Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2. (Q38044428)

27 August 2017

Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2. (English)

1 reference

27 August 2017

1 reference

Youren Tong

1

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PubMed ID

22988862

27 August 2017

Jie Shen

series ordinal

2

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27 August 2017

1 October 2012

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Biochemical Society Transactions

27 August 2017

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27 August 2017

40

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27 August 2017

5

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27 August 2017

1042-1046

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Alpha-synuclein in Lewy bodies

27 August 2017

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Comprehensive evaluation of common genetic variation within LRRK2 reveals evidence for association with sporadic Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Kinase activity of mutant LRRK2 mediates neuronal toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

The familial Parkinsonism gene LRRK2 regulates neurite process morphology

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

LRRK2 regulates synaptic vesicle endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

A Drosophila model for LRRK2-linked parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

A closer look at amphetamine-induced reverse transport and trafficking of the dopamine and norepinephrine transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Intracellular Ca2+ regulates amphetamine-induced dopamine efflux and currents mediated by the human dopamine transporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Distinct functions of the two isoforms of dopamine D2 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Loss of autoreceptor function in dopaminergic neurons from dopamine D2 receptor deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Dopamine D2 receptor-mediated inhibition of dopaminergic neurons in mice lacking D2L receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

The DRD2 gene in psychiatric and neurological disorders and its phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Neuroprotective mechanisms of antiparkinsonian dopamine D2-receptor subfamily agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Dynamic and redundant regulation of LRRK2 and LRRK1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Autophagy in neurodegenerative disease: friend, foe or turncoat?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

The roles of intracellular protein-degradation pathways in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Methods in mammalian autophagy research

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

Lrrk2 pathogenic substitutions in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120112

21 January 2018

Identifiers

DOI

10.1042/BST20120112

1 reference

27 August 2017

1 reference

PubMed ID

22988862