Recent progress in mucosal vaccine development: potential and limitations (Q38029250)

27 August 2017

Recent progress in mucosal vaccine development: potential and limitations (English)

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27 August 2017

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1

Nils Lycke

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27 August 2017

25 July 2012

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Nature Reviews Immunology

27 August 2017

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27 August 2017

12

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27 August 2017

592-605

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27 August 2017

8

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Mucosal immunity and vaccines

27 August 2017

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Mucosal vaccines: the promise and the challenge

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Immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine

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Considerations for development of whole cell bacterial vaccines to prevent diarrheal diseases in children in developing countries

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Optimism over vaccines administered via mucosal surfaces.

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Mucosal vaccines: novel advances in technology and delivery

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Needle-free influenza vaccination.

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Proteosome-adjuvanted intranasal influenza vaccines: advantages, progress and future considerations

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Live attenuated influenza vaccine (FluMist®; Fluenz™): a review of its use in the prevention of seasonal influenza in children and adults

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A nasally administered trivalent inactivated influenza vaccine is well tolerated, stimulates both mucosal and systemic immunity, and potentially protects against influenza illness

31 March 2020

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Function of mucosa-associated lymphoid tissue in antibody formation

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Induction of secretory immunity and memory at mucosal surfaces

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Regional and mucosal memory T cells

31 March 2020

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Role of retinoic acid in the imprinting of gut-homing IgA-secreting cells

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NALT- versus Peyer's-patch-mediated mucosal immunity

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Anatomical and cellular basis of immunity and tolerance in the intestine

31 March 2020

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Update on mucosal immunoglobulin A in gastrointestinal disease

31 March 2020

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Memory T cells as an occupying force.

31 March 2020

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Th17 cytokines and the gut mucosal barrier

31 March 2020

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Adaptive immunity in the host-microbiota dialog

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Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism

31 March 2020

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Enteric vaccines for the developing world: a challenge for mucosal immunology

31 March 2020

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Modulation of adaptive immunity with Toll-like receptors

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Oral adenoviral-based vaccines: historical perspective and future opportunity

31 March 2020

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Immunology of Gut Mucosal Vaccines

31 March 2020

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Rotaviruses: from pathogenesis to vaccination

31 March 2020

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Safety and Efficacy of an Attenuated Vaccine against Severe Rotavirus Gastroenteritis

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Evaluation of Salmonella enterica serovar Typhi (Ty2 aroC-ssaV-) M01ZH09, with a defined mutation in the Salmonella pathogenicity island 2, as a live, oral typhoid vaccine in human volunteers

31 March 2020

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Attenuated Bordetella pertussis BPZE1 as a live vehicle for heterologous vaccine antigens delivery through the nasal route

31 March 2020

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Antigen-specific IgA B memory cell responses to Shigella antigens elicited in volunteers immunized with live attenuated Shigella flexneri 2a oral vaccine candidates.

31 March 2020

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Safety and immunogenicity of a Shigella flexneri 2a Invaplex 50 intranasal vaccine in adult volunteers

31 March 2020

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Adjuvanted intranasal Norwalk virus-like particle vaccine elicits antibodies and antibody-secreting cells that express homing receptors for mucosal and peripheral lymphoid tissues

31 March 2020

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Effectiveness of inactivated influenza vaccine in children aged 9 months to 3 years: an observational cohort study

31 March 2020

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Typhoid vaccination: the Asian experience.

31 March 2020

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Oral vaccines against cholera

31 March 2020

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Human influenza vaccines and assessment of immunogenicity

31 March 2020

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Effect of Human Rotavirus Vaccine on Severe Diarrhea in African Infants

31 March 2020

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Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine

31 March 2020

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Acute and persistent diarrhea

31 March 2020

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Bile retinoids imprint intestinal CD103+ dendritic cells with the ability to generate gut-tropic T cells

31 March 2020

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Impact of early life exposures to geohelminth infections on the development of vaccine immunity, allergic sensitization, and allergic inflammatory diseases in children living in tropical Ecuador: the ECUAVIDA birth cohort study

31 March 2020

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Actions of cholera toxin and the prevention and treatment of cholera

