Beyond TGFβ: roles of other TGFβ superfamily members in cancer (Q38101205)

28 August 2017

Beyond TGFβ: roles of other TGFβ superfamily members in cancer (English)

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28 August 2017

Lalage M Wakefield

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Caroline S. Hill

object named as

Caroline S Hill

series ordinal

2

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language of work or name

English

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publication date

1 May 2013

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28 August 2017

Nature Reviews Cancer

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28 August 2017

13

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28 August 2017

328-341

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28 August 2017

5

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https://scigraph.springernature.com/pub.10.1038/nrc3500

28 August 2017

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Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling

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Transforming growth factor beta-induced Smad1/5 phosphorylation in epithelial cells is mediated by novel receptor complexes and is essential for anchorage-independent growth

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TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch

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Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors

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Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo

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Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses

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Transforming growth factor β inhibits bone morphogenetic protein-induced transcription through novel phosphorylated Smad1/5-Smad3 complexes

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A transcriptional partner for MAD proteins in TGF-beta signalling

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Phosphatases in SMAD regulation

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Spatial regulation of BMP activity

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TGFβ signalling in context

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Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation

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GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses

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Negative regulation of TGF-beta receptor/Smad signal transduction.

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Nodal signaling regulates the bone morphogenic protein pluripotency pathway in mouse embryonic stem cells

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Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo

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Nodal Signaling in Vertebrate Development

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Role of Cripto-1 in stem cell maintenance and malignant progression

31 March 2020

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Extrinsic regulation of pluripotent stem cells

31 March 2020

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Activin/Nodal signalling maintains pluripotency by controlling Nanog expression.

31 March 2020

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Bone morphogenetic protein receptors and signal transduction

31 March 2020

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Nodal expression and detection in cancer: experience and challenges

31 March 2020

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Cancer stem cells: impact, heterogeneity, and uncertainty

31 March 2020

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Epidermal homeostasis: a balancing act of stem cells in the skin

31 March 2020

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The dynamic role of bone morphogenetic proteins in neural stem cell fate and maturation.

31 March 2020

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BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling

31 March 2020

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Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors

31 March 2020

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From developmental disorder to heritable cancer: it's all in the BMP/TGF-beta family

31 March 2020

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Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1.

31 March 2020

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De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine.

31 March 2020

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Bone morphogenetic protein signaling is essential for terminal differentiation of the intestinal secretory cell lineage

31 March 2020

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Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast

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The control of neural stem cells by morphogenic signals

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Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells.

31 March 2020

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Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells

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Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation

31 March 2020

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The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation

31 March 2020

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Stem cell antigen-1 enhances tumorigenicity by disruption of growth differentiation factor-10 (GDF10)-dependent TGF-beta signaling

31 March 2020

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BMP4 administration induces differentiation of CD133+ hepatic cancer stem cells, blocking their contributions to hepatocellular carcinoma.

31 March 2020

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An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia

31 March 2020

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Human ovarian carcinoma–associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production

31 March 2020

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Nodal signalling in embryogenesis and tumourigenesis.

31 March 2020

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Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness.

31 March 2020

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Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells

31 March 2020

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Potential for the embryonic morphogen Nodal as a prognostic and predictive biomarker in breast cancer

31 March 2020

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Endogenous Nodal signaling regulates germ cell potency during mammalian testis development

31 March 2020

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Targeting the embryonic gene Cripto-1 in cancer and beyond

31 March 2020

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Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.

31 March 2020

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Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells

31 March 2020

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Regulation of the embryonic morphogen Nodal by Notch4 facilitates manifestation of the aggressive melanoma phenotype

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Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment

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Tumor cell vasculogenic mimicry: from controversy to therapeutic promise

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Embryonic Protein Nodal Promotes Breast Cancer Vascularization

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Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness.

31 March 2020

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Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1.

31 March 2020

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Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis

31 March 2020

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To differentiate or not--routes towards metastasis

31 March 2020

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Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

31 March 2020

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BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo

31 March 2020

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SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression

31 March 2020

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Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins

31 March 2020

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The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites

31 March 2020

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Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone

31 March 2020

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Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming

31 March 2020

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Identification of NOG as a specific breast cancer bone metastasis-supporting gene

31 March 2020

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Bone morphogenetic protein signaling enhances invasion and bone metastasis of breast cancer cells through Smad pathway

31 March 2020

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Prostate cancer cells and bone stromal cells mutually interact with each other through bone morphogenetic protein-mediated signals.

31 March 2020

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ALK1 as an emerging target for antiangiogenic therapy of cancer

31 March 2020

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Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis.

31 March 2020

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Targeting activin receptor-like kinase 1 inhibits angiogenesis and tumorigenesis through a mechanism of action complementary to anti-VEGF therapies

31 March 2020

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Nodal as a biomarker for melanoma progression and a new therapeutic target for clinical intervention

31 March 2020

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The regulation and functions of activin and follistatin in inflammation and immunity.

31 March 2020

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Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response

31 March 2020

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GDF-15 contributes to proliferation and immune escape of malignant gliomas

31 March 2020

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Bioactivity and prognostic significance of growth differentiation factor GDF15 secreted by bone marrow mesenchymal stem cells in multiple myeloma.

31 March 2020

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Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease

31 March 2020

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Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival

31 March 2020

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Activin receptor antagonists for cancer-related anemia and bone disease

31 March 2020

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Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q- syndrome patients

31 March 2020

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Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice

31 March 2020

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Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.

31 March 2020

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Induction of cachexia in mice by systemically administered myostatin.

31 March 2020

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Pathologic fractures correlate with reduced survival in patients with malignant bone disease

31 March 2020

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A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength

31 March 2020

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A soluble activin type IIA receptor induces bone formation and improves skeletal integrity

31 March 2020

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The specificities of small molecule inhibitors of the TGFß and BMP pathways

31 March 2020

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Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer

31 March 2020

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Targeting the TGFβ signalling pathway in disease

31 March 2020

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Cancer stem cells: in the line of fire

31 March 2020

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Bone morphogenetic protein 4 induces differentiation of colorectal cancer stem cells and increases their response to chemotherapy in mice.

31 March 2020

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Integrated epigenomics identifies BMP4 as a modulator of cisplatin sensitivity in gastric cancer

31 March 2020

1 reference

The bright and the dark sides of activin in wound healing and cancer

31 March 2020

1 reference

Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway.

31 March 2020

1 reference

Mechanism of osteogenic induction by FK506 via BMP/Smad pathways

31 March 2020

1 reference

Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads

31 March 2020

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12 December 2020

Rapamycin induces Smad activity in prostate cancer cell lines

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12 December 2020

Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning

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12 December 2020

Crosstalk between Wnt and bone morphogenic protein signaling: a turbulent relationship

1 reference

12 December 2020

Genomic Determinants of PI3K Pathway Inhibitor Response in Cancer

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12 December 2020

Serum immunoreactive activin A levels in normal subjects and patients with various diseases.

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12 December 2020

BMPs: from bone to body morphogenetic proteins

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12 December 2020

SPC4/PACE4 regulates a TGFbeta signaling network during axis formation

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12 December 2020

Identifiers

DOI

10.1038/NRC3500

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PubMed ID

23612460

Dimensions Publication ID

28 August 2017

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1 reference

PubMed ID

23612460