Convection-enhanced drug delivery to the brain: therapeutic potential and neuropathological considerations (Q38128898)

29 August 2017

Convection-enhanced drug delivery to the brain: therapeutic potential and neuropathological considerations (English)

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convection-enhanced delivery

29 August 2017

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Neil U Barua

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PubMed ID

23944716

29 August 2017

Steven S Gill

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2

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PubMed ID

23944716

29 August 2017

Seth Love

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3

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29 August 2017

11 September 2013

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29 August 2017

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29 August 2017

24

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29 August 2017

117-127

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29 August 2017

2

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The cranial arachnoid and pia mater in man: anatomical and ultrastructural observations

29 August 2017

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188Re-loaded lipid nanocapsules as a promising radiopharmaceutical carrier for internal radiotherapy of malignant gliomas

21 January 2018

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GDNF, NGF and BDNF as therapeutic options for neurodegeneration.

21 January 2018

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Intrastriatal convection-enhanced delivery results in widespread perivascular distribution in a pre-clinical model

21 January 2018

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Robot-guided convection-enhanced delivery of carboplatin for advanced brainstem glioma

21 January 2018

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Intermittent convection-enhanced delivery to the brain through a novel transcutaneous bone-anchored port

21 January 2018

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The development of an implantable catheter system for chronic or intermittent convection-enhanced delivery.

21 January 2018

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Convection-enhanced delivery of macromolecules in the brain

21 January 2018

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Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: results of a randomized and controlled phase IIb study

21 January 2018

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Regression of recurrent malignant gliomas with convection-enhanced delivery of topotecan

21 January 2018

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Gene transfer corrects acute GM2 gangliosidosis--potential therapeutic contribution of perivascular enzyme flow

21 January 2018

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Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

21 January 2018

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Intracerebral administration of CpG oligonucleotide for patients with recurrent glioblastoma: a phase II study

21 January 2018

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Influence of needle insertion speed on backflow for convection-enhanced delivery

21 January 2018

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Variables affecting convection-enhanced delivery to the striatum: a systematic examination of rate of infusion, cannula size, infusate concentration, and tissue-cannula sealing time.

21 January 2018

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Surface properties, more than size, limiting convective distribution of virus-sized particles and viruses in the central nervous system

21 January 2018

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Safety and tolerability of putaminal AADC gene therapy for Parkinson disease

21 January 2018

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Neprilysin: an enzyme candidate to slow the progression of Alzheimer's disease

21 January 2018

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Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy

21 January 2018

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Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease

21 January 2018

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In vitro and in vivo testing of a novel recessed-step catheter for reflux-free convection-enhanced drug delivery to the brain

21 January 2018

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Image-guided convection-enhanced delivery of GDNF protein into monkey putamen

21 January 2018

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A method for microscopic studies of cerebral angioarchitecture and vascular-parenchymal relationships, based on the demonstration of 'paravascular' fluid pathways in the mammalian central nervous system.

21 January 2018

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Atrophy of the cholinergic Basal forebrain over the adult age range and in early stages of Alzheimer's disease

21 January 2018

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The "perivascular pump" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain

21 January 2018

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Heparin coinfusion during convection-enhanced delivery (CED) increases the distribution of the glial-derived neurotrophic factor (GDNF) ligand family in rat striatum and enhances the pharmacological activity of neurturin

21 January 2018

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Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.

21 January 2018

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Anatomical relationships of the pia mater to cerebral blood vessels in man.

21 January 2018

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Distribution of extracellular tracers in perivascular spaces of the rat brain

21 January 2018

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Metabolic regulation of brain Abeta by neprilysin.

21 January 2018

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Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

21 January 2018

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Tracking accuracy of T2- and diffusion-weighted magnetic resonance imaging for infusate distribution by convection-enhanced delivery

21 January 2018

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Efficient gene therapy-based method for the delivery of therapeutics to primate cortex

21 January 2018

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Convection-enhanced delivery of polyethylene glycol-coated liposomal doxorubicin: characterization and efficacy in rat intracranial glioma models

21 January 2018

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Effects of the perivascular space on convection-enhanced delivery of liposomes in primate putamen

21 January 2018

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Reflux-free cannula for convection-enhanced high-speed delivery of therapeutic agents

21 January 2018

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Convection-enhanced delivery of M13 bacteriophage to the brain

21 January 2018

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Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma

21 January 2018

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Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease

21 January 2018

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Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

21 January 2018

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Convection-enhanced delivery of paclitaxel for the treatment of recurrent malignant glioma: a phase I/II clinical study.