31 March 2020

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Intestinal immune responses in humans. Oral cholera vaccination induces strong intestinal antibody responses and interferon-gamma production and evokes local immunological memory

31 March 2020

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Robust gut associated vaccine-specific antibody-secreting cell responses are detected at the mucosal surface of Bangladeshi subjects after immunization with an oral killed bivalent V. cholerae O1/O139 whole cell cholera vaccine: comparison with other

31 March 2020

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Herd immunity conferred by killed oral cholera vaccines in Bangladesh: a reanalysis

31 March 2020

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Innate secretory antibodies protect against natural Salmonella typhimurium infection

31 March 2020

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Nanotechnology solutions for mucosal immunization

31 March 2020

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Nanotechnology in vaccine delivery

31 March 2020

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Potential of nasopharynx-associated lymphoid tissue for vaccine responses in the airways

31 March 2020

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31 March 2020

Nasal vaccine innovation

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Immune responses to influenza virus infection

31 March 2020

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Oral spray immunization may be an alternative to intranasal vaccine delivery to induce systemic antibodies but not nasal mucosal or cellular immunity.

31 March 2020

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Nasal deposition and clearance in man: comparison of a bidirectional powder device and a traditional liquid spray pump

31 March 2020

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Methods for evaluation of humoral immune responses in human genital tract secretions

31 March 2020

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Immunization with HIV-1 gp41 Subunit Virosomes Induces Mucosal Antibodies Protecting Nonhuman Primates against Vaginal SHIV Challenges

31 March 2020

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Protecting the initial site of viral entry: an alternative HIV vaccine target

31 March 2020

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CD4⁺ T-cell immunity in the female genital tract is critically dependent on local mucosal immunization.

31 March 2020

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Mucosally-targeted HIV-1 vaccines.

31 March 2020

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Phase I randomised clinical trial of an HIV-1(CN54), clade C, trimeric envelope vaccine candidate delivered vaginally

31 March 2020

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31 March 2020

Sublingual vaccination

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Sublingual mucosa: A new vaccination route for systemic and mucosal immunity

31 March 2020

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Induction of protection against vaginal shedding and infertility by a recombinant Chlamydia vaccine

31 March 2020

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Enhanced humoral and cellular immune responses after sublingual immunization against human papillomavirus 16 L1 protein with adjuvants

31 March 2020

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Robust antigen-specific humoral immune responses to sublingually delivered adenoviral vectors encoding HIV-1 Env: association with mucoadhesion and efficient penetration of the sublingual barrier.

31 March 2020

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Sublingual vaccination with influenza virus protects mice against lethal viral infection

31 March 2020

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A truncated form of HpaA is a promising antigen for use in a vaccine against Helicobacter pylori

31 March 2020

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Systemic and mucosal immune responses to sublingual or intramuscular human papilloma virus antigens in healthy female volunteers

31 March 2020

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Chitosan for mucosal vaccination

31 March 2020

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Mucosal delivery of vaccines: role of mucoadhesive/biodegradable polymers

31 March 2020

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Local intravaginal vaccination of the female genital tract

31 March 2020

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A novel non-toxic combined CTA1-DD and ISCOMS adjuvant vector for effective mucosal immunization against influenza virus

31 March 2020

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Mucosal adjuvant activity of oligomannose-coated liposomes for nasal immunization

31 March 2020

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M cell-targeted delivery of vaccines and therapeutics

31 March 2020

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Recent progress in understanding the phenotype and function of intestinal dendritic cells and macrophages

31 March 2020

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Enhancing oral vaccine potency by targeting intestinal M cells

31 March 2020

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Fast rise of broadly cross-reactive antibodies after boosting long-lived human memory B cells primed by an MF59 adjuvanted prepandemic vaccine.

31 March 2020

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Influenza vaccine immunology

31 March 2020

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Mechanism of action of clinically approved adjuvants

31 March 2020

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31 March 2020

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CpG-oligodeoxynucleotides stimulate immunoglobulin A secretion in intestinal mucosal B cells

31 March 2020

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Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.

