Proteases in Mycobacterium tuberculosis pathogenesis: potential as drug targets (Q38103940)

28 August 2017

Proteases in Mycobacterium tuberculosis pathogenesis: potential as drug targets (English)

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Mycobacterium tuberculosis

28 August 2017

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author name string

David M Roberts

1

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28 August 2017

Yoann Personne

2

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28 August 2017

Juliane Ollinger

3

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28 August 2017

Tanya Parish

4

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28 August 2017

1 May 2013

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28 August 2017

11

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based on heuristic

inferred from page(s)

published in

Future Microbiology

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28 August 2017

8

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28 August 2017

5

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28 August 2017

621-631

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28 August 2017

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Inhibition of the sole type I signal peptidase of Mycobacterium tuberculosis is bactericidal under replicating and nonreplicating conditions

21 January 2018

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The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target

21 January 2018

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Regulated expression of the Escherichia coli lepB gene as a tool for cellular testing of antimicrobial compounds that inhibit signal peptidase I in vitro

21 January 2018

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On the catalytic mechanism of prokaryotic leader peptidase 1.

21 January 2018

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Escherichia coli leader peptidase: production of an active form lacking a requirement for detergent and development of peptide substrates

21 January 2018

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Synthesis and biological evaluation of penem inhibitors of bacterial signal peptidase.

21 January 2018

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Crystallographic and biophysical analysis of a bacterial signal peptidase in complex with a lipopeptide-based inhibitor

21 January 2018

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Structural and initial biological analysis of synthetic arylomycin A2.

21 January 2018

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Broad-spectrum antibiotic activity of the arylomycin natural products is masked by natural target mutations

21 January 2018

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Lipoprotein processing is required for virulence of Mycobacterium tuberculosis

21 January 2018

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The ESAT-6 gene cluster of Mycobacterium tuberculosis and other high G+C Gram-positive bacteria

21 January 2018

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The mycosins of Mycobacterium tuberculosis H37Rv: a family of subtilisin-like serine proteases

21 January 2018

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Type VII secretion--mycobacteria show the way.

21 January 2018

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Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence

21 January 2018

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C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis

21 January 2018

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Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling

21 January 2018

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Mechanisms of iron regulation in mycobacteria: role in physiology and virulence

21 January 2018

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Global analysis of the Mycobacterium tuberculosis Zur (FurB) regulon

21 January 2018

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Genes required for mycobacterial growth defined by high density mutagenesis

21 January 2018

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Clp ATPases and ClpP proteolytic complexes regulate vital biological processes in low GC, Gram-positive bacteria

21 January 2018

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Protein targeting to ATP-dependent proteases

21 January 2018

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Insights into the inter-ring plasticity of caseinolytic proteases from the X-ray structure of Mycobacterium tuberculosis ClpP1

21 January 2018

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ATP-dependent proteases of bacteria: recognition logic and operating principles

21 January 2018

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Validation of the essential ClpP protease in Mycobacterium tuberculosis as a novel drug target

21 January 2018

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Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection

21 January 2018

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The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring.

21 January 2018

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Assembly and proteolytic processing of mycobacterial ClpP1 and ClpP2.

21 January 2018

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Gene expression profile of Mycobacterium tuberculosis in a non-replicating state

21 January 2018

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Characterization of a Clp protease gene regulator and the reaeration response in Mycobacterium tuberculosis

21 January 2018

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Identifying vulnerable pathways in Mycobacterium tuberculosis by using a knockdown approach

21 January 2018

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An Escherichia coli chromosomal "addiction module" regulated by guanosine [corrected] 3',5'-bispyrophosphate: a model for programmed bacterial cell death

21 January 2018

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Proteolytic regulation of toxin-antitoxin systems by ClpPC in Staphylococcus aureus

21 January 2018

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Addiction protein Phd of plasmid prophage P1 is a substrate of the ClpXP serine protease of Escherichia coli

21 January 2018

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The ClpP peptidase is the major determinant of bulk protein turnover in Bacillus subtilis

21 January 2018

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ClpP of Bacillus subtilis is required for competence development, motility, degradative enzyme synthesis, growth at high temperature and sporulation.

