The actin-MRTF-SRF gene regulatory axis and myofibroblast differentiation (Q38035166)

27 August 2017

The actin-MRTF-SRF gene regulatory axis and myofibroblast differentiation (English)

1 reference

27 August 2017

Eric M Small

1

1 reference

PubMed ID

22898751

27 August 2017

language of work or name

English

0 references

publication date

17 August 2012

1 reference

Journal of Cardiovascular Translational Research

27 August 2017

1 reference

27 August 2017

5

1 reference

27 August 2017

6

1 reference

27 August 2017

794-804

1 reference

https://scigraph.springernature.com/pub.10.1007/s12265-012-9397-0

27 August 2017

0 references

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Molecular pathways underlying cardiac remodeling during pathophysiological stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Gene expression in fibroblasts and fibrosis: involvement in cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Myofibroblasts and mechano-regulation of connective tissue remodelling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Formation and function of the myofibroblast during tissue repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Mechanisms of myofibroblast activity and phenotypic modulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Sarcomeric gene expression and contractility in myofibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Normal and pathologic soft tissue remodeling: role of the myofibroblast, with special emphasis on liver and kidney fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

The role of TGF-beta signaling in myocardial infarction and cardiac remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Serum response factor is essential for mesoderm formation during mouse embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Role of serum response factor in the pathogenesis of disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Restricted inactivation of serum response factor to the cardiovascular system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Mosaic inactivation of the serum response factor gene in the myocardium induces focal lesions and heart failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Serum response factor: toggling between disparate programs of gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Identifying functional single nucleotide polymorphisms in the human CArGome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Myocardin is sufficient and necessary for cardiac gene expression in Xenopus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

The serum response factor coactivator myocardin is required for vascular smooth muscle development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Potentiation of serum response factor activity by a family of myocardin-related transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Actin dynamics control SRF activity by regulation of its coactivator MAL

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

RPEL motifs link the serum response factor cofactor MAL but not myocardin to Rho signaling via actin binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Structure of a pentavalent G-actin*MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Smooth muscle cell-specific transcription is regulated by nuclear localization of the myocardin-related transcription factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Linking actin dynamics and gene transcription to drive cellular motile functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Actin' together: serum response factor, its cofactors and the link to signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Regulation of alpha-smooth muscle actin expression in granulation tissue myofibroblasts is dependent on the intronic CArG element and the transforming growth factor-beta1 control element

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Critical role of serum response factor in pulmonary myofibroblast differentiation induced by TGF-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Integrity of cell-cell contacts is a critical regulator of TGF-beta 1-induced epithelial-to-myofibroblast transition: role for beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Cell contact-dependent regulation of epithelial-myofibroblast transition via the rho-rho kinase-phospho-myosin pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

MKL1 mediates TGF-beta1-induced alpha-smooth muscle actin expression in human renal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

E-cadherin regulates MAL-SRF-mediated transcription in epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

β-catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Nuclear transport of the serum response factor coactivator MRTF-A is downregulated at tensional homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Smooth muscle differentiation marker gene expression is regulated by RhoA-mediated actin polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Signal-regulated activation of serum response factor is mediated by changes in actin dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Force-induced myofibroblast differentiation through collagen receptors is dependent on mammalian diaphanous (mDia).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Mechanical force regulation of myofibroblast differentiation in cardiac fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Force activates smooth muscle alpha-actin promoter activity through the Rho signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Muscle-specific signaling mechanism that links actin dynamics to serum response factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Valvular myofibroblast activation by transforming growth factor-beta: implications for pathological extracellular matrix remodeling in heart valve disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Interaction of Smad3 and SRF-associated complex mediates TGF-beta1 signals to regulate SM22 transcription during myofibroblast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Myocardin enhances Smad3-mediated transforming growth factor-beta1 signaling in a CArG box-independent manner: Smad-binding element is an important cis element for SM22alpha transcription in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Serum-induced phosphorylation of the serum response factor coactivator MKL1 by the extracellular signal-regulated kinase 1/2 pathway inhibits its nuclear localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Transcriptional activity of megakaryoblastic leukemia 1 (MKL1) is repressed by SUMO modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Regulation of myocardin factor protein stability by the LIM-only protein FHL2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Deficiency in the LIM-only protein Fhl2 impairs skin wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Combinatorial expression of GATA4, Nkx2-5, and serum response factor directs early cardiac gene activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Actin in transcription and transcription regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

A competitive mechanism of CArG element regulation by YY1 and SRF: implications for assessment of Phox1/MHox transcription factor interactions at CArG elements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Increased actin polymerization reduces the inhibition of serum response factor activity by Yin Yang 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Evidence for tension-based regulation of Drosophila MAL and SRF during invasive cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Requirement of myocardin-related transcription factor-B for remodeling of branchial arch arteries and smooth muscle differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Requirement of a myocardin-related transcription factor for development of mammary myoepithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Actin-targeting natural products: structures, properties and mechanisms of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Effects of Rho-kinase inhibitor on vasopressin-induced chronic myocardial damage in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Transforming growth factor beta as a therapeutic target in systemic sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Heart repair by reprogramming non-myocytes with cardiac transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Elevation of Expression of Smads 2, 3, and 4, Decorin and TGF-βin the Chronic Phase of Myocardial Infarct Scar Healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9397-0

Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice

21 January 2018

1 reference

12 December 2020

Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis

1 reference

12 December 2020

Competition between negative acting YY1 versus positive acting serum response factor and tinman homologue Nkx-2.5 regulates cardiac alpha-actin promoter activity.

1 reference

12 December 2020

The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter

1 reference

12 December 2020

Contraction of myofibroblasts in granulation tissue is dependent on Rho/Rho kinase/myosin light chain phosphatase activity

1 reference

12 December 2020

Cdc42 regulates myocardin-related transcription factor nuclear shuttling and alpha-smooth muscle actin promoter activity during renal tubular epithelial-mesenchymal transition

1 reference

12 December 2020

Muscle specificity encoded by specific serum response factor-binding sites

1 reference

12 December 2020

Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium

1 reference

12 December 2020

Temporally controlled onset of dilated cardiomyopathy through disruption of the SRF gene in adult heart

1 reference

12 December 2020

The RhoA/Rho kinase pathway regulates nuclear localization of serum response factor

1 reference

12 December 2020

Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice

1 reference

12 December 2020

Molecular mechanisms of myocardial remodeling

1 reference

12 December 2020

10.1007/S12265-012-9397-0

Identifiers

DOI

1 reference

PubMed ID

22898751

Dimensions Publication ID

27 August 2017

0 references

1 reference

PubMed ID

22898751