Glycans as targets for therapeutic antitumor antibodies (Q38034815)

27 August 2017

title

Glycans as targets for therapeutic antitumor antibodies (English)

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27 August 2017

Catherine Rabu

1

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27 August 2017

Richard McIntosh

series ordinal

2

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27 August 2017

Zuzana Jurasova

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3

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27 August 2017

Lindy Durrant

series ordinal

4

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27 August 2017

language of work or name

English

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publication date

1 August 2012

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27 August 2017

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27 August 2017

volume

8

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27 August 2017

issue

8

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27 August 2017

page(s)

943-960

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The repertoire of glycan determinants in the human glycome

27 August 2017

cites work

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IUPAC-IUB Joint Commission on Biochemical Nomenclature (JCBN). Nomenclature of glycolipids--recommendations 1997.

21 January 2018

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Glycosylation defining cancer malignancy: new wine in an old bottle

21 January 2018

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The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research

21 January 2018

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Tumor-associated glycolipid antigens, their metabolism and organization

21 January 2018

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Molecular mechanism for cancer-associated induction of sialyl Lewis X and sialyl Lewis A expression-The Warburg effect revisited.

21 January 2018

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The sweet and sour of cancer: glycans as novel therapeutic targets

21 January 2018

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21 January 2018

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Monosialyl-Gb5 organized with cSrc and FAK in GEM of human breast carcinoma MCF-7 cells defines their invasive properties

21 January 2018

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Clustering of monosialyl-Gb5 initiates downstream signalling events leading to invasion of MCF-7 breast cancer cells

21 January 2018

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A specific microdomain ("glycosynapse 3") controls phenotypic conversion and reversion of bladder cancer cells through GM3-mediated interaction of alpha3beta1 integrin with CD9.

21 January 2018

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Metastatic potential of mouse Lewis lung cancer cells is regulated via ganglioside GM1 by modulating the matrix metalloprotease-9 localization in lipid rafts.

21 January 2018

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Human melanoma cell lines deficient in GD3 ganglioside expression exhibit altered growth and tumorigenic characteristics

21 January 2018

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Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cells.

21 January 2018

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Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling

21 January 2018

1 reference

Role of tumor-associated gangliosides in cancer progression

21 January 2018

1 reference

IgM anti-ganglioside antibodies induced by melanoma cell vaccine correlate with survival of melanoma patients.

21 January 2018

1 reference

Anti-neuroblastoma effect of ch14.18 antibody produced in CHO cells is mediated by NK-cells in mice.

21 January 2018

1 reference

Complement-mediated mechanisms in anti-GD2 monoclonal antibody therapy of murine metastatic cancer

21 January 2018

1 reference

Optimizing engagement of the immune system by anti-tumor antibodies: an engineer's perspective

21 January 2018

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A complement-dependent cytotoxicity-enhancing anti-CD20 antibody mediating potent antitumor activity in the humanized NOD/Shi-scid, IL-2Rγ(null) mouse lymphoma model

21 January 2018

1 reference

Fully human antibodies from transgenic mouse and phage display platforms

21 January 2018

1 reference

Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity

21 January 2018

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Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans

21 January 2018

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In vivo glyco-engineered antibody with improved lytic potential produced by an innovative non-mammalian expression system.

21 January 2018

1 reference

Engineered antibodies of IgG1/IgG3 mixed isotype with enhanced cytotoxic activities

21 January 2018

1 reference

Anti-NeuGcGM3 antibodies, actively elicited by idiotypic vaccination in nonsmall cell lung cancer patients, induce tumor cell death by an oncosis-like mechanism

21 January 2018

1 reference

The glycotope-specific RAV12 monoclonal antibody induces oncosis in vitro and has antitumor activity against gastrointestinal adenocarcinoma tumor xenografts in vivo.

21 January 2018

1 reference

Suppression of human prostate tumor growth by a unique prostate-specific monoclonal antibody F77 targeting a glycolipid marker

21 January 2018

1 reference

Mechanisms for the apoptosis of small cell lung cancer cells induced by anti-GD2 monoclonal antibodies: roles of anoikis

21 January 2018

1 reference

Selection of tumor antigens as targets for immune attack using immunohistochemistry: I. Focus on gangliosides

21 January 2018

1 reference

Regression of cutaneous metastatic melanoma by intralesional injection with human monoclonal antibody to ganglioside GD2.

