Imaging agents for the chemokine receptor 4 (CXCR4). (Q38022430)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22743644%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

Imaging agents for the chemokine receptor 4 (CXCR4) (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22743644%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22743644%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Fijs W.B. van Leeuwen

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22743644%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1

Joeri Kuil

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22743644%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

publication date

28 June 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22743644%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

published in

Chemical Society Reviews

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22743644%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

volume

41

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22743644%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

issue

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22743644%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

page(s)

5239-5261

1 reference

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CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion

6 February 2020

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Tumor imaging and therapy using radiolabeled somatostatin analogues.

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CXCR4 is expressed in ductal carcinoma in situ of the breast and in atypical ductal hyperplasia

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Strong expression of chemokine receptor CXCR4 by renal cell carcinoma correlates with advanced disease

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The influence of tumor-host interactions in the stromal cell-derived factor-1/CXCR4 ligand/receptor axis in determining metastatic risk in breast cancer

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21 January 2018

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Expression of chemokine receptor CXCR4 in esophageal squamous cell and adenocarcinoma

21 January 2018

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CXCR4 expression is elevated in glioblastoma multiforme and correlates with an increase in intensity and extent of peritumoral T2-weighted magnetic resonance imaging signal abnormalities

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21 January 2018

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21 January 2018

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Positron emission tomography imaging of tumors expressing the human chemokine receptor CXCR4 in mice with the use of 64Cu-AMD3100

21 January 2018

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PET imaging of CXCR4 receptors in cancer by a new optimized ligand

21 January 2018

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Design, synthesis, and functionalization of dimeric peptides targeting chemokine receptor CXCR4.

21 January 2018

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21 January 2018

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Molecular imaging of CXCR4 receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography

21 January 2018

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Imaging CXCR4 expression in human cancer xenografts: evaluation of monocyclam 64Cu-AMD3465.

21 January 2018

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A novel anti-HIV synthetic peptide, T-22 ([Tyr5,12,Lys7]-polyphemusin II)

21 January 2018

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A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140.

21 January 2018

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A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists

21 January 2018

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21 January 2018

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21 January 2018

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Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes

21 January 2018

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21 January 2018

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Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140.

21 January 2018

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Conformational study of a highly specific CXCR4 inhibitor, T140, disclosing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity

21 January 2018

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Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives

21 January 2018

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Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists

21 January 2018

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21 January 2018

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Discovery of novel, highly potent and selective beta-hairpin mimetic CXCR4 inhibitors with excellent anti-HIV activity and pharmacokinetic profiles

21 January 2018

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Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs.

21 January 2018

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21 January 2018

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21 January 2018

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Targeted non-covalent self-assembled nanoparticles based on human serum albumin

21 January 2018

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Fluorescent imaging of high-grade bladder cancer using a specific antagonist for chemokine receptor CXCR4.

21 January 2018

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Peptide-functionalized luminescent iridium complexes for lifetime imaging of CXCR4 expression.

21 January 2018

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New strategies for fluorescent probe design in medical diagnostic imaging

21 January 2018

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Concise site-specific synthesis of DTPA-peptide conjugates: application to imaging probes for the chemokine receptor CXCR4.

21 January 2018

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Synthesis and in vitro evaluation of 68Ga-DOTA-4-FBn-TN14003, a novel tracer for the imaging of CXCR4 expression

21 January 2018

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Simplified syntheses of complex multifunctional nanomaterials

21 January 2018

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Divergent oriented synthesis for the design of reagents for protein conjugation

21 January 2018

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Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries

21 January 2018

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Synthesis and biological evaluation of selective CXCR4 antagonists containing alkene dipeptide isosteres

21 January 2018

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Molecular modeling study of cyclic pentapeptide CXCR4 antagonists: new insight into CXCR4-FC131 interactions.

21 January 2018

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Insight into the binding mode for cyclopentapeptide antagonists of the CXCR4 receptor.

21 January 2018

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Computational analysis of the structural mechanism of inhibition of chemokine receptor CXCR4 by small molecule antagonists

21 January 2018

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Identification of novel low molecular weight CXCR4 antagonists by structural tuning of cyclic tetrapeptide scaffolds.

21 January 2018

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Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalities

21 January 2018

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Topochemical exploration of potent compounds using retro-enantiomer libraries of cyclic pentapeptides

21 January 2018

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Structure-activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2CS35085H

Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131.

21 January 2018

1 reference

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Design and synthesis of all diastereomers of cyclic pseudo-dipeptides as mimics of cyclic CXCR4 pentapeptide antagonists.

