Diagnosis and treatment of hereditary hemochromatosis: an update (Q38132275)

29 August 2017

Diagnosis and treatment of hereditary hemochromatosis: an update (English)

1 reference

29 August 2017

2

Kris V Kowdley

1 reference

29 August 2017

Pushpjeet Kanwar

1

1 reference

29 August 2017

1 August 2013

1 reference

Expert Review of Gastroenterology & Hepatology

29 August 2017

1 reference

29 August 2017

7

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29 August 2017

517-530

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29 August 2017

6

1 reference

Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.

29 August 2017

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Penetrance of 845G--> A (C282Y) HFE hereditary haemochromatosis mutation in the USA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Mutation analysis in hereditary hemochromatosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

EASL clinical practice guidelines for HFE hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Hemochromatosis in Ireland and HFE

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Geography of HFE C282Y and H63D mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Hemochromatosis and iron-overload screening in a racially diverse population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Global prevalence of putative haemochromatosis mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Hemochromatosis: a Neolithic adaptation to cereal grain diets

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Hereditary hemochromatosis--a new look at an old disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Molecular insights into the pathogenesis of hereditary haemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

The molecular mechanism of hepcidin-mediated ferroportin down-regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Severe iron deficiency anemia in transgenic mice expressing liver hepcidin

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Natural history and management of HFE-hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

The hepcidin circuits act: balancing iron and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

A novel missense mutation in SLC40A1 results in resistance to hepcidin and confirms the existence of two ferroportin-associated iron overload diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Effects of alcohol consumption on iron metabolism in mice with hemochromatosis mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

EASL International Consensus Conference on Haemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Review article: the iron overload syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Liver diseases in the hemochromatosis and iron overload screening study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Iron-overload-related disease in HFE hereditary hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Screening for hemochromatosis in asymptomatic subjects with or without a family history.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Insulin resistance-associated hepatic iron overload.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Clinical cofactors and hepatic fibrosis in hereditary hemochromatosis: the role of diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Hypogonadism in hereditary hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Increased risk of death from iron overload among 422 treated probands with HFE hemochromatosis and serum levels of ferritin greater than 1000 μg/L at diagnosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

HFE Cys282Tyr homozygotes with serum ferritin concentrations below 1000 microg/L are at low risk of hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Initial screening transferrin saturation values, serum ferritin concentrations, and HFE genotypes in whites and blacks in the Hemochromatosis and Iron Overload Screening Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

The natural history of serum iron indices for HFE C282Y homozygosity associated with hereditary hemochromatosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

HLA haplotype A*03-B*07 in hemochromatosis probands with HFE C282Y homozygosity: frequency disparity in men and women and lack of association with severity of iron overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Differences in hepatic phenotype between hemochromatosis patients with HFE C282Y homozygosity and other HFE genotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

HFE C282Y/H63D compound heterozygotes are at low risk of hemochromatosis-related morbidity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

A population-based study of the clinical expression of the hemochromatosis gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Biological variability of transferrin saturation and unsaturated iron-binding capacity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Serum ferritin and risk of the metabolic syndrome in U.S. adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Association between serum ferritin and the insulin resistance syndrome in a representative population

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Serial serum ferritin measurements in untreated HFE C282Y homozygotes in the Hemochromatosis and Iron Overload Screening Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Environmental and genetic modifiers of the progression to fibrosis and cirrhosis in hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Excess alcohol greatly increases the prevalence of cirrhosis in hereditary hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Accelerated hepatic fibrosis in patients with combined hereditary hemochromatosis and chronic hepatitis C infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Steatosis is a cofactor in liver injury in hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

SNP selection for genes of iron metabolism in a study of genetic modifiers of hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

A study of 82 extended HLA haplotypes in HFE-C282Y homozygous hemochromatosis subjects: relationship to the genetic control of CD8+ T-lymphocyte numbers and severity of iron overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Clinical penetrance of C282Y homozygous HFE hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Non-HFE hepatic iron overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

HFE genotype in patients with hemochromatosis and other liver diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Management of Hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Serum Ferritin Level Predicts Advanced Hepatic Fibrosis among U.S. Patients with Phenotypic Hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Diagnosis and management of hemochromatosis: 2011 practice guideline by the American Association for the Study of Liver Diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Measurement and mapping of liver iron concentrations using magnetic resonance imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Liver fat: effect of hepatic iron deposition on evaluation with opposed-phase MR imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Magnetic resonance imaging measurement of iron overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Hereditary hemochromatosis: update for 2003.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Reversibility of hepatic fibrosis in treated genetic hemochromatosis: a study of 36 cases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Effective treatment of hereditary haemochromatosis with desferrioxamine in selected cases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

A phase 1/2, dose-escalation trial of deferasirox for the treatment of iron overload in HFE-related hereditary hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Therapeutic erythrocytapheresis versus phlebotomy in the initial treatment of hereditary hemochromatosis - A pilot study

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

INTERACTION OF VITAMIN C AND IRON

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Diagnosis and management of hemochromatosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Proton pump inhibitors suppress absorption of dietary non-haem iron in hereditary haemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

How I treat hemochromatosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Hepcidin: the missing link between hemochromatosis and infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Copper availability contributes to iron perturbations in human nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Mechanisms for copper acquisition, distribution and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Survival of liver transplant recipients with hemochromatosis in the United States

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

The epidemiology of haemochromatosis: a population-based study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Increased mortality risk in patients with phenotypic hereditary hemochromatosis but not in their first-degree relatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Hemochromatosis-associated mortality in the United States from 1979 to 1992: an analysis of Multiple-Cause Mortality Data

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Clinically overt hereditary hemochromatosis in Denmark 1948-1985: epidemiology, factors of significance for long-term survival, and causes of death in 179 patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Iron, hemochromatosis, and hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Survival and causes of death in hemochromatosis. Observations in 163 patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Cancer risk following primary hemochromatosis: a population-based cohort study in Denmark.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Increased cancer risk in a cohort of 230 patients with hereditary hemochromatosis in comparison to matched control patients with non-iron-related chronic liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Hereditary haemochromatosis and hepatocellular carcinoma in males: a strategy for estimating the potential for primary prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Occurrence of hepatocellular carcinoma in nonfibrotic livers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Prevalence of hepatic iron overload and association with hepatocellular cancer in end-stage liver disease: results from the National Hemochromatosis Transplant Registry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

HFE C282Y homozygotes are at increased risk of breast and colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Body iron stores and the risk of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Comparison of genotypic and phenotypic strategies for population screening in hemochromatosis: assessment of anxiety, depression, and perception of health.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Psychosocial aspects of DNA testing for hereditary hemochromatosis in at-risk individuals: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Hereditary hemochromatosis: genetic complexity and new diagnostic approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

HFE C282Y Homozygosity Is Associated with an Increased Risk of Total Hip Replacement for Osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Hepatocellular carcinoma occurring in nonfibrotic liver: Epidemiologic and histopathologic analysis of 80 French cases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Hereditary hemochromatosis is characterized by a clinically definable arthropathy that correlates with iron load

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Use of community genetic screening to prevent HFE-associated hereditary haemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

Why Do People Choose Not to Have Screening for Hemochromatosis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F17474124.2013.816114

10.1586/17474124.2013.816114

21 January 2018

Identifiers

DOI

1 reference

29 August 2017

1 reference

PubMed ID

23985001