The TRPM2 ion channel, an oxidative stress and metabolic sensor regulating innate immunity and inflammation (Q38043290)

27 August 2017

The TRPM2 ion channel, an oxidative stress and metabolic sensor regulating innate immunity and inflammation (English)

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27 August 2017

Heather Knowles

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27 August 2017

Yuan Li

series ordinal

2

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27 August 2017

Anne-Laure Perraud

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3

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27 August 2017

1 March 2013

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27 August 2017

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27 August 2017

55

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27 August 2017

1-3

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27 August 2017

241-248

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https://scigraph.springernature.com/pub.10.1007/s12026-012-8373-8

27 August 2017

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cites work

TRP channels: an overview

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRP channels as cellular sensors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

How many drug targets are there?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Novel aspects of signaling and ion-homeostasis regulation in immunocytes. The TRPM ion channels and their potential role in modulating the immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRPM2 Ca2+ permeable cation channels: from gene to biological function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Evolutionary determinants of divergent calcium selectivity of TRPM channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Mg2+ Homeostasis: The Mg2+nificent TRPM Chanzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

The Nudix hydrolase superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Emerging roles of NAD+ and its metabolites in cell signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Critical intracellular Ca2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

CD38 plays a dual role in allergen-induced airway hyperresponsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: impact on the development of humoral immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca2+ fluxes in oxidative cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

The Poly(ADP-ribose) polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Expression profile of the transient receptor potential (TRP) family in neutrophil granulocytes: evidence for currents through long TRP channel 2 induced by ADP-ribose and NAD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Immunocyte Ca2+ influx system mediated by LTRPC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Endogenous ADP-ribose enables calcium-regulated cation currents through TRPM2 channels in neutrophil granulocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Regulation of TRPM2 by extra- and intracellular calcium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Transient receptor potential melastatin 2 is required for lipopolysaccharide-induced cytokine production in human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRPM2 contributes to inflammatory and neuropathic pain through the aggravation of pronociceptive inflammatory responses in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Regulation of the antimicrobial response by NLR proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Toll-like receptors and their crosstalk with other innate receptors in infection and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRPM2 Ca2+ channel regulates energy balance and glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRPV2 has a pivotal role in macrophage particle binding and phagocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

The ion channel transient receptor potential melastatin-2 does not play a role in inflammatory mouse models of chronic obstructive pulmonary diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Role and regulation of TRP channels in neutrophil granulocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRPM2 functions as a lysosomal Ca2+-release channel in beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurones

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Ca2+-dependent induction of TRPM2 currents in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

A critical role of TRPM2 in neuronal cell death by hydrogen peroxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Calcium, ischemia and excitotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Transient receptor potential channels of the melastatin family and ischemic responses of central neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Altered functional properties of a TRPM2 variant in Guamanian ALS and PD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRPM2 variants and bipolar disorder risk: confirmation in a family-based association study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Transient receptor potential melastatin 2 expression is increased following experimental traumatic brain injury in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated, and functionally expressed in C13 microglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Sex differences in neuroprotection provided by inhibition of TRPM2 channels following experimental stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Gender and the injured brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

The juvenile myoclonic epilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 channel linked to cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

21 January 2018

TRP channels of islets.

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Roles of TRPM2 in oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes

21 January 2018

1 reference

12 December 2020

Facilitation of H2O2-induced A172 human glioblastoma cell death by insertion of oxidative stress-sensitive TRPM2 channels

1 reference

12 December 2020

Transient receptor potential cation channels in pancreatic β cells

1 reference

12 December 2020

Amyloid beta-peptide(1-42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures

1 reference

12 December 2020

Activation of the transient receptor potential M2 channel and poly(ADP-ribose) polymerase is involved in oxidative stress-induced cardiomyocyte death

1 reference

12 December 2020

Calcium-activated non-selective cation currents are involved in generation of tonic and bursting activity in dopamine neurons of the substantia nigra pars compacta

1 reference

12 December 2020

Mechanisms of calcium signaling by cyclic ADP-ribose and NAADP.

1 reference

12 December 2020

Targeting ion channels for drug discovery.

1 reference

12 December 2020

The calcium-permeable non-selective cation channel TRPM2 is modulated by cellular acidification

1 reference

12 December 2020

10.1007/S12026-012-8373-8

Identifiers

DOI

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Dimensions Publication ID

27 August 2017

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