Organotypic systems in drug metabolism and toxicity: challenges and opportunities (Q38013255)

27 August 2017

Organotypic systems in drug metabolism and toxicity: challenges and opportunities (English)

1 reference

27 August 2017

3

Brian R Wamhoff

1 reference

27 August 2017

2

Brett R Blackman

1 reference

27 August 2017

Ajit Dash

1

1 reference

PubMed ID

22632603

27 August 2017

language of work or name

English

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publication date

26 May 2012

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Expert Opinion on Drug Metabolism & Toxicology

27 August 2017

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27 August 2017

8

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27 August 2017

8

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27 August 2017

999-1014

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Can the pharmaceutical industry reduce attrition rates?

27 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Gene expression in two hepatic cell lines, cultured primary hepatocytes, and liver slices compared to the in vivo liver gene expression in rats: possible implications for toxicogenomics use of in vitro systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Mitochondrial dysfunction and delayed hepatotoxicity: another lesson from troglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Drug-induced liver injury: mechanisms and test systems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Liver tissue engineering in the evaluation of drug safety

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Microscale culture of human liver cells for drug development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Human IL-8 regulates smooth muscle cell VCAM-1 expression in response to endothelial cells exposed to atheroprone flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Atherosclerosis-prone hemodynamics differentially regulates endothelial and smooth muscle cell phenotypes and promotes pro-inflammatory priming

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

The use of a porcine organotypic cornea construct for permeation studies from formulations containing befunolol hydrochloride

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Dynamics of basement membrane formation by keratinocyte-fibroblast interactions in organotypic skin culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Guidance of liver and kidney organotypic cultures inside rectangular silicone microchannels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Organotypic culture of fetal lung type II alveolar epithelial cells: applications to pulmonary toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Gradients in the liver's extracellular matrix chemistry from periportal to pericentral zones: influence on human hepatic progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Zonation of parenchymal and nonparenchymal metabolism in liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Zonation of cytochrome P450 expression, drug metabolism and toxicity in liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Effects of medium composition on the morphology and function of rat hepatocytes cultured as spheroids and monolayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Spheroidal aggregate culture of rat liver cells: histotypic reorganization, biomatrix deposition, and maintenance of functional activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Identification of differentially expressed genes in hepatocyte/endothelial cell co-culture system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Functional behavior of primary rat liver cells in a three-dimensional perfused microarray bioreactor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Perfused multiwell plate for 3D liver tissue engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

A murine tumor producing a matrix of basement membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Identification of multiple active growth factors in basement membrane Matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Hepatocyte proliferation in vitro: its dependence on the use of serum-free hormonally defined medium and substrata of extracellular matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Lineage restriction of human hepatic stem cells to mature fates is made efficient by tissue-specific biomatrix scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Structural polarity and functional bile canaliculi in rat hepatocyte spheroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Monolayer and spheroid culture of human liver hepatocellular carcinoma cell line cells demonstrate distinct global gene expression patterns and functional phenotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Optimizing the enzymatic determination of galactose in the culture medium of rat liver and HepG2 cell spheroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Hepatobiliary disposition of the metabolically stable opioid peptide [D-Pen2, D-Pen5]-enkephalin (DPDPE): pharmacokinetic consequences of the interplay between multiple transport systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Novel approach for achieving double-layered cell sheets co-culture: overlaying endothelial cell sheets onto monolayer hepatocytes utilizing temperature-responsive culture dishes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Elevated expression of hormone-regulated rat hepatocyte functions in a new serum-free hepatocyte-stromal cell coculture model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Hepatocyte growth factor/hepatopoietin A is expressed in fat-storing cells from rat liver but not myofibroblast-like cells derived from fat-storing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Ranitidine treatment during a modest inflammatory response precipitates idiosyncrasy-like liver injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Sinusoidal endothelial cells as a target for acetaminophen toxicity. Direct action versus requirement for hepatocyte activation in different mouse strains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Three-dimensional co-culture of rat hepatocyte spheroids and NIH/3T3 fibroblasts enhances hepatocyte functional maintenance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

A stereotypic, transplantable liver tissue-culture system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Cell patterning technologies for organotypic tissue fabrication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Assessment of a micropatterned hepatocyte coculture system to generate major human excretory and circulating drug metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Layered patterning of hepatocytes in co-culture systems using microfabricated stencils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Hepatocyte and kupffer cells co-cultured on micropatterned surfaces to optimize hepatocyte function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

The applicability of rat and human liver slices to the study of mechanisms of hepatic drug uptake.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Dynamic organ culture of precision liver slices for in vitro toxicology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Hydrogel embedding of precision-cut liver slices in a microfluidic device improves drug metabolic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

In vitro zonation and toxicity in a hepatocyte bioreactor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Rat liver sinusoidal endothelial cells survive without exogenous VEGF in 3D perfused co-cultures with hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Effects of oxygenation and flow on the viability and function of rat hepatocytes cocultured in a microchannel flat-plate bioreactor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

A comparison of whole genome gene expression profiles of HepaRG cells and HepG2 cells to primary human hepatocytes and human liver tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Stem cell-derived hepatocytes and their use in toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Phenobarbital-induced protection against toxicity of toluene and benzene in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Phenobarbital induction of cytochromes P-450. High-level long-term responsiveness of primary rat hepatocyte cultures to drug induction, and glucocorticoid dependence of the phenobarbital response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

A multi-endpoint evaluation of cytochrome P450 1A2, 2B6 and 3A4 induction response in human hepatocyte cultures after treatment with β-naphthoflavone, phenobarbital and rifampicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Interspecies differences in acetaminophen sensitivity of human, rat, and mouse primary hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

Spatial and spectral heterogeneity of time-varying shear stress profiles in the carotid bifurcation by phase-contrast MRI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.693161

10.1517/17425255.2012.693161

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference

PubMed ID

22632603