Role of Nrf2 in protection against acute kidney injury (Q38115682)

29 August 2017

Role of Nrf2 in protection against acute kidney injury (English)

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29 August 2017

Luke M Shelton

1

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29 August 2017

B Kevin Park

series ordinal

2

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29 August 2017

Ian M Copple

series ordinal

3

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29 August 2017

language of work or name

English

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publication date

19 June 2013

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29 August 2017

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29 August 2017

84

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29 August 2017

6

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29 August 2017

1090-1095

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https://scigraph.springernature.com/pub.10.1038/ki.2013.248

29 August 2017

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cites work

The Keap1-Nrf2 cell defense pathway--a promising therapeutic target?

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Functional antioxidant responsive elements.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway

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https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Cysteine-based regulation of the CUL3 adaptor protein Keap1

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Keap1 degradation by autophagy for the maintenance of redox homeostasis

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https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution

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https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

The NRF2 gene variant, -653G/A, is associated with nephritis in childhood-onset systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Nrf2-deficient female mice develop lupus-like autoimmune nephritis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Bardoxolone methyl and kidney function in CKD with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Nrf2 activators as attractive therapeutics for diabetic nephropathy.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

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https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.

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https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Diabetic nephropathy: Could problems with bardoxolone methyl have been predicted?

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Analogs of bardoxolone methyl worsen diabetic nephropathy in rats with additional adverse effects

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Bardoxolone methyl decreases megalin and activates nrf2 in the kidney

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Drug-associated renal dysfunction and injury

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Renal hypoxia and dysoxia after reperfusion of the ischemic kidney

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Treatment of acute renal failure

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Human exposure to metals. Pathways of exposure, biomarkers of effect, and host factors

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Silibinin ameliorates arsenic induced nephrotoxicity by abrogation of oxidative stress, inflammation and apoptosis in rats

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Curcumin prevents Cr(VI)-induced renal oxidant damage by a mitochondrial pathway

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Activation of Nrf2 by cadmium and its role in protection against cadmium-induced apoptosis in rat kidney cells

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Cyclosporine nephrotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Lipoic acid supplementation prevents cyclosporine-induced hypertension and nephrotoxicity in spontaneously hypertensive rats.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

The NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Apoptosis and oxidative stress induced by ochratoxin A in rat kidney.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

A toxicogenomics approach to identify new plausible epigenetic mechanisms of ochratoxin a carcinogenicity in rat.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Reduction in antioxidant defenses may contribute to ochratoxin A toxicity and carcinogenicity

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Cross-talk between microRNAs, nuclear factor E2-related factor 2, and heme oxygenase-1 in ochratoxin A-induced toxic effects in renal proximal tubular epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Ochratoxin A-mediated DNA and protein damage: roles of nitrosative and oxidative stresses

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Oxidative DNA damage, lipid peroxidation and nephrotoxicity induced in the rat kidney after ferric nitrilotriacetate administration

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

A possible role of nrf2 in prevention of renal oxidative damage by ferric nitrilotriacetate

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Oral administration of a nephrotoxic dose of potassium bromate, a food additive, alters renal redox and metabolic status and inhibits brush border membrane enzymes in rats

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Oxidative stress induced by potassium bromate exposure results in altered tight junction protein expression in renal proximal tubule cells

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Dysfunction of Nrf2 decreases KBrO3-induced oxidative DNA damage in Ogg1-null mice.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Cisplatin nephrotoxicity: mechanisms and renoprotective strategies

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Renal protection by 3H-1,2-dithiole-3-thione against cisplatin through the Nrf2-antioxidant pathway

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Nrf2/HO-1 signaling pathway may be the prime target for chemoprevention of cisplatin-induced nephrotoxicity by lycopene

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Epigallocatechin-3-gallate activates Nrf2/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Ginsenoside Rg3 enhances the chemosensitivity of tumors to cisplatin by reducing the basal level of nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1/NAD(P)H quinone oxidoreductase-1 and prevents normal tissue damage by scavengin

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Two-dimensional electrophoretic profiling of normal human kidney glomerulus proteome and construction of an extensible markup language (XML)-based database

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

The GI-GPx gene is a target for Nrf2

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Hemin-induced activation of the thioredoxin gene by Nrf2. A differential regulation of the antioxidant responsive element by a switch of its binding factors

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Induction of rat UDP-glucuronosyltransferases in liver and duodenum by microsomal enzyme inducers that activate various transcriptional pathways.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.248

7 January 2021

Identifiers

DOI

10.1038/KI.2013.248

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Dimensions Publication ID

29 August 2017

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