31 March 2020

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Oral QS-21 requires early IL-4 help for induction of mucosal and systemic immunity

31 March 2020

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Liposome-based cationic adjuvant formulations (CAF): past, present, and future

31 March 2020

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Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome

31 March 2020

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The potency of the adjuvant, CpG oligos, is enhanced by encapsulation in PLG microparticles

31 March 2020

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Heat-labile enterotoxins as adjuvants or anti-inflammatory agents

31 March 2020

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CD11c(high )dendritic cells are essential for activation of CD4+ T cells and generation of specific antibodies following mucosal immunization

31 March 2020

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Cholera toxin, LT-I, LT-IIa and LT-IIb: the critical role of ganglioside binding in immunomodulation by type I and type II heat-labile enterotoxins

31 March 2020

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Cholera toxin, E. coli heat-labile toxin, and non-toxic derivatives induce dendritic cell migration into the follicle-associated epithelium of Peyer's patches

31 March 2020

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A dilemma for mucosal vaccination: efficacy versus toxicity using enterotoxin-based adjuvants

31 March 2020

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Pre-clinical and clinical investigation of the safety of a novel adjuvant for intranasal immunization

31 March 2020

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Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland

31 March 2020

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Mucosal vaccines: non toxic derivatives of LT and CT as mucosal adjuvants.

31 March 2020

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Toward the development of a stable, freeze-dried formulation of Helicobacter pylori killed whole cell vaccine adjuvanted with a novel mutant of Escherichia coli heat-labile toxin

31 March 2020

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Escherichia coli heat-labile enterotoxin promotes protective Th17 responses against infection by driving innate IL-1 and IL-23 production.

31 March 2020

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Transient facial nerve paralysis (Bell's palsy) following intranasal delivery of a genetically detoxified mutant of Escherichia coli heat labile toxin

31 March 2020

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A second generation of double mutant cholera toxin adjuvants: enhanced immunity without intracellular trafficking

31 March 2020

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Mucosal adjuvants and long-term memory development with special focus on CTA1-DD and other ADP-ribosylating toxins

31 March 2020

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The cholera toxin-derived CTA1-DD vaccine adjuvant administered intranasally does not cause inflammation or accumulate in the nervous tissues

31 March 2020

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CTA1-DD adjuvant promotes strong immunity against human immunodeficiency virus type 1 envelope glycoproteins following mucosal immunization

31 March 2020

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Role of CTA1R7K-COL-DD as a novel therapeutic mucosal tolerance-inducing vector for treatment of collagen-induced arthritis.

31 March 2020

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ADP-ribosylation controls the outcome of tolerance or enhanced priming following mucosal immunization

31 March 2020

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Correlates of protection induced by vaccination

31 March 2020

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Antigen-specific memory B-cell responses in Bangladeshi adults after one- or two-dose oral killed cholera vaccination and comparison with responses in patients with naturally acquired cholera

31 March 2020

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Vaginal immunization of Cynomolgus monkeys with Streptococcus gordonii expressing HIV-1 and HPV 16 antigens

31 March 2020

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Live attenuated pandemic influenza vaccine: clinical studies on A/17/California/2009/38 (H1N1) and licensing of the Russian-developed technology to WHO for pandemic influenza preparedness in developing countries.

31 March 2020

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BAFF, stimulatory DNA and IL-15 stimulates IgA(+) memory B cells and provides a novel approach for analysis of memory responses to mucosal vaccines.

31 March 2020

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Long-term cholera antitoxin memory in the gut can be triggered to antibody formation associated with protection within hours of an oral challenge immunization

31 March 2020

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Re-utilization of germinal centers in multiple Peyer's patches results in highly synchronized, oligoclonal, and affinity-matured gut IgA responses

31 March 2020

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Central memory and effector memory T cell subsets: function, generation, and maintenance

31 March 2020

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Mechanisms controlling Th17 cytokine expression and host defense

31 March 2020

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Intestinal microbiota, evolution of the immune system and the bad reputation of pro-inflammatory immunity

31 March 2020

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Control of TH17 cells occurs in the small intestine.

