The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer (Q38069877)

28 August 2017

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title

The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer (English)

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28 August 2017

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Lars Dyrskjøt

2

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author name string

Anders Christiansen

series ordinal

1

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28 August 2017

language of work or name

English

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publication date

23 December 2012

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28 August 2017

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28 August 2017

volume

331

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28 August 2017

issue

1

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28 August 2017

page(s)

18-23

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Triggering neural differentiation of ES cells by subtype switching of importin-alpha

28 August 2017

cites work

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12 December 2020

Significance of karyopherin-{alpha} 2 (KPNA2) expression in esophageal squamous cell carcinoma

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12 December 2020

Differential expression and sequence-specific interaction of karyopherin alpha with nuclear localization sequences

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12 December 2020

The importin-alpha/nucleophosmin switch controls taspase1 protease function

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12 December 2020

Nuclear transport and cancer: from mechanism to intervention

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12 December 2020

Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis

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12 December 2020

Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus

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12 December 2020

Karyopherin alpha2: a control step of glucose-sensitive gene expression in hepatic cells

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12 December 2020

Nuclear karyopherin a2: a novel biomarker for infiltrative astrocytomas

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12 December 2020

AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: involvement in the nuclear import of RNA-binding protein HuR.

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12 December 2020

Cleavage stage porcine embryos may have differing developmental requirements for karyopherins alpha2 and alpha3.

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12 December 2020

Karyopherin-alpha2 protein interacts with Chk2 and contributes to its nuclear import.

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12 December 2020

Nuclear import and DNA binding of human papillomavirus type 45 L1 capsid protein

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12 December 2020

The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin

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12 December 2020

BARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear export

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12 December 2020

Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-delta11b

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12 December 2020

Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins

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12 December 2020

Sgk kinases and their role in epithelial transport

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12 December 2020

Nuclear import of HPV11 L1 capsid protein is mediated by karyopherin alpha2beta1 heterodimers

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12 December 2020

In vivo analysis of importin alpha proteins reveals cellular proliferation inhibition and substrate specificity

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12 December 2020

Importin alpha-mediated nuclear import of cytoplasmic poly(A) binding protein occurs as a direct consequence of cytoplasmic mRNA depletion

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12 December 2020

Gene Expression Profiling of Primary Cutaneous Melanoma and Clinical Outcome

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12 December 2020

Structural basis for the nuclear import of the human androgen receptor

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12 December 2020

Overexpression of Kpnβ1 and Kpnα2 importin proteins in cancer derives from deregulated E2F activity

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12 December 2020

Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal

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12 December 2020

Acetylation of importin-alpha nuclear import factors by CBP/p300.

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12 December 2020

Cross-talk between distinct nuclear import pathways enables efficient nuclear import of E47 in conjunction with its partner transcription factors

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12 December 2020

Characterization of the auto-inhibitory sequence within the N-terminal domain of importin alpha

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12 December 2020

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

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12 December 2020

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12 December 2020

Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis

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12 December 2020

Nuclear import of the BTB/POZ transcriptional regulator Kaiso

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12 December 2020

BSAP (Pax5)-importin alpha 1 (Rch1) interaction identifies a nuclear localization sequence

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12 December 2020

Importin α: a multipurpose nuclear-transport receptor

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12 December 2020

Identification of a selective nuclear import signal in adenosine deaminases acting on RNA.

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12 December 2020

Importin-alpha mediates the regulated nuclear targeting of serum- and glucocorticoid-inducible protein kinase (Sgk) by recognition of a nuclear localization signal in the kinase central domain

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12 December 2020

Cellular stresses induce the nuclear accumulation of importin alpha and cause a conventional nuclear import block

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12 December 2020

RAG: a recombinase diversified

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12 December 2020

Analysis of molecular intra-patient variation and delineation of a prognostic 12-gene signature in non-muscle invasive bladder cancer; technology transfer from microarrays to PCR.

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12 December 2020

The conserved amino-terminal domain of hSRP1 alpha is essential for nuclear protein import

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12 December 2020

A role for Kaiso-p120ctn complexes in cancer?

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12 December 2020

Cell type-specific transcriptional regulation of the gene encoding importin-α1.

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12 December 2020

Tumor metastasis: molecular insights and evolving paradigms

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12 December 2020

Nuclear transport receptor karyopherin-α2 promotes malignant breast cancer phenotypes in vitro

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12 December 2020

Importin subunit alpha-2 is identified as a potential biomarker for non-small cell lung cancer by integration of the cancer cell secretome and tissue transcriptome

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12 December 2020

Importin alpha mRNAs have distinct expression profiles during spermatogenesis.

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12 December 2020

Regulation of nuclear localization signal‐importin α interaction by Ca2+/S100A6

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12 December 2020

Importin-α1 as a novel prognostic target for hepatocellular carcinoma

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12 December 2020

LOT1 (ZAC1/PLAGL1) and its family members: mechanisms and functions

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12 December 2020

A Rac switch regulates random versus directionally persistent cell migration

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12 December 2020

Identification of importin alpha1 as a novel constituent of RNA stress granules

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12 December 2020

Karyopherins and nuclear import

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12 December 2020

Nuclear importin α and its physiological importance

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12 December 2020

Truncated form of importin alpha identified in breast cancer cell inhibits nuclear import of p53.

