Molecular mechanisms of platelet P2Y(12) receptor regulation (Q38077232)

28 August 2017

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title

Molecular mechanisms of platelet P2Y(12) receptor regulation (English)

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28 August 2017

author name string

Margaret R Cunningham

series ordinal

1

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28 August 2017

Shaista P Nisar

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2

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28 August 2017

Stuart J Mundell

series ordinal

3

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28 August 2017

publication date

1 February 2013

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Biochemical Society Transactions

28 August 2017

published in

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28 August 2017

volume

41

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28 August 2017

issue

1

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28 August 2017

page(s)

225-230

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International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy

28 August 2017

cites work

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Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation

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Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets

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Rapid resensitization of purinergic receptor function in human platelets.

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P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms.

21 January 2018

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Role of ADP receptor P2Y(12) in platelet adhesion and thrombus formation in flowing blood

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Differential regulation and relocalization of the platelet P2Y receptors after activation: a way to avoid loss of hemostatic properties?

21 January 2018

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Distinct clathrin-coated pits sort different G protein-coupled receptor cargo.

21 January 2018

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An intact PDZ motif is essential for correct P2Y12 purinoceptor traffic in human platelets.

21 January 2018

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Arrestin scaffolds NHERF1 to the P2Y12 receptor to regulate receptor internalization

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ARF6-dependent regulation of P2Y receptor traffic and function in human platelets.

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Cargo regulates clathrin-coated pit dynamics

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Regulation of P2Y1 receptor traffic by sorting Nexin 1 is retromer independent

21 January 2018

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Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin

21 January 2018

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Haploinsufficiency of the platelet P2Y12 gene in a family with congenital bleeding diathesis

21 January 2018

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Platelets from a patient heterozygous for the defect of P2CYC receptors for ADP have a secretion defect despite normal thromboxane A2 production and normal granule stores: further evidence that some cases of platelet 'primary secretion defect' are h

21 January 2018

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Impaired platelet function in a patient with P2Y12 deficiency caused by a mutation in the translation initiation codon

21 January 2018

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Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding

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Identification and characterization of a novel P2Y 12 variant in a patient diagnosed with type 1 von Willebrand disease in the European MCMDM-1VWD study

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Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling.

21 January 2018

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The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts

21 January 2018

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Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4).

21 January 2018

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N-linked glycosylation of platelet P2Y12 ADP receptor is essential for signal transduction but not for ligand binding or cell surface expression

21 January 2018

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Role of PDZ proteins in regulating trafficking, signaling, and function of GPCRs: means, motif, and opportunity

21 January 2018

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P2Y1 receptor signaling is controlled by interaction with the PDZ scaffold NHERF-2

21 January 2018

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A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins

21 January 2018

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Regulation of G protein-coupled receptor function by Na+/H+ exchange regulatory factors

21 January 2018

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Internal PDZ ligands: novel endocytic recycling motifs for G protein-coupled receptors

21 January 2018

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Role of the PAR1 receptor 8th helix in signaling: the 7-8-1 receptor activation mechanism.

21 January 2018

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Role of helix 8 of the thyrotropin-releasing hormone receptor in phosphorylation by G protein-coupled receptor kinase

21 January 2018

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Identification and analysis of functionally important amino acids in human purinergic 12 receptor using a Saccharomyces cerevisiae expression system

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21 January 2018

Identifiers

DOI

10.1042/BST20120295

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28 August 2017

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