Amyloids and yeast prion biology (Q38078949)

28 August 2017

Amyloids and yeast prion biology (English)

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28 August 2017

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1

Reed B Wickner

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28 August 2017

Herman K Edskes

2

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28 August 2017

David A Bateman

3

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28 August 2017

Amy C Kelly

4

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28 August 2017

Anton Gorkovskiy

5

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28 August 2017

Yaron Dayani

6

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28 August 2017

Albert Zhou

7

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28 August 2017

language of work or name

English

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publication date

12 February 2013

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28 August 2017

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28 August 2017

52

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9

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28 August 2017

1514-1527

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Protein-only transmission of three yeast prion strains.

28 August 2017

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12 December 2020

Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates

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12 December 2020

Epigenetic control of polyamines by the prion [PSI+]

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12 December 2020

The yeast 2 micron plasmid: strategies for the survival of a selfish DNA

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12 December 2020

The prion model for [URE3] of yeast: spontaneous generation and requirements for propagation

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12 December 2020

The native-like conformation of Ure2p in fibrils assembled under physiologically relevant conditions switches to an amyloid-like conformation upon heat-treatment of the fibrils

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12 December 2020

Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p

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12 December 2020

Sexual transmission of the [Het-s] prion leads to meiotic drive in Podospora anserina

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12 December 2020

Sequestration of essential proteins causes prion associated toxicity in yeast

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12 December 2020

Regulation of chaperone effects on a yeast prion by cochaperone Sgt2.

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12 December 2020

[PSI+] Prion transmission barriers protect Saccharomyces cerevisiae from infection: intraspecies 'species barriers'.

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12 December 2020

The elimination of the yeast [PSI+] prion by guanidine hydrochloride is the result of Hsp104 inactivation

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12 December 2020

Yeast [PSI+] "prions" that are crosstransmissible and susceptible beyond a species barrier through a quasi-prion state.

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12 December 2020

Mot3 is a transcriptional repressor of ergosterol biosynthetic genes and is required for normal vacuolar function in Saccharomyces cerevisiae

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12 December 2020

Population genomics of the wild yeast Saccharomyces paradoxus: Quantifying the life cycle

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12 December 2020

Glucosamine resistance in yeast. I. A preliminary genetic analysis

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12 December 2020

Hierarchical organization in the amyloid core of yeast prion protein Ure2.

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12 December 2020

Self-replication and scrapie

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12 December 2020

Endocytosis machinery is involved in aggregation of proteins with expanded polyglutamine domains

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12 December 2020

The GTP-binding release factor eRF3 as a key mediator coupling translation termination to mRNA decay

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12 December 2020

De novo design of synthetic prion domains

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12 December 2020

Suicidal [PSI+] is a lethal yeast prion

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12 December 2020

Guanidine hydrochloride inhibits Hsp104 activity in vivo: a possible explanation for its effect in curing yeast prions

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12 December 2020

Genesis and variability of [PSI] prion factors in Saccharomyces cerevisiae.

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12 December 2020

Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic core

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12 December 2020

Prion-forming ability of Ure2 of yeasts is not evolutionarily conserved

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12 December 2020

Darwinian evolution of prions in cell culture

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12 December 2020

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

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12 December 2020

A yeast prion, Mod5, promotes acquired drug resistance and cell survival under environmental stress

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12 December 2020

Single methyl group determines prion propagation and protein degradation activities of yeast heat shock protein (Hsp)-70 chaperones Ssa1p and Ssa2p

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12 December 2020

Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae

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12 December 2020

Yeast [PSI+] Prion Aggregates Are Formed by Small Sup35 Polymers Fragmented by Hsp104

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12 December 2020

Balancing selection at the prion protein gene consistent with prehistoric kurulike epidemics

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12 December 2020

Strong growth polarity of yeast prion fiber revealed by single fiber imaging

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12 December 2020

Comprehensive phenotypic analysis of single-gene deletion and overexpression strains of Saccharomyces cerevisiae