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12 December 2020

KPNA2 protein expression in invasive breast carcinoma and matched peritumoral ductal carcinoma in situ

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12 December 2020

Localization, interaction, and RNA binding properties of the V(D)J recombination-activating proteins RAG1 and RAG2.

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12 December 2020

Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-alpha3 binding

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12 December 2020

Localization of BRCA1 and a splice variant identifies the nuclear localization signal

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12 December 2020

Emerging roles of E2Fs in cancer: an exit from cell cycle control

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12 December 2020

Functional interaction of CREB binding protein (CBP) with nuclear transport proteins and modulation by HDAC inhibitors.

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12 December 2020

Identification of karyopherin-alpha 2 as an Oct4 associated protein

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12 December 2020

Differential regulation of karyopherin alpha 2 expression by TGF-beta1 and IFN-gamma in normal human epidermal keratinocytes: evident contribution of KPNA2 for nuclear translocation of IRF-1

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12 December 2020

The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation.

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12 December 2020

The nuclear localization sequences of the BRCA1 protein interact with the importin-alpha subunit of the nuclear transport signal receptor

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12 December 2020

Importin alpha1 (Rch1) mediates nuclear translocation of thioredoxin-binding protein-2/vitamin D(3)-up-regulated protein 1

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12 December 2020

Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression

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12 December 2020

E2Fs link the control of G1/S and G2/M transcription

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12 December 2020

ITK inhibitors in inflammation and immune-mediated disorders

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12 December 2020

Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1.

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12 December 2020

Distinct roles for classical nuclear import receptors in the growth of multinucleated muscle cells

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12 December 2020

Nuclear retention of importin α coordinates cell fate through changes in gene expression.

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12 December 2020

Heat-shock induced nuclear retention and recycling inhibition of importin alpha

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12 December 2020

Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors

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12 December 2020

Possible role for cellular karyopherins in regulating polyomavirus and papillomavirus capsid assembly

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12 December 2020

Nuclear entry of high-risk human papillomavirus type 16 E6 oncoprotein occurs via several pathways

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12 December 2020

Molecular profiling of laser-microdissected matched tumor and normal breast tissue identifies karyopherin alpha2 as a potential novel prognostic marker in breast cancer

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12 December 2020

Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import

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12 December 2020

Nuclear karyopherin alpha2 expression predicts poor survival in patients with advanced breast cancer irrespective of treatment intensity

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12 December 2020

Multiple mechanisms promote the inhibition of classical nuclear import upon exposure to severe oxidative stress

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12 December 2020

Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences

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12 December 2020

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1

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12 December 2020

KPNA2 expression is an independent adverse predictor of biochemical recurrence after radical prostatectomy

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12 December 2020

Importin KPNA2, NBS1, DNA repair and tumorigenesis

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12 December 2020

Impaired DNA damage response in cells expressing an exon 11-deleted murine Brca1 variant that localizes to nuclear foci

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12 December 2020

Oct-4: gatekeeper in the beginnings of mammalian development.

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12 December 2020

Localization of importin alpha (Rch1) at the plasma membrane and subcellular redistribution during lymphocyte activation

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12 December 2020

Importin alpha1 is involved in the nuclear localization of Zac1 and the induction of p21WAF1/CIP1 by Zac1.

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12 December 2020

p21(WAF1/CIP1) and cancer: a shifting paradigm?

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12 December 2020

Quantitative proteomics reveals regulation of karyopherin subunit alpha-2 (KPNA2) and its potential novel cargo proteins in nonsmall cell lung cancer

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12 December 2020

Epstein-Barr virus nuclear antigen 1 forms a complex with the nuclear transporter karyopherin alpha2.

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12 December 2020

Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein

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12 December 2020

Nuclear entry mechanism of the human polyomavirus JC virus-like particle: role of importins and the nuclear pore complex

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12 December 2020

Kaiso-deficient mice show resistance to intestinal cancer

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12 December 2020

The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin alpha2.

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12 December 2020

BRCA1 and BRCA2: 1994 and beyond

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12 December 2020

A karyopherin alpha2 nuclear transport pathway is regulated by glucose in hepatic and pancreatic cells.

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12 December 2020

A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleus

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12 December 2020

Overexpression of Karyopherin-2 in Epithelial Ovarian Cancer and Correlation With Poor Prognosis

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12 December 2020

Molecular mechanism of the nuclear protein import cycle

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12 December 2020

The Pax-5 gene: a pluripotent regulator of B-cell differentiation and cancer disease

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12 December 2020

High expression of karyopherin-α2 defines poor prognosis in non-muscle-invasive bladder cancer and in patients with invasive bladder cancer undergoing radical cystectomy

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12 December 2020

Stress-mediated inhibition of the classical nuclear protein import pathway and nuclear accumulation of the small GTPase Gsp1p

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12 December 2020

Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin alpha (Rch1alpha)

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12 December 2020

Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane

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12 December 2020

Aberrant localization of importin alpha1 in hippocampal neurons in Alzheimer disease

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12 December 2020

10.1016/J.CANLET.2012.12.013

Identifiers

DOI

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28 August 2017

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