Integrin bi-directional signaling across the plasma membrane (Q38024314)

27 August 2017

title

Integrin bi-directional signaling across the plasma membrane (English)

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27 August 2017

Ping Hu

1

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27 August 2017

Bing-Hao Luo

series ordinal

2

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27 August 2017

publication date

1 February 2013

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Journal of Cellular Physiology

27 August 2017

published in

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27 August 2017

volume

228

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27 August 2017

issue

2

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27 August 2017

page(s)

306-312

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Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation

27 August 2017

cites work

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The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.

21 January 2018

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Src kinase activation by direct interaction with the integrin β cytoplasmic domain

21 January 2018

1 reference

RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity

21 January 2018

1 reference

21 January 2018

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Control of cell adhesion dynamics by Rap1 signaling

21 January 2018

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Linking Rap to cell adhesion

21 January 2018

1 reference

21 January 2018

1 reference

The phosphotyrosine binding-like domain of talin activates integrins

21 January 2018

1 reference

Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling

21 January 2018

1 reference

Requirement of open headpiece conformation for activation of leukocyte integrin αXβ2

21 January 2018

1 reference

Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner

21 January 2018

1 reference

Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction

21 January 2018

1 reference

Protease-activated receptors in hemostasis, thrombosis and vascular biology

21 January 2018

1 reference

FERM domain interaction promotes FAK signaling

21 January 2018

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Intact alphaIIbbeta3 integrin is extended after activation as measured by solution X-ray scattering and electron microscopy

21 January 2018

1 reference

Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk

21 January 2018

1 reference

21 January 2018

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Structural basis for the autoinhibition of talin in regulating integrin activation

21 January 2018

1 reference

CDC-42 controls early cell polarity and spindle orientation in C. elegans

21 January 2018

1 reference

Transmembrane signal transduction of the alpha(IIb)beta(3) integrin

21 January 2018

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Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.

21 January 2018

1 reference

Integrin-linked kinase: not so 'pseudo' after all.

21 January 2018

1 reference

Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects

21 January 2018

1 reference

Complementary roles for receptor clustering and conformational change in the adhesive and signaling functions of integrin alphaIIb beta3

21 January 2018

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Breaking the integrin hinge. A defined structural constraint regulates integrin signaling

21 January 2018

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Integrin ligands at a glance

21 January 2018

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Integrins: bidirectional, allosteric signaling machines

21 January 2018

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Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

21 January 2018

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Identification and characterization of multiple similar ligand-binding repeats in filamin: implication on filamin-mediated receptor clustering and cross-talk

21 January 2018

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Kindlins, integrin activation and the regulation of talin recruitment to αIIbβ3.

21 January 2018

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Rap1 and integrin inside-out signaling

21 January 2018

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The molecular basis of filamin binding to integrins and competition with talin

21 January 2018

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Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins

21 January 2018

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Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation

21 January 2018

1 reference

Regulation of integrin activation

21 January 2018

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Basic amino-acid side chains regulate transmembrane integrin signalling

21 January 2018

1 reference

Intracellular signalling controlling integrin activation in lymphocytes

21 January 2018

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Ras GTPases: integrins' friends or foes?

21 January 2018

1 reference

Mechanism and role of localized activation of Rho-family GTPases in growth factor-stimulated fibroblasts and neuronal cells.

21 January 2018

1 reference

Kindlins: essential regulators of integrin signalling and cell-matrix adhesion

21 January 2018

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Structure of the Integrin IIb Transmembrane Segment

21 January 2018

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Structure of the integrin beta3 transmembrane segment in phospholipid bicelles and detergent micelles

21 January 2018

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The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling

21 January 2018

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RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences

21 January 2018

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Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation

21 January 2018

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Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails

21 January 2018

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ILK, PINCH and parvin: the tIPP of integrin signalling

21 January 2018

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Oligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domains

21 January 2018

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Structural basis for integrin alphaIIbbeta3 clustering.

21 January 2018

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Dimerization of the transmembrane domain of Integrin alphaIIb subunit in cell membranes

21 January 2018

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A push-pull mechanism for regulating integrin function

21 January 2018

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Structural basis for the autoinhibition of focal adhesion kinase

21 January 2018

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Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state

21 January 2018

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A specific interface between integrin transmembrane helices and affinity for ligand

21 January 2018

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Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering.