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12 December 2020

Solid-state NMR studies of amyloid fibril structure

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12 December 2020

Specificity of the J-protein Sis1 in the propagation of 3 yeast prions

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12 December 2020

Characterization of beta-sheet structure in Ure2p1-89 yeast prion fibrils by solid-state nuclear magnetic resonance

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12 December 2020

Yeast prions: could they be exaptations? The URE2/[URE3] system in Kluyveromyces lactis

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12 December 2020

The SUP35 omnipotent suppressor gene is involved in the maintenance of the non-Mendelian determinant [psi+] in the yeast Saccharomyces cerevisiae.

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12 December 2020

Strain-specific morphologies of yeast prion amyloid fibrils

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12 December 2020

Destabilizing interactions among [PSI(+)] and [PIN(+)] yeast prion variants.

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12 December 2020

Prion generation in vitro: amyloid of Ure2p is infectious

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12 December 2020

The yeast model for batten disease: mutations in BTN1, BTN2, and HSP30 alter pH homeostasis

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12 December 2020

Structural characterization of Saccharomyces cerevisiae prion-like protein Ure2

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12 December 2020

Amyloid of the prion domain of Sup35p has an in-register parallel beta-sheet structure

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12 December 2020

Structure of the cross-beta spine of amyloid-like fibrils

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12 December 2020

"Prion-proof" for [PIN+]: infection with in vitro-made amyloid aggregates of Rnq1p-(132-405) induces [PIN+]

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12 December 2020

The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein

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12 December 2020

Prion-like aggregates: infectious agents in human disease

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12 December 2020

Evidence for a protein mutator in yeast: role of the Hsp70-related chaperone ssb in formation, stability, and toxicity of the [PSI] prion

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12 December 2020

Conservation of the prion properties of Ure2p through evolution

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12 December 2020

Occurrence, transmission, and zoonotic potential of chronic wasting disease

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12 December 2020

The core of Ure2p prion fibrils is formed by the N-terminal segment in a parallel cross-β structure: evidence from solid-state NMR.

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12 December 2020

SUP35 expression is enhanced in yeast containing [ISP+], a prion form of the transcriptional regulator Sfp1.

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12 December 2020

Strain-specific sequences required for yeast [PSI+] prion propagation

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12 December 2020

Bidirectional amyloid fiber growth for a yeast prion determinant.

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12 December 2020

[PSI+] maintenance is dependent on the composition, not primary sequence, of the oligopeptide repeat domain.

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12 December 2020

Influence of Hsp70s and their regulators on yeast prion propagation

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12 December 2020

The [Het-s] prion of Podospora anserina and its role in heterokaryon incompatibility.

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12 December 2020

Modulation of prion formation, aggregation, and toxicity by the actin cytoskeleton in yeast

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12 December 2020

Propagating structure of Alzheimer's beta-amyloid(10-35) is parallel beta-sheet with residues in exact register

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12 December 2020

Sti1 regulation of Hsp70 and Hsp90 is critical for curing of Saccharomyces cerevisiae [PSI+] prions by Hsp104.

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12 December 2020

Competition between a sterol biosynthetic enzyme and tRNA modification in addition to changes in the protein synthesis machinery causes altered nonsense suppression

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12 December 2020

Ure2p function is enhanced by its prion domain in Saccharomyces cerevisiae

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12 December 2020

High natural prevalence of a fungal prion

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12 December 2020

Genetic properties of mutations at the PEP4 locus in Saccharomyces cerevisiae.

