Vitamin D: metabolism, molecular mechanisms, and mutations to malignancies (Q38077504)

28 August 2017

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title

Vitamin D: metabolism, molecular mechanisms, and mutations to malignancies (English)

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28 August 2017

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Natalie Nemazannikova

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1

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PubMed ID

23359295

28 August 2017

Kiriakos Antonas

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2

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PubMed ID

23359295

28 August 2017

Crispin R Dass

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3

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28 August 2017

28 January 2013

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28 August 2017

Molecular Carcinogenesis

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28 August 2017

53

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28 August 2017

6

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28 August 2017

421-431

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Mice lacking 25OHD 1alpha-hydroxylase demonstrate decreased epidermal differentiation and barrier function

28 August 2017

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High Prevalence of Vitamin D Inadequacy and Implications for Health

21 January 2018

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Estimated benefit of increased vitamin D status in reducing the economic burden of disease in western Europe

21 January 2018

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Who, what, where and when-influences on cutaneous vitamin D synthesis

21 January 2018

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Vitamin D signaling in immune-mediated disorders: Evolving insights and therapeutic opportunities

21 January 2018

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Keratinocyte proliferation, differentiation, and apoptosis--differential mechanisms of regulation by curcumin, EGCG and apigenin

21 January 2018

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Antiproliferative role of vitamin D and its analogs--a brief overview

21 January 2018

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Ethnic dress, vitamin D intake, and calcaneal bone health in young women in the United Kingdom

21 January 2018

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Serum 25-hydroxyvitamin D levels in vitamin D-insufficient hip fracture patients after supplementation with ergocalciferol and cholecalciferol.

21 January 2018

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Nutritional osteomalacia and late rickets in Greater London, 1974--1979: clinical and metabolic studies in 45 patients

21 January 2018

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Vitamin D and type 2 diabetes mellitus: where do we stand?

21 January 2018

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Positive octreotide scintigraphy and determination of lanreotide activity in Paget's disease of bone associated with phosphate diabetes: a case report

21 January 2018

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Vitamin D: a negative endocrine regulator of the renin-angiotensin system and blood pressure

21 January 2018

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Can vitamin D deficiency cause diabetes and cardiovascular diseases? Present evidence and future perspectives

21 January 2018

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Serum vitamin D, parathyroid hormone levels, and carotid atherosclerosis

21 January 2018

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Renal versus extrarenal activation of vitamin D in relation to atherosclerosis, arterial stiffening, and hypertension

21 January 2018

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The relationship between vitamin D and the renin-angiotensin system in the pathophysiology of hypertension, kidney disease, and diabetes

21 January 2018

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The effects of vitamin D on brain development and adult brain function

21 January 2018

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21 January 2018

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Assessment of evidence for a protective role of vitamin D in multiple sclerosis

21 January 2018

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Vitamin D in rheumatoid arthritis

21 January 2018

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Management of inflammatory bowel disease with vitamin D: beyond bone health

21 January 2018

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Regulatory role of 1, 25-dihydroxyvitamin D3 and vitamin D receptor gene variants on intracellular granzyme A expression in pulmonary tuberculosis

21 January 2018

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Vitamin D: modulator of the immune system.

21 January 2018

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Vitamin D: its role in cancer prevention and treatment

21 January 2018

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Selective vitamin D receptor modulators and their effects on colorectal tumor growth

21 January 2018

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1alpha,25-Dihydroxyvitamin D3 inhibits transcriptional potential of nuclear factor kappa B in breast cancer cells.

21 January 2018

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New targets for therapy in prostate cancer: modulation of stromal–epithelial interactions

21 January 2018

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The coupling of epidermal growth factor receptor down regulation by 1alpha,25-dihydroxyvitamin D3 to the hormone-induced cell cycle arrest at the G1-S checkpoint in ovarian cancer cells

21 January 2018

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Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis

21 January 2018

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Relation between prediagnostic serum 25-hydroxyvitamin D level and incidence of breast, colorectal, and other cancers

21 January 2018

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Inverse association between serum 25(OH) vitamin D levels and non-melanoma skin cancer in elderly men

21 January 2018

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Vitamin D: an ancient hormone

21 January 2018

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Vitamin D signalling pathways in cancer: potential for anticancer therapeutics

21 January 2018

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Increased expression of the 25-hydroxyvitamin D(3)-1alpha-hydroxylase gene in alveolar macrophages of patients with lung cancer

21 January 2018

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Seasonal and geographical variations in lung cancer prognosis in Norway. Does Vitamin D from the sun play a role?

