal fluid isolates

18 December 2020

0 references

1 reference

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Raltegravir cerebrospinal fluid concentrations in HIV-1 infection

6 September 2017

1 reference

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Tissue-specific sequence alterations in the human immunodeficiency virus type 1 envelope favoring CCR5 usage contribute to persistence of dual-tropic virus in the brain

6 September 2017

1 reference

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Darunavir concentrations in cerebrospinal fluid and blood in HIV-1-infected individuals

6 September 2017

1 reference

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The transport of anti-HIV drugs across blood-CNS interfaces: summary of current knowledge and recommendations for further research.

6 September 2017

1 reference

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Low atazanavir concentrations in cerebrospinal fluid

6 September 2017

1 reference

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Adjunctive therapies for AIDS dementia complex

6 September 2017

1 reference

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Enfuvirtide cerebrospinal fluid (CSF) pharmacokinetics and potential use in defining CSF HIV-1 origin

6 September 2017

1 reference

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Investigation of the role of breast cancer resistance protein (Bcrp/Abcg2) on pharmacokinetics and central nervous system penetration of abacavir and zidovudine in the mouse.

6 September 2017

1 reference

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Interactions of pluronic block copolymers on P-gp efflux activity: experience with HIV-1 protease inhibitors

6 September 2017

1 reference

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Antiretroviral treatment effect on immune activation reduces cerebrospinal fluid HIV-1 infection

6 September 2017

1 reference

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Role of OATP transporters in the disposition of drugs

6 September 2017

1 reference

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Role of psychiatric medications as adjunct therapy in the treatment of HIV associated neurocognitive disorders

6 September 2017

1 reference

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Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system

6 September 2017

1 reference

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Strategies to advance translational research into brain barriers

6 September 2017

1 reference

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Inhibition of MRP1/ABCC1, MRP2/ABCC2, and MRP3/ABCC3 by nucleoside, nucleotide, and non-nucleoside reverse transcriptase inhibitors

6 September 2017

1 reference

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The distribution of the anti-HIV drug, tenofovir (PMPA), into the brain, CSF and choroid plexuses.

6 September 2017

1 reference

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Population pharmacokinetics of abacavir in plasma and cerebrospinal fluid

6 September 2017

1 reference

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Lopinavir concentrations in cerebrospinal fluid exceed the 50% inhibitory concentration for HIV.

6 September 2017

1 reference

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Neuroprotective and anti-human immunodeficiency virus activity of minocycline

6 September 2017

1 reference

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Blood-brain barrier drug discovery for central nervous system infections

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Active efflux across the blood-brain barrier: role of the solute carrier family

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Factors affecting delivery of antiviral drugs to the brain

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Independent evolution of human immunodeficiency virus (HIV) drug resistance mutations in diverse areas of the brain in HIV-infected patients, with and without dementia, on antiretroviral treatment

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

ABC transporters and the blood-brain barrier

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Reservoirs of HIV-1 in vivo: implications for antiretroviral therapy

6 September 2017

1 reference

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The equilibrative nucleoside transporter family, SLC29

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Effects of ritonavir on indinavir pharmacokinetics in cerebrospinal fluid and plasma

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Antiretroviral therapy regimens for neuro-AIDS.

6 September 2017

1 reference

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The role of drug transporters at the blood-brain barrier

6 September 2017

1 reference

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Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate.

6 September 2017

1 reference

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Stable concentrations of zidovudine, stavudine, lamivudine, abacavir, and nevirapine in serum and cerebrospinal fluid during 2 years of therapy

6 September 2017

1 reference

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Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity

6 September 2017

1 reference

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Indinavir population pharmacokinetics in plasma and cerebrospinal fluid. The HIV Neurobehavioral Research Center Group

6 September 2017

1 reference

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Persistent CCR5 utilization and enhanced macrophage tropism by primary blood human immunodeficiency virus type 1 isolates from advanced stages of disease and comparison to tissue-derived isolates

6 September 2017

1 reference

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Human immunodeficiency virus-associated dementia: review of pathogenesis, prophylaxis, and treatment studies of zidovudine therapy

6 September 2017

1 reference

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Antiretroviral-drug concentrations in semen: implications for sexual transmission of human immunodeficiency virus type 1

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Localization of HIV-1 co-receptors CCR5 and CXCR4 in the brain of children with AIDS.

