Fc-fusion proteins: new developments and future perspectives. (Q38029985)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22837174%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

2 November 2020

Fc-fusion proteins: new developments and future perspectives (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22837174%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

20 November 2019

1 reference

27 November 2019

1 reference

13 December 2019

1 reference

21 December 2019

1 reference

2 November 2020

4

1 reference

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9 February 2020

author name string

Daniel M Czajkowsky

series ordinal

1

1 reference

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9 February 2020

Jun Hu

series ordinal

2

1 reference

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9 February 2020

Zhifeng Shao

series ordinal

3

1 reference

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publication date

26 July 2012

1 reference

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9 February 2020

1 October 2012

1 reference

2 November 2020

EMBO Molecular Medicine

7 references

25 June 2019

20 November 2019

27 November 2019

13 December 2019

21 December 2019

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9 February 2020

2 November 2020

4

1 reference

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9 February 2020

page(s)

1015-1028

1 reference

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9 February 2020

issue

10

1 reference

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Creative Commons Attribution 2.5 Generic

9 February 2020

copyright license

6 references

25 June 2019

20 November 2019

27 November 2019

13 December 2019

21 December 2019

Cutting edge: human FcRL4 and FcRL5 are receptors for IgA and IgG.

2 November 2020

cites work

1 reference

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Abnormalities in IgA and IgM are associated with treatment-resistant ITP.

6 September 2017

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Immune-correlates analysis of an HIV-1 vaccine efficacy trial

6 September 2017

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Mouse model recapitulating human Fcγ receptor structural and functional diversity

6 September 2017

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Polymeric human Fc-fusion proteins with modified effector functions

6 September 2017

1 reference

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IVIg-mediated amelioration of ITP in mice is dependent on sialic acid and SIGNR1.

6 September 2017

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Natural IgM in immune equilibrium and harnessing their therapeutic potential

6 September 2017

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Monocyte subsets responsible for immunoglobulin G-dependent effector functions in vivo

6 September 2017

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Recombinant IgE antibodies for passive immunotherapy of solid tumours: from concept towards clinical application.

6 September 2017

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A secreted protein microarray platform for extracellular protein interaction discovery

6 September 2017

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A conserved host and pathogen recognition site on immunoglobulins: structural and functional aspects

6 September 2017

1 reference

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Do regulatory antibodies offer an alternative mechanism to explain the hygiene hypothesis?

6 September 2017

1 reference

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The human immunoglobulin A Fc receptor FcαRI: a multifaceted regulator of mucosal immunity

6 September 2017

1 reference

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TOSO, the Fcmicro receptor, is highly expressed on chronic lymphocytic leukemia B cells, internalizes upon IgM binding, shuttles to the lysosome, and is downregulated in response to TLR activation

6 September 2017

1 reference

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Strategies for extended serum half-life of protein therapeutics

6 September 2017

1 reference

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Inhibitory Fcγ receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies

6 September 2017

1 reference

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A neonatal Fc receptor-targeted mucosal vaccine strategy effectively induces HIV-1 antigen-specific immunity to genital infection

6 September 2017

1 reference

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The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19).

6 September 2017

1 reference

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Rituximab infusion induces NK activation in lymphoma patients with the high-affinity CD16 polymorphism.

6 September 2017

1 reference

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Non-immunoglobulin based protein scaffolds.

6 September 2017

1 reference

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Polymer--drug conjugates as nano-sized medicines

6 September 2017

1 reference

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Immunoglobulin A: A next generation of therapeutic antibodies?

6 September 2017

1 reference

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Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway.

6 September 2017

1 reference

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Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors

6 September 2017

1 reference

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Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells

6 September 2017

1 reference

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Introduction to current and future protein therapeutics: a protein engineering perspective

6 September 2017

1 reference

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A novel human IgA monoclonal antibody protects against tuberculosis

6 September 2017

1 reference

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Efficient mucosal vaccination mediated by the neonatal Fc receptor.

6 September 2017

1 reference

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Conserved natural IgM antibodies mediate innate and adaptive immunity against the opportunistic fungus Pneumocystis murina.

6 September 2017

1 reference

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FCRLA is a resident endoplasmic reticulum protein that associates with intracellular Igs, IgM, IgG and IgA

6 September 2017

1 reference

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Antibody-based therapeutics to watch in 2011.

