Current therapeutic interventions in the glycation pathway: evidence from clinical studies (Q38070906)

28 August 2017

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title

Current therapeutic interventions in the glycation pathway: evidence from clinical studies (English)

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Coenraad Dirk Adriaan Stehouwer

28 August 2017

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ChEBI release 2020-05-28

ChEBI ID

41039

author

series ordinal

2

object named as

C D A Stehouwer

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28 August 2017

3

C G Schalkwijk

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28 August 2017

L Engelen

1

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28 August 2017

25 January 2013

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Diabetes, Obesity and Metabolism

28 August 2017

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28 August 2017

15

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28 August 2017

677-689

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28 August 2017

8

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Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies

28 August 2017

1 reference

Diabetes mellitus, fasting glucose, and risk of cause-specific death

21 January 2018

1 reference

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

21 January 2018

1 reference

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

21 January 2018

1 reference

Diabetes and advanced glycation endproducts

21 January 2018

1 reference

Biochemistry and molecular cell biology of diabetic complications

21 January 2018

1 reference

Advanced glycation: an important pathological event in diabetic and age related ocular disease

21 January 2018

1 reference

Nonenzymatic browning in vivo: possible process for aging of long-lived proteins

21 January 2018

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Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes

21 January 2018

1 reference

BCL-2 expression or antioxidants prevent hyperglycemia-induced formation of intracellular advanced glycation endproducts in bovine endothelial cells

21 January 2018

1 reference

Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose

21 January 2018

1 reference

Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors.

21 January 2018

1 reference

Advanced glycation endproducts--role in pathology of diabetic complications

21 January 2018

1 reference

The role of AGEs in aging: causation or correlation

21 January 2018

1 reference

Advanced glycation end-products: a review

21 January 2018

1 reference

The clinical relevance of advanced glycation endproducts (AGE) and recent developments in pharmaceutics to reduce AGE accumulation

21 January 2018

1 reference

Glycation in diabetic neuropathy: characteristics, consequences, causes, and therapeutic options

21 January 2018

1 reference

Diabetic vascular dysfunction: links to glucose-induced reductive stress and VEGF.

21 January 2018

1 reference

Clinical review: The role of advanced glycation end products in progression and complications of diabetes

21 January 2018

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Advanced glycation endproducts: what is their relevance to diabetic complications?

21 January 2018

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Advanced glycation end products: sparking the development of diabetic vascular injury

21 January 2018

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Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes

21 January 2018

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Scavenger receptors that recognize advanced glycation end products

21 January 2018

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Receptor for advanced glycation endproducts (RAGE) and the complications of diabetes

21 January 2018

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Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis

21 January 2018

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Chelation: a fundamental mechanism of action of AGE inhibitors, AGE breakers, and other inhibitors of diabetes complications

21 January 2018

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A new perspective on therapeutic inhibition of advanced glycation in diabetic microvascular complications: common downstream endpoints achieved through disparate therapeutic approaches?

21 January 2018

1 reference

Advanced glycation endproducts (AGEs): Pharmacological inhibition in diabetes

21 January 2018

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Early- and advanced non-enzymatic glycation in diabetic vascular complications: the search for therapeutics

21 January 2018

1 reference

Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts

21 January 2018

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Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking

21 January 2018

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Aminoguanidine treatment increases elasticity and decreases fluid filtration of large arteries from diabetic rats

21 January 2018

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The effects of aminoguanidine on renal changes in a baboon model of Type 1 diabetes

21 January 2018

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Aminoguanidine ameliorates albuminuria in diabetic hypertensive rats

21 January 2018

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Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy

21 January 2018

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Pharmacological inhibition of diabetic retinopathy: aminoguanidine and aspirin

21 January 2018

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An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness.

21 January 2018

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A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes

21 January 2018

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A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys

21 January 2018

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An agent cleaving glucose-derived protein crosslinks in vitro and in vivo

21 January 2018

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Breakers of advanced glycation end products restore large artery properties in experimental diabetes.

21 January 2018

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Advanced glycation end product interventions reduce diabetes-accelerated atherosclerosis.

21 January 2018

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Accelerated nephropathy in diabetic apolipoprotein e-knockout mouse: role of advanced glycation end products.

21 January 2018

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Attenuation of extracellular matrix accumulation in diabetic nephropathy by the advanced glycation end product cross-link breaker ALT-711 via a protein kinase C-alpha-dependent pathway.

21 January 2018

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A double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathy

21 January 2018

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Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat.

21 January 2018

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Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy

21 January 2018

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The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes.

21 January 2018

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Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine

21 January 2018

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Ameliorative effect of combination of benfotiamine and fenofibrate in diabetes-induced vascular endothelial dysfunction and nephropathy in the rat.