21 January 2018

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Vitamin D inhibition of pro-fibrotic effects of transforming growth factor beta1 in lung fibroblasts and epithelial cells

21 January 2018

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Vitamin D and prostate cancer prevention and treatment

21 January 2018

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Clusterin over-expression modulates proapoptotic and antiproliferative effects of 1,25(OH)2D3 in prostate cancer cells in vitro

21 January 2018

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Review article: vitamin D acquisition and breast cancer risk

21 January 2018

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Increased UVA exposures and decreased cutaneous Vitamin D(3) levels may be responsible for the increasing incidence of melanoma.

21 January 2018

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Metastatic growth of lung cancer cells is extremely reduced in Vitamin D receptor knockout mice

21 January 2018

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Nuclear vitamin D receptor expression is associated with improved survival in non-small cell lung cancer

21 January 2018

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CYP24A1 is an independent prognostic marker of survival in patients with lung adenocarcinoma

21 January 2018

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Vitamin D-induced up-regulation of tumour necrosis factor alpha (TNF-alpha) in prostate cancer cells

21 January 2018

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Tumour necrosis factor alpha: a potential target for the therapy of solid tumours.

21 January 2018

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Vitamin D metabolism in mammary gland and breast cancer

21 January 2018

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Vitamin D deficiency promotes growth of MCF-7 human breast cancer in a rodent model of osteosclerotic bone metastasis

21 January 2018

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Meta-analysis: serum vitamin D and breast cancer risk

21 January 2018

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Down-regulation of NF-kappaB signals is involved in loss of 1alpha,25-dihydroxyvitamin D3 responsiveness

21 January 2018

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Vitamin D compounds in leukemia

21 January 2018

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Vitamin D, nervous system and aging

21 January 2018

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Role of vitamin D receptor in the antiproliferative effects of calcitriol in tumor-derived endothelial cells and tumor angiogenesis in vivo

21 January 2018

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Vitamin D and skin cancer: a problem in gene regulation

21 January 2018

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Differential biological effects of 1,25-dihydroxyVitamin D3 on melanoma cell lines in vitro

21 January 2018

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Molecular tools for study of genomic and rapid signal transduction responses initiated by 1 alpha,25(OH)(2)-vitamin D(3).

21 January 2018

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Role of the vitamin D3 pathway in healthy and diseased skin--facts, contradictions and hypotheses

21 January 2018

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Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model

21 January 2018

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New insights into the mechanisms of vitamin D action

21 January 2018

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Vitamin D and genomic stability

21 January 2018

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Antiproliferative effect of a vitamin D3 analog, EB1089, on HL-60 cells by the induction of TGF-beta receptor

21 January 2018

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1,25(OH)2 vitamin D3 induces elevated expression of the cell cycle-regulating genes P21 and P27 in squamous carcinoma cell lines of the head and neck

21 January 2018

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PPARgamma influences susceptibility to DMBA-induced mammary, ovarian and skin carcinogenesis.

21 January 2018

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Peroxisome proliferator-activated receptor (PPAR) and vitamin D receptor (VDR) signaling pathways in melanoma cells: promising new therapeutic targets?

21 January 2018

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Vitamin D influences gap junctional communication in C3H/10T 1/2 murine fibroblast cells

21 January 2018

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Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase

21 January 2018

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Vitamin D inhibits myometrial and leiomyoma cell proliferation in vitro

21 January 2018

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Photoprotection by 1alpha,25-dihydroxyvitamin D and analogs: further studies on mechanisms and implications for UV-damage

21 January 2018

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1,25-dihydroxyvitamin D3 regulates VEGF production through a vitamin D response element in the VEGF promoter

21 January 2018

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1alpha,25-dihydroxyvitamin D3 (Calcitriol) inhibits hypoxia-inducible factor-1/vascular endothelial growth factor pathway in human cancer cells

21 January 2018

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HaCaT cell line as a model system for vitamin D3 metabolism in human skin

21 January 2018

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The antiproliferative and differentiative activities of 1,25-dihydroxyvitamin D3 are potentiated by epidermal growth factor and attenuated by insulin in cultured human keratinocytes

