Influence of the OPRM1 A118G polymorphism on alcohol-induced euphoria, risk for alcoholism and the clinical efficacy of naltrexone (Q38036386)

27 August 2017

Influence of the OPRM1 A118G polymorphism on alcohol-induced euphoria, risk for alcoholism and the clinical efficacy of naltrexone (English)

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27 August 2017

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3

Chawki Benkelfat

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author name string

Elaine Setiawan

1

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27 August 2017

Robert O Pihl

2

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27 August 2017

Chawki Benkelfat

3

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27 August 2017

Marco Leyton

4

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27 August 2017

language of work or name

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1 July 2012

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27 August 2017

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27 August 2017

13

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27 August 2017

1161-1172

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27 August 2017

10

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Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders

27 August 2017

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Pharmacogenetic approaches to the treatment of alcohol addiction

21 January 2018

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Opiate Receptor: Demonstration in Nervous Tissue

21 January 2018

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Antagonism of Stimulation-Produced Analgesia by Naloxone, a Narcotic Antagonist

21 January 2018

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Identification of two related pentapeptides from the brain with potent opiate agonist activity

21 January 2018

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Dynorphin-(1-13), an extraordinarily potent opioid peptide

21 January 2018

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Reward processing by the opioid system in the brain.

21 January 2018

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OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models

21 January 2018

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Expansion of the human mu-opioid receptor gene architecture: novel functional variants

21 January 2018

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Mu opioid receptor gene variants: lack of association with alcohol dependence

21 January 2018

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Genetics of two mu opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjects

21 January 2018

1 reference

Pharmacogenetics of naltrexone in asian americans: a randomized placebo-controlled laboratory study

21 January 2018

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Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction

21 January 2018

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A mu-opioid receptor single nucleotide polymorphism in rhesus monkey: association with stress response and aggression

21 January 2018

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Human expression variation in the mu-opioid receptor is paralleled in rhesus macaque

21 January 2018

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Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor

21 January 2018

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Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G.

21 January 2018

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Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior

21 January 2018

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Reduced expression of the μ opioid receptor in some, but not all, brain regions in mice with OPRM1 A112G

21 January 2018

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A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability

21 January 2018

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Influence of OPRM1 Asn40Asp variant (A118G) on [11C]carfentanil binding potential: preliminary findings in human subjects.

21 January 2018

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A microdialysis profile of Met-enkephalin release in the rat nucleus accumbens following alcohol administration

21 January 2018

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A microdialysis profile of beta-endorphin and catecholamines in the rat nucleus accumbens following alcohol administration

21 January 2018

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Effects of acute ethanol on corticotropin-releasing hormone and β-endorphin systems at the level of the rat central amygdala

21 January 2018

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Effect of acute ethanol administration on the release of opioid peptides from the midbrain including the ventral tegmental area

21 January 2018

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Intake of saccharin, salt, and ethanol solutions is increased by infusion of a mu opioid agonist into the nucleus accumbens

21 January 2018

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Ethanol consumption and reward are decreased in mu-opiate receptor knockout mice

21 January 2018

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Enhanced sensitivity of pituitary beta-endorphin to ethanol in subjects at high risk of alcoholism

21 January 2018

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Alcohol consumption induces endogenous opioid release in the human orbitofrontal cortex and nucleus accumbens.

21 January 2018

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The role of mesolimbic dopamine in the development and maintenance of ethanol reinforcement.

21 January 2018

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Endogenous opioid systems and alcohol addiction

21 January 2018

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Opioid-sensitive GABA inputs from rostromedial tegmental nucleus synapse onto midbrain dopamine neurons

21 January 2018

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Dynorphin-containing pathways in the substantia nigra and ventral tegmentum: a double labeling study using combined immunofluorescence and retrograde tracing.

21 January 2018

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Effect of experimenter-delivered and self-administered cocaine on extracellular beta-endorphin levels in the nucleus accumbens

21 January 2018

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A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans

21 January 2018

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Effects of naltrexone on alcohol sensitivity and genetic moderators of medication response: a double-blind placebo-controlled study

21 January 2018

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Polymorphisms of the mu-opioid receptor and dopamine D4 receptor genes and subjective responses to alcohol in the natural environment

21 January 2018

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Relatively strong automatic appetitive action-tendencies in male carriers of the OPRM1 G-allele.

21 January 2018

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A functional polymorphism of the mu-opioid receptor gene (OPRM1) influences cue-induced craving for alcohol in male heavy drinkers.

21 January 2018

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Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques

21 January 2018

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A pharmacogenetic model of naltrexone-induced attenuation of alcohol consumption in rhesus monkeys

21 January 2018

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A genetic determinant of the striatal dopamine response to alcohol in men

21 January 2018

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The debate over dopamine's role in reward: the case for incentive salience

21 January 2018

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Dissecting components of reward: 'liking', 'wanting', and learning

21 January 2018

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Rewarding, stimulant, and sedative alcohol responses and relationship to future binge drinking

21 January 2018

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Enhanced sensitivity of the nucleus accumbens proenkephalin system to alcohol in rats selectively bred for alcohol preference.

