Physiological roles and potential therapeutic applications of the P2X7 receptor in inflammation and pain (Q38135247)

30 June 2019

5 references

31 July 2019

2 October 2019

28 November 2019

15 December 2019

24 January 2021

Physiological roles and potential therapeutic applications of the P2X7 receptor in inflammation and pain (English)

1 reference

30 June 2019

main subject

cell surface receptor

1 reference

31 July 2019

1 reference

2 October 2019

1 reference

28 November 2019

1 reference

15 December 2019

1 reference

24 January 2021

Luiz Anastacio Alves

1

1 reference

30 June 2019

Rômulo José Soares Bezerra

2

1 reference

30 June 2019

Robson Xavier Faria

3

1 reference

30 June 2019

Leonardo Gomes Braga Ferreira

4

1 reference

30 June 2019

Valber da Silva Frutuoso

5

1 reference

30 June 2019

language of work or name

English

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publication date

5 September 2013

6 references

30 June 2019

31 July 2019

2 October 2019

28 November 2019

15 December 2019

24 January 2021

6 references

30 June 2019

31 July 2019

2 October 2019

28 November 2019

15 December 2019

24 January 2021

18

1 reference

30 June 2019

issue

9

1 reference

30 June 2019

page(s)

10953-10972

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30 June 2019

Creative Commons Attribution 3.0 Unported

copyright license

5 references

31 July 2019

2 October 2019

28 November 2019

15 December 2019

Hemodynamic regulation of inflammation at the endothelial-neutrophil interface

24 January 2021

0 references

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

P2X1 ion channels promote neutrophil chemotaxis through Rho kinase activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Autocrine Purinergic Receptor Signaling Is Essential for Macrophage Chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Is there a basis for distinguishing two types of P2-purinoceptor?

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Molecular physiology of P2X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Permeabilization of transformed mouse fibroblasts by 3'-O-(4-benzoyl)benzoyl adenosine 5'-triphosphate and the desensitization of the process.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Cellular distribution and functions of P2 receptor subtypes in different systems

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Pharmacological characterization of the human P2Y11 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Effects of diadenosine polyphosphates on glomerular volume

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Effects of divalent cations, protons and calmidazolium at the rat P2X7 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Differential role of extracellular histidines in copper, zinc, magnesium and proton modulation of the P2X7 purinergic receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Identification of key residues coordinating functional inhibition of P2X7 receptors by zinc and copper

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Activation and regulation of purinergic P2X receptor channels

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Purine and pyrimidine (P2) receptors as drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Cross-talk between P2X4 and gamma-aminobutyric acid, type A receptors determines synaptic efficacy at a central synapse.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Effects of antagonists at the human recombinant P2X7 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Ionic effects on human recombinant P2X7 receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Chelerythrine and other benzophenanthridine alkaloids block the human P2X7 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Modulation of P2X7 receptor expression in macrophages from mineral oil-injected mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Inhibition of ATP-induced macrophage death by emodin via antagonizing P2X7 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Colchicine inhibits cationic dye uptake induced by ATP in P2X2 and P2X7 receptor-expressing cells: implications for its therapeutic action

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Action of natural products on p2 receptors: a reinvented era for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Natural Products as a Source for New Anti-Inflammatory and Analgesic Compounds through the Inhibition of Purinergic P2X Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Proteomic and functional evidence for a P2X7 receptor signalling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Synthesis and structure-activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB(2) agonists for the treatment of inflammatory pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1alphabeta knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

The P2X7‐Egr pathway regulates nucleotide‐dependent inflammatory gene expression in microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

P2X purinergic receptor ligands: recently patented compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

P2X receptors as drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Experimental characterization and mathematical modeling of P2X7 receptor channel gating.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Selective P2X(7) receptor antagonists for chronic inflammation and pain

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Recent patents on novel P2X(7) receptor antagonists and their potential for reducing central nervous system inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

P2X7 receptors: channels, pores and more

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

The role of the purinergic P2X7 receptor in inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

The P2X7 purinergic receptor on bovine macrophages mediates mycobacterial death

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

ATP-stimulated release of interleukin (IL)-1beta and IL-18 requires priming by lipopolysaccharide and is independent of caspase-1 cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Detection of P2X purinergic receptors on human B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Extracellular ATP induces cytokine expression and apoptosis through P2X7 receptor in murine mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

P2 purinergic receptor modulation of cytokine production

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1 beta in the murine brain

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

P2X7 receptor activation amplifies lipopolysaccharide-induced vascular hyporeactivity via interleukin-1 beta release

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Peripheral origin of IL-1beta production in the rodent hippocampus under in vivo systemic bacterial lipopolysaccharide (LPS) challenge and its regulation by P2X(7) receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

A potential role for P2X7R in allergic airway inflammation in mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

The nucleotide receptor P2X7 mediates actin reorganization and membrane blebbing in RAW 264.7 macrophages via p38 MAP kinase and Rho.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Association of P2X7 receptor polymorphisms with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