21 January 2018

1 reference

Structural basis of integrin regulation and signaling

21 January 2018

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Kindlin-2 (Mig-2): a co-activator of beta3 integrins.

21 January 2018

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Coordination of Rho GTPase activities during cell protrusion

21 January 2018

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Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival

21 January 2018

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Cell adaptive response to extracellular matrix density is controlled by ICAP-1-dependent beta1-integrin affinity

21 January 2018

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Focal adhesion kinase: in command and control of cell motility

21 January 2018

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Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function.

21 January 2018

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Kindlin-2 controls bidirectional signaling of integrins

21 January 2018

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Kindlin-3: a new gene involved in the pathogenesis of LAD-III.

21 January 2018

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Kindlin-3 is essential for integrin activation and platelet aggregation

21 January 2018

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The tail of integrins, talin, and kindlins

21 January 2018

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Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain

21 January 2018

1 reference

Platelet-collagen interaction: is GPVI the central receptor?

21 January 2018

1 reference

Redox-dependent downregulation of Rho by Rac.

21 January 2018

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Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton

21 January 2018

1 reference

Integrin cytoplasmic domains mediate inside-out signal transduction

21 January 2018

1 reference

An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding

21 January 2018

1 reference

Dynamic conformational changes in the FERM domain of FAK are involved in focal-adhesion behavior during cell spreading and motility.

21 January 2018

1 reference

Focal adhesion kinase: the first ten years

21 January 2018

1 reference

Transmembrane helices that form two opposite homodimeric interactions: an asparagine scan study of alphaM and beta2 integrins

21 January 2018

1 reference

Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity state

21 January 2018

1 reference

The interplay between Src and integrins in normal and tumor biology

21 January 2018

1 reference

Helical membrane protein folding, stability, and evolution

21 January 2018

1 reference

CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans

21 January 2018

1 reference

Analysis of Fyn function in hemostasis and alphaIIbbeta3-integrin signaling

21 January 2018

1 reference

Sequence and domain structure of talin

21 January 2018

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Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation

21 January 2018

1 reference

New PI(4,5)P2- and membrane proximal integrin-binding motifs in the talin head control beta3-integrin clustering

21 January 2018

1 reference

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

21 January 2018

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Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains

21 January 2018

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Multiple connections link FAK to cell motility and invasion

21 January 2018

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Regulation of integrin affinity on cell surfaces

21 January 2018

1 reference

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

21 January 2018

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Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

21 January 2018

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Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

21 January 2018

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Beta2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding

21 January 2018

1 reference

An interaction between integrin and the talin FERM domain mediates integrin activation but not linkage to the cytoskeleton.

21 January 2018

1 reference

Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility

21 January 2018

1 reference

Continuous cell injury promotes hepatic tumorigenesis in cdc42-deficient mouse liver

21 January 2018

1 reference

Role of the cytoskeleton during leukocyte responses

21 January 2018

1 reference

Dissociation of the α-subunit Calf-2 domain and the β-subunit I-EGF4 domain in integrin activation and signaling

21 January 2018

1 reference

The C terminus of talin links integrins to cell cycle progression.

21 January 2018

1 reference

Tests of integrin transmembrane domain homo-oligomerization during integrin ligand binding and signaling

21 January 2018

1 reference

Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3

21 January 2018

1 reference

Transmembrane and cytoplasmic domains in integrin activation and protein-protein interactions (review).

21 January 2018

1 reference

Structural basis of integrin activation by talin

21 January 2018

1 reference

The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!

21 January 2018

1 reference

A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein

21 January 2018

1 reference

Structure of an integrin with an αI domain, complement receptor type 4

21 January 2018

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Crystal structure of the extracellular segment of integrin alpha Vbeta3

21 January 2018

1 reference

Integrin transmembrane signaling and cytoskeletal control

21 January 2018

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Recreation of the terminal events in physiological integrin activation

21 January 2018

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Molecular mechanism of inside-out integrin regulation

21 January 2018

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CIB1 is an endogenous inhibitor of agonist-induced integrin alphaIIbbeta3 activation

21 January 2018

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The switchable integrin adhesome.

21 January 2018

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Talin depletion reveals independence of initial cell spreading from integrin activation and traction

21 January 2018

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Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling

21 January 2018

1 reference

Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

21 January 2018

1 reference

The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/JCP.24154

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27 August 2017

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