21 January 2018

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Glial cell line-derived neurotrophic factor induces neuronal sprouting in human brain

21 January 2018

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Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions

21 January 2018

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Distribution in brain of liposomes after convection enhanced delivery; modulation by particle charge, particle diameter, and presence of steric coating.

21 January 2018

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HIV TAT peptide modifies the distribution of DNA nanolipoparticles following convection-enhanced delivery

21 January 2018

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Lack of neprilysin suffices to generate murine amyloid-like deposits in the brain and behavioral deficit in vivo

21 January 2018

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Aβ-degrading enzymes: potential for treatment of Alzheimer disease.

21 January 2018

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Convective delivery of glial cell line-derived neurotrophic factor in the human putamen

21 January 2018

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Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid beta and impairment of learning and memory

21 January 2018

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Effect of imaging and catheter characteristics on clinical outcome for patients in the PRECISE study

21 January 2018

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Convection-enhanced delivery of AAV-2 combined with heparin increases TK gene transfer in the rat brain.

21 January 2018

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Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: a two-year outcome study.

21 January 2018

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Lentivirus-expressed siRNA vectors against Alzheimer disease

21 January 2018

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Convection-enhanced delivery of maghemite nanoparticles: Increased efficacy and MRI monitoring

21 January 2018

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Neuronal neprilysin overexpression is associated with attenuation of Abeta-related spatial memory deficit.

21 January 2018

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Perivascular spaces in the basal ganglia of the human brain: their relationship to lacunes

21 January 2018

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Evidence for a 'paravascular' fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space

21 January 2018

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Tissue affinity of the infusate affects the distribution volume during convection-enhanced delivery into rodent brains: implications for local drug delivery.

21 January 2018

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Point source concentration of GDNF may explain failure of phase II clinical trial

21 January 2018

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Comparison of intratumoral bolus injection and convection-enhanced delivery of radiolabeled antitenascin monoclonal antibodies.

21 January 2018

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Induction of hyperintense signal on T2-weighted MR images correlates with infusion distribution from intracerebral convection-enhanced delivery of a tumor-targeted cytotoxin.

21 January 2018

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Poor drug distribution as a possible explanation for the results of the PRECISE trial.

21 January 2018

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Colocalization of gadolinium-diethylene triamine pentaacetic acid with high-molecular-weight molecules after intracerebral convection-enhanced delivery in humans

21 January 2018

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AAV2-mediated gene delivery to monkey putamen: evaluation of an infusion device and delivery parameters

21 January 2018

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Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases

21 January 2018

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Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice

21 January 2018

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A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

21 January 2018

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Anatomic compression caused by high-volume convection-enhanced delivery to the brain

21 January 2018

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Qualitative imaging of adeno-associated virus serotype 2-human aromatic L-amino acid decarboxylase gene therapy in a phase I study for the treatment of Parkinson disease.

21 January 2018

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Controlled dissemination of AAV vectors in the primate brain

21 January 2018

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Targeted delivery of nerve growth factor via encapsulated cell biodelivery in Alzheimer disease: a technology platform for restorative neurosurgery

21 January 2018

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Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease

21 January 2018

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Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease.

21 January 2018

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An evaluation of the relationships between catheter design and tissue mechanics in achieving high-flow convection-enhanced delivery.

21 January 2018

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Platinum distribution in malignant glioma following intraoperative intravenous infusion of carboplatin

21 January 2018

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Optimized cannula design and placement for convection-enhanced delivery in rat striatum

21 January 2018

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Optimal region of the putamen for image-guided convection-enhanced delivery of therapeutics in human and non-human primates

21 January 2018

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Delivery, distribution, and neuronal uptake of exogenous mannose-terminal glucocerebrosidase in the intact rat brain.

21 January 2018

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Inhibition of neprilysin by infusion of thiorphan into the hippocampus causes an accumulation of amyloid Beta and impairment of learning and memory

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/BPA.12082

1 reference

29 August 2017

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PubMed ID

23944716