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12 December 2020

Hsp70/Hsp90 co-chaperones are required for efficient Hsp104-mediated elimination of the yeast [PSI(+)] prion but not for prion propagation

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12 December 2020

Amino acid residue 184 of yeast Hsp104 chaperone is critical for prion-curing by guanidine, prion propagation, and thermotolerance

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12 December 2020

Hsp42 is required for sequestration of protein aggregates into deposition sites in Saccharomyces cerevisiae

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12 December 2020

Compositional determinants of prion formation in yeast

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12 December 2020

Prokaryotic chaperones support yeast prions and thermotolerance and define disaggregation machinery interactions

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12 December 2020

Structural insights into a yeast prion illuminate nucleation and strain diversity

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12 December 2020

Mechanism of prion propagation: amyloid growth occurs by monomer addition

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12 December 2020

A yeast model of optineurin proteinopathy reveals a unique aggregation pattern associated with cellular toxicity

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12 December 2020

The [PSI+] prion exists as a dynamic cloud of variants

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12 December 2020

Hsp104 binds to yeast Sup35 prion fiber but needs other factor(s) to sever it.

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12 December 2020

Amyloid of Rnq1p, the basis of the [PIN+] prion, has a parallel in-register beta-sheet structure

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12 December 2020

Functions of yeast Hsp40 chaperone Sis1p dispensable for prion propagation but important for prion curing and protection from prion toxicity.

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12 December 2020

Misfolded proteins partition between two distinct quality control compartments

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12 December 2020

Genetic and environmental factors affecting the de novo appearance of the [PSI+] prion in Saccharomyces cerevisiae

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12 December 2020

Amyloid fibrils from muscle myoglobin

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12 December 2020

Experimentally derived structural constraints for amyloid fibrils of wild-type transthyretin

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12 December 2020

[URE3] as an altered URE2 protein: evidence for a prion analog in Saccharomyces cerevisiae

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12 December 2020

Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins

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12 December 2020

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

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12 December 2020

Multiple Gln/Asn-rich prion domains confer susceptibility to induction of the yeast [PSI(+)] prion.

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12 December 2020

Sex, prions, and plasmids in yeast

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12 December 2020

A general model of prion strains and their pathogenicity

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12 December 2020

Heterologous cross-seeding mimics cross-species prion conversion in a yeast model.

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12 December 2020

Prion fibrils of Ure2p assembled under physiological conditions contain highly ordered, natively folded modules

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12 December 2020

Ageing in yeast does not enhance prion generation

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12 December 2020

Antagonistic interactions between yeast [PSI(+)] and [URE3] prions and curing of [URE3] by Hsp70 protein chaperone Ssa1p but not by Ssa2p

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12 December 2020

Prion domains: sequences, structures and interactions

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12 December 2020

Filaments of the Ure2p prion protein have a cross-beta core structure.

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12 December 2020

Prion switching in response to environmental stress

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12 December 2020

Isolation of phosphatidylethanolamine as a solitary cofactor for prion formation in the absence of nucleic acids

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12 December 2020

An intrinsically disordered yeast prion arrests the cell cycle by sequestering a spindle pole body component

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12 December 2020

The yeast global transcriptional co-repressor protein Cyc8 can propagate as a prion

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12 December 2020

Molecular structure of amyloid fibrils: insights from solid-state NMR.

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12 December 2020

A systematic survey identifies prions and illuminates sequence features of prionogenic proteins

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12 December 2020

The yeast model for Batten disease: a role for Btn2p in the trafficking of the Golgi-associated vesicular targeting protein, Yif1p

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12 December 2020

Translation termination efficiency can be regulated in Saccharomyces cerevisiae by environmental stress through a prion-mediated mechanism

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12 December 2020

Amyloid aggregates of the HET-s prion protein are infectious

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12 December 2020

Prion-inducing domain 2-114 of yeast Sup35 protein transforms in vitro into amyloid-like filaments

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12 December 2020

A yeast prion provides a mechanism for genetic variation and phenotypic diversity

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12 December 2020

Is the prion domain of soluble Ure2p unstructured?

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12 December 2020

Two prion variants of Sup35p have in-register parallel beta-sheet structures, independent of hydration

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12 December 2020

Asymmetric inheritance of oxidatively damaged proteins during cytokinesis

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12 December 2020

Prions affect the appearance of other prions: the story of [PIN(+)].

