The role of uric acid in the pathogenesis of human cardiovascular disease (Q38076242)

28 August 2017

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title

The role of uric acid in the pathogenesis of human cardiovascular disease (English)

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28 August 2017

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cardiovascular disease

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Mehmet Kanbay

1

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28 August 2017

Mark Segal

2

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28 August 2017

Baris Afsar

3

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28 August 2017

Duk-Hee Kang

4

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28 August 2017

Bernardo Rodriguez-Iturbe

5

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28 August 2017

Richard J Johnson

6

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28 August 2017

language of work or name

English

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publication date

23 January 2013

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28 August 2017

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28 August 2017

99

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28 August 2017

759-766

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28 August 2017

11

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Two independent mutational events in the loss of urate oxidase during hominoid evolution

28 August 2017

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Loss of urate oxidase activity in hominoids and its evolutionary implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society?

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Uric acid, evolution and primitive cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Adiponectin and adiponectin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Precursors of essential hypertension: pulmonary function, heart rate, uric acid, serum cholesterol, and other serum chemistries

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Predictors of an increased risk of future hypertension in Utah. A screening analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Ten-year incidence of elevated blood pressure and its predictors: the CARDIA study. Coronary Artery Risk Development in (Young) Adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Serum uric acid and the risk for hypertension and Type 2 diabetes in Japanese men: The Osaka Health Survey

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Hyperinsulinemia for the development of hypertension: data from the Hawaii-Los Angeles-Hiroshima Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Hyperuricemia and cardiovascular risk factor clustering in a screened cohort in Okinawa, Japan.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

The association between serum uric acid level and long-term incidence of hypertension: Population-based cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Uric acid and the development of hypertension: the normative aging study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Serum uric acid predicts incident hypertension in a biethnic cohort: the atherosclerosis risk in communities study

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Hyperuricemia and incidence of hypertension among men without metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Plasma uric acid and hypertension in a Chinese community: prospective study and metaanalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Uric acid and insulin sensitivity and risk of incident hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Hyperuricemia and incident hypertension: a systematic review and meta-analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Mild hyperuricemia induces vasoconstriction and maintains glomerular hypertension in normal and remnant kidney rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Subtle acquired renal injury as a mechanism of salt-sensitive hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Hyperuricemia in childhood primary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Hyperuricemia and risk of stroke: a systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Association between hyperuricemia and incident heart failure among older adults: a propensity-matched study

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Long-term effects of chlorthalidone versus hydrochlorothiazide on electrocardiographic left ventricular hypertrophy in the multiple risk factor intervention trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Comparative antihypertensive effects of hydrochlorothiazide and chlorthalidone on ambulatory and office blood pressure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

The impact of serum uric acid on cardiovascular outcomes in the LIFE study

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Uric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Hypertension and cognitive function: Pathophysiologic effects of hypertension on the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Serum urate as an independent predictor of poor outcome and future vascular events after acute stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Elevated serum urate concentration independently predicts poor outcome following stroke in patients with diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Editorial comment--Elevated uric acid and ischemic stroke: accumulating evidence that it is injurious and not neuroprotective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Prognostic significance of uric acid serum concentration in patients with acute ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Serum uric acid as an index of impaired oxidative metabolism in chronic heart failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Serum uric acid levels as a predictor of in-hospital death in patients hospitalized for decompensated heart failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Serum level of uric acid, partly secreted from the failing heart, is a prognostic marker in patients with congestive heart failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Xanthine oxidoreductase in respiratory and cardiovascular disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Uric acid predicts clinical outcomes in heart failure: insights regarding the role of xanthine oxidase and uric acid in disease pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure: results from 2 placebo-controlled studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Allopurinol improves endothelial dysfunction in chronic heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Allopurinol improves myocardial efficiency in patients with idiopathic dilated cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Xanthine oxidoreductase inhibition causes reverse remodeling in rats with dilated cardiomyopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Impact of oxypurinol in patients with symptomatic heart failure. Results of the OPT-CHF study

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Uric acid, heart failure survival, and the impact of xanthine oxidase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Serum uric acid and coronary heart disease in 9,458 incident cases and 155,084 controls: prospective study and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Relation of serum uric acid to mortality and ischemic heart disease. The NHANES I Epidemiologic Follow-up Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Hyperuricemia as a risk factor on cardiovascular events in Taiwan: The Chin-Shan Community Cardiovascular Cohort Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Fatty liver and uric acid levels predict incident coronary heart disease but not stroke among atomic bomb survivors in Nagasaki.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Uric Acid Levels Are Associated With All-Cause and Cardiovascular Disease Mortality Independent of Systemic Inflammation in Men From the General Population

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Identification of Products from Oxidation of Uric Acid Induced by Hydroxyl Radicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Uric acid: the oxidant-antioxidant paradox

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Reactions of peroxynitrite with uric acid: formation of reactive intermediates, alkylated products and triuret, and in vivo production of triuret under conditions of oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Triuret: a novel product of peroxynitrite-mediated oxidation of urate

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Inactivation of nitric oxide by uric acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography-mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Radicals in the reaction between peroxynitrite and uric acid identified by electron spin resonance spectroscopy and liquid chromatography mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Uric acid stimulates endothelin-1 gene expression associated with NADPH oxidase in human aortic smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

A role for uric acid in the progression of renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Uric acid and inflammatory markers

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Hyperuricemia attenuates aortic nitric oxide generation, through inhibition of arginine transport, in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Hyperuricemia induces endothelial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Hyperuricemia, oxidative stress, and carotid artery tone in experimental renal insufficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Xanthine oxidase inhibition reverses endothelial dysfunction in heavy smokers

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Effect of hyperuricemia upon endothelial function in patients at increased cardiovascular risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Allopurinol improves endothelial function and reduces oxidant-inflammatory enzyme of myeloperoxidase in metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

A randomized study of allopurinol on endothelial function and estimated glomular filtration rate in asymptomatic hyperuricemic subjects with normal renal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Allopurinol benefits left ventricular mass and endothelial dysfunction in chronic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Serum uric acid and the renin-angiotensin system in hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

The adolescent with essential hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Uric acid and the state of the intrarenal renin-angiotensin system in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Molecular identification of a danger signal that alerts the immune system to dying cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Cutting edge: elimination of an endogenous adjuvant reduces the activation of CD8 T lymphocytes to transplanted cells and in an autoimmune diabetes model

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Heat shock proteins and the immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Reactive oxygen species play an important role in the activation of heat shock factor 1 in ischemic-reperfused heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Association between serum uric acid and development of type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Contribution of uric acid to cancer risk, recurrence, and mortality

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Uric acid reduces exercise-induced oxidative stress in healthy adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

SLC2A9 is a high-capacity urate transporter in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Serum Uric Acid and Risk for Cardiovascular Disease and Death: The Framingham Heart Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

Uric acid-induced endothelial dysfunction is associated with mitochondrial alterations and decreased intracellular ATP concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FHEARTJNL-2012-302535

10.1136/HEARTJNL-2012-302535

21 January 2018

Identifiers

DOI

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28 August 2017

1 reference