The clinical implications of medulloblastoma subgroups (Q38008153)

26 August 2017

The clinical implications of medulloblastoma subgroups (English)

1 reference

26 August 2017

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Stefan M Pfister

3

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Paul A Northcott

series ordinal

1

object named as

Paul A Northcott

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26 August 2017

2

Andrey Korshunov

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26 August 2017

4

Michael D Taylor

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PubMed ID

22565209

26 August 2017

language of work or name

English

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publication date

8 May 2012

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26 August 2017

Nature Reviews Neurology

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26 August 2017

8

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26 August 2017

6

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26 August 2017

340-351

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https://scigraph.springernature.com/pub.10.1038/nrneurol.2012.78

26 August 2017

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Nodule formation and desmoplasia in medulloblastomas-defining the nodular/desmoplastic variant and its biological behavior.

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Survival and prognostic factors of early childhood medulloblastoma: an international meta-analysis

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Medulloblastoma variants: age-dependent occurrence and relation to Gorlin syndrome--a new clinical perspective

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Preponderance of sonic hedgehog pathway activation characterizes adult medulloblastoma.

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Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.

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Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome

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Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables

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Subtypes of medulloblastoma have distinct developmental origins

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Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

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Medulloblastoma comprises four distinct molecular variants

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Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma

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Adult medulloblastoma comprises three major molecular variants.

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Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

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Molecular subgroups of medulloblastoma: the current consensus

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Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations

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Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

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Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features

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Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct

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FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma

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Role of Wnt pathway in medulloblastoma oncogenesis.

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Altered neural cell fates and medulloblastoma in mouse patched mutants

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Mutations in SUFU predispose to medulloblastoma

21 January 2018

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Heterogeneity of familial medulloblastoma and contribution of germline PTCH1 and SUFU mutations to sporadic medulloblastoma

21 January 2018

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Identification of a SUFU germline mutation in a family with Gorlin syndrome.

21 January 2018

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Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Medulloblastoma: a problem of developmental biology

21 January 2018

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Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation

21 January 2018

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YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation

21 January 2018

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Normal and oncogenic roles for microRNAs in the developing brain

21 January 2018

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The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

N-myc can substitute for insulin-like growth factor signaling in a mouse model of sonic hedgehog-induced medulloblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Molecular diagnostics of CNS embryonal tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Pleiotropic role for MYCN in medulloblastoma.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Joint binding of OTX2 and MYC in promotor regions is associated with high gene expression in medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

OTX1 and OTX2 expression correlates with the clinicopathologic classification of medulloblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Multiplexed measurements of gene signatures in different analytes using the Nanostring nCounter Assay System

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Direct multiplexed measurement of gene expression with color-coded probe pairs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

The SFRP family of WNT inhibitors function as novel tumor suppressor genes epigenetically silenced in medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

An epigenetic genome-wide screen identifies SPINT2 as a novel tumor suppressor gene in pediatric medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Expression of MAGE and GAGE genes in medulloblastoma and modulation of resistance to chemotherapy. Laboratory investigation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

PCDH10 is a candidate tumour suppressor gene in medulloblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

The genetic landscape of the childhood cancer medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Clonal selection drives genetic divergence of metastatic medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Identification of human brain tumour initiating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Medulloblastoma stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Mouse models of medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

An animal model of MYC-driven medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

A mouse model of the most aggressive subgroup of human medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

The origins of medulloblastoma subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

The developmental biology of brain tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

International network of cancer genome projects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Childhood medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Embryonal tumor with abundant neuropil and true rosettes (ETANTR) with a focal amplification at chromosome 19q13.42 locus: further evidence of two new instances in China

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

Incomplete penetrance of the predisposition to medulloblastoma associated with germ-line SUFU mutations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

OTX2 directly activates cell cycle genes and inhibits differentiation in medulloblastoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.78

31 March 2020

1 reference

12 December 2020

Medulloblastoma: presentation, diagnosis and management.

1 reference

12 December 2020

Management of children with primitive neuroectodermal tumors of the posterior fossa/medulloblastoma

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12 December 2020

Mutations of the INI1 rhabdoid tumor suppressor gene in medulloblastomas and primitive neuroectodermal tumors of the central nervous system.

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12 December 2020

Pediatric brain tumors: a contemporary prospectus

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12 December 2020

Monosomy 22 in rhabdoid or atypical teratoid tumors of the brain

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12 December 2020

The cerebellar medulloblastoma and its relationship to primitive neuroectodermal tumors

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12 December 2020

Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid

1 reference

12 December 2020

Sporadic medulloblastomas contain oncogenic beta-catenin mutations.

1 reference

12 December 2020

Genomic amplification of orthodenticle homologue 2 in medulloblastomas

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRNEUROL.2012.78

1 reference

PubMed ID

22565209

Dimensions Publication ID

26 August 2017

0 references

1 reference

PubMed ID

22565209