21 January 2018

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Increased protein damage in renal glomeruli, retina, nerve, plasma and urine and its prevention by thiamine and benfotiamine therapy in a rat model of diabetes

21 January 2018

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Randomized trial of an inhibitor of formation of advanced glycation end products in diabetic nephropathy

21 January 2018

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Design and baseline characteristics for the aminoguanidine Clinical Trial in Overt Type 2 Diabetic Nephropathy (ACTION II).

21 January 2018

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Potential new therapeutic agents for diabetic kidney disease

21 January 2018

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Improved arterial compliance by a novel advanced glycation end-product crosslink breaker

21 January 2018

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Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension.

21 January 2018

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The effect of alagebrium chloride (ALT-711), a novel glucose cross-link breaker, in the treatment of elderly patients with diastolic heart failure

21 January 2018

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Modification of proteins in vitro by physiological levels of glucose: pyridoxamine inhibits conversion of Amadori intermediate to advanced glycation end-products through binding of redox metal ions

21 January 2018

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Effects of pyridoxamine in combined phase 2 studies of patients with type 1 and type 2 diabetes and overt nephropathy

21 January 2018

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Pyridorin in type 2 diabetic nephropathy

21 January 2018

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Effect of benfotiamine on advanced glycation endproducts and markers of endothelial dysfunction and inflammation in diabetic nephropathy

21 January 2018

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Benfotiamine reduces genomic damage in peripheral lymphocytes of hemodialysis patients

21 January 2018

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Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes

21 January 2018

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Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes

21 January 2018

1 reference

High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind placebo-controlled pilot study.

21 January 2018

1 reference

Effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy in patients with type 2 diabetes, in relation to suppression of N(ɛ)-carboxymethyl lysine

21 January 2018

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Effects of an aldose reductase inhibitor on erythrocyte fructose 3-phosphate and sorbitol 3-phosphate levels in diabetic patients.

21 January 2018

1 reference

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group

21 January 2018

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Impairment of the antioxidant properties of serum albumin in patients with diabetes: protective effects of metformin

21 January 2018

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Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin

21 January 2018

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Effect of metformin administration on plasma advanced glycation end product levels in women with polycystic ovary syndrome

21 January 2018

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Improved glycemic control induced by both metformin and repaglinide is associated with a reduction in blood levels of 3-deoxyglucosone in nonobese patients with type 2 diabetes.

21 January 2018

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Impact of metformin versus repaglinide on non-glycaemic cardiovascular risk markers related to inflammation and endothelial dysfunction in non-obese patients with type 2 diabetes

21 January 2018

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Skin collagen glycation, glycoxidation, and crosslinking are lower in subjects with long-term intensive versus conventional therapy of type 1 diabetes: relevance of glycated collagen products versus HbA1c as markers of diabetic complications. DCCT S

21 January 2018

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The effects of short-term, rapid glycemic control on the peroneal nerve function and serum VCAM-1 and AGE in type 2 diabetic patients in Malaysia.

21 January 2018

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Identification of Amadori-modified plasma proteins in type 2 diabetes and the effect of short-term intensive insulin treatment

21 January 2018

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Improved metabolic control in patients with non-insulin-dependent diabetes mellitus is associated with a slower accumulation of glycation products in collagen.

21 January 2018

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Improvement in quality of diabetes control and concentrations of AGE-products in patients with type 1 and insulin-treated type 2 diabetes mellitus studied over a period of 10 years (JEVIN).

21 January 2018

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Decrease in skin collagen glycation with improved glycemic control in patients with insulin-dependent diabetes mellitus

21 January 2018

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Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy

21 January 2018

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The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes

21 January 2018

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Angiotensin II receptor antagonists and angiotensin-converting enzyme inhibitors lower in vitro the formation of advanced glycation end products: biochemical mechanisms

21 January 2018

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The effects of valsartan on the accumulation of circulating and renal advanced glycation end products in experimental diabetes.

21 January 2018

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Anti-Hypertensive Agents Inhibit In Vivo the Formation of Advanced Glycation End Products and Improve Renal Damage in a Type 2 Diabetic Nephropathy Rat Model

21 January 2018

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Candesartan reduced advanced glycation end-products accumulation and diminished nitro-oxidative stress in type 2 diabetic KK/Ta mice

21 January 2018

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A novel Sartan derivative with very low angiotensin II type 1 receptor affinity protects the kidney in type 2 diabetic rats.

21 January 2018

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Interactions between renin angiotensin system and advanced glycation in the kidney.

