Molecular mechanisms of central leptin resistance in obesity (Q38077483)

28 August 2017

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title

Molecular mechanisms of central leptin resistance in obesity (English)

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28 August 2017

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Chang Hee Jung

1

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PubMed ID

23359004

28 August 2017

Min-Seon Kim

series ordinal

2

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28 August 2017

29 January 2013

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Archives of Pharmacal Research

28 August 2017

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28 August 2017

36

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28 August 2017

2

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28 August 2017

201-207

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https://scigraph.springernature.com/pub.10.1007/s12272-013-0020-y

28 August 2017

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cites work

The stomach is a source of leptin

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Activation of downstream signals by the long form of the leptin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Neuronal PTP1B regulates body weight, adiposity and leptin action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Identification of SOCS-3 as a potential mediator of central leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Serum immunoreactive-leptin concentrations in normal-weight and obese humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Megalin mediates the transport of leptin across the blood-CSF barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

From lesions to leptin: hypothalamic control of food intake and body weight.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Leptin and the regulation of body weight in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Endoplasmic reticulum stress induces leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Inflammation and metabolic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Global burden of obesity in 2005 and projections to 2030.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Autophagy as a regulated pathway of cellular degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Regulation of Jak kinases by intracellular leptin receptor sequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Autophagy in the Pathogenesis of Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Endoplasmic reticulum stress signaling in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Hypothalamic lipotoxicity and the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Congenital leptin deficiency is associated with severe early-onset obesity in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Recent advances in understanding leptin signaling and leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Region-specific leptin resistance within the hypothalamus of diet-induced obese mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Immunohistochemical evidence of functional leptin receptor expression in neuronal and endothelial cells of the rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Molecular mechanisms associated with leptin resistance: n-3 polyunsaturated fatty acids induce alterations in the tight junction of the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Leptin-replacement therapy for lipodystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Endoplasmic reticulum stress plays a central role in development of leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Effects of the obese gene product on body weight regulation in ob/ob mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Role of hypothalamic proopiomelanocortin neuron autophagy in the control of appetite and leptin response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

21 January 2018

Lipoatrophy revisited

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

One step at a time: endoplasmic reticulum-associated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Central administration of an endoplasmic reticulum stress inducer inhibits the anorexigenic effects of leptin and insulin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-013-0020-Y

10.1007/S12272-013-0020-Y

21 January 2018

Identifiers

DOI

1 reference

PubMed ID

23359004

Dimensions Publication ID

28 August 2017

0 references

1 reference

PubMed ID

23359004