Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress (Q42829265)

8 November 2017

Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress (English)

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8 November 2017

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1

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8 November 2017

2

Takahiko Nakagawa

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8 November 2017

Sergey Zharikov

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PubMed ID

17428837

8 November 2017

Richard J Johnson

series ordinal

4

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8 November 2017

11 April 2007

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American Journal of Physiology - Cell Physiology

8 November 2017

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8 November 2017

293

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8 November 2017

C584-96

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8 November 2017

2

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Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis

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The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

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Adipocyte differentiation induces dynamic changes in NF-kappaB expression and activity

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Adipose tissue, inflammation, and cardiovascular disease

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NADPH oxidases: not just for leukocytes anymore!

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C11-BODIPY(581/591), an oxidation-sensitive fluorescent lipid peroxidation probe: (micro)spectroscopic characterization and validation of methodology

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Pathophysiology of nitric oxide and related species: free radical reactions and modification of biomolecules

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PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox

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Regulation of the nitric oxide system in human adipose tissue

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Increased oxidative stress in obesity and its impact on metabolic syndrome

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Uric acid and oxidative stress

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Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells

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An established preadipose cell line and its differentiation in culture II. Factors affecting the adipose conversion

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N-acetylcysteine attenuates TNF-alpha-induced p38 MAP kinase activation and p38 MAP kinase-mediated IL-8 production by human pulmonary vascular endothelial cells

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Reactive oxygen species have a causal role in multiple forms of insulin resistance

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Oxidative stress and diabetic cardiovascular complications

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Uric acid, evolution and primitive cultures

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Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?

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Uric acid and diet--insights into the epidemic of cardiovascular disease

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Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease

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Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2.

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Uric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate transporter

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Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells

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Permeation of phospholipid membranes by peroxynitrite.

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Hyperuricemia induces endothelial dysfunction

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Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase.

21 January 2018

1 reference

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NOX enzymes and the biology of reactive oxygen

21 January 2018

1 reference

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The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction

21 January 2018

1 reference

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Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases

21 January 2018

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Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation

21 January 2018

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Effect of visceral fat accumulation on uric acid metabolism in male obese subjects: visceral fat obesity is linked more closely to overproduction of uric acid than subcutaneous fat obesity.

21 January 2018

1 reference

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p40phox: the last NADPH oxidase subunit

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The multispecific organic anion transporter family: properties and pharmacological significance

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Inhibition by uric acid of free radicals that damage biological molecules

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A causal role for uric acid in fructose-induced metabolic syndrome

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Serum uric acid and risk for development of hypertension and impaired fasting glucose or Type II diabetes in Japanese male office workers

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Loss of urate oxidase activity in hominoids and its evolutionary implications

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Recent trends of hyperuricemia and obesity in Japanese male adolescents, 1991 through 2002.

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Pancreatic beta-cells express phagocyte-like NAD(P)H oxidase

21 January 2018

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Human vascular smooth muscle cells express a urate transporter

21 January 2018

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The kidney: an unwilling accomplice in syndrome X.

21 January 2018

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Uric acid oxidation by peroxynitrite: multiple reactions, free radical formation, and amplification of lipid oxidation

21 January 2018

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Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation.

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Role of oxidative modifications in atherosclerosis

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Mitochondrial respiratory chain and NAD(P)H oxidase are targets for the antiproliferative effect of carbon monoxide in human airway smooth muscle

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Redox regulation of reactive oxygen species-induced p38 MAP kinase activation and barrier dysfunction in lung microvascular endothelial cells

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Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity

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Inflammation, stress, and diabetes

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Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome.

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10.1152/AJPCELL.00600.2006

21 January 2018

Identifiers

DOI

1 reference

8 November 2017

1 reference

PubMed ID

17428837