21 January 2018

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Structure-activity relationship study of CXCR4 antagonists bearing the cyclic pentapeptide scaffold: identification of the new pharmacophore

21 January 2018

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Potent CXCR4 antagonists containing amidine type Peptide bond isosteres

21 January 2018

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The cyclic pentapeptide d-Arg3FC131, a CXCR4 antagonist, induces apoptosis of somatotrope tumor and inhibits tumor growth in nude mice

21 January 2018

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Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event

21 January 2018

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Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100

21 January 2018

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Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4

21 January 2018

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AMD3100 is a CXCR7 ligand with allosteric agonist properties

21 January 2018

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ATP-dependent activation of the intermediate conductance, Ca2+-activated K+ channel, hIK1, is conferred by a C-terminal domain

21 January 2018

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Metal ion enhanced binding of AMD3100 to Asp262 in the CXCR4 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Novel monocyclam derivatives as HIV entry inhibitors: Design, synthesis, anti-HIV evaluation, and their interaction with the CXCR4 co-receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit HIV replication. Effects of macrocyclic ring size and substituents on the aromatic linker

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2CS35085H

AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Identification of a new class of low molecular weight antagonists against the chemokine receptor CXCR4 having the dipicolylamine-zinc(II) complex structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Configurationally restricted bismacrocyclic CXCR4 receptor antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Small molecule CXCR4 chemokine receptor antagonists: developing drug candidates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Probing key coordination interactions: configurationally restricted metal activated CXCR4 antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Discovery of small molecule CXCR4 antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Binding optimization through coordination chemistry: CXCR4 chemokine receptor antagonists from ultrarigid metal complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Targeting SDF-1/CXCL12 with a ligand that prevents activation of CXCR4 through structure-based drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Synthesis and SAR of novel CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Comparison of the potential multiple binding modes of bicyclam, monocylam, and noncyclam small-molecule CXC chemokine receptor 4 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

The AMD3100 story: the path to the discovery of a stem cell mobilizer (Mozobil).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Update on clinical experience with AMD3100, an SDF-1/CXCL12-CXCR4 inhibitor, in mobilization of hematopoietic stem and progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Plerixafor: a review of its use in stem-cell mobilization in patients with lymphoma or multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

How I treat patients who mobilize hematopoietic stem cells poorly

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2CS35085H

Fluorescent CXCR4 chemokine receptor antagonists: metal activated binding

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2CS35085H

Evaluation of a fluorescent derivative of AMD3100 and its interaction with the CXCR4 chemokine receptor.

21 January 2018

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64Cu-AMD3100--a novel imaging agent for targeting chemokine receptor CXCR4.

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Development of a unique small molecule modulator of CXCR4

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

A CXCR4 antagonist CTCE-9908 inhibits primary tumor growth and metastasis of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Effects of CXCR4 antagonist CTCE-9908 on prostate tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Evaluation of a CXCR4 antagonist in a xenograft mouse model of inflammatory breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

The CXCR4 agonist peptide, CTCE-0021, rapidly mobilizes polymorphonuclear neutrophils and hematopoietic progenitor cells into peripheral blood and synergizes with granulocyte colony-stimulating factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

The role of positively charged residues in CXCR4 recognition probed with synthetic peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

A small-molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Safe use of the CXCR4 inhibitor ALX40-4C in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Structure-function relationship of novel X4 HIV-1 entry inhibitors - L- and D-arginine peptide-aminoglycoside conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Novel compounds containing multiple guanide groups that bind the HIV coreceptor CXCR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Efficient signaling platforms built from a small catalytic DNA and doubly labeled fluorogenic substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Fluorescent CXCL12AF647 as a novel probe for nonradioactive CXCL12/CXCR4 cellular interaction studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Near-infrared molecular imaging of tumors via chemokine receptors CXCR4 and CXCR7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Characterization and visualization of [125I] stromal cell-derived factor-1alpha binding to CXCR4 receptors in rat brain and human neuroblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Quantitation of CXCR4 expression in myocardial infarction using 99mTc-labeled SDF-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Production of multimeric prostate-specific membrane antigen small-molecule radiotracers using a solid-phase 99mTc preloading strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Differential processing of stromal-derived factor-1alpha and stromal-derived factor-1beta explains functional diversity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Stromal cell-derived factor-1 retention and cardioprotection for ischemic myocardium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Immunoimaging of CXCR4 expression in brain tumor xenografts using SPECT/CT

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Antigenically distinct conformations of CXCR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

CD4-independent infection by HIV-2 is mediated by fusin/CXCR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

N-linked glycosylation of CXCR4 masks coreceptor function for CCR5-dependent human immunodeficiency virus type 1 isolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

The role of N-glycosylation sites on the CXCR4 receptor for CXCL-12 binding and signaling and X4 HIV-1 viral infectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Exploiting the enhanced permeability and retention effect for tumor targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Antibody-protein A conjugated quantum dots for multiplexed imaging of surface receptors in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Detection of CXCR4 receptors on cell surface using a fluorescent metal nanoshell

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Direct interaction between an allosteric agonist pepducin and the chemokine receptor CXCR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Bioluminescent CXCL12 fusion protein for cellular studies of CXCR4 and CXCR7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

In vivo imaging of ligand receptor binding with Gaussia luciferase complementation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Imaging chemokine receptor dimerization with firefly luciferase complementation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Bioluminescence resonance energy transfer reveals ligand-induced conformational changes in CXCR4 homo- and heterodimers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Imaging CXCR4 signaling with firefly luciferase complementation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Quantitative PET of EGFR expression in xenograft-bearing mice using 64Cu-labeled cetuximab, a chimeric anti-EGFR monoclonal antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H

Design and synthesis of amidine-type peptide bond isosteres: application of nitrile oxide derivatives as active ester equivalents in peptide and peptidomimetics synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35085H