A comparative study of interleukin-1beta production and p2x7 expression after ATP stimulation by peripheral blood mononuclear cells isolated from rheumatoid arthritis patients and normal healthy controls.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Expression and function of the P2X(7) purinergic receptor in patients with systemic lupus erythematosus and rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

The His155Tyr (489C>T) single nucleotide polymorphism of P2RX7 gene confers an enhanced function of P2X7 receptor in immune cells from patients with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Clinical evaluation of the efficacy of the P2X7purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Induction of the P2X7 receptor in spinal microglia in a neuropathic pain model

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

The induction of pain: an integrative review

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Antagonism by aspirin and fenamates of bronchoconstriction and nociception induced by adenosine-5'-triphosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Identification of algogenic substances in human erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Purinergic signalling in neuron-glia interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut. 1970.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Purinergic signalling: Its unpopular beginning, its acceptance and its exciting future

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Contribution of the spinal P2X7 receptors to bee venom-induced nociception and inflammation in conscious rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Astrocyte calcium waves: what they are and what they do.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Potentiation of the glutamatergic synaptic input to rat locus coeruleus neurons by P2X7 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Role of the immune system in chronic pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Tests and models of nociception and pain in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Central sensitization of nociceptive neurons in rat medullary dorsal horn involves purinergic P2X7 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Activated microglia contribute to the maintenance of chronic pain after spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Minocycline attenuates mechanical allodynia and central sensitization following peripheral second-degree burn injury

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Endogenous ATP involvement in mustard-oil-induced central sensitization in trigeminal subnucleus caudalis (medullary dorsal horn).

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Relief of inflammatory pain in rats by local use of the selective P2X7 ATP receptor inhibitor, oxidized ATP.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Immune and inflammatory mechanisms in neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Liaisons dangereuses: P2X(7) and the inflammasome.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Block of purinergic P2X(7) receptor is neuroprotective in an animal model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

P2 receptors for extracellular nucleotides in the central nervous system: role of P2X7 and P2Y₂ receptor interactions in neuroinflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Functional expression of P2X7 receptors in non-neuronal cells of rat dorsal root ganglia

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Pharmacological characterization of P2X7 receptors in rat peritoneal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

P2X7 receptor-deficient mice are susceptible to bone cancer pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

P2X7 receptor-stimulation causes fever via PGE2 and IL-1β release

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

A new definition of neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES180910953

Brilliant blue G selectively blocks ATP-gated rat P2X(7) receptors.

21 January 2018

1 reference

12 December 2020

Musculoskeletal Pain in Patients With Myotonic Dystrophy Type 2

1 reference

12 December 2020

ATP activates a cation-permeable pathway in rat parotid acinar cells

1 reference

12 December 2020

Covalent incorporation of 3'-O-(4-benzoyl)benzoyl-ATP into a P2 purinoceptor in transformed mouse fibroblasts

1 reference

12 December 2020

A polymorphism in the P2X7 gene increases susceptibility to extrapulmonary tuberculosis

1 reference

12 December 2020

Benefits and side effects of different vegetable oil vectors on apoptosis, oxidative stress, and P2X7 cell death receptor activation

1 reference

12 December 2020

[Chemotaxis and disease].

1 reference

12 December 2020

P2X(7) Receptors in Neurological and Cardiovascular Disorders

1 reference

12 December 2020

Purinergic receptor agonists modulate phagocytosis and clearance of apoptotic cells in macrophages.

1 reference

12 December 2020

Effect of Rheedia longifolia leaf extract and fractions on the P2X₇ receptor in vitro: novel antagonists?

1 reference

12 December 2020

Peripheral inflammation upregulates P2X receptor expression in satellite glial cells of mouse trigeminal ganglia: a calcium imaging study

1 reference

12 December 2020

1 reference

12 December 2020

Myelinated afferent fibres responding specifically to noxious stimulation of the skin

1 reference

12 December 2020

Differential activation of cation channels and non-selective pores by macrophage P2z purinergic receptors expressed in Xenopus oocytes.

1 reference

12 December 2020

Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2x purinoceptors).

1 reference

12 December 2020

Expression of the pore-forming P2Z purinoreceptor in Xenopus oocytes injected with poly(A)+ RNA from murine macrophages.

1 reference

12 December 2020

Extracellular ATP prevents the release of stored Ca2+ by autonomic agonists in rat submandibular gland acini

1 reference

12 December 2020

Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor

1 reference

12 December 2020

Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages

1 reference

12 December 2020

Mediators of inflammation

1 reference

12 December 2020

Isoquinolines as antagonists of the P2X7 nucleotide receptor: high selectivity for the human versus rat receptor homologues

1 reference

12 December 2020

Blockade of human P2X7 receptor function with a monoclonal antibody

1 reference

12 December 2020

10.3390/MOLECULES180910953

Identifiers

DOI

1 reference

30 June 2019

PMC publication ID

6270334

1 reference

30 June 2019

PubMed publication ID

24013409

1 reference

30 June 2019