Unravelling the mechanisms of durable control of HIV-1. (Q38116710)

29 August 2017

Unravelling the mechanisms of durable control of HIV-1. (English)

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29 August 2017

1

Bruce D Walker

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29 August 2017

2

Xu G Yu

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PubMed ID

23797064

29 August 2017

language of work or name

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1 July 2013

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Nature Reviews Immunology

29 August 2017

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29 August 2017

13

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29 August 2017

487-498

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29 August 2017

7

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Redefining chronic viral infection

29 August 2017

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Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence

21 January 2018

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Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy

21 January 2018

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The major genetic determinants of HIV-1 control affect HLA class I peptide presentation

21 January 2018

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Unusual polymorphisms in human immunodeficiency virus type 1 associated with nonprogressive infection

21 January 2018

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Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes

21 January 2018

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Infrequent recovery of HIV from but robust exogenous infection of activated CD4(+) T cells in HIV elite controllers.

21 January 2018

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Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors.

21 January 2018

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Transmission of human immunodeficiency virus type 1 from a patient who developed AIDS to an elite suppressor

21 January 2018

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Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs

21 January 2018

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Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutations

21 January 2018

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Evidence of CD8+ T-cell-mediated selective pressure on human immunodeficiency virus type 1 nef in HLA-B*57+ elite suppressors

21 January 2018

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HLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllers

21 January 2018

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HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1.

21 January 2018

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Reduced replication capacity of NL4-3 recombinant viruses encoding reverse transcriptase-integrase sequences from HIV-1 elite controllers

21 January 2018

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Impaired replication capacity of acute/early viruses in persons who become HIV controllers

21 January 2018

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Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection

21 January 2018

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HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage

21 January 2018

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Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.

21 January 2018

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HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors

21 January 2018

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A whole-genome association study of major determinants for host control of HIV-1

21 January 2018

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Host determinants of HIV-1 control in African Americans

21 January 2018

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Genomewide Association Study of an AIDS‐Nonprogression Cohort Emphasizes the Role Played byHLAGenes (ANRS Genomewide Association Study 02)

21 January 2018

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Host genetic polymorphisms associated with innate immune factors and HIV-1.

21 January 2018

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Host genetic factors in susceptibility to HIV-1 infection and progression to AIDS.

21 January 2018

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Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection

21 January 2018

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Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity

21 January 2018

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TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection

21 January 2018

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HLA-B*57 versus HLA-B*81 in HIV-1 infection: slow and steady wins the race?

21 January 2018

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Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African Americans

21 January 2018

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HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C.

21 January 2018

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Differential microRNA regulation of HLA-C expression and its association with HIV control

21 January 2018

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HIV and HLA class I: an evolving relationship

21 January 2018

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Multistage genomewide association study identifies a locus at 1q41 associated with rate of HIV-1 disease progression to clinical AIDS.

21 January 2018

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Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1.

21 January 2018

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Role of natural killer cells in a cohort of elite suppressors: low frequency of the protective KIR3DS1 allele and limited inhibition of human immunodeficiency virus type 1 replication in vitro

21 January 2018

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HLA-B*35-Px-mediated acceleration of HIV-1 infection by increased inhibitory immunoregulatory impulses

21 January 2018

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HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding

21 January 2018

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Epigenetic regulation of telomerase expression in HIV-1-specific CD8+ T cells

21 January 2018

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Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection.

21 January 2018

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HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype

21 January 2018

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Heterogeneity in HIV suppression by CD8 T cells from HIV controllers: association with Gag-specific CD8 T cell responses

21 January 2018

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Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF

21 January 2018

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Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control

21 January 2018

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Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control

21 January 2018

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Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression

21 January 2018

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HIV-1-specific IFN-gamma/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells.