21 January 2018

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1,25-Dihydroxyvitamin D downregulation of TGFalpha/EGFR expression and growth signaling: a mechanism for the antiproliferative actions of the sterol in parathyroid hyperplasia of renal failure

21 January 2018

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Cytochromes P450 are essential players in the vitamin D signaling system

21 January 2018

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Characterization of the vitamin D endocrine system in human sebocytes in vitro

21 January 2018

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Modulation of the differentiated phenotype of keratinocytes of the hair follicle and from epidermis

21 January 2018

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21 January 2018

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Vitamin D receptor (VDR)-mediated actions of 1α,25(OH)₂vitamin D₃: genomic and non-genomic mechanisms

21 January 2018

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Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells

21 January 2018

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Tumor-stroma interactions: their role in the control of tumor cell invasion.

21 January 2018

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Regulation of migration of primary prostate epithelial cells by secreted factors from prostate stromal cells.

21 January 2018

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Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures

21 January 2018

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Tissue kallikrein proteolytic cascade pathways in normal physiology and cancer

21 January 2018

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Regulation of keratinocyte signaling and function via changes in epidermal growth factor presentation

21 January 2018

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UVA-mediated activation of signaling pathways involved in skin tumor promotion and progression

21 January 2018

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Analysis of 1,25-dihydroxyvitamin D(3) receptors (VDR) in basal cell carcinomas

21 January 2018

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Taking treatment decisions in non-melanoma skin cancer--the place for topical photodynamic therapy (PDT).

21 January 2018

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The expression of matrix metalloproteinase-13 and osteocalcin in mouse osteoblasts is related to osteoblastic differentiation and is modulated by 1,25-dihydroxyvitamin D3 and thyroid hormones.

21 January 2018

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1alpha,25(OH)2D3 is an autocrine regulator of extracellular matrix turnover and growth factor release via ERp60 activated matrix vesicle metalloproteinases

21 January 2018

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Direct epithelial-stromal interaction in corneal wound healing: Role of EMMPRIN/CD147 in MMPs induction and beyond.

21 January 2018

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Mutual induction of growth factor gene expression by epidermal-dermal cell interaction

21 January 2018

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Cutaneous vascular patterns in psoriasis

21 January 2018

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Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development

21 January 2018

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Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy?

21 January 2018

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HaCaT keratinocyte migration is dependent on epidermal growth factor receptor signaling and glycogen synthase kinase-3alpha

21 January 2018

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Angiogenesis and host immune response contribute to the aggressive character of non-melanoma skin cancers in renal transplant recipients

21 January 2018

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Photochemoprevention of ultraviolet B signaling and photocarcinogenesis

21 January 2018

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1,25-Dihydroxyvitamin D3 and analogues protect primary human keratinocytes against UVB-induced DNA damage

21 January 2018

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Vitamin D signaling is modulated on multiple levels in health and disease.

21 January 2018

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UV-induced DNA damage in carcinogenesis and its repair.

21 January 2018

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Conversion of vitamin D3 to hormonally active 1alpha,25-dihydroxyvitamin D3 in cultured keratinocytes: relevance to cell growth and differentiation

21 January 2018

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Epidermal differentiation and basement membrane formation by HaCaT cells in surface transplants

21 January 2018

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Skin cancer prevention: a possible role of 1,25dihydroxyvitamin D3 and its analogs

21 January 2018

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The vitamin D pathway: a new target for control of the skin's immune response?

21 January 2018

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In vitro modulation of proliferation and phenotype of resting and mitogen-stimulated bovine mononuclear leukocytes by 1,25-dihydroxyvitamin D3.

21 January 2018

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Vitamin D and the immune system: new perspectives on an old theme

21 January 2018

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Calcitriol stimulates prolactin expression in non-activated human peripheral blood mononuclear cells: breaking paradigms.

21 January 2018

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The effect of vitamin D supplementation on peripheral regulatory T cells and β cell function in healthy humans: a randomized controlled trial.

21 January 2018

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Vitamin D and barrier function: a novel role for extra-renal 1 alpha-hydroxylase

21 January 2018

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Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune system

21 January 2018

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Vitamin D and 1,25-dihydroxyvitamin D3 as modulators in the immune system

21 January 2018

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Non-melanoma skin cancers

21 January 2018

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Season of diagnosis is a predictor of cancer survival. Sun-induced vitamin D may be involved: A possible role of sun-induced Vitamin D

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MC.21999

1 reference

28 August 2017

1 reference

PubMed ID

23359295