Making sense of therapeutics using antisense technology (Q38014478)

27 August 2017

Making sense of therapeutics using antisense technology (English)

1 reference

27 August 2017

Ravinder Malik

1

1 reference

PubMed ID

22646076

27 August 2017

Ipsita Roy

series ordinal

2

1 reference

PubMed ID

22646076

27 August 2017

language of work or name

English

0 references

publication date

16 March 2011

1 reference

Expert Opinion on Drug Discovery

27 August 2017

1 reference

27 August 2017

6

1 reference

27 August 2017

5

1 reference

27 August 2017

507-526

1 reference

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

27 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

21 January 2018

In search of antisense

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

The plasticity of the mammalian transcriptome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

What are natural antisense transcripts good for?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Natural antisense transcripts regulate gene expression in an epigenetic manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Natural antisense transcripts of hypoxia-inducible factor 1alpha are detected in different normal and tumour human tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Natural antisense transcripts are co-expressed with sense mRNAs in synaptoneurosomes of adult mouse forebrain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62(P392L) mutation to Paget's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Endothelial ICAM-1 protein induction is regulated by cytosolic phospholipase A2α via both NF-κB and CREB transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Design and development of antisense drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Development of aptamer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Role of RNase H in hybrid-arrested translation by antisense oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Influence of base-pairing in the leader region on in vitro translation of Rous sarcoma virus RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Short peptide nucleic acids (PNA) inhibit hepatitis C virus internal ribosome entry site (IRES) dependent translation in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Nuclear antisense RNA induces extensive adenosine modifications and nuclear retention of target transcripts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Natural antisense transcripts: sound or silence?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Regulation of microRNA by antagomirs: a new class of pharmacological antagonists for the specific regulation of gene function?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Silencing of microRNAs in vivo with 'antagomirs'

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Evaluation of retinal toxicity and efficacy of anti-cytomegalovirus and anti-herpes simplex virus antiviral phosphorothioate oligonucleotides ISIS 2922 and ISIS 4015.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Novel therapies for cytomegalovirus disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Targeting transcription factor Stat4 uncovers a role for interleukin-18 in the pathogenesis of severe lupus nephritis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Administration of antisense oligonucleotides to Galpha(Q/11) reduces the severity of murine lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Gonadotropin-releasing hormone: potential role in autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Analysis of the influence of PTPN22 gene polymorphisms in systemic sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Conjugation of antisense oligonucleotides to PEGylated carbon nanotubes enables efficient knockdown of PTPN22 in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Antisense treatment for myasthenia gravis: experience with monarsen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Accelerated wound healing by smad3 antisense oligonucleotides-impregnated chitosan/alginate polyelectrolyte complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Propionic and methylmalonic acidemia: antisense therapeutics for intronic variations causing aberrantly spliced messenger RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Present and future of antisense therapy for splicing modulation in inherited metabolic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Inhibition of cell proliferation and glucose uptake in human laryngeal carcinoma cells by antisense oligonucleotides against glucose transporter-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2'-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

A phase I study of OGX-011, a 2'-methoxyethyl phosphorothioate antisense to clusterin, in combination with docetaxel in patients with advanced cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Selective targeting of HPV-16 E6/E7 in cervical cancer cells with a potent oncolytic adenovirus and its enhanced effect with radiotherapy in vitro and vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Activation of the interleukin-32 pro-inflammatory pathway in response to human papillomavirus infection and over-expression of interleukin-32 controls the expression of the human papillomavirus oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Advanced antisense therapies for postexposure protection against lethal filovirus infections.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Age at first viral infection determines the pattern of T cell-mediated disease during reinfection in adulthood

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Immunomodulation with IL-4R alpha antisense oligonucleotide prevents respiratory syncytial virus-mediated pulmonary disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Gene silencing of HIV chemokine receptors using ribozymes and single-stranded antisense RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Mipomersen, an antisense apolipoprotein B synthesis inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Effect of mipomersen, an apolipoprotein B synthesis inhibitor, on low-density lipoprotein cholesterol in patients with familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

PCSK9: an emerging target for treatment of hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Progress in therapeutic antisense applications for neuromuscular disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Antisense modulation of both exonic and intronic splicing motifs induces skipping of a DMD pseudo-exon responsible for x-linked dilated cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

The predicted structure of the headpiece of the Huntingtin protein and its implications on Huntingtin aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Loss of normal huntingtin function: new developments in Huntington's disease research

