Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions (Q36498773)

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English	Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions	scientific article

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9 January 2020

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Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions (English)

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9 January 2020

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vector-borne disease

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based on heuristic

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based on heuristic

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based on heuristic

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Maria G. Castro

5

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9 January 2020

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Pedro R Lowenstein

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9 January 2020

Ronald J Mandel

2

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9 January 2020

Wei-Dong Xiong

3

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9 January 2020

Kurt Kroeger

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1 October 2007

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9 January 2020

Current Gene Therapy

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9 January 2020

7

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9 January 2020

5

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9 January 2020

347-360

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9 January 2020

Immunological thresholds in neurological gene therapy: highly efficient elimination of transduced cells might be related to the specific formation of immunological synapses between T cells and virus-infected brain cells.

1 reference

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30 September 2017

Modulation of tolerance to the transgene product in a nonhuman primate model of AAV-mediated gene transfer to liver.

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30 September 2017

Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial

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30 September 2017

In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain

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30 September 2017

Recombinant adeno-associated viral vectors as therapeutic agents to treat neurological disorders.

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Lentivirus-mediated gene transfer to the central nervous system: therapeutic and research applications

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30 September 2017

Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses.

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Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.

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30 September 2017

Tuning immune responses: diversity and adaptation of the immunological synapse.

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30 September 2017

Immune responses to adeno-associated virus vectors

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30 September 2017

Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis.

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30 September 2017

Clinical trials in neurological disorders using AAV vectors: promises and challenges.

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30 September 2017

Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain

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30 September 2017

Striatal delivery of rAAV-hAADC to rats with preexisting immunity to AAV.

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30 September 2017

Rapid uncoating of vector genomes is the key to efficient liver transduction with pseudotyped adeno-associated virus vectors

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30 September 2017

Inflammation in the central nervous system: the role for dendritic cells

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30 September 2017

Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant adeno-associated virus

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30 September 2017

Immunological aspects of recombinant adeno-associated virus delivery to the mammalian brain

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30 September 2017

T cell receptor signaling precedes immunological synapse formation

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30 September 2017

Subthalamic GAD gene transfer in Parkinson disease patients who are candidates for deep brain stimulation.

1 reference

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30 September 2017

An improved helper-dependent adenoviral vector allows persistent gene expression after intramuscular delivery and overcomes preexisting immunity to adenovirus

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30 September 2017

Dendritic cell biology and regulation of dendritic cell trafficking by chemokines

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30 September 2017

Toxicity associated with repeated administration of first-generation adenovirus vectors does not occur with a helper-dependent vector.

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30 September 2017

The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling.

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30 September 2017

Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: toward realistic long-term neurological gene therapy for ch

1 reference

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30 September 2017

Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials

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30 September 2017

Immune responses to adenovirus and adeno-associated virus in humans.

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30 September 2017

The immunological synapse: a molecular machine controlling T cell activation

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30 September 2017

Adeno-associated virus-mediated gene transfer to the brain: duration and modulation of expression

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30 September 2017

Three-dimensional segregation of supramolecular activation clusters in T cells

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30 September 2017

The immunogenicity of intracerebral virus infection depends on anatomical site.

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30 September 2017

The nerve growth factor 35 years later

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30 September 2017

The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse

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28 June 2018

Factor VIII ectopically targeted to platelets is therapeutic in hemophilia A with high-titer inhibitory antibodies

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28 June 2018

Rapid upregulation of interferon-regulated and chemokine mRNAs upon injection of 108 international units, but not lower doses, of adenoviral vectors into the brain

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28 June 2018

A phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-Attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent malignant gliomas, in the adjuvant setting.

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28 June 2018

Interleukin-1 mediates a rapid inflammatory response after injection of adenoviral vectors into the brain.

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28 June 2018

Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease.

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28 June 2018

Virus dissemination through the brain parenchyma without immunologic control

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28 June 2018

The potential role of dendritic cells in immune-mediated inflammatory diseases in the central nervous system.

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28 June 2018

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28 June 2018

Time course of transgene expression after intrastriatal pseudotyped rAAV2/1, rAAV2/2, rAAV2/5, and rAAV2/8 transduction in the rat.

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21 September 2018

Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania

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21 September 2018

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21 September 2018

What is the blood-brain barrier (not)?

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21 September 2018

Limited transgene immune response and long-term expression of human alpha-L-iduronidase in young adult mice with mucopolysaccharidosis type I by liver-directed gene therapy

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21 September 2018

Immune responses to AAV in a phase I study for Canavan disease.

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21 September 2018

T cells use two directionally distinct pathways for cytokine secretion.

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21 September 2018

A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

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21 September 2018

Immune responses against tetracycline-dependent transactivators affect long-term expression of mouse erythropoietin delivered by a helper-dependent adenoviral vector

1 reference

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21 September 2018

Toxicity and adaptive immune response to intracellular transgenes delivered by helper-dependent vs. first generation adenoviral vectors

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21 September 2018

AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: a randomised, controlled study

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21 September 2018

Input virion proteins: cryptic targets of antivector immune responses in preimmunized subjects

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21 September 2018

T-cell-antigen recognition and the immunological synapse

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21 September 2018

Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes

1 reference

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21 September 2018

Muscle-directed gene transfer and transient immune suppression result in sustained partial correction of canine hemophilia B caused by a null mutation

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21 September 2018

Preexisting antiadenoviral immunity is not a barrier to efficient and stable transduction of the brain, mediated by novel high-capacity adenovirus vectors

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21 September 2018

Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain

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21 September 2018

Update on the prevalence of serum antibodies (IgG and IgM) to adeno-associated virus (AAV).

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21 September 2018

Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration

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21 September 2018

Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparations.

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21 September 2018

Impact of preexisting and induced humoral and cellular immune responses in an adenovirus-based gene therapy phase I clinical trial for localized mesothelioma.

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21 September 2018

Inflammation in the CNS: balance between immunological privilege and immune responses.

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21 September 2018

Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease.

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21 September 2018

Antigen-dependent intrathecal antibody synthesis in the normal rat brain: tissue entry and local retention of antigen-specific B cells.

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21 September 2018

Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view

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21 September 2018

Dendritic cells and immune responses in the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/17979681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serologic evidence for human infection with adenovirus-associated viruses

1 reference

https://pubmed.ncbi.nlm.nih.gov/17979681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The case for immunosuppression in clinical gene transfer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17979681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2174/156652307782151498

1 reference

Europe PubMed Central

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9 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17979681%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

Europe PubMed Central

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9 January 2020

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