21 January 2018

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Reduction of the accumulation of advanced glycation end products by ACE inhibition in experimental diabetic nephropathy

21 January 2018

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Benazepril, an angiotensin-converting enzyme inhibitor, alleviates renal injury in spontaneously hypertensive rats by inhibiting advanced glycation end-product-mediated pathways

21 January 2018

1 reference

Angiotensin II receptor blockers and angiotensin converting enzyme inhibitors: implication of radical scavenging and transition metal chelation in inhibition of advanced glycation end product formation

21 January 2018

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Effects of 12-month valsartan therapy on glycation and oxidative stress markers in type 2 diabetic subjects with hypertension

21 January 2018

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Effect of losartan on ambulatory short-term blood pressure variability and cardiovascular remodeling in hypertensive patients on hemodialysis.

21 January 2018

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Effect of valsartan, an angiotensin II receptor blocker, on markers of oxidation and glycation in Japanese type 2 diabetic subjects: blood pressure-independent effect of valsartan.

21 January 2018

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Modulation of advanced glycation end products by candesartan in patients with diabetic kidney disease--a dose-response relationship study

21 January 2018

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Irbesartan treatment reduces biomarkers of inflammatory activity in patients with type 2 diabetes and microalbuminuria: an IRMA 2 substudy.

21 January 2018

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Irbesartan treatment does not influence plasma levels of the advanced glycation end products N(epsilon)(1-carboxymethyl)lysine and N(epsilon)(1-carboxyethyl)lysine in patients with type 2 diabetes and microalbuminuria. A randomized controlled trial

21 January 2018

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Effects of ramipril in nondiabetic nephropathy: improved parameters of oxidatives stress and potential modulation of advanced glycation end products.

21 January 2018

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Atorvastatin and gemfibrozil metabolites, but not the parent drugs, are potent antioxidants against lipoprotein oxidation

21 January 2018

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Inhibitory effects of amlodipine and fluvastatin on the deposition of advanced glycation end products in aortic wall of cholesterol and fructose-fed rabbits

21 January 2018

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Effect of atorvastatin therapy on oxidant-antioxidant status and atherosclerotic plaque formation

21 January 2018

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Atorvastatin decreases serum levels of advanced glycation endproducts (AGEs) in nonalcoholic steatohepatitis (NASH) patients with dyslipidemia: clinical usefulness of AGEs as a biomarker for the attenuation of NASH.

21 January 2018

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The HMG-CoA reductase inhibitor cerivastatin lowers advanced glycation end products in patients with type 2 diabetes.

21 January 2018

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Effects of atorvastatin on serum soluble receptors for advanced glycation end-products in type 2 diabetes

21 January 2018

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Short-term low calorie diet intervention reduces serum advanced glycation end products in healthy overweight or obese adults.

21 January 2018

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Calorie restricted diet and urinary pentosidine in patients with rheumatoid arthritis

21 January 2018

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Short-term effect of orlistat on dietary glycotoxins in healthy women and women with polycystic ovary syndrome

21 January 2018

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High levels of dietary advanced glycation end products transform low-density lipoprotein into a potent redox-sensitive mitogen-activated protein kinase stimulant in diabetic patients

21 January 2018

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Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1

21 January 2018

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Restriction of dietary glycotoxins reduces excessive advanced glycation end products in renal failure patients

21 January 2018

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Protection against loss of innate defenses in adulthood by low advanced glycation end products (AGE) intake: role of the antiinflammatory AGE receptor-1.

21 January 2018

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The effect of oestradiol on vaginal collagen metabolism in postmenopausal women with genuine stress incontinence

21 January 2018

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Increased plasma malondialdehyde and fructosamine in iron deficiency anemia: effect of treatment.

21 January 2018

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Increased plasma malondialdehyde and fructosamine in anemic H pylori infected patients: effect of treatment

21 January 2018

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Therapeutic effects of modified Danggui Sini Decoction on plasma level of advanced glycation end products in patients with Wagner grade 0 diabetic foot: a randomized controlled trial

21 January 2018

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Effect of sevelamer and calcium-based phosphate binders on coronary artery calcification and accumulation of circulating advanced glycation end products in hemodialysis patients.

21 January 2018

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Effects of Vitamin E on susceptibility of low-density lipoprotein and low-density lipoprotein subfractions to oxidation and on protein glycation in NIDDM.

21 January 2018

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Measurement of pentosidine in human plasma protein by a single-column high-performance liquid chromatography method with fluorescence detection

21 January 2018

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Measurement of Nepsilon-(carboxymethyl)lysine and Nepsilon-(carboxyethyl)lysine in human plasma protein by stable-isotope-dilution tandem mass spectrometry

21 January 2018

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Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/DOM.12058

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28 August 2017

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PubMed ID

23279611