Structure of an integrin with an αI domain, complement receptor type 4 (Q27658770)

1

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Jianghai Zhu

2

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Xing Chen

3

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Lizhi Mi

4

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Noritaka Nishida

5

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Timothy A Springer

Crystal structure of the complete integrin αVβ3 ectodomain plus an α/β transmembrane fragment

6

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language of work or name

English

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publication date

3 February 2010

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published in

The EMBO Journal

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volume

29

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issue

3

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page(s)

666-79

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cites work

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20 March 2017

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Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

20 March 2017

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Structural basis for distinctive recognition of fibrinogen γC peptide by the platelet integrin α IIb β 3

20 March 2017

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A structural hypothesis for the transition between bent and extended conformations of the leukocyte beta2 integrins

20 March 2017

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20 March 2017

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Structure and allosteric regulation of the X 2 integrin I domain

20 March 2017

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Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation

20 March 2017

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Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

20 March 2017

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Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

20 March 2017

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Crystal structure of the extracellular segment of integrin alpha Vbeta3

20 March 2017

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20 March 2017

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PHENIX: building new software for automated crystallographic structure determination

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Maximum-likelihood density modification

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The atomic structure of protein-protein recognition sites

20 March 2017

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20 March 2017

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Comparative protein modelling by satisfaction of spatial restraints

20 March 2017

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Structural basis of integrin regulation and signaling

20 March 2017

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MOLREP: an Automated Program for Molecular Replacement

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Tests of the extension and deadbolt models of integrin activation

22 April 2017

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The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18

29 September 2017

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Importance of force linkage in mechanochemistry of adhesion receptors.

29 September 2017

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Epitope mapping of monoclonal antibody to integrin alphaL beta2 hybrid domain suggests different requirements of affinity states for intercellular adhesion molecules (ICAM)-1 and ICAM-3 binding

29 September 2017

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Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin alphaXbeta2

29 September 2017

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The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion

29 September 2017

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The integrin alpha-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activation

29 September 2017

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The integrin alpha L beta 2 hybrid domain serves as a link for the propagation of activation signal from its stalk regions to the I-like domain

29 September 2017

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Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics

29 September 2017

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Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring.

29 September 2017

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Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides

29 September 2017

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New insights into the structural basis of integrin activation.

29 September 2017

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Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin beta subunits

29 September 2017

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Mechanism of integrin activation by disulfide bond reduction

29 September 2017

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Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation

29 September 2017

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Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains

29 September 2017

1 reference

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Amino acid residues in the PSI domain and cysteine-rich repeats of the integrin beta2 subunit that restrain activation of the integrin alpha(X)beta(2).

29 September 2017

1 reference

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NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding

29 September 2017

1 reference

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The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830704

Conversion between three conformational states of integrin I domains with a C-terminal pull spring studied with molecular dynamics

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830704

The crystal structure of the plexin-semaphorin-integrin domain/hybrid domain/I-EGF1 segment from the human integrin beta2 subunit at 1.8-A resolution.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830704

The role of the CPNKEKEC sequence in the beta(2) subunit I domain in regulation of integrin alpha(L)beta(2) (LFA-1).

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830704

The platelet integrin alpha IIbbeta 3 has an endogenous thiol isomerase activity.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830704

Thiol-specific probes indicate that the beta-chain of platelet glycoprotein Ib is a transmembrane protein with a reactive endofacial sulfhydryl group

27 November 2018

1 reference

12 December 2020

Activation of leukocyte beta2 integrins by conversion from bent to extended conformations

1 reference

12 December 2020

Does the integrin alphaA domain act as a ligand for its betaA domain?

1 reference

12 December 2020

The top of the inserted-like domain of the integrin lymphocyte function-associated antigen-1 beta subunit contacts the alpha subunit beta -propeller domain near beta-sheet 3

1 reference

12 December 2020

Identifiers

DOI

10.1038/EMBOJ.2009.367

1 reference

release_g4yxdxajljg6rclf53lf2wfubq

Fatcat ID

0 references

1 reference

1 reference

PubMed publication ID

20033057

1 reference