Mitochondria as sensors and regulators of calcium signalling (Q38031124)

27 August 2017

Mitochondria as sensors and regulators of calcium signalling (English)

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27 August 2017

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Diego De Stefani

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Rosario Rizzuto

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Rosario Rizzuto

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1

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Anna Raffaello

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Anna Raffaello

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3

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Cristina Mammucari

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4

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Cristina Mammucari

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27 August 2017

1 August 2012

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Nature Reviews Molecular Cell Biology

27 August 2017

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27 August 2017

13

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27 August 2017

566-578

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27 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/nrm3412

27 August 2017

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Calcium signalling: dynamics, homeostasis and remodelling

31 March 2020

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A third contribution regarding the Influence of the Inorganic Constituents of the Blood on the Ventricular Contraction

31 March 2020

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Decoding of cytosolic calcium oscillations in the mitochondria

31 March 2020

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Calcium oscillations increase the efficiency and specificity of gene expression

31 March 2020

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Microdomains of intracellular Ca2+: molecular determinants and functional consequences.

31 March 2020

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Molecular and cellular physiology of intracellular calcium stores

31 March 2020

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Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

31 March 2020

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The Golgi apparatus is an inositol 1,4,5-trisphosphate-sensitive Ca2+ store, with functional properties distinct from those of the endoplasmic reticulum

31 March 2020

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NAADP mobilizes calcium from acidic organelles through two-pore channels

31 March 2020

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Calcium uptake by rat kidney mitochondria

31 March 2020

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Respiration-dependent accumulation of inorganic phosphate and Ca ions by rat liver mitochondria

31 March 2020

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Chemiosmotic hypothesis of oxidative phosphorylation

31 March 2020

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Molecular architecture of the rotary motor in ATP synthase

31 March 2020

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Pathway for uncoupler-induced calcium efflux in rat liver mitochondria: inhibition by ruthenium red.

31 March 2020

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Inhibition and activation of calcium transport in mitochondria. Effect of lanthanides and local anesthetic drugs

31 March 2020

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Activation energies and enthalpies during Ca2+ transport in rat liver mitochondria

31 March 2020

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The calcium-induced and sodium-induced effluxes of calcium from heart mitochondria. Evidence for a sodium-calcium carrier

31 March 2020

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Disequilibrium between steady-state Ca2+ ion accumulation ratio and membrane potential in mitochondria. Pathway and role of Ca2+ ion efflux

31 March 2020

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Selectivity of inhibition of Na(+)-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157

31 March 2020

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Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin

31 March 2020

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Dynamic and quantitative Ca2+ measurements using improved cameleons

31 March 2020

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Circularly permuted green fluorescent proteins engineered to sense Ca2+.

31 March 2020

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Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria

31 March 2020

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Mitochondrial Ca2+ uptake requires sustained Ca2+ release from the endoplasmic reticulum

31 March 2020

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Chromaffin-cell stimulation triggers fast millimolar mitochondrial Ca2+ transients that modulate secretion

31 March 2020

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Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses

31 March 2020

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Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria

31 March 2020

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Calcium signal transmission between ryanodine receptors and mitochondria

31 March 2020

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Electron microscopic tomography of rat-liver mitochondria and their interaction with the endoplasmic reticulum

31 March 2020

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Store-operated calcium channels

31 March 2020

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Store-operated Ca2+ entry depends on mitochondrial Ca2+ uptake

31 March 2020

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Evidence that mitochondria buffer physiological Ca2+ loads in lizard motor nerve terminals

31 March 2020

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Mitochondrial Ca2+ signalling in hippocampal neurons.

31 March 2020

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Ca2+ hot spots on the mitochondrial surface are generated by Ca2+ mobilization from stores, but not by activation of store-operated Ca2+ channels.

31 March 2020

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Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface

31 March 2020

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VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release

31 March 2020

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Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria

31 March 2020

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VDAC closure increases calcium ion flux

31 March 2020

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VDAC regulation: role of cytosolic proteins and mitochondrial lipids

31 March 2020

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Mouse VDAC isoforms expressed in yeast: channel properties and their roles in mitochondrial outer membrane permeability

31 March 2020

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VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria.