21 January 2018

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Quantitative autoradiography of mu-opioid receptors in the CNS of alcohol-naive alcohol-preferring P and -nonpreferring NP rats

21 January 2018

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Opioid propeptide mRNA content and receptor density in the brains of AA and ANA rats

21 January 2018

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Differences in the opioid system in selected brain regions of alcohol-preferring and alcohol-nonpreferring rats

21 January 2018

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Correlation of stable elevations in striatal mu-opioid receptor availability in detoxified alcoholic patients with alcohol craving: a positron emission tomography study using carbon 11-labeled carfentanil

21 January 2018

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Positron emission tomography imaging of mu- and delta-opioid receptor binding in alcohol-dependent and healthy control subjects

21 January 2018

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Brain opioid receptor binding in early abstinence from alcohol dependence and relationship to craving: an [11C]diprenorphine PET study.

21 January 2018

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Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden

21 January 2018

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Initial evidence of an association between OPRM1 and adolescent alcohol misuse

21 January 2018

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Ethnic-specific meta-analyses of association between the OPRM1 A118G polymorphism and alcohol dependence among Asians and Caucasians

21 January 2018

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Association of mu-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population

21 January 2018

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Epistatic effects between variants of kappa-opioid receptor gene and A118G of mu-opioid receptor gene increase susceptibility to addiction in Indian population

21 January 2018

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Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis

21 January 2018

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OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques

21 January 2018

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Role of the HPA axis and the A118G polymorphism of the mu-opioid receptor in stress-induced drinking behavior

21 January 2018

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Dissection of hypothalamic-pituitary-adrenal axis pathology in 1-month-abstinent alcohol-dependent men, part 2: response to ovine corticotropin-releasing factor and naloxone

21 January 2018

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Neurochemical characteristics associated with ethanol preference in selected alcohol-preferring and -nonpreferring rats: a quantitative microdialysis study

21 January 2018

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Conditioned and sensitized responses to stimulant drugs in humans

21 January 2018

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Effects of naltrexone administered repeatedly across 30 or 60 days on ethanol consumption using a limited access procedure in the rat.

21 January 2018

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Alteration of ethanol self-administration by naltrexone.

21 January 2018

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Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamo-pituitary-adrenocortical axis.

21 January 2018

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Naltrexone in the treatment of alcohol dependence

21 January 2018

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Alcohol urge and plasma beta-endorphin change after alcohol challenge with naltrexone pretreatment in social drinkers

21 January 2018

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Naltrexone alters subjective and psychomotor responses to alcohol in heavy drinking subjects

21 January 2018

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Effects of naltrexone on alcohol self-administration in heavy drinkers.

21 January 2018

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Does effect size in naltrexone trials for alcohol dependence differ for single-site vs. multi-center studies?

21 January 2018

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Effect of naltrexone on subjective alcohol response in subjects at high and low risk for future alcohol dependence

21 January 2018

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Family history of alcoholism influences naltrexone-induced reduction in alcohol drinking.

21 January 2018

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A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients

21 January 2018

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An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study

21 January 2018

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Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial.

21 January 2018

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OPRM1 Asn40Asp predicts response to naltrexone treatment: a haplotype-based approach

21 January 2018

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A micro opioid receptor gene polymorphism (A118G) and naltrexone treatment response in adherent Korean alcohol-dependent patients

21 January 2018

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The effect of naltrexone on alcohol's stimulant properties and self-administration behavior in social drinkers: influence of gender and genotype.

21 January 2018

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Moderators of naltrexone's effects on drinking, urge, and alcohol effects in non-treatment-seeking heavy drinkers in the natural environment

21 January 2018

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Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions

21 January 2018

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Sex differences in striatal dopamine release in young adults after oral alcohol challenge: a positron emission tomography imaging study with [¹¹C]raclopride

21 January 2018

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A neuroendocrinological hypothesis on gender effects of naltrexone in relapse prevention treatment

21 January 2018

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Mu (mu) opioid receptor regulation of ethanol-induced dopamine response in the ventral striatum: evidence of genotype specific sexual dimorphic epistasis.

21 January 2018

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Functional polymorphism of the mu-opioid receptor gene (OPRM1) influences reinforcement learning in humans

21 January 2018

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Social hedonic capacity is associated with the A118G polymorphism of the mu-opioid receptor gene (OPRM1) in adult healthy volunteers and psychiatric patients

21 January 2018

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Association of OPRM1 A118G variant with the relative reinforcing value of nicotine.

21 January 2018

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Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects

21 January 2018

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Roles of opioid receptor subtypes in mediating alcohol-seeking induced by discrete cues and context.

21 January 2018

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OPRM1 A118G genotype fails to predict the effectiveness of naltrexone treatment for alcohol dependence

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/PGS.12.99

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27 August 2017

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