21 January 2018

1 reference

Targeting of small-cell lung cancer using the anti-GD2 ganglioside monoclonal antibody 3F8: a pilot trial

21 January 2018

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Successful multifold dose escalation of anti-GD2 monoclonal antibody 3F8 in patients with neuroblastoma: a phase I study.

21 January 2018

1 reference

Phase I trial of murine monoclonal antibody 14G2a administered by prolonged intravenous infusion in patients with neuroectodermal tumors

21 January 2018

1 reference

A phase I/IB trial of murine monoclonal anti-GD2 antibody 14.G2a plus interleukin-2 in children with refractory neuroblastoma: a report of the Children's Cancer Group

21 January 2018

1 reference

Phase I study of ch14.18 with granulocyte-macrophage colony-stimulating factor and interleukin-2 in children with neuroblastoma after autologous bone marrow transplantation or stem-cell rescue: a report from the Children's Oncology Group

21 January 2018

1 reference

Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma

21 January 2018

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Consolidation treatment with chimeric anti-GD2-antibody ch14.18 in children older than 1 year with metastatic neuroblastoma

21 January 2018

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Long term outcome of high-risk neuroblastoma patients after immunotherapy with antibody ch14.18 or oral metronomic chemotherapy

21 January 2018

1 reference

Phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody ch14.18 in patients with refractory neuroblastoma and osteosarcoma.

21 January 2018

1 reference

Immunogenicity of the hu14.18-IL2 immunocytokine molecule in adults with melanoma and children with neuroblastoma

21 January 2018

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Antitumor activity of hu14.18-IL2 in patients with relapsed/refractory neuroblastoma: a Children's Oncology Group (COG) phase II study

21 January 2018

1 reference

Differential internalization of hu14.18-IL2 immunocytokine by NK and tumor cell: impact on conjugation, cytotoxicity, and targeting

21 January 2018

1 reference

A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells

21 January 2018

1 reference

Anti-GD3 chimeric sFv-CD28/T-cell receptor zeta designer T cells for treatment of metastatic melanoma and other neuroectodermal tumors

21 January 2018

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Immunotherapy of metastatic melanoma using genetically engineered GD2-specific T cells

21 January 2018

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Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma

21 January 2018

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A monoclonal antibody to O-acetyl-GD2 ganglioside and not to GD2 shows potent anti-tumor activity without peripheral nervous system cross-reactivity

21 January 2018

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Mechanism of uptake and incorporation of the non-human sialic acid N-glycolylneuraminic acid into human cells

21 January 2018

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Colloquium paper: uniquely human evolution of sialic acid genetics and biology

21 January 2018

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N-Glycolylneuraminic acid in human tumours

21 January 2018

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Effects of natural human antibodies against a nonhuman sialic acid that metabolically incorporates into activated and malignant immune cells

21 January 2018

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A cytotoxic humanized anti-ganglioside antibody produced in a murine cell line defective of N-glycolylated-glycoconjugates

21 January 2018

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Anti-ganglioside antibody-induced tumor cell death by loss of membrane integrity

21 January 2018

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Combined therapeutic effect of a monoclonal anti-idiotype tumor vaccine against NeuGc-containing gangliosides with chemotherapy in a breast carcinoma model

21 January 2018

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Anti-ganglioside anti-idiotypic monoclonal antibody-based cancer vaccine induces apoptosis and antiangiogenic effect in a metastatic lung carcinoma

21 January 2018

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An anti-idiotype vaccine elicits a specific response to N-glycolyl sialic acid residues of glycoconjugates in melanoma patients

21 January 2018

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Characterization of the antibody response against NeuGcGM3 ganglioside elicited in non-small cell lung cancer patients immunized with an anti-idiotype antibody

21 January 2018

1 reference

A phase I study of anti-GD3 ganglioside monoclonal antibody R24 and recombinant human macrophage-colony stimulating factor in patients with metastatic melanoma

21 January 2018

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A phase II trial comparing five dose levels of BEC2 anti-idiotypic monoclonal antibody vaccine that mimics GD3 ganglioside

21 January 2018

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Phase III study of adjuvant vaccination with Bec2/bacille Calmette-Guerin in responding patients with limited-disease small-cell lung cancer (European Organisation for Research and Treatment of Cancer 08971-08971B; Silva Study).

21 January 2018

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The idiotype (Id) cascade in mice elicited the production of anti-R24 Id and anti-anti-Id monoclonal antibodies with antitumor and protective activity against human melanoma

21 January 2018

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Genetically engineered humanized anti-ganglioside GM2 antibody against multiple organ metastasis produced by GM2-expressing small-cell lung cancer cells.

