What is the nature of the mitochondrial permeability transition pore and what is it not? (Q38076069)

28 August 2017

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title

What is the nature of the mitochondrial permeability transition pore and what is it not? (English)

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28 August 2017

Detlef Siemen

1

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PubMed ID

23341030

28 August 2017

Mirjam Ziemer

series ordinal

2

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28 August 2017

22 January 2013

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28 August 2017

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28 August 2017

65

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28 August 2017

255-262

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28 August 2017

3

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Volume changes in liver mitochondria

28 August 2017

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The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

21 January 2018

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Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

21 January 2018

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Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

21 January 2018

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The mitochondrial permeability transition from in vitro artifact to disease target

21 January 2018

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Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart.

21 January 2018

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The control of brain mitochondrial energization by cytosolic calcium: the mitochondrial gas pedal.

21 January 2018

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The mitochondrial calcium uniporter is a highly selective ion channel.

21 January 2018

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A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

21 January 2018

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Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

21 January 2018

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Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter

21 January 2018

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Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection

21 January 2018

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From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance state

21 January 2018

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Fatty acid-induced uncoupling of oxidative phosphorylation is partly due to opening of the mitochondrial permeability transition pore.

21 January 2018

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Effects of cyclosporine A and its immunosuppressive or non-immunosuppressive derivatives [D-Ser]8-CsA and Cs9 on mitochondria from different brain regions

21 January 2018

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Oxygen glucose deprivation causes mitochondrial dysfunction in cultivated rat hippocampal slices: protective effects of CsA, its immunosuppressive congener [D-Ser](8)CsA, the novel non-immunosuppressive cyclosporin derivative Cs9, and the NMDA recep

21 January 2018

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Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore

21 January 2018

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Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria

21 January 2018

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The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet.

21 January 2018

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Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart

21 January 2018

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Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions

21 January 2018

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Bax regulates primary necrosis through mitochondrial dynamics

21 January 2018

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Activation of the permeability transition pore by Bax via inhibition of the mitochondrial BK channel.

21 January 2018

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The inner mitochondrial membrane contains ion-conducting channels similar to those found in bacteria.

21 January 2018

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Mitochondrial channel activity studied by patch-clamping mitoplasts

21 January 2018

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Single-channel currents of the permeability transition pore from the inner mitochondrial membrane of rat liver and of a human hepatoma cell line

21 January 2018

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The cation-selective substate of the mitochondrial outer membrane pore: single-channel conductance and influence on intermembrane and peripheral kinases

21 January 2018

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Ca2+-activated K channel of the BK-type in the inner mitochondrial membrane of a human glioma cell line

21 January 2018

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Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes

21 January 2018

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Interaction of mitochondrial potassium channels with the permeability transition pore

21 January 2018

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Channel formation by antiapoptotic protein Bcl-2.

21 January 2018

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Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2.

21 January 2018

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Inhibition of Bax channel-forming activity by Bcl-2

21 January 2018

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MAC inhibitors suppress mitochondrial apoptosis

21 January 2018

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Ceramide channels and their role in mitochondria-mediated apoptosis

21 January 2018

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Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

21 January 2018

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Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells

21 January 2018

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The voltage-dependent anion channel: an essential player in apoptosis

21 January 2018

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The voltage-dependent anion channel: characterization, modulation, and role in mitochondrial function in cell life and death

21 January 2018

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The molecular structure of mitochondrial contact sites. Their role in regulation of energy metabolism and permeability transition

21 January 2018

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Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis

21 January 2018

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Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore. Implication for regulation of permeability transition by the kinases

21 January 2018

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The voltage-dependent anion channel is the target for a new class of inhibitors of the mitochondrial permeability transition pore

21 January 2018

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Properties of the permeability transition in VDAC1(-/-) mitochondria

21 January 2018

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On the role of VDAC in apoptosis: fact and fiction

21 January 2018

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Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

21 January 2018

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Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier

21 January 2018

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Structural and functional study of reconstituted peripheral benzodiazepine receptor

21 January 2018

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Mitochondrial benzodiazepine receptor linked to inner membrane ion channels by nanomolar actions of ligands

21 January 2018

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Mitochondria and apoptosis

21 January 2018

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Is mPTP the gatekeeper for necrosis, apoptosis, or both?

21 January 2018

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Reconstituted adenine nucleotide translocase forms a channel for small molecules comparable to the mitochondrial permeability transition pore

21 January 2018

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The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

21 January 2018

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Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

21 January 2018

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Mitochondrial membrane permeability transition and cell death

21 January 2018

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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

21 January 2018

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Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D.

21 January 2018

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Inhibition of the mitochondrial F1F0-ATPase by ligands of the peripheral benzodiazepine receptor

21 January 2018

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NMR studies of an immunomodulatory benzodiazepine binding to its molecular target on the mitochondrial F(1)F(0)-ATPase

21 January 2018

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The dopamine-D2-receptor agonist ropinirole dose-dependently blocks the Ca2+-triggered permeability transition of mitochondria

21 January 2018

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The roles of phosphate and the phosphate carrier in the mitochondrial permeability transition pore

21 January 2018

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Mitochondrial carrier proteins can reversibly change their transport mode: the cases of the aspartate/glutamate and the phosphate carrier

21 January 2018

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A CaPful of mechanisms regulating the mitochondrial permeability transition

21 January 2018

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Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation

21 January 2018

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p53 opens the mitochondrial permeability transition pore to trigger necrosis

21 January 2018

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A large, voltage-dependent channel, isolated from mitochondria by water-free chloroform extraction.

21 January 2018

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Targeted polyphosphatase expression alters mitochondrial metabolism and inhibits calcium-dependent cell death

21 January 2018

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Inhibitory modulation of the mitochondrial permeability transition by minocycline

21 January 2018

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Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial.

21 January 2018

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Impairment of mitochondrial function by minocycline

21 January 2018

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Optic atrophy 1-dependent mitochondrial remodeling controls steroidogenesis in trophoblasts.

21 January 2018

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New insights into mitochondrial fusion

21 January 2018

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OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion

21 January 2018

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Evaluation of putative inhibitors of mitochondrial permeability transition for brain disorders--specificity vs. toxicity

21 January 2018

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Is p53 the Long-Sought Molecular Trigger for Cyclophilin D–Regulated Mitochondrial Permeability Transition Pore Formation and Necrosis?

21 January 2018

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The mitochondrial permeability transition pore may comprise VDAC molecules

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IUB.1130

1 reference

release_4npcvuaonvgw3c5fuob5w7tn6m

28 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/4npcvuaonvgw3c5fuob5w7tn6m

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

23341030

1 reference

PubMed ID

23341030