21 January 2018

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RseA, the SigE specific anti-sigma factor of Mycobacterium tuberculosis, is inactivated by phosphorylation-dependent ClpC1P2 proteolysis

21 January 2018

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Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease

21 January 2018

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The ClpP serine protease is essential for the intracellular parasitism and virulence of Listeria monocytogenes

21 January 2018

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Dysregulation of bacterial proteolytic machinery by a new class of antibiotics

21 January 2018

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Diversity-oriented synthesis of cyclic acyldepsipeptides leads to the discovery of a potent antibacterial agent

21 January 2018

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Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism

21 January 2018

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Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: A model for the ClpX/ClpA-bound state of ClpP.

21 January 2018

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The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease

21 January 2018

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Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ

21 January 2018

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Acyl depsipeptide (ADEP) resistance in Streptomyces

21 January 2018

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Activators of cylindrical proteases as antimicrobials: identification and development of small molecule activators of ClpP protease

21 January 2018

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The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease

21 January 2018

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Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate

21 January 2018

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Back to the future with ubiquitin

21 January 2018

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"Depupylation" of prokaryotic ubiquitin-like protein from mycobacterial proteasome substrates

21 January 2018

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Pupylation: proteasomal targeting by a protein modifier in bacteria

21 January 2018

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Deletion of dop in Mycobacterium smegmatis abolishes pupylation of protein substrates in vivo

21 January 2018

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Characterization of a Mycobacterium tuberculosis proteasomal ATPase homologue

21 January 2018

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Structural Insights on the Mycobacterium tuberculosis Proteasomal ATPase Mpa

21 January 2018

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Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected]

21 January 2018

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Identification of substrates of the Mycobacterium tuberculosis proteasome

21 January 2018

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Expansion of the mycobacterial "PUPylome"

21 January 2018

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In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice

21 January 2018

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The Mycobacterium tuberculosis proteasome active site threonine is essential for persistence yet dispensable for replication and resistance to nitric oxide

21 January 2018

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The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide

21 January 2018

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Inhibitors selective for mycobacterial versus human proteasomes

21 January 2018

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Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome

21 January 2018

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Proteasome inhibition by fellutamide B induces nerve growth factor synthesis

21 January 2018

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Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis

21 January 2018

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HTRA proteases: regulated proteolysis in protein quality control

21 January 2018

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The structural basis of mode of activation and functional diversity: a case study with HtrA family of serine proteases

21 January 2018

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Investigation into the role of the serine protease HtrA in Yersinia pestis pathogenesis

21 January 2018

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Role of the htrA gene in Klebsiella pneumoniae virulence

21 January 2018

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Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling

21 January 2018

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Staphylococcus aureus nuclease is a useful secretion reporter for mycobacteria

21 January 2018

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Identification of genes encoding exported Mycobacterium tuberculosis proteins using a Tn552'phoA in vitro transposition system

21 January 2018

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HtrA serine proteases as potential therapeutic targets in cancer

21 January 2018

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Inhibitors of Helicobacter pylori protease HtrA found by 'virtual ligand' screening combat bacterial invasion of epithelia

21 January 2018

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Functional characterization of AAA family FtsH protease of Mycobacterium tuberculosis

21 January 2018

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AAA proteases: cellular machines for degrading membrane proteins

21 January 2018

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Sequence analysis of the AAA protein family

21 January 2018

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Cloning and expression of the gene coding for FtsH protease from Mycobacterium tuberculosis H37Rv

21 January 2018

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Portrait of a pathogen: the Mycobacterium tuberculosis proteome in vivo

21 January 2018

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High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism

21 January 2018

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Membrane proteases and aminoglycoside antibiotic resistance

21 January 2018

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The FtsH protease is involved in development, stress response and heat shock control in Caulobacter crescentus.

21 January 2018

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LspA-independent action of globomycin on Mycobacterium tuberculosis

21 January 2018

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Arylomycins A and B, new biaryl-bridged lipopeptide antibiotics produced by Streptomyces sp. Tü 6075. I. Taxonomy, fermentation, isolation and biological activities.

21 January 2018

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12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.55.565

Identifiers

DOI

10.2217/FMB.13.25

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28 August 2017

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