Paediatric and adult malignant glioma: close relatives or distant cousins? (Q38013990)

27 August 2017

Paediatric and adult malignant glioma: close relatives or distant cousins? (English)

1 reference

27 August 2017

3

1 reference

27 August 2017

Chris Jones

1

0 references

author name string

Lara Perryman

series ordinal

2

1 reference

PubMed ID

22641364

27 August 2017

language of work or name

English

0 references

publication date

29 May 2012

1 reference

Nature Reviews Clinical Oncology

27 August 2017

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27 August 2017

9

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27 August 2017

7

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27 August 2017

400-413

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Grading of astrocytomas. A simple and reproducible method.

21 January 2018

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Limitations of the World Health Organization classification of childhood supratentorial astrocytic tumors. Children Brain Tumor Consortium

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Prognostic limitations of the Daumas-Duport grading scheme in childhood supratentorial astroglial tumors.

21 January 2018

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Neuropathological and neuroradiological spectrum of pediatric malignant gliomas: correlation with outcome.

21 January 2018

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Age-incidence patterns of primary CNS tumors in children, adolescents, and adults in England

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Characterization and outcomes of infratentorial malignant glioma: a population-based study using the Surveillance Epidemiology and End-Results database.

21 January 2018

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Guidelines on management of low-grade gliomas: report of an EFNS-EANO Task Force.

21 January 2018

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Clinical and molecular characteristics of malignant transformation of low-grade glioma in children.

21 January 2018

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Outcome and prognostic features in pediatric gliomas: a review of 6212 cases from the Surveillance, Epidemiology, and End Results database

21 January 2018

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Diffuse brainstem glioma in children: critical review of clinical trials

21 January 2018

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Thalamic high-grade gliomas in children: a distinct clinical subset?

21 January 2018

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Subpopulations of malignant gliomas in pediatric patients: analysis of the HIT-GBM database

21 January 2018

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Pediatric high grade glioma of the spinal cord: results of the HIT-GBM database

21 January 2018

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Randomized phase III trial in childhood high-grade astrocytoma comparing vincristine, lomustine, and prednisone with the eight-drugs-in-1-day regimen. Childrens Cancer Group.

21 January 2018

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Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas

21 January 2018

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A distinct spectrum of copy number aberrations in pediatric high-grade gliomas

21 January 2018

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Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease

21 January 2018

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Genome-wide profiling using single-nucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomas

21 January 2018

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Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas.

21 January 2018

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Genome-wide allelic imbalance analysis of pediatric gliomas by single nucleotide polymorphic allele array.

21 January 2018

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Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

21 January 2018

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Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

21 January 2018

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Cross-species genomics matches driver mutations and cell compartments to model ependymoma

21 January 2018

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Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors

21 January 2018

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Malignant gliomas with primitive neuroectodermal tumor-like components: a clinicopathologic and genetic study of 53 cases.

21 January 2018

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Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets.

21 January 2018

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

21 January 2018

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An integrated genomic analysis of human glioblastoma multiforme

21 January 2018

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EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines

21 January 2018

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Innovative Therapies for Children with Cancer pediatric phase I study of erlotinib in brainstem glioma and relapsing/refractory brain tumors

21 January 2018

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Genetic alterations in pediatric high-grade astrocytomas.

21 January 2018

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Heterozygosity status of 1p and 19q and its correlation with p53 protein expression and EGFR amplification in patients with astrocytic tumors: novel series from India.

21 January 2018

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Molecular genetic analysis of the TP53, PTEN, CDKN2A, EGFR, CDK4 and MDM2 tumour-associated genes in supratentorial primitive neuroectodermal tumours and glioblastomas of childhood.

21 January 2018

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Molecular pathogenesis of pediatric astrocytic tumors

21 January 2018

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Preferential inactivation of the p53 tumor suppressor pathway and lack of EGFR amplification distinguish de novo high grade pediatric astrocytomas from de novo adult astrocytomas

21 January 2018

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Pediatric glioblastomas: a histopathological and molecular genetic study

21 January 2018

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Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma

21 January 2018

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Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities.

21 January 2018

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Tyrosine kinase expression in pediatric high grade astrocytoma

21 January 2018

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Protein expression of platelet-derived growth factor receptor correlates with malignant histology and PTEN with survival in childhood gliomas

21 January 2018

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Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased YB-1 expression in tumors.