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Allele-selective inhibition of mutant huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Antisense oligonucleotides effectively inhibit the co-transcriptional splicing of a Candida group I intron in vitro and in vivo: Implications for antifungal therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Drug delivery trends in clinical trials and translational medicine: challenges and opportunities in the delivery of nucleic acid-based therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Knocking down barriers: advances in siRNA delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Controlled delivery of antisense oligonucleotides: a brief review of current strategies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Free-radical ring closure to conformationally locked α-L-carba-LNAs and synthesis of their oligos: nuclease stability, target RNA specificity, and elicitation of RNase H.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

2'-O-Lysylaminohexyl oligonucleotides: modifications for antisense and siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Transferrin receptor targeted lipopolyplexes for delivery of antisense oligonucleotide g3139 in a murine k562 xenograft model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

An efficient biodelivery system for antisense polyamide nucleic acid (PNA).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Peptide nucleic acids (PNAs) antisense effect to bacterial growth and their application potentiality in biotechnology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Effect of sodium caprate on the intestinal absorption of two modified antisense oligonucleotides in pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Oral bioavailability and multiple dose tolerability of an antisense oligonucleotide tablet formulated with sodium caprate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Oral delivery of antisense oligonucleotides in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Integration of adeno-associated virus 2 DNA in human MKR melanoma cells induces a peptide with oncosuppressive properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Long-term benefit of adeno-associated virus/antisense-mediated exon skipping in dystrophic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Antisense hypoxia-inducible factor-1alpha augments transcatheter arterial embolization in the treatment of hepatocellular carcinomas in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Knocking down gene expression with dendritic vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Generation 4 polyamidoamine dendrimers is a novel candidate of nano-carrier for gene delivery agents in breast cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Inhibition of brain tumor growth by intravenous poly (β-L-malic acid) nanobioconjugate with pH-dependent drug release [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Inhibition of lung tumor growth by complex pulmonary delivery of drugs with oligonucleotides as suppressors of cellular resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Antitumor vectorized oligonucleotides in a model of ewing sarcoma: unexpected role of nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Topical and intravitreous administration of cationic nanoemulsions to deliver antisense oligonucleotides directed towards VEGF KDR receptors to the eye.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Influence of emulsion droplet surface charge on indomethacin ocular tissue distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Cellular delivery and antisense effects of peptide nucleic acid conjugated to polyethyleneimine via disulfide linkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Cellular delivery and biological activity of antisense oligonucleotides conjugated to a targeted protein carrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Inhibition of ataxia-telangiectasia mutated by antisense oligonucleotide nanoparticles induces radiosensitization of head and neck squamous-cell carcinoma in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Antitumor mechanisms of systemically administered epidermal growth factor receptor antisense oligonucleotides in combination with docetaxel in squamous cell carcinoma of the head and neck

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Randomized phase II study of docetaxel and prednisone with or without OGX-011 in patients with metastatic castration-resistant prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Direct comparison of the specificity of gene silencing using antisense oligonucleotides and RNAi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Restoration of the balanced alpha/beta-globin gene expression in beta654-thalassemia mice using combined RNAi and antisense RNA approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Improving the efficiency of RNA interference in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Role of the double-stranded RNA-activated protein kinase (PKR) in cell regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

The 2-5A system: modulation of viral and cellular processes through acceleration of RNA degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Killing the messenger: short RNAs that silence gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

RNA interference is mediated by 21- and 22-nucleotide RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Genomewide view of gene silencing by small interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Activation of the interferon system by short-interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Phase I study of MG98, an oligonucleotide antisense inhibitor of human DNA methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Spleen-specific suppression of TNF-alpha by cationic hydrogel-delivered antisense nucleotides for the prevention of arthritis in animal models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Reversion of multidrug resistance by tumor targeted delivery of antisense oligodeoxynucleotides in hydroxypropyl-chitosan nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Development of an antisense RNA delivery system using conjugates of the MS2 bacteriophage capsids and HIV-1 TAT cell-penetrating peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Improved cellular activity of antisense peptide nucleic acids by conjugation to a cationic peptide-lipid (CatLip) domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

Delivery of NADPH-cytochrome P450 reductase antisense oligos using avidin-biotin approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

A fusion peptide directs enhanced systemic dystrophin exon skipping and functional restoration in dystrophin-deficient mdx mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.565744

10.1517/17460441.2011.565744

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference

PubMed ID

22646076