31 March 2020

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Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death

31 March 2020

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VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria

31 March 2020

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VDAC2 inhibits BAK activation and mitochondrial apoptosis

31 March 2020

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The mitochondrial calcium uniporter is a highly selective ion channel.

31 March 2020

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A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

31 March 2020

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Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

31 March 2020

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MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake

31 March 2020

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Mechanisms by which mitochondria transport calcium

31 March 2020

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Mitochondrial transport of cations: channels, exchangers, and permeability transition.

31 March 2020

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NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

31 March 2020

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Molecular cloning of a sixth member of the K+-dependent Na+/Ca2+ exchanger gene family, NCKX6

31 March 2020

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Pivotal role of mitochondrial Na⁺₋Ca²⁺ exchange in antigen receptor mediated Ca²⁺ signalling in DT40 and A20 B lymphocytes

31 March 2020

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Release of Ca2+ from mitochondria via the saturable mechanisms and the permeability transition

31 March 2020

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Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals.

31 March 2020

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Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice

31 March 2020

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Activation of the mitochondrial permeability transition pore modulates Ca2+ responses to physiological stimuli in adult neurons

31 March 2020

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Mitochondrial calcium and its regulation in neurodegeneration induced by oxidative stress

31 March 2020

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Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria?

31 March 2020

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Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently

31 March 2020

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Interactions between the endoplasmic reticulum, mitochondria, plasma membrane and other subcellular organelles

31 March 2020

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Structural and functional link between the mitochondrial network and the endoplasmic reticulum

31 March 2020

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Structural and functional features and significance of the physical linkage between ER and mitochondria.

31 March 2020

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Controlling metabolism and cell death: at the heart of mitochondrial calcium signalling

31 March 2020

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Ca(2+) transfer from the ER to mitochondria: when, how and why

31 March 2020

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Mitofusin 2 tethers endoplasmic reticulum to mitochondria

31 March 2020

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Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis

31 March 2020

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Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase

31 March 2020

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Ca(2+) homeostasis during mitochondrial fragmentation and perinuclear clustering induced by hFis1

31 March 2020

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Trichoplein/mitostatin regulates endoplasmic reticulum-mitochondria juxtaposition

31 March 2020

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Alignment of sarcoplasmic reticulum-mitochondrial junctions with mitochondrial contact points

31 March 2020

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MAM: more than just a housekeeper

31 March 2020

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An intimate liaison: spatial organization of the endoplasmic reticulum-mitochondria relationship

31 March 2020

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Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival

31 March 2020

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The subcellular distribution of calnexin is mediated by PACS-2

31 March 2020

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Calreticulin inhibits repetitive intracellular Ca2+ waves

31 March 2020

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Ca2+-dependent redox modulation of SERCA 2b by ERp57.

31 March 2020

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Cytosolic phosphorylation of calnexin controls intracellular Ca(2+) oscillations via an interaction with SERCA2b

31 March 2020

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Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.

31 March 2020

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PML regulates apoptosis at endoplasmic reticulum by modulating calcium release

31 March 2020

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Bell-shaped calcium-response curves of Ins(1,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum

31 March 2020

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Synchronization of calcium waves by mitochondrial substrates in Xenopus laevis oocytes.

31 March 2020

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Mitochondria suppress local feedback activation of inositol 1,4, 5-trisphosphate receptors by Ca2+

31 March 2020

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Mitochondria exert a negative feedback on the propagation of intracellular Ca2+ waves in rat cortical astrocytes

31 March 2020

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Ca2+ marks: miniature calcium signals in single mitochondria driven by ryanodine receptors

31 March 2020

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Calcium microdomains at the immunological synapse: how ORAI channels, mitochondria and calcium pumps generate local calcium signals for efficient T-cell activation.