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12 December 2020

Prion amyloid structure explains templating: how proteins can be genes

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12 December 2020

[URE3] prion propagation in Saccharomyces cerevisiae: requirement for chaperone Hsp104 and curing by overexpressed chaperone Ydj1p

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12 December 2020

X-ray diffraction studies on amyloid filaments

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12 December 2020

Biochemical and functional analysis of the assembly of full-length Sup35p and its prion-forming domain

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12 December 2020

Prion diseases of yeast: amyloid structure and biology

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12 December 2020

Structure of L-A virus: a specialized compartment for the transcription and replication of double-stranded RNA.

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12 December 2020

Substrate threading through the central pore of the Hsp104 chaperone as a common mechanism for protein disaggregation and prion propagation

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12 December 2020

Domain organization and structure-function relationship of the HET-s prion protein of Podospora anserina

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12 December 2020

Chaperones that cure yeast artificial [PSI+] and their prion-specific effects.

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12 December 2020

Btn2, a Hook1 ortholog and potential Batten disease-related protein, mediates late endosome-Golgi protein sorting in yeast

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12 December 2020

Prion-inducing domain of yeast Ure2p and protease resistance of Ure2p in prion-containing cells

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12 December 2020

Primary sequence independence for prion formation

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12 December 2020

Conformational variations in an infectious protein determine prion strain differences

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12 December 2020

The Paf1 complex subunit Rtf1 buffers cells against the toxic effects of [PSI+] and defects in Rkr1-dependent protein quality control in Saccharomyces cerevisiae.

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12 December 2020

Mass analysis by scanning transmission electron microscopy and electron diffraction validate predictions of stacked beta-solenoid model of HET-s prion fibrils

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12 December 2020

Maintenance of the 2 microns circle plasmid in populations of Saccharomyces cerevisiae.

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12 December 2020

Mammalian prions generated from bacterially expressed prion protein in the absence of any mammalian cofactors

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12 December 2020

A new prion controls fungal cell fusion incompatibility

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12 December 2020

Yeast prions [URE3] and [PSI+] are diseases

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12 December 2020

Modulation and elimination of yeast prions by protein chaperones and co-chaperones

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12 December 2020

A heritable switch in carbon source utilization driven by an unusual yeast prion

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12 December 2020

Novel non-Mendelian determinant involved in the control of translation accuracy in Saccharomyces cerevisiae

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12 December 2020

The structural basis of yeast prion strain variants

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12 December 2020

Insight into molecular basis of curing of [PSI+] prion by overexpression of 104-kDa heat shock protein (Hsp104).

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12 December 2020

Prion variant maintained only at high levels of the Hsp104 disaggregase

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12 December 2020

Action of BTN1, the yeast orthologue of the gene mutated in Batten disease

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12 December 2020

Segmental polymorphism in a functional amyloid

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12 December 2020

Rnq1: an epigenetic modifier of protein function in yeast

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12 December 2020

Scrambled prion domains form prions and amyloid

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12 December 2020

Evidence for an unfolding/threading mechanism for protein disaggregation by Saccharomyces cerevisiae Hsp104.

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12 December 2020

Prions are a common mechanism for phenotypic inheritance in wild yeasts.

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12 December 2020

Molecular chaperone Hsp104 can promote yeast prion generation

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12 December 2020

Prion variants and species barriers among Saccharomyces Ure2 proteins

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12 December 2020

Sfp1 is a stress- and nutrient-sensitive regulator of ribosomal protein gene expression

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12 December 2020

Conservation of a portion of the S. cerevisiae Ure2p prion domain that interacts with the full-length protein

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12 December 2020

Molecular structural basis for polymorphism in Alzheimer's -amyloid fibrils

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12 December 2020

Curing of the [URE3] prion by Btn2p, a Batten disease-related protein

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12 December 2020

Population genomic analysis of outcrossing and recombination in yeast

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12 December 2020

The yeast prion Ure2p retains its native alpha-helical conformation upon assembly into protein fibrils in vitro

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12 December 2020

C-terminal truncation of the Sup35 protein increases the frequency of de novo generation of a prion-based [PSI+] determinant in Saccharomyces cerevisiae

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12 December 2020

Propagation of the yeast prion-like [psi+] determinant is mediated by oligomerization of the SUP35-encoded polypeptide chain release factor

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12 December 2020

The Sup35 domains required for maintenance of weak, strong or undifferentiated yeast [PSI+] prions.

