Regulatory T cells, mTOR kinase, and metabolic activity (Q38023734)

27 August 2017

Regulatory T cells, mTOR kinase, and metabolic activity (English)

1 reference

27 August 2017

Claudio Procaccini

1

1 reference

PubMed ID

22760498

27 August 2017

Giuseppe Matarese

series ordinal

2

1 reference

27 August 2017

4 July 2012

1 reference

Cellular and Molecular Life Sciences

27 August 2017

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27 August 2017

69

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27 August 2017

23

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27 August 2017

3975-3987

1 reference

https://scigraph.springernature.com/pub.10.1007/s00018-012-1058-6

27 August 2017

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cites work

Regulatory T cells and immune tolerance

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Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

21 January 2018

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CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

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Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells.

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Targeting IL-1beta in disease; the expanding role of NLRP3 inflammasome

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Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis

21 January 2018

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Adipose tissue distribution and risk of metabolic disease: does thiazolidinedione-induced adipose tissue redistribution provide a clue to the answer?

21 January 2018

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The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity

21 January 2018

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Statins' immunomodulatory potential against Th17 cell-mediated autoimmune response

21 January 2018

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Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

21 January 2018

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The intricate interface between immune system and metabolism

21 January 2018

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An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness.

21 January 2018

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Intracellular metabolic pathways control immune tolerance.

21 January 2018

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Leptin as an immunomodulator

21 January 2018

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21 January 2018

Expanding mTOR signaling

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The AMP-activated protein kinase pathway--new players upstream and downstream.

21 January 2018

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Foxo: in command of T lymphocyte homeostasis and tolerance

21 January 2018

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Revving the engine: signal transduction fuels T cell activation.

21 January 2018

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The CD28 signaling pathway regulates glucose metabolism

21 January 2018

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Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells

21 January 2018

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The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells

21 January 2018

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Anergic T cells are metabolically anergic

21 January 2018

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Regulation of T lymphocyte metabolism

21 January 2018

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Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma

21 January 2018

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Fuel feeds function: energy metabolism and the T-cell response

21 January 2018

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mTOR signalling and metabolic regulation of T cell differentiation

21 January 2018

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The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism

21 January 2018

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mTOR: from growth signal integration to cancer, diabetes and ageing

21 January 2018

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Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes

21 January 2018

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Adiponectin is a negative regulator of antigen-activated T cells.

21 January 2018

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Current development of mTOR inhibitors as anticancer agents

21 January 2018

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mTOR signaling at a glance

21 January 2018

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Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis

21 January 2018

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Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress

21 January 2018

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Immunoregulatory functions of mTOR inhibition.

21 January 2018

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Origins of CD4(+) effector and central memory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Plasticity of CD4+ T cell lineage differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Sirolimus enhances the magnitude and quality of viral-specific CD8+ T-cell responses to vaccinia virus vaccination in rhesus macaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

mTOR regulates memory CD8 T-cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

The TSC-mTOR signaling pathway regulates the innate inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Mechanisms of foxp3+ T regulatory cell-mediated suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Defective regulatory and effector T cell functions in patients with FOXP3 mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Inhibitory feedback loop between tolerogenic dendritic cells and regulatory T cells in transplant tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Control of Foxp3+ CD25+CD4+ regulatory cell activation and function by dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

NKT cells, Treg, and their interactions in bone marrow transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Regulatory T cells and regulatory natural killer (NK) cells play important roles in feto-maternal tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Cutting edge: Regulatory T cells directly suppress B cells in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Regulatory T cells and dendritic cells in transplantation tolerance: molecular markers and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Regulatory T cells and their role in pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Regulatory T cells in pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

T regulatory cells in childhood asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Role of Treg in immune regulation of allergic diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Interleukin-2 receptor signaling in regulatory T cell development and homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Nonredundant roles for Stat5a/b in directly regulating Foxp3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Cutting edge: Foxp3-mediated induction of pim 2 allows human T regulatory cells to preferentially expand in rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Regulatory T-cell immunity and its relevance to atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

How suppressor cells led to anergy, costimulation, and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Impact of culture medium on the expansion of T cells for immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Nutritional programming of the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Inflammation and metabolic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Adipocytokines and the metabolic complications of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health span

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Direct and macrophage-mediated actions of fatty acids causing insulin resistance in muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Role of macrophage tissue infiltration in obesity and insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Normalization of obesity-associated insulin resistance through immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Reversal of Behavioral and Metabolic Abnormalities, and Insulin Resistance Syndrome, by Dietary Restriction in Mice Deficient in Brain-Derived Neurotrophic Factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

The effects of dietary restriction on immune function and development of autoimmune disease in BXSB mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Leptin modulates the survival of autoreactive CD4+ T cells through the nutrient/energy-sensing mammalian target of rapamycin signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Body size and risk of MS in two cohorts of US women

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Chronic calorie restriction attenuates experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Leptin is a link between adipose tissue and inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Treatment with rapamycin ameliorates clinical and histological signs of protracted relapsing experimental allergic encephalomyelitis in Dark Agouti rats and induces expansion of peripheral CD4+CD25+Foxp3+ regulatory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Rapamycin inhibits relapsing experimental autoimmune encephalomyelitis by both effector and regulatory T cells modulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Use of a cocktail regimen consisting of soluble galectin-1, rapamycin and histone deacetylase inhibitor may effectively prevent type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

FOXO-dependent regulation of innate immune homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

T-ing up inflammation in fat

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Effects of Salicylate, Tolbutamide, and Prostaglandin E2 on Insulin Responses to Glucose in Noninsulin- Dependent Diabetes Mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Foxp3-dependent programme of regulatory T-cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1058-6

Novel immunomodulatory effects of adiponectin on dendritic cell functions

21 January 2018

1 reference

12 December 2020

Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycin

1 reference

12 December 2020

Adipokines and the immune system: an adipocentric view.

1 reference

12 December 2020

Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo

1 reference

12 December 2020

Association between infant growth before onset of juvenile type-1 diabetes and autoantibodies to IA-2. Netherlands Kolibrie study group of childhood diabetes

1 reference

12 December 2020

Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production

1 reference

12 December 2020

Metabolic changes in activated T cells: an NMR study of human peripheral blood lymphocytes.

1 reference

12 December 2020

Direct activation of mTOR in B lymphocytes confers impairment in B-cell maturation andloss of marginal zone B cells

1 reference

12 December 2020

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

1 reference

12 December 2020

Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4+ T

1 reference

12 December 2020

Age associated alterations in costimulatory and adhesion molecule expression in lupus-prone mice are attenuated by food restriction with n-6 and n-3 fatty acids

1 reference

12 December 2020

A key role of leptin in the control of regulatory T cell proliferation

1 reference

12 December 2020

10.1007/S00018-012-1058-6

Identifiers

DOI

1 reference

27 August 2017

1 reference

PubMed ID

22760498