31 March 2020

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Mitochondrial regulation of store-operated calcium signaling in T lymphocytes

31 March 2020

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Mitochondrial control of calcium-channel gating: a mechanism for sustained signaling and transcriptional activation in T lymphocytes

31 March 2020

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Mitofusin 2 regulates STIM1 migration from the Ca2+ store to the plasma membrane in cells with depolarized mitochondria.

31 March 2020

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Respiring mitochondria determine the pattern of activation and inactivation of the store-operated Ca(2+) current I(CRAC).

31 March 2020

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Energized mitochondria increase the dynamic range over which inositol 1,4,5-trisphosphate activates store-operated calcium influx.

31 March 2020

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Depolarization-induced mitochondrial Ca accumulation in sympathetic neurons: spatial and temporal characteristics

31 March 2020

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Mitochondrial involvement in post-tetanic potentiation of synaptic transmission

31 March 2020

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Presynaptic mitochondrial calcium sequestration influences transmission at mammalian central synapses.

31 March 2020

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Mitochondrial Ca(2+) buffering regulates synaptic transmission between retinal amacrine cells

31 March 2020

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Inhibition of mitochondrial Ca2+ uptake affects phasic release from motor terminals differently depending on external [Ca2+].

31 March 2020

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Mitochondrial Ca2+ uptake prevents desynchronization of quantal release and minimizes depletion during repetitive stimulation of mouse motor nerve terminals

31 March 2020

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WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines

31 March 2020

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Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitation

31 March 2020

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Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses.

31 March 2020

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Mitochondrial matrix Ca2+ as an intrinsic signal regulating mitochondrial motility in axons.

31 March 2020

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Mitochondrial Ca(2+) mobilization is a key element in olfactory signaling.

31 March 2020

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Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

31 March 2020

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Correlation of NADH and Ca2+ signals in mouse pancreatic acinar cells.

31 March 2020

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Transformation of local Ca2+ spikes to global Ca2+ transients: the combinatorial roles of multiple Ca2+ releasing messengers

31 March 2020

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Signal transduction, calcium and acute pancreatitis.

31 March 2020

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Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells.

31 March 2020

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Active mitochondria surrounding the pancreatic acinar granule region prevent spreading of inositol trisphosphate-evoked local cytosolic Ca(2+) signals.

31 March 2020

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Role of calcium ions in regulation of mammalian intramitochondrial metabolism

31 March 2020

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Physiological role of mitochondrial Ca2+ transport

31 March 2020

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The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex

31 March 2020

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Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic priming

31 March 2020

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A calcium signaling defect in the pathogenesis of a mitochondrial DNA inherited oxidative phosphorylation deficiency

31 March 2020

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Inhibition of mitochondrial Na+-Ca2+ exchange restores agonist-induced ATP production and Ca2+ handling in human complex I deficiency.

31 March 2020

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Dynamic changes in cytosolic and mitochondrial ATP levels in pancreatic acinar cells

31 March 2020

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The role of Ca(2+) signaling in the coordination of mitochondrial ATP production with cardiac work

31 March 2020

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Recombinant expression of the Ca(2+)-sensitive aspartate/glutamate carrier increases mitochondrial ATP production in agonist-stimulated Chinese hamster ovary cells

31 March 2020

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Ca2+ Activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin: role in the heart malate-aspartate NADH shuttle

31 March 2020

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Mitochondrial transporters as novel targets for intracellular calcium signaling.

31 March 2020

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Regulation of cell death: the calcium-apoptosis link

31 March 2020

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Pathophysiological and protective roles of mitochondrial ion channels

31 March 2020

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A CaPful of mechanisms regulating the mitochondrial permeability transition

31 March 2020

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Mitochondrial calcium function and dysfunction in the central nervous system

31 March 2020

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Calcium-dependent mitochondrial function and dysfunction in neurons

31 March 2020

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Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity

31 March 2020

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Mitochondrial permeability transition in Ca(2+)-dependent apoptosis and necrosis

31 March 2020

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Apoptosis driven by IP(3)-linked mitochondrial calcium signals

31 March 2020

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Slow calcium waves and redox changes precede mitochondrial permeability transition pore opening in the intact heart during hypoxia and reoxygenation

31 March 2020

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A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis

31 March 2020

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Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

31 March 2020

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Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death

31 March 2020

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The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis

31 March 2020

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Which came first, the cytochrome c release or the mitochondrial fission?