6 September 2017

1 reference

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Novel GLP-1 fusion chimera as potent long acting GLP-1 receptor agonist

6 September 2017

1 reference

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Unmet needs in modern vaccinology: adjuvants to improve the immune response

6 September 2017

1 reference

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IgM, Fc mu Rs, and malarial immune evasion

6 September 2017

1 reference

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Rituximab: mechanism of action

6 September 2017

1 reference

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Transmembrane TNF-alpha: structure, function and interaction with anti-TNF agents

6 September 2017

1 reference

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Antibody fragments: hope and hype

6 September 2017

1 reference

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Optimization of Fc-mediated effector functions of monoclonal antibodies

6 September 2017

1 reference

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Receptor-Fc fusion therapeutics, traps, and MIMETIBODY technology

6 September 2017

1 reference

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Targeting a mimotope vaccine to activating Fcgamma receptors empowers dendritic cells to prime specific CD8+ T cell responses in tumor-bearing mice

6 September 2017

1 reference

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Profiling carbohydrate-receptor interaction with recombinant innate immunity receptor-Fc fusion proteins

6 September 2017

1 reference

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Toll-like receptor 4 decoy, TOY, attenuates gram-negative bacterial sepsis

6 September 2017

1 reference

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Signal initiation in biological systems: the properties and detection of transient extracellular protein interactions

6 September 2017

1 reference

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Hexavalent bispecific antibodies represent a new class of anticancer therapeutics: 1. Properties of anti-CD20/CD22 antibodies in lymphoma

6 September 2017

1 reference

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Glycosylation as a strategy to improve antibody-based therapeutics

6 September 2017

1 reference

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Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies

6 September 2017

1 reference

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Effector mechanisms of therapeutic antibodies against ErbB receptors

6 September 2017

1 reference

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Bifunctional CD22 ligands use multimeric immunoglobulins as protein scaffolds in assembly of immune complexes on B cells

6 September 2017

1 reference

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Entry of herpesviruses into mammalian cells

6 September 2017

1 reference

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"Accentuate the negative, eliminate the positive": engineering allergy therapeutics to block allergic reactivity through negative signaling

6 September 2017

1 reference

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Isotype selection in antibody engineering

6 September 2017

1 reference

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Fcgamma receptors as regulators of immune responses

6 September 2017

1 reference

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A vast repertoire of Dscam binding specificities arises from modular interactions of variable Ig domains.

6 September 2017

1 reference

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Antibody therapeutics: isotype and glycoform selection

6 September 2017

1 reference

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Recombinant therapeutic monoclonal antibodies: mechanisms of action in relation to structural and functional duality.

6 September 2017

1 reference

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FcRn: the neonatal Fc receptor comes of age.

6 September 2017

1 reference

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Enhanced Fc-dependent cellular cytotoxicity of Fc fusion proteins derived from TNF receptor II and LFA-3 by fucose removal from Asn-linked oligosaccharides

6 September 2017

1 reference

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Structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly.

6 September 2017

1 reference

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Natural IgM antibodies: the orphaned molecules in immune surveillance

6 September 2017

1 reference

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Expression and role of Fc- and complement-receptors on human dendritic cells.

6 September 2017

1 reference

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How antibodies act as natural adjuvants.

6 September 2017

1 reference

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A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator

6 September 2017

1 reference

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Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway

6 September 2017

1 reference

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Human antibody-Fc receptor interactions illuminated by crystal structures

6 September 2017

1 reference

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The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons

6 September 2017

1 reference

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The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Etanercept for active Crohn's disease: a randomized, double-blind, placebo-controlled trial

6 September 2017

1 reference

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6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Engineered antibodies with increased activity to recruit complement

6 September 2017

1 reference

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Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Metabolic properties of IgG subclasses in man

6 September 2017

1 reference

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A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

An antitumor cellular vaccine based on a mini-membrane IgE.

6 September 2017

1 reference

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Single-chain Fv-based anti-HIV proteins: potential and limitations

6 September 2017

1 reference

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CD22 serves as a receptor for soluble IgM.