31 March 2020

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Immunity and vaccines against sexually transmitted Chlamydia trachomatis infection

31 March 2020

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Advances in vaccination against Helicobacter pylori

31 March 2020

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Migration, maintenance and recall of memory T cells in peripheral tissues

31 March 2020

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Improving vaccines by targeting antigens to dendritic cells

31 March 2020

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The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement

31 March 2020

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Mast cells contribute to the mucosal adjuvant effect of CTA1-DD after IgG-complex formation

31 March 2020

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Systems vaccinology: its promise and challenge for HIV vaccine development

31 March 2020

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Systems biology in vaccine design

31 March 2020

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A genomics-based approach to assessment of vaccine safety and immunogenicity in children.

31 March 2020

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Translating innate immunity into immunological memory: implications for vaccine development

31 March 2020

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Lymphocyte homing to the gut: attraction, adhesion, and commitment

31 March 2020

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Role of beta7 integrins in intestinal lymphocyte homing and retention

31 March 2020

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Differentiation and homing of IgA-secreting cells

31 March 2020

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Development and functional specialization of CD103+ dendritic cells.

31 March 2020

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Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions.

31 March 2020

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Intestinal CD103+ dendritic cells: master regulators of tolerance?

31 March 2020

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Directed antigen targeting in vivo identifies a role for CD103+ dendritic cells in both tolerogenic and immunogenic T-cell responses

31 March 2020

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Mucosa-associated epithelial chemokine/CCL28 expression in the uterus attracts CCR10+ IgA plasma cells following mucosal vaccination via estrogen control

31 March 2020

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Th17 cytokines and vaccine-induced immunity

31 March 2020

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Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa

31 March 2020

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What role does the route of immunization play in the generation of protective immunity against mucosal pathogens?

31 March 2020

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Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.

31 March 2020

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A unique role of the cholera toxin A1-DD adjuvant for long-term plasma and memory B cell development.

31 March 2020

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A pandemic influenza vaccine in India: from strain to sale within 12 months

31 March 2020

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Eradicating polio: today's challenges and tomorrow's legacy

31 March 2020

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Oral poliovirus vaccine: history of its development and use and current challenge to eliminate poliomyelitis from the world

31 March 2020

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Comparative efficacy of two, three, or four doses of TY21a live oral typhoid vaccine in enteric-coated capsules: a field trial in an endemic area

31 March 2020

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Induction of mucosal and systemic immunity against respiratory syncytial virus by inactivated virus supplemented with TLR9 and NOD2 ligands

31 March 2020

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Bacterial ghosts as carriers of protein subunit and DNA-encoded antigens for vaccine applications

31 March 2020

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Maximal adjuvant activity of nasally delivered IL-1α requires adjuvant-responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine production

31 March 2020

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Enhanced control of pathogenic Simian immunodeficiency virus SIVmac239 replication in macaques immunized with an interleukin-12 plasmid and a DNA prime-viral vector boost vaccine regimen

31 March 2020

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Adjuvanticity of the cholera toxin A1-based gene fusion protein, CTA1-DD, is critically dependent on the ADP-ribosyltransferase and Ig-binding activity.

31 March 2020

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12 December 2020

Genetically engineered nontoxic vaccine adjuvant that combines B cell targeting with immunomodulation by cholera toxin A1 subunit.

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12 December 2020

Oral vaccines against cholera and enterotoxigenic Escherichia coli diarrhea.

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12 December 2020

Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin

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12 December 2020

Adoptive transfer of gut mucosal antitoxin memory by isolated B cells 1 year after oral immunization with cholera toxin.

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12 December 2020

Virus-like particles for antigen delivery at mucosal surfaces

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12 December 2020

Evaluation in humans of attenuated Vibrio cholerae El Tor Ogawa strain Texas Star-SR as a live oral vaccine

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12 December 2020

The mucosal adjuvant activities of ADP-ribosylating bacterial enterotoxins

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12 December 2020

Cholera toxin and its subunits as potential oral adjuvants

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12 December 2020

Mucosal delivery routes for optimal immunization: targeting immunity to the right tissues

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12 December 2020

Identifiers

DOI

10.1038/NRI3251

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27 August 2017

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PubMed ID

22828912