Aging and intellectual disability: insights from mouse models of Down syndrome (Q38129324)

29 August 2017

Aging and intellectual disability: insights from mouse models of Down syndrome (English)

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29 August 2017

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intellectual disability

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disability affecting intellectual abilities

inferred from title

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Aarti Ruparelia

1

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29 August 2017

Matthew L Pearn

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2

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29 August 2017

William C Mobley

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3

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29 August 2017

1 January 2013

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Developmental Disabilities Research Reviews

29 August 2017

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29 August 2017

18

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29 August 2017

1

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29 August 2017

43-50

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Language development in Down syndrome: from the prelinguistic period to the acquisition of literacy

29 August 2017

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Classification of human chromosome 21 gene-expression variations in Down syndrome: impact on disease phenotypes

21 January 2018

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Chromosome 21 and down syndrome: from genomics to pathophysiology

21 January 2018

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Cerebellar volume in adults with Down syndrome.

21 January 2018

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Neurofibrillary tangles, granulovacuolar degeneration, and neuron loss in Down Syndrome: quantitative comparison with Alzheimer dementia.

21 January 2018

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Brain anatomy and ageing in non-demented adults with Down's syndrome: an in vivo MRI study.

21 January 2018

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The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome

21 January 2018

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The four ages of Down syndrome

21 January 2018

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A review of the literature relating to psychological interventions and people with intellectual disabilities: issues for research, policy, education and clinical practice

21 January 2018

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Phenotype associated with APP duplication in five families.

21 January 2018

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Long-term memory in mental retardation: evidence for a specific impairment in subjects with Down's syndrome.

21 January 2018

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Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects

21 January 2018

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Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome.

21 January 2018

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Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome

21 January 2018

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Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome.

21 January 2018

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Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model.

21 January 2018

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Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion

21 January 2018

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Dementia and mortality in persons with Down's syndrome

21 January 2018

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The use of mouse models to understand and improve cognitive deficits in Down syndrome

21 January 2018

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Aneuploidy: from a physiological mechanism of variance to Down syndrome

21 January 2018

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Object recognition memory is conserved in Ts1Cje, a mouse model of Down syndrome.

21 January 2018

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Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome

21 January 2018

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Pattern of malignant disorders in individuals with Down's syndrome.

21 January 2018

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The DNA sequence of human chromosome 21

21 January 2018

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Complex contributions of Ets2 to craniofacial and thymus phenotypes of trisomic "Down syndrome" mice.

21 January 2018

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Families of persons with Down syndrome: new perspectives, findings, and research and service needs

21 January 2018

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Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

21 January 2018

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Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndrome.

21 January 2018

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Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome.

21 January 2018

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21 January 2018

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Magnetic resonance imaging analysis of age-related changes in the brains of individuals with Down's syndrome

21 January 2018

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The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

21 January 2018

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Age-dependent and selective impairment of long-term potentiation in the anterior piriform cortex of mice lacking the fragile X mental retardation protein.

21 January 2018

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Cognitive deficits and associated neurological complications in individuals with Down's syndrome

21 January 2018

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Genotype-phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21

21 January 2018

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Adult neural function requires MeCP2.

21 January 2018

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Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome

21 January 2018

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Down's syndrome affects results of surgical correction of complete atrioventricular canal

21 January 2018

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Down's syndrome: a genetic disorder in biobehavioral perspective

21 January 2018

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An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes

21 January 2018

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Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice.

21 January 2018

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A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome

21 January 2018

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Amygdala and hippocampal volumes in children with Down syndrome: a high-resolution MRI study.

21 January 2018

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Neuroanatomy of Down's syndrome: a high-resolution MRI study.

21 January 2018

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Natural gene-expression variation in Down syndrome modulates the outcome of gene-dosage imbalance

21 January 2018

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ApoE genotype and Alzheimer's disease in adults with Down syndrome: meta-analysis.

21 January 2018

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A mouse model for Down syndrome exhibits learning and behaviour deficits.

21 January 2018

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APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

21 January 2018

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Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome

21 January 2018

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DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease

21 January 2018

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Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities

21 January 2018

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Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome

21 January 2018

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Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

21 January 2018

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Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome.

21 January 2018

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Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndrome.

21 January 2018

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Fragile x mental retardation (Fmr-1) gene expression is down regulated in brain of mice during aging.

21 January 2018

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Differential expression of Fmr-1 mRNA and FMRP in female mice brain during aging.

21 January 2018

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APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy

21 January 2018

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Clinical and EEG features of epilepsy in children and adolescents in Down syndrome.

21 January 2018

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Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions

21 January 2018

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Relation of corpus callosum and hippocampal size to age in nondemented adults with Down's syndrome

21 January 2018

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Aging in fragile X syndrome.

21 January 2018

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Short-term memory deficits are not uniform in Down and Williams syndromes.

21 January 2018

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Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

21 January 2018

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Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study

21 January 2018

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A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions

21 January 2018

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Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice.

21 January 2018

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Mortality is associated with apolipoprotein E epsilon4 in nondemented adults with Down syndrome.

21 January 2018

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Ethnicity, sex, and the incidence of congenital heart defects: a report from the National Down Syndrome Project

21 January 2018

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The changing survival profile of people with Down's syndrome: implications for genetic counselling

21 January 2018

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Comparative survival advantage of males with down syndrome

21 January 2018

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Differential effects of trisomy on brain shape and volume in related aneuploid mouse models

21 January 2018

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7 January 2021

The Influence of Intellectual Disability on Life Expectancy

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7 January 2021

Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis.

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7 January 2021

App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome

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7 January 2021

Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome.

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7 January 2021

Epidemiology of menstruation and its relevance to women's health

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7 January 2021

Aging in persons with Rett syndrome: an updated review

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7 January 2021

A prospective study of menopause in women with Down's syndrome

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7 January 2021

Identifiers

DOI

10.1002/DDRR.1127

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release_5rwz5ccfqrgwbabf2n3eeubbly

29 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/5rwz5ccfqrgwbabf2n3eeubbly

24 November 2022

mapped directly with Wikidata item

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