21 January 2018

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Gene expression profiling from formalin-fixed paraffin-embedded tumors of pediatric glioblastoma

21 January 2018

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Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis

21 January 2018

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Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

21 January 2018

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MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature

21 January 2018

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Prognostic significance of histological grading, p53 status, YKL-40 expression, and IDH1 mutations in pediatric high-grade gliomas

21 January 2018

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Expression of p53, EGFR, pRb and bcl-2 proteins in pediatric glioblastoma multiforme: a study of 54 patients

21 January 2018

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Expression of p53 and prognosis in children with malignant gliomas.

21 January 2018

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IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children's Oncology Group

21 January 2018

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IDH1 and IDH2 mutations in gliomas.

21 January 2018

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

21 January 2018

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Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells

21 January 2018

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The genetic landscape of the childhood cancer medulloblastoma

21 January 2018

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Targeted therapy for BRAFV600E malignant astrocytoma.

21 January 2018

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BRAF activation induces transformation and then senescence in human neural stem cells: a pilocytic astrocytoma model.

21 January 2018

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Genetic aberrations leading to MAPK pathway activation mediate oncogene-induced senescence in sporadic pilocytic astrocytomas

21 January 2018

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Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas

21 January 2018

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Prospective study of awake craniotomy used routinely and nonselectively for supratentorial tumors.

21 January 2018

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Prospective collection of tissue samples at autopsy in children with diffuse intrinsic pontine glioma

21 January 2018

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Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma

21 January 2018

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Genomic aberrations in pediatric diffuse intrinsic pontine gliomas

21 January 2018

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Critical oncogenic mutations in newly diagnosed pediatric diffuse intrinsic pontine glioma.

21 January 2018

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Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma

21 January 2018

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Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma

21 January 2018

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Subtypes of medulloblastoma have distinct developmental origins

21 January 2018

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Mosaic analysis with double markers reveals tumor cell of origin in glioma

21 January 2018

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Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma

21 January 2018

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21 January 2018

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Joint NCCTG and NABTC prognostic factors analysis for high-grade recurrent glioma

21 January 2018

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Supratentorial anaplastic gliomas in adults. The prognostic importance of extent of resection and prior low-grade glioma

21 January 2018

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Current neurosurgical management and the impact of the extent of resection in the treatment of malignant gliomas of childhood: a report of the Children's Cancer Group trial no. CCG-945.

21 January 2018

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Magnetic resonance scans should replace biopsies for the diagnosis of diffuse brain stem gliomas: a report from the Children's Cancer Group.

21 January 2018

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Pontine glioma. To biopsy or not to biopsy: that is the question.

21 January 2018

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Diffuse intrinsic pontine glioma (DIPG): time to biopsy again?

21 January 2018

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Radiotherapy for newly diagnosed malignant glioma in adults: a systematic review

21 January 2018

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Hypofractionated radiotherapy as palliative treatment in poor prognosis patients with high grade glioma.

21 January 2018

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The role of hypofractionation radiotherapy for diffuse intrinsic brainstem glioma in children: a pilot study

21 January 2018

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Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults.

21 January 2018

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Changing paradigms--an update on the multidisciplinary management of malignant glioma

21 January 2018

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Chemotherapy for high-grade gliomas of childhood

21 January 2018

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Chemotherapy for high-grade gliomas

21 January 2018

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The effectiveness of chemotherapy for treatment of high grade astrocytoma in children: results of a randomized trial. A report from the Childrens Cancer Study Group

21 January 2018

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The influence of central review on outcome associations in childhood malignant gliomas: results from the CCG-945 experience

21 January 2018

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Outcome of children treated with preradiation chemotherapy for a high-grade glioma: results of a French Society of Pediatric Oncology (SFOP) Pilot Study.

21 January 2018

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Pathologist interobserver variability of histologic features in childhood brain tumors: results from the CCG-945 study.

21 January 2018

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Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

21 January 2018

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Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

21 January 2018

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Temozolomide in the treatment of high-grade gliomas in children: a report from the Children's Oncology Group

21 January 2018

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Temozolomide in the treatment of children with newly diagnosed diffuse intrinsic pontine gliomas: a report from the Children's Oncology Group

21 January 2018

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Radiotherapy with concurrent and adjuvant temozolomide in children with newly diagnosed diffuse intrinsic pontine glioma

21 January 2018

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High-grade glioma in children under 5 years of age: a chemotherapy only approach with the BBSFOP protocol.