31 March 2020

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Reduced loading of intracellular Ca(2+) stores and downregulation of capacitative Ca(2+) influx in Bcl-2-overexpressing cells.

31 March 2020

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The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action

31 March 2020

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Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor

31 March 2020

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Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum

31 March 2020

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BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

31 March 2020

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Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis

31 March 2020

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The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis

31 March 2020

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The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R

31 March 2020

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Bcl-2 suppresses Ca2+ release through inositol 1,4,5-trisphosphate receptors and inhibits Ca2+ uptake by mitochondria without affecting ER calcium store content

31 March 2020

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Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate.

31 March 2020

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Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis.

31 March 2020

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Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

31 March 2020

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The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor

31 March 2020

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Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals

31 March 2020

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Caspase-dependent alterations of Ca2+ signaling in the induction of apoptosis by hepatitis B virus X protein.

31 March 2020

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The coxsackievirus 2B protein suppresses apoptotic host cell responses by manipulating intracellular Ca2+ homeostasis.

31 March 2020

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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

31 March 2020

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Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2.

31 March 2020

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Ca 2+ -dependent autophagy is enhanced by the pharmacological agent PK11195.

31 March 2020

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Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

31 March 2020

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Lithium induces autophagy by inhibiting inositol monophosphatase

31 March 2020

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The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1.

31 March 2020

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Regulation of autophagy by the inositol trisphosphate receptor

31 March 2020

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Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.

31 March 2020

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Role of inositol trisphosphate receptors in autophagy in DT40 cells

31 March 2020

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Ins(1,4,5)P3 receptor-mediated Ca2+ signaling and autophagy induction are interrelated

31 March 2020

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Specific inhibition of mitochondrial Ca2+ transport by antibodies directed to the Ca2+-binding glycoprotein

31 March 2020

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Identification of a ryanodine receptor in rat heart mitochondria

31 March 2020

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Single channel characterization of the mitochondrial ryanodine receptor in heart mitoplasts

31 March 2020

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Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca2+ uniport

31 March 2020

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UCPs--unlikely calcium porters.

31 March 2020

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Uncoupling protein 3 (UCP3) modulates the activity of Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) by decreasing mitochondrial ATP production

31 March 2020

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Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter

31 March 2020

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LETM1, deleted in Wolf-Hirschhorn syndrome is required for normal mitochondrial morphology and cellular viability

31 March 2020

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The stoichiometry of the exchange catalysed by the mitochondrial calcium/sodium antiporter

31 March 2020

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Analysis of cardiac mitochondrial Na+-Ca2+ exchanger kinetics with a biophysical model of mitochondrial Ca2+ handling suggests a 3:1 stoichiometry

31 March 2020

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A mitochondrial protein compendium elucidates complex I disease biology

31 March 2020

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Mitochondrial oxidative stress and cell death in astrocytes--requirement for stored Ca2+ and sustained opening of the permeability transition pore.

31 March 2020

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12 December 2020

Calcium oscillations: phenomena, mechanisms and significance.

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12 December 2020

Phospholipid synthesis in a membrane fraction associated with mitochondria

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12 December 2020

A unique mitochondria-associated membrane fraction from rat liver has a high capacity for lipid synthesis and contains pre-Golgi secretory proteins including nascent lipoproteins

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12 December 2020

The versatility and complexity of calcium signalling

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12 December 2020

Ca ion uptake by rat kidney mitochondria and its dependence on respiration and phosphorylation

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12 December 2020

Identifiers

DOI

10.1038/NRM3412

1 reference

PubMed ID

22850819

Dimensions Publication ID

27 August 2017

0 references

1 reference

PubMed ID

22850819