Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling (Q35456356)

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English	Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling	scientific article

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Europe PubMed Central

8 August 2017

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling (English)

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Europe PubMed Central

8 August 2017

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Benedikt M. Kessler

18

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8 August 2017

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Julie Adam

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Patrick J Pollard

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Patrick J Pollard

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Nicola Ternette

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Nicola Ternette

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Roman Fischer

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Peter J. Ratcliffe

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Peter J Ratcliffe

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Peter Carmeliet

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Peter Carmeliet

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8 August 2017

Linda O'Flaherty

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Linda O'Flaherty

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8 August 2017

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Emine Hatipoglu

2

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8 August 2017

Natasha Sahgal

5

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8 August 2017

Helen Lockstone

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8 August 2017

Dilair Baban

7

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8 August 2017

Emma Nye

8

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8 August 2017

Gordon W Stamp

9

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Kathryn Wolhuter

10

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8 August 2017

Marcus Stevens

11

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8 August 2017

Patrick H Maxwell

14

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Chris W Pugh

15

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Norma Frizzell

16

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Tomoyoshi Soga

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Mona El-Bahrawy

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1 October 2011

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8 August 2017

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Europe PubMed Central

8 August 2017

20

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524-537

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8 August 2017

4

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Europe PubMed Central

8 August 2017

Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3202623

12 July 2018

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3202623

12 July 2018

Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3202623

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Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

1 reference

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12 July 2018

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.

1 reference

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Inborn and acquired metabolic defects in cancer

1 reference

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12 July 2018

Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution

1 reference

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12 July 2018

Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis

1 reference

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12 July 2018

Succination of proteins in diabetes

1 reference

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12 July 2018

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

1 reference

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12 July 2018

Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.

1 reference

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12 July 2018

Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway

1 reference

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12 July 2018

HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression

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Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

1 reference

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UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer

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Role of Nrf1 in antioxidant response element-mediated gene expression and beyond

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NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

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Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

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The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress

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Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

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12 July 2018

Succination of proteins by fumarate: mechanism of inactivation of glyceraldehyde-3-phosphate dehydrogenase in diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3202623

12 July 2018

Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3202623

12 July 2018

Role and regulation of prolyl hydroxylase domain proteins

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12 July 2018

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

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Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

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12 July 2018

Inactivation of glyceraldehyde-3-phosphate dehydrogenase by fumarate in diabetes: formation of S-(2-succinyl)cysteine, a novel chemical modification of protein and possible biomarker of mitochondrial stress

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3202623

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Succination of protein thiols during adipocyte maturation: a biomarker of mitochondrial stress

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12 July 2018

HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity

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12 July 2018

Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway

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12 July 2018

Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

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12 July 2018

Acute postnatal ablation of Hif-2alpha results in anemia

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12 July 2018

The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma

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12 July 2018

Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

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12 July 2018

Mechanistic studies of the Nrf2-Keap1 signaling pathway

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Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

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Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

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Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway

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Increased risk of cancer in patients with fumarate hydratase germline mutation

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HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

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Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

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Hypoxic induction of Ctgf is directly mediated by Hif-1.

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Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America

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Fumarate Hydratase Deficiency and Cancer: Activation of Hypoxia Signaling?

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S-(2-Succinyl)cysteine: a novel chemical modification of tissue proteins by a Krebs cycle intermediate

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12 December 2020

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10.1016/J.CCR.2011.09.006

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Europe PubMed Central

8 August 2017

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Europe PubMed Central

8 August 2017

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Europe PubMed Central

8 August 2017

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