A yeast model of optineurin proteinopathy reveals a unique aggregation pattern associated with cellular toxicity (Q39256992)

10 September 2017

A yeast model of optineurin proteinopathy reveals a unique aggregation pattern associated with cellular toxicity (English)

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10 September 2017

Dmitry Kryndushkin

1

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10 September 2017

Gudrun Ihrke

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2

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10 September 2017

Tetsade C Piermartiri

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3

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10 September 2017

Frank Shewmaker

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4

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10 September 2017

language of work or name

English

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publication date

9 November 2012

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10 September 2017

Molecular Microbiology

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10 September 2017

86

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10 September 2017

6

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10 September 2017

1531-1547

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High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A.

10 September 2017

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Myosin VI and its binding partner optineurin are involved in secretory vesicle fusion at the plasma membrane.

21 January 2018

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Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice

21 January 2018

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Myosin VI and optineurin are required for polarized EGFR delivery and directed migration

21 January 2018

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Optineurin increases cell survival and translocates to the nucleus in a Rab8-dependent manner upon an apoptotic stimulus

21 January 2018

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Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

21 January 2018

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Differential involvement of optineurin in amyotrophic lateral sclerosis with or without SOD1 mutations

21 January 2018

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Prions affect the appearance of other prions: the story of [PIN(+)].

21 January 2018

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Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

21 January 2018

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Modulation of prion formation, aggregation, and toxicity by the actin cytoskeleton in yeast

21 January 2018

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RNA-binding proteins with prion-like domains in ALS and FTLD-U.

21 January 2018

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Polyglutamine toxicity is controlled by prion composition and gene dosage in yeast

21 January 2018

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FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis

21 January 2018

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Novel deletion mutations of OPTN in amyotrophic lateral sclerosis in Japanese.

21 January 2018

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Molecular pathology and genetic advances in amyotrophic lateral sclerosis: an emerging molecular pathway and the significance of glial pathology

21 January 2018

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TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity

21 January 2018

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Aggresomes: a cellular response to misfolded proteins

21 January 2018

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A yeast model of FUS/TLS-dependent cytotoxicity

21 January 2018

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TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

21 January 2018

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Toward an integrative view of Optineurin functions

21 January 2018

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Misfolded proteins partition between two distinct quality control compartments

21 January 2018

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Btn2, a Hook1 ortholog and potential Batten disease-related protein, mediates late endosome-Golgi protein sorting in yeast

21 January 2018

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Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS

21 January 2018

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FUS/TLS forms cytoplasmic aggregates, inhibits cell growth and interacts with TDP-43 in a yeast model of amyotrophic lateral sclerosis

21 January 2018

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Curing of the [URE3] prion by Btn2p, a Batten disease-related protein

21 January 2018

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Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis

21 January 2018

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Rethinking ALS: the FUS about TDP-43.

21 January 2018

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TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

21 January 2018

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Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains

21 January 2018

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DICHROWEB: an interactive website for the analysis of protein secondary structure from circular dichroism spectra.

21 January 2018

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Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway

21 January 2018

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Suicidal [PSI+] is a lethal yeast prion

21 January 2018

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Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates

21 January 2018

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Mutations of optineurin in amyotrophic lateral sclerosis

21 January 2018

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Analyzing the birth and propagation of two distinct prions, [PSI+] and [Het-s](y), in yeast

21 January 2018

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Overexpressed mutant optineurin(E50K) induces retinal ganglion cells apoptosis via the mitochondrial pathway

21 January 2018

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Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1

21 January 2018

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Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

21 January 2018

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Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant

21 January 2018

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Cell type-specific localization of optineurin in the striatal neurons of mice: implications for neuronal vulnerability in Huntington's disease

21 January 2018

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Aggresome formation and neurodegenerative diseases: therapeutic implications

21 January 2018

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Impairment of protein trafficking upon overexpression and mutation of optineurin

21 January 2018

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Studies of optineurin, a glaucoma gene: Golgi fragmentation and cell death from overexpression of wild-type and mutant optineurin in two ocular cell types

21 January 2018

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Adult-onset primary open-angle glaucoma caused by mutations in optineurin

21 January 2018

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

21 January 2018

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Protein aggregation and neurodegenerative disease

21 January 2018

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Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis

21 January 2018

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Processing of optineurin in neuronal cells

21 January 2018

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Amyloid of the prion domain of Sup35p has an in-register parallel beta-sheet structure

21 January 2018

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Hsp42 is required for sequestration of protein aggregates into deposition sites in Saccharomyces cerevisiae

21 January 2018

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TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

21 January 2018

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Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models

21 January 2018

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Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS

21 January 2018

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Hook2 contributes to aggresome formation

21 January 2018

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An intrinsically disordered yeast prion arrests the cell cycle by sequestering a spindle pole body component

21 January 2018

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Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6

21 January 2018

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Sequestration of essential proteins causes prion associated toxicity in yeast

21 January 2018

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Abnormal proteins can form aggresome in yeast: aggresome-targeting signals and components of the machinery

21 January 2018

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Elevation of Hook1 in a disease model of Batten disease does not affect a novel interaction between Ankyrin G and Hook1

21 January 2018

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Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth

21 January 2018

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Protein folding diseases and neurodegeneration: lessons learned from yeast

21 January 2018

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Autophagy-mediated clearance of aggresomes is not a universal phenomenon

21 January 2018

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Cellular and molecular biology of optineurin

21 January 2018

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The relationship between visible intracellular aggregates that appear after overexpression of Sup35 and the yeast prion-like elements [PSI(+)] and [PIN(+)].

21 January 2018

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Emerging targets and treatments in amyotrophic lateral sclerosis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/MMI.12075

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10 September 2017

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