21 January 2018

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HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

21 January 2018

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Elite controllers with low to absent effector CD8+ T cell responses maintain highly functional, broadly directed central memory responses

21 January 2018

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Mucosal immune responses to HIV-1 in elite controllers: a potential correlate of immune control

21 January 2018

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Protective HIV-specific CD8+ T cells evade Treg cell suppression

21 January 2018

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Coordinate linkage of HIV evolution reveals regions of immunological vulnerability

21 January 2018

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CD8+ T-cell responses to different HIV proteins have discordant associations with viral load

21 January 2018

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Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control

21 January 2018

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Magnitude of functional CD8+ T-cell responses to the gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma

21 January 2018

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Interactive association of proviral load and IFN-gamma-secreting T cell responses in HIV-1C infection

21 January 2018

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Vaccine-induced CD8+ T cells control AIDS virus replication

21 January 2018

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HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control

21 January 2018

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Early HLA-B*57-restricted CD8+ T lymphocyte responses predict HIV-1 disease progression

21 January 2018

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Clonotype and repertoire changes drive the functional improvement of HIV-specific CD8 T cell populations under conditions of limited antigenic stimulation

21 January 2018

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Inadequate T follicular cell help impairs B cell immunity during HIV infection.

21 January 2018

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HIV controller CD4+ T cells respond to minimal amounts of Gag antigen due to high TCR avidity

21 January 2018

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HIV-1-specific interleukin-21+ CD4+ T cell responses contribute to durable viral control through the modulation of HIV-specific CD8+ T cell function

21 January 2018

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Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells

21 January 2018

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Changes in paracrine interleukin-2 requirement, CCR7 expression, frequency, and cytokine secretion of human immunodeficiency virus-specific CD4+ T cells are a consequence of antigen load

21 January 2018

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HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome

21 January 2018

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HIV controllers with HLA-DRB1*13 and HLA-DQB1*06 alleles have strong, polyfunctional mucosal CD4+ T-cell responses

21 January 2018

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Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides

21 January 2018

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Breadth of human immunodeficiency virus-specific neutralizing activity in sera: clustering analysis and association with clinical variables

21 January 2018

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Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers

21 January 2018

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Neutralizing antibodies do not mediate suppression of human immunodeficiency virus type 1 in elite suppressors or selection of plasma virus variants in patients on highly active antiretroviral therapy

21 January 2018

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Neutralizing antibody responses against autologous and heterologous viruses in acute versus chronic human immunodeficiency virus (HIV) infection: evidence for a constraint on the ability of HIV to completely evade neutralizing antibody responses

21 January 2018

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Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection

21 January 2018

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Cross‐Reactive Neutralizing Humoral Immunity Does Not Protect from HIV Type 1 Disease Progression

21 January 2018

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Continuous viral escape and selection by autologous neutralizing antibodies in drug-naive human immunodeficiency virus controllers

21 January 2018

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Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

21 January 2018

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Fc receptor but not complement binding is important in antibody protection against HIV.

21 January 2018

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Vaccine-elicited SIV and HIV envelope-specific IgA and IgG memory B cells in rhesus macaque peripheral blood correlate with functional antibody responses and reduced viremia

21 January 2018

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Antibody-dependent cellular cytotoxicity against primary HIV-infected CD4+ T cells is directly associated with the magnitude of surface IgG binding

21 January 2018

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Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers

21 January 2018

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Plasmacytoid dendritic cells reduce HIV production in elite controllers

21 January 2018

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DCs and NK cells: critical effectors in the immune response to HIV-1.

21 January 2018

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HIV-1 adaptation to NK-cell-mediated immune pressure

21 January 2018

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Natural viral suppressors of HIV-1 have a unique capacity to maintain gammadelta T cells.

21 January 2018

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CD4+ T cells from elite suppressors are more susceptible to HIV-1 but produce fewer virions than cells from chronic progressors

21 January 2018

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CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21

21 January 2018

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Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllers

21 January 2018

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Galectin-9 binding to Tim-3 renders activated human CD4+ T cells less susceptible to HIV-1 infection

21 January 2018

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A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells

21 January 2018

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The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1.

21 January 2018

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Decreased immune activation in resistance to HIV-1 infection is associated with an elevated frequency of CD4(+)CD25(+)FOXP3(+) regulatory T cells

21 January 2018

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Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy

21 January 2018

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T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers

21 January 2018

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Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy

21 January 2018

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Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters

21 January 2018

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HIV-1 continues to replicate and evolve in patients with natural control of HIV infection

21 January 2018

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A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers

21 January 2018

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Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease

21 January 2018

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Transcriptional profiling of CD4 T cells identifies distinct subgroups of HIV-1 elite controllers

21 January 2018

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Comprehensive analysis of unique cases with extraordinary control over HIV replication

21 January 2018

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Virus-host interactions: from systems biology to translational research

21 January 2018

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A systems biology approach to infectious disease research: innovating the pathogen-host research paradigm

21 January 2018

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A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer.

21 January 2018

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A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus

21 January 2018

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Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

21 January 2018

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Systems vaccinology: learning to compute the behavior of vaccine induced immunity

21 January 2018

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Systems biology of vaccination for seasonal influenza in humans

21 January 2018

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The challenge of finding a cure for HIV infection

21 January 2018

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Towards an HIV cure: a global scientific strategy

21 January 2018

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Long-Term Human Immunodeficiency Virus Infection in Asymptomatic Homosexual and Bisexual Men with Normal CD4+ Lymphocyte Counts: Immunologic and Virologic Characteristics

21 January 2018

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HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis

21 January 2018

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CD4 T-cell regeneration in HIV-1 elite controllers

21 January 2018

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Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers

21 January 2018

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Elite suppressors harbor low levels of integrated HIV DNA and high levels of 2-LTR circular HIV DNA compared to HIV+ patients on and off HAART.

21 January 2018

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Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation

21 January 2018

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Mamu-B*08-positive macaques control simian immunodeficiency virus replication

21 January 2018

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Patterns of CD8+ immunodominance may influence the ability of Mamu-B*08-positive macaques to naturally control simian immunodeficiency virus SIVmac239 replication

21 January 2018

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Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection.

21 January 2018

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Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection

21 January 2018

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Infection with "escaped" virus variants impairs control of simian immunodeficiency virus SIVmac239 replication in Mamu-B*08-positive macaques

21 January 2018

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Immune control of HIV-1 after early treatment of acute infection

21 January 2018

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Limited durability of viral control following treated acute HIV infection

21 January 2018

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Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study

21 January 2018

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Immunovirologic control 24 months after interruption of antiretroviral therapy initiated close to HIV seroconversion.

21 January 2018

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Low Level of Regulatory T Cells and Maintenance of Balance Between Regulatory T Cells and TH17 Cells in HIV-1–Infected Elite Controllers

21 January 2018

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Replication-competent HIV strains infect HIV controllers despite undetectable viremia (ANRS EP36 study)

21 January 2018

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HLA and AIDS: a cautionary tale

31 March 2020

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Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS

31 March 2020

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HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

31 March 2020

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Plasmacytoid Dendritic Cells (pDCs) From HIV Controllers Produce Interferon-α and Differentiate Into Functional Killer pDCs Under HIV Activation

31 March 2020

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Dysfunctional natural killer cells, in vivo, are governed by HIV viremia regardless of whether the infected individual is on antiretroviral therapy

31 March 2020

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Specific phenotypic and functional features of natural killer cells from HIV-infected long-term nonprogressors and HIV controllers

31 March 2020

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Association of HLA-DRB1-restricted CD4⁺ T cell responses with HIV immune control

31 March 2020

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12 December 2020

High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection.

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12 December 2020

Defective accessory genes in a human immunodeficiency virus type 1-infected long-term survivor lacking recoverable virus

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12 December 2020

HIV-1 infection does not induce tumor necrosis factor-alpha or interferon-beta gene transcription

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12 December 2020

Molecular basis of organ-specific selection of viral variants during chronic infection

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12 December 2020

Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients

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12 December 2020

Identifiers

DOI

10.1038/NRI3478

1 reference

29 August 2017

1 reference

PubMed ID

23797064