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12 December 2020

Prion properties of the Sup35 protein of yeast Pichia methanolica

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12 December 2020

The [URE3] prion is an aggregated form of Ure2p that can be cured by overexpression of Ure2p fragments

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12 December 2020

Oligopeptide repeats in the yeast protein Sup35p stabilize intermolecular prion interactions

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12 December 2020

[URE3] prion propagation is abolished by a mutation of the primary cytosolic Hsp70 of budding yeast

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12 December 2020

Measurement of amyloid fibril mass-per-length by tilted-beam transmission electron microscopy

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12 December 2020

Guanidine hydrochloride inhibits the generation of prion "seeds" but not prion protein aggregation in yeast.

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12 December 2020

Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae

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12 December 2020

Maintenance of the 2 micron circle plasmid of Saccharomyces cerevisiae by sexual transmission: an example of a selfish DNA.

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12 December 2020

The [URE3] prion in Candida

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12 December 2020

Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders

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12 December 2020

A role for cytosolic hsp70 in yeast [PSI(+)] prion propagation and [PSI(+)] as a cellular stress.

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12 December 2020

Prion domain initiation of amyloid formation in vitro from native Ure2p

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12 December 2020

Non-Mendelian Mutation Allowing Ureidosuccinic Acid Uptake in Yeast

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12 December 2020

Evolutionary conservation of prion-forming abilities of the yeast Sup35 protein

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12 December 2020

Analysis of the Generation and Segregation of Propagons: Entities That Propagate the [PSI+] Prion in Yeast

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12 December 2020

Novel proteinaceous infectious particles cause scrapie

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12 December 2020

Isolation and characterization of MOD5, a gene required for isopentenylation of cytoplasmic and mitochondrial tRNAs of Saccharomyces cerevisiae

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12 December 2020

Molecular basis of a yeast prion species barrier

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12 December 2020

Protein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugs

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12 December 2020

Antagonistic interactions between yeast chaperones Hsp104 and Hsp70 in prion curing

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12 December 2020

Support for the prion hypothesis for inheritance of a phenotypic trait in yeast

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12 December 2020

Self-seeded fibers formed by Sup35, the protein determinant of [PSI+], a heritable prion-like factor of S. cerevisiae.

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12 December 2020

Heritable activity: a prion that propagates by covalent autoactivation

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12 December 2020

Effects of ubiquitin system alterations on the formation and loss of a yeast prion

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12 December 2020

Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+]

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12 December 2020

Amyloid nucleation and hierarchical assembly of Ure2p fibrils. Role of asparagine/glutamine repeat and nonrepeat regions of the prion domains

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12 December 2020

The functional curli amyloid is not based on in-register parallel beta-sheet structure

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12 December 2020

Non-Mendelian determinant [ISP+] in yeast is a nuclear-residing prion form of the global transcriptional regulator Sfp1

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12 December 2020

In vivo evidence for the fibrillar structures of Sup35 prions in yeast cells

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12 December 2020

In vitro propagation of the prion-like state of yeast Sup35 protein

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12 December 2020

The protein product of the het-s heterokaryon incompatibility gene of the fungus Podospora anserina behaves as a prion analog

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12 December 2020

N-terminal domain of yeast Hsp104 chaperone is dispensable for thermotolerance and prion propagation but necessary for curing prions by Hsp104 overexpression

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12 December 2020

Molecular structures of amyloid and prion fibrils: consensus versus controversy

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12 December 2020

Architecture of Ure2p prion filaments: the N-terminal domains form a central core fiber

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12 December 2020

Identifiers

DOI

10.1021/BI301686A

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28 August 2017

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