6 September 2017

1 reference

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Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Targeting FcαRI on polymorphonuclear cells induces tumor cell killing through autophagy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Therapeutic assessment of SEED: a new engineered antibody platform designed to generate mono- and bispecific antibodies

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Recombinant dimeric IgA antibodies against the epidermal growth factor receptor mediate effective tumor cell killing.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Fc receptor-like A associates with intracellular IgG and IgM but is dispensable for antigen-specific immune responses

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

IVIg modulates BCR signaling through CD22 and promotes apoptosis in mature human B lymphocytes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Enhanced antibody half-life improves in vivo activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

A novel Fc gamma receptor ligand augments humoral responses by targeting antigen to Fc gamma receptors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Gene therapy of diabetes using a novel GLP-1/IgG1-Fc fusion construct normalizes glucose levels in db/db mice

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

IgG2a-mediated enhancement of antibody and T cell responses and its relation to inhibitory and activating Fc gamma receptors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

The influence of the hinge region length in binding of human IgG to human Fcgamma receptors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Characterization of the 2:1 complex between the class I MHC-related Fc receptor and its Fc ligand in solution

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Designing CD4 immunoadhesins for AIDS therapy

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Detection of weak receptor-ligand interactions using IgM and J-chain-based fusion proteins.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Mannose-functionalized "pathogen-like" polyanhydride nanoparticles target C-type lectin receptors on dendritic cells

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Therapeutic Fc-fusion proteins and peptides as successful alternatives to antibodies

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

SEEDbodies: fusion proteins based on strand-exchange engineered domain (SEED) CH3 heterodimers in an Fc analogue platform for asymmetric binders or immunofusions and bispecific antibodies

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Importance of neonatal FcR in regulating the serum half-life of therapeutic proteins containing the Fc domain of human IgG1: a comparative study of the affinity of monoclonal antibodies and Fc-fusion proteins to human neonatal FcR.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Development trends for therapeutic antibody fragments.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Antigen-specific humoral tolerance or immune augmentation induced by intramuscular delivery of adeno-associated viruses encoding CTLA4-Ig-antigen fusion molecules

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Soluble Fc fusion proteins for biomedical research.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Systemic administration of an Fcgamma-Fc(epsilon)-fusion protein in house dust mite sensitive nonhuman primates

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Enhancing the potency of therapeutic monoclonal antibodies via Fc optimization.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

In vivo expression of GLP-1/IgG-Fc fusion protein enhances beta-cell mass and protects against streptozotocin-induced diabetes

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Synthetic therapeutic antibodies.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn).

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Enhanced circulating half-life and hematopoietic properties of a human granulocyte colony-stimulating factor/immunoglobulin fusion protein.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

IgEs targeted on tumor cells: therapeutic activity and potential in the design of tumor vaccines.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Tumor cell expression of CD59 is associated with resistance to CD20 serotherapy in patients with B-cell malignancies.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Specific monoclonal IgM is a potent adjuvant in murine malaria vaccination.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491832

Binding and Functional Comparisons of Two Types of Tumor Necrosis Factor Antagonists

31 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FEMMM.201201379

Inhibitory ITAM Signaling Traps Activating Receptors with the Phosphatase SHP-1 to Form Polarized "Inhibisome" Clusters

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FEMMM.201201379

Engineering human IgG1 affinity to human neonatal Fc receptor: impact of affinity improvement on pharmacokinetics in primates

21 January 2018

1 reference

12 December 2020

Discovery and development of biopharmaceuticals: current issues

1 reference

12 December 2020

Fusion partners as a tool for the expression of difficult proteins in mammalian cells

1 reference

12 December 2020

Neonatal FcR Overexpression Boosts Humoral Immune Response in Transgenic Mice

1 reference

12 December 2020

TNF receptor II fusion protein with tandemly repeated Fc domains

1 reference

12 December 2020

Intracellular antibody-mediated immunity and the role of TRIM21

1 reference

12 December 2020

Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors

1 reference

12 December 2020

IgA antibody, antibody-dependent cellular cytotoxicity and prognosis in patients with nasopharyngeal carcinoma

1 reference

12 December 2020

IgA blocks IgM and IgG-initiated immune lysis by separate molecular mechanisms

1 reference

12 December 2020

Human amniotic IgA inhibits natural IgG autoantibodies of maternal or unrelated origin

1 reference

12 December 2020

Identifiers

DOI

10.1002/EMMM.201201379

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22837174%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22837174%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22837174%20AND%20SRC:MED&resulttype=core&format=json