6 September 2017

1 reference

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CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Lipid solubility and drug penetration of the blood brain barrier

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Presence of HIV-1 R5 viruses in cerebrospinal fluid even in patients harboring R5X4/X4 viruses in plasma

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Microglia express CCR5, CXCR4, and CCR3, but of these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1 dementia isolates.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Solid lipid nanoparticles enhance the delivery of the HIV protease inhibitor, atazanavir, by a human brain endothelial cell line

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Expression and functionality of anti-human immunodeficiency virus and anticancer drug uptake transporters in immune cells

14 September 2017

1 reference

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The impact of HIV-associated neuropsychological impairment on everyday functioning

14 September 2017

1 reference

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Therapy failure following selection of enfuvirtide-resistant HIV-1 in cerebrospinal fluid

14 September 2017

1 reference

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Lopinavir cerebrospinal fluid steady-state trough concentrations in HIV-infected adults

23 June 2018

1 reference

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Identification of potential HIV-1 targets of minocycline

23 June 2018

1 reference

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Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor.

23 June 2018

1 reference

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In vitro blood-brain barrier permeability of nevirapine compared to other HIV antiretroviral agents.

23 June 2018

1 reference

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Study on didanosine concentrations in cerebrospinal fluid. Implications for the treatment and prevention of AIDS dementia complex

23 June 2018

1 reference

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Cerebrospinal fluid maraviroc concentrations in HIV-1 infected patients.

23 June 2018

1 reference

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Efficacy of cerebrospinal fluid (CSF)-penetrating antiretroviral drugs against HIV in the neurological compartment: different patterns of phenotypic resistance in CSF and plasma

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Minocycline shown to have protection for the brain against HIV. Results of a preclinical study recently published in JAMA.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Cerebrospinal fluid and plasma HIV-1 RNA levels and lopinavir concentrations following lopinavir/ritonavir regimen

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Enhancing antiretroviral therapy for human immunodeficiency virus cognitive disorders

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Suppression of cerebrospinal fluid HIV burden in antiretroviral naive patients on a potent four-drug antiretroviral regimen

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Effect of transport inhibitors and additional anti-HIV drugs on the movement of lamivudine (3TC) across the guinea pig brain barriers

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Changes in CSF and plasma HIV-1 RNA and cognition after starting potent antiretroviral therapy

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Mechanisms by which 2',3'-dideoxyinosine (ddI) crosses the guinea-pig CNS barriers; relevance to HIV therapy

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Differential modulation of P-glycoprotein expression and activity by non-nucleoside HIV-1 reverse transcriptase inhibitors in cell culture

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

The distribution of the anti-HIV drug, 2'3'-dideoxycytidine (ddC), across the blood-brain and blood-cerebrospinal fluid barriers and the influence of organic anion transport inhibitors.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Transport characteristics of the anti-human immunodeficiency virus nucleoside analog, abacavir, into brain and cerebrospinal fluid

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Varied tropism of HIV-1 isolates derived from different regions of adult brain cortex discriminate between patients with and without AIDS dementia complex (ADC): evidence for neurotropic HIV variants.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Evidence for independent development of resistance to HIV-1 reverse transcriptase inhibitors in the cerebrospinal fluid.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Cerebrospinal fluid HIV-1 RNA during treatment with ritonavir/saquinavir or ritonavir/saquinavir/stavudine

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

An antibody-avidin fusion protein specific for the transferrin receptor serves as a delivery vehicle for effective brain targeting: initial applications in anti-HIV antisense drug delivery to the brain.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Cerebrospinal fluid human immunodeficiency virus type 1 (HIV-1) suppression and efavirenz drug concentrations in HIV-1-infected patients receiving combination therapy

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Indinavir-based treatment of HIV-1 infected patients: efficacy in the central nervous system.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Failure to detect nelfinavir in the cerebrospinal fluid of HIV-1--infected patients with and without AIDS dementia complex.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Discordance Between Cerebral Spinal Fluid and Plasma HIV Replication in Patients with Neurological Symptoms Who Are Receiving Suppressive Antiretroviral Therapy

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227164

Plasma population pharmacokinetics and penetration into cerebrospinal fluid of indinavir in combination with zidovudine and lamivudine in HIV-1-infected patients

3 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22514580

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Penetration of zidovudine into the cerebrospinal fluid of patients infected with HIV

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22514580

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22514580%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference