Omics technologies and the study of human ageing (Q38128467)

29 August 2017

title

Omics technologies and the study of human ageing (English)

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29 August 2017

Ana M Valdes

1

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Tim D. Spector

series ordinal

3

object named as

Tim D Spector

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29 August 2017

Daniel Glass

2

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29 August 2017

publication date

13 August 2013

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29 August 2017

published in

Nature Reviews Genetics

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29 August 2017

volume

14

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29 August 2017

issue

9

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29 August 2017

page(s)

601-607

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Colloquium paper: working toward a synthesis of archaeological, linguistic, and genetic data for inferring African population history

29 August 2017

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Genome-wide detection and characterization of positive selection in human populations

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A map of recent positive selection in the human genome

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Global landscape of recent inferred Darwinian selection for Homo sapiens

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Localizing recent adaptive evolution in the human genome

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Genomic signatures of positive selection in humans and the limits of outlier approaches

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A practical genome scan for population-specific strong selective sweeps that have reached fixation

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Signals of recent positive selection in a worldwide sample of human populations

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Signatures of environmental genetic adaptation pinpoint pathogens as the main selective pressure through human evolution

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21 January 2018

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Genome-wide insights into the patterns and determinants of fine-scale population structure in humans

21 January 2018

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Ancient admixture in human history

21 January 2018

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The genetic prehistory of southern Africa

21 January 2018

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How reliable are empirical genomic scans for selective sweeps?

21 January 2018

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Genetics in geographically structured populations: defining, estimating and interpreting F(ST)

21 January 2018

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The genomic distribution of population substructure in four populations using 8,525 autosomal SNPs.

21 January 2018

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Sequencing of 50 human exomes reveals adaptation to high altitude

21 January 2018

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Population differentiation as a test for selective sweeps

21 January 2018

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A composite of multiple signals distinguishes causal variants in regions of positive selection

21 January 2018

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Detecting and characterizing genomic signatures of positive selection in global populations

21 January 2018

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Positive natural selection in the human lineage

21 January 2018

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Genome-wide scans for footprints of natural selection

21 January 2018

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Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome.

21 January 2018

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Long-range LD can confound genome scans in admixed populations

21 January 2018

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Detecting local adaptation using the joint sampling of polymorphism data in the parental and derived populations

21 January 2018

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The genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptation

21 January 2018

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Genomic signatures of selection at linked sites: unifying the disparity among species

21 January 2018

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The role of geography in human adaptation

21 January 2018

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Evidence for polygenic adaptation to pathogens in the human genome

21 January 2018

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Classic selective sweeps were rare in recent human evolution

21 January 2018

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Genetic evidence for high-altitude adaptation in Tibet

21 January 2018

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Adaptations to climate-mediated selective pressures in humans

21 January 2018

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Maternal adaptation to high-altitude pregnancy: an experiment of nature--a review.

21 January 2018

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Inference on the strength of balancing selection for epistatically interacting loci.

21 January 2018

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Clusters of adaptive evolution in the human genome

21 January 2018

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Constructing genomic maps of positive selection in humans: where do we go from here?

21 January 2018

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Joint analysis of demography and selection in population genetics: where do we stand and where could we go?

21 January 2018

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Limited evidence for classic selective sweeps in African populations

21 January 2018

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Signatures of purifying and local positive selection in human miRNAs

21 January 2018

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Targets of balancing selection in the human genome

21 January 2018

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Darwinian and demographic forces affecting human protein coding genes

21 January 2018

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Likelihood-free inference of population structure and local adaptation in a Bayesian hierarchical model

21 January 2018

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Identifying loci under selection against gene flow in isolation-with-migration models

21 January 2018

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Genetic signatures of strong recent positive selection at the lactase gene

21 January 2018

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Convergent adaptation of human lactase persistence in Africa and Europe

21 January 2018

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SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans

21 January 2018

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The evolution of human skin coloration

21 January 2018

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Genetic architecture of skin and eye color in an African-European admixed population

21 January 2018

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Hundreds of variants clustered in genomic loci and biological pathways affect human height

21 January 2018

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Genome-wide association of anthropometric traits in African- and African-derived populations

21 January 2018

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Patterns of ancestry, signatures of natural selection, and genetic association with stature in Western African pygmies

21 January 2018

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Life history trade-offs explain the evolution of human pygmies

21 January 2018

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Evolution of the human pygmy phenotype

21 January 2018

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Adaptive evolution of loci covarying with the human African Pygmy phenotype

21 January 2018

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Evidence of widespread selection on standing variation in Europe at height-associated SNPs

21 January 2018

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Andean and Tibetan patterns of adaptation to high altitude

21 January 2018

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Genetic variations in Tibetan populations and high-altitude adaptation at the Himalayas

21 January 2018

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Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders

21 January 2018

1 reference

Genetic adaptation to high altitude in the Ethiopian highlands

21 January 2018

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The genetic architecture of adaptations to high altitude in Ethiopia

21 January 2018

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Genetic signatures reveal high-altitude adaptation in a set of ethiopian populations

21 January 2018

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Living the high life: high-altitude adaptation

21 January 2018

1 reference

Independent introduction of two lactase-persistence alleles into human populations reflects different history of adaptation to milk culture

21 January 2018

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The T/G 13915 variant upstream of the lactase gene (LCT) is the founder allele of lactase persistence in an urban Saudi population

21 January 2018

1 reference

A novel polymorphism associated with lactose tolerance in Africa: multiple causes for lactase persistence?

21 January 2018

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Lactose digestion and the evolutionary genetics of lactase persistence

21 January 2018

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Multiple rare variants as a cause of a common phenotype: several different lactase persistence associated alleles in a single ethnic group

21 January 2018

1 reference

Genetic evidence for the convergent evolution of light skin in Europeans and East Asians

21 January 2018

1 reference

Hunter-gatherer genomic diversity suggests a southern African origin for modern humans

21 January 2018

1 reference

Gene expression levels are a target of recent natural selection in the human genome

21 January 2018

1 reference

Identifying recent adaptations in large-scale genomic data

21 January 2018

1 reference

Genetic structure in African populations: implications for human demographic history

21 January 2018

1 reference

Sickle cell anaemia and malaria

21 January 2018

1 reference

Personal and population genomics of human regulatory variation

21 January 2018

1 reference

Lactase persistence DNA variant enhances lactase promoter activity in vitro: functional role as a cis regulatory element

21 January 2018

1 reference

Parallel selection on TRPV6 in human populations

21 January 2018

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TRPV6 exhibits unusual patterns of polymorphism and divergence in worldwide populations

21 January 2018

1 reference

Modeling recent human evolution in mice by expression of a selected EDAR variant

21 January 2018

1 reference

cis-Regulatory changes in Kit ligand expression and parallel evolution of pigmentation in sticklebacks and humans

21 January 2018

1 reference

Signatures of positive selection in genes associated with human skin pigmentation as revealed from analyses of single nucleotide polymorphisms.

21 January 2018

1 reference

Enriching the gene set analysis of genome-wide data by incorporating directionality of gene expression and combining statistical hypotheses and methods

21 January 2018

1 reference

Population genomics in a disease targeted primary cell model

21 January 2018

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Integrating genetic and gene expression evidence into genome-wide association analysis of gene sets

21 January 2018

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Combining p-values in large-scale genomics experiments.

21 January 2018

1 reference

Pattern discovery and cancer gene identification in integrated cancer genomic data

21 January 2018

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An integrative genomics approach to infer causal associations between gene expression and disease

21 January 2018

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Systematic detection of polygenic cis-regulatory evolution

21 January 2018

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Q(ST)-F(ST) comparisons: evolutionary and ecological insights from genomic heterogeneity.

21 January 2018

1 reference

Evolutionary history and adaptation from high-coverage whole-genome sequences of diverse African hunter-gatherers

21 January 2018

1 reference

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

21 January 2018

1 reference

Extending healthy life span--from yeast to humans

21 January 2018

1 reference

Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges

31 March 2020

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Somatic mutations in aging, cancer and neurodegeneration

31 March 2020

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Detectable clonal mosaicism from birth to old age and its relationship to cancer

31 March 2020

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Detectable clonal mosaicism and its relationship to aging and cancer

31 March 2020

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Neutral mitochondrial heteroplasmy and the influence of aging

31 March 2020

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Mitochondrial DNA heteroplasmy in diabetes and normal adults: role of acquired and inherited mutational patterns in twins.

31 March 2020

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A twin study of mitochondrial DNA polymorphisms shows that heteroplasmy at multiple sites is associated with mtDNA variant 16093 but not with zygosity

31 March 2020

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Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations

31 March 2020

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Mapping cis- and trans-regulatory effects across multiple tissues in twins

31 March 2020

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Gene expression profiling in Werner syndrome closely resembles that of normal aging

31 March 2020

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Meta-analysis of age-related gene expression profiles identifies common signatures of aging.

31 March 2020

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Transcriptome-wide assessment of human brain and lymphocyte senescence.

31 March 2020

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Gene expression analysis of mTOR pathway: association with human longevity

31 March 2020

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Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease

31 March 2020

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Transcriptional profiling of aging in human muscle reveals a common aging signature

31 March 2020

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Genome-wide miRNA signatures of human longevity.

31 March 2020

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Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome

31 March 2020

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Widespread splicing changes in human brain development and aging

31 March 2020

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Principles and challenges of genomewide DNA methylation analysis

31 March 2020

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Aging effects on DNA methylation modules in human brain and blood tissue

31 March 2020

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Distinct DNA methylomes of newborns and centenarians

31 March 2020

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Age-associated DNA methylation in pediatric populations

31 March 2020

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On the programmed/non-programmed nature of ageing within the life history

31 March 2020

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Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs

31 March 2020

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Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains

31 March 2020

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An integrative network algorithm identifies age-associated differential methylation interactome hotspots targeting stem-cell differentiation pathways

31 March 2020

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Genome-wide methylation profiles reveal quantitative views of human aging rates

31 March 2020

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Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population

31 March 2020

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Inborn variation in metabolism

31 March 2020

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Metabolomics platforms for genome wide association studies--linking the genome to the metabolome

31 March 2020

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Analysis of the adult human plasma metabolome

31 March 2020

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Human serum metabolic profiles are age dependent

31 March 2020

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Metabolomic markers reveal novel pathways of ageing and early development in human populations

31 March 2020

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Developmental origins of noncommunicable disease: population and public health implications.

31 March 2020

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Lipidomics of familial longevity

31 March 2020

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Enterotypes of the human gut microbiome

31 March 2020

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Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians

31 March 2020

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Gut microbiota composition correlates with diet and health in the elderly

31 March 2020

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The secret languages of coevolved symbioses: insights from the Euprymna scolopes-Vibrio fischeri symbiosis

31 March 2020

1 reference

High throughput isolation and glycosylation analysis of IgG-variability and heritability of the IgG glycome in three isolated human populations

31 March 2020

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Serum N-glycan profile shift during human ageing

31 March 2020

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Plasma protein N-glycan profiles are associated with calendar age, familial longevity and health.

31 March 2020

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A transcriptional profile of aging in the human kidney

31 March 2020

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Temporal dynamics and genetic control of transcription in the human prefrontal cortex

31 March 2020

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Meta-profiles of gene expression during aging: limited similarities between mouse and human and an unexpectedly decreased inflammatory signature

31 March 2020

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Gene expression changes with age in skin, adipose tissue, blood and brain

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG3553

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Dimensions Publication ID

29 August 2017

1011523159

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