21 January 2018

1 reference

Selective tumor sensitization to taxanes with the mAb-drug conjugate cBR96-doxorubicin

21 January 2018

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A randomized, multicenter study to determine the safety and efficacy of the immunoconjugate SGN-15 plus docetaxel for the treatment of non-small cell lung carcinoma

21 January 2018

1 reference

A phase I biodistribution and pharmacokinetic trial of humanized monoclonal antibody Hu3s193 in patients with advanced epithelial cancers that express the Lewis-Y antigen.

21 January 2018

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Phase I biodistribution and pharmacokinetic study of Lewis Y-targeting immunoconjugate CMD-193 in patients with advanced epithelial cancers

21 January 2018

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The Lewis-Y carbohydrate antigen is expressed by many human tumors and can serve as a target for genetically redirected T cells despite the presence of soluble antigen in serum

21 January 2018

1 reference

A new anticancer glycolipid monoclonal antibody, SC104, which directly induces tumor cell apoptosis.

21 January 2018

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Lewis x antigen mediates adhesion of human breast carcinoma cells to activated endothelium. Possible involvement of the endothelial scavenger receptor C-type lectin.

21 January 2018

1 reference

Human monoclonal antibodies to sialyl-Lewis (CA19.9) with potent CDC, ADCC, and antitumor activity

21 January 2018

1 reference

Cell surface antigens of human malignant melanoma: definition of six antigenic systems with mouse monoclonal antibodies

21 January 2018

1 reference

Antitumor effects of a novel monoclonal antibody with high binding affinity to ganglioside GD3.

21 January 2018

1 reference

B-cell activation by T-cell-independent type 2 antigens as an integral part of the humoral immune response to pathogenic microorganisms

21 January 2018

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Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses.

21 January 2018

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Establishment of monoclonal antibodies specific for ganglioside GM1: detection of ganglioside GM1 in small cell lung carcinoma cell lines and tissues

21 January 2018

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Lewis rats immunized with GM1 ganglioside do not develop peripheral neuropathy

21 January 2018

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Efficient generation of useful monoclonal antibodies reactive with globotriaosylceramide using knockout mice lacking Gb3/CD77 synthase

21 January 2018

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Tolerance to self gangliosides is the major factor restricting the antibody response to lipopolysaccharide core oligosaccharides in Campylobacter jejuni strains associated with Guillain-Barré syndrome

21 January 2018

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Glycosphingolipid antigens in neural tumor cell lines and anti-glycosphingolipid antibodies in sera of patients with neural tumors

21 January 2018

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High-affinity anti-ganglioside IgG antibodies raised in complex ganglioside knockout mice: reexamination of GD1a immunolocalization.

21 January 2018

1 reference

The detergent-insoluble microdomains, rafts, can be used as an effective immunogen

21 January 2018

1 reference

Generation and application of type-specific anti-heparan sulfate antibodies using phage display technology. Further evidence for heparan sulfate heterogeneity in the kidney

21 January 2018

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Production of anti-carbohydrate antibodies by phage display technologies: potential impairment of cell growth as a result of endogenous expression

21 January 2018

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Phage-display library selection of high-affinity human single-chain antibodies to tumor-associated carbohydrate antigens sialyl Lewisx and Lewisx

21 January 2018

1 reference

Molecular characterization of the anti-idiotypic immune response of a relapse-free neuroblastoma patient following antibody therapy: a possible vaccine against tumors of neuroectodermal origin?

21 January 2018

1 reference

Cancer vaccines and carbohydrate epitopes

21 January 2018

1 reference

Clinical and immune responses in advanced melanoma patients immunized with an anti-idiotype antibody mimicking disialoganglioside GD2.

21 January 2018

1 reference

Enhanced activity of hu14.18-IL2 immunocytokine against murine NXS2 neuroblastoma when combined with interleukin 2 therapy

21 January 2018

1 reference

Identification of epitopes on a mutant form of Pseudomonas exotoxin using serum from humans treated with Pseudomonas exotoxin containing immunotoxins

21 January 2018

1 reference

Characteristic Expression of Lewis-antigenic Glycolipids in Human Ovarian Carcinoma-derived Cells with Anticancer Drug-resistance

21 January 2018

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FCGR2APolymorphism Is Correlated With Clinical Outcome After Immunotherapy of Neuroblastoma With Anti-GD2 Antibody and Granulocyte Macrophage Colony-Stimulating Factor

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/FON.12.88

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27 August 2017

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