21 January 2018

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Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response

21 January 2018

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Receptor tyrosine kinase genes amplified in glioblastoma exhibit a mutual exclusivity in variable proportions reflective of individual tumor heterogeneity.

21 January 2018

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Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma.

21 January 2018

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Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises

21 January 2018

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Enhanced efficacy of IGF1R inhibition in pediatric glioblastoma by combinatorial targeting of PDGFRα/β.

21 January 2018

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Perifosine and CCI 779 co-operate to induce cell death and decrease proliferation in PTEN-intact and PTEN-deficient PDGF-driven murine glioblastoma

21 January 2018

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Antiangiogenic agents for the treatment of glioblastoma

21 January 2018

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Signal transduction inhibitors and antiangiogenic therapies for malignant glioma

21 January 2018

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PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation.

21 January 2018

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Pediatric high-grade glioma: identification of poly(ADP-ribose) polymerase as a potential therapeutic target.

21 January 2018

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Immunotherapy for the treatment of glioblastoma

21 January 2018

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Novel delivery strategies for glioblastoma

21 January 2018

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Capturing the molecular and biological diversity of high-grade astrocytoma in genetically engineered mouse models

21 January 2018

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The use of immortalized cell lines in GPCR screening: the good, bad and ugly.

21 January 2018

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Identification of human brain tumour initiating cells

21 January 2018

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The genomic profile of human malignant glioma is altered early in primary cell culture and preserved in spheroids.

21 January 2018

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Molecular characterization of the pediatric preclinical testing panel

21 January 2018

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Direct orthotopic transplantation of fresh surgical specimen preserves CD133+ tumor cells in clinically relevant mouse models of medulloblastoma and glioma.

21 January 2018

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Cancer stem cells in nervous system tumors

21 January 2018

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Clinical relevance of tumor cells with stem-like properties in pediatric brain tumors.

21 January 2018

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An efficient method for derivation and propagation of glioblastoma cell lines that conserves the molecular profile of their original tumours

21 January 2018

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Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens

21 January 2018

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Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines

21 January 2018

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Inhibition of notch signaling in glioblastoma targets cancer stem cells via an endothelial cell intermediate

21 January 2018

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The pediatric preclinical testing program: description of models and early testing results.

21 January 2018

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Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing program

21 January 2018

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Combination testing (Stage 2) of the Anti-IGF-1 receptor antibody IMC-A12 with rapamycin by the pediatric preclinical testing program.

21 January 2018

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Combination testing of cediranib (AZD2171) against childhood cancer models by the pediatric preclinical testing program.

21 January 2018

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Diffuse glioma growth: a guerilla war

21 January 2018

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Monitoring of tumor growth and post-irradiation recurrence in a diffuse intrinsic pontine glioma mouse model

21 January 2018

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An experimental xenograft mouse model of diffuse pontine glioma designed for therapeutic testing

21 January 2018

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A human brainstem glioma xenograft model enabled for bioluminescence imaging

21 January 2018

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Genetic modeling of gliomas in mice: new tools to tackle old problems

21 January 2018

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Non-germline genetically engineered mouse models for translational cancer research

21 January 2018

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Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain

21 January 2018

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Treatment of recurrent malignant supratentorial gliomas with carboplatin (CBDCA).

21 January 2018

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Carboplatin in childhood brain tumors. A Children's Cancer Study Group Phase II trial.

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Cisplatin in the treatment of recurrent childhood primary brain tumors.

21 January 2018

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PCNU and recurrent childhood brain tumors

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Phase II study of prolonged oral therapy with etoposide (VP16) for patients with recurrent malignant glioma.

21 January 2018

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Recurrent brainstem gliomas treated with oral VP-16.

21 January 2018

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Recurrent supratentorial malignant gliomas in children. Long-term salvage therapy with oral etoposide

21 January 2018

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Phase II study of ifosfamide with mesna in adult patients with recurrent diffuse astrocytoma.

21 January 2018

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Identifiers

DOI

1 reference

27 August 2017

1 reference

PubMed ID

22641364