Delivery materials for siRNA therapeutics (Q38154803)

29 August 2017

Delivery materials for siRNA therapeutics (English)

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29 August 2017

Rosemary Kanasty

1

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29 August 2017

Joseph Robert Dorkin

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2

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29 August 2017

Arturo Vegas

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3

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29 August 2017

Daniel Anderson

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4

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29 August 2017

language of work or name

English

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publication date

1 November 2013

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29 August 2017

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29 August 2017

12

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29 August 2017

967-977

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29 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nmat3765

29 August 2017

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cites work

New class of polymers for the delivery of macromolecular therapeutics

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12 December 2020

Effects of structure of beta-cyclodextrin-containing polymers on gene delivery

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12 December 2020

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

1 reference

12 December 2020

pH-triggered nanoparticle mediated delivery of siRNA to liver cells in vitro and in vivo

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12 December 2020

Challenges in the pharmaceutical development of lipid-based short interfering ribonucleic acid therapeutics

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12 December 2020

A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo

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12 December 2020

Co-injection of a targeted, reversibly masked endosomolytic polymer dramatically improves the efficacy of cholesterol-conjugated small interfering RNAs in vivo

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12 December 2020

Development of a nonviral gene delivery vehicle for systemic application

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12 December 2020

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

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12 December 2020

Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication.

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12 December 2020

In vivo disassembly of IV administered siRNA matrix nanoparticles at the renal filtration barrier

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12 December 2020

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

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12 December 2020

Efficient in vivo delivery of siRNA to the liver by conjugation of alpha-tocopherol

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12 December 2020

Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA.

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12 December 2020

Polymers in small-interfering RNA delivery

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12 December 2020

Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging

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12 December 2020

Triggered release of doxorubicin following mixing of cationic and anionic liposomes

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12 December 2020

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12 December 2020

Lateral organization of liquid-crystalline cholesterol-dimyristoylphosphatidylcholine bilayers. Evidence for domains with hexagonal and centered rectangular cholesterol superlattices

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12 December 2020

Nanoparticle delivery of cancer drugs.

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12 December 2020

Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis

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12 December 2020

An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice

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12 December 2020

Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane.

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12 December 2020

Cyclodextrin-modified polyethylenimine polymers for gene delivery

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12 December 2020

ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity

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12 December 2020

Action and reaction: the biological response to siRNA and its delivery vehicles

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12 December 2020

The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic.

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12 December 2020

Current progress of siRNA/shRNA therapeutics in clinical trials

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12 December 2020

Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma

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12 December 2020

In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(-PEG)/siRNA complexes

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12 December 2020

Determination of the upper size limit for uptake and processing of ligands by the asialoglycoprotein receptor on hepatocytes in vitro and in vivo.

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12 December 2020

Lipid-like materials for low-dose, in vivo gene silencing

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12 December 2020

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

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12 December 2020

PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles

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12 December 2020

Structural effects of carbohydrate-containing polycations on gene delivery. 1. Carbohydrate size and its distance from charge centers

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12 December 2020

Treatment of pancreatic fibrosis with siRNA against a collagen-specific chaperone in vitamin A-coupled liposomes.

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12 December 2020

Rapid discovery of potent siRNA-containing lipid nanoparticles enabled by controlled microfluidic formulation

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12 December 2020

Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection

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12 December 2020

Imidazole groups on a linear, cyclodextrin-containing polycation produce enhanced gene delivery via multiple processes

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12 December 2020

Silencing or stimulation? siRNA delivery and the immune system

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12 December 2020

Sterically polymer-based liposomal complexes with dual-shell structure for enhancing the siRNA delivery

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12 December 2020

Nanovector delivery of siRNA for cancer therapy

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12 December 2020

In vivo activity of nuclease-resistant siRNAs

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12 December 2020

Galactose and N-acetylgalactosamine-specific endocytosis of glycopeptides by isolated rat hepatocytes

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12 December 2020

Folate-linked lipid-based nanoparticles for synthetic siRNA delivery in KB tumor xenografts.

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12 December 2020

Ionization behavior of amino lipids for siRNA delivery: determination of ionization constants, SAR, and the impact of lipid pKa on cationic lipid-biomembrane interactions

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12 December 2020

Physicochemical and biological characterization of targeted, nucleic acid-containing nanoparticles

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12 December 2020

In vivo tumor imaging using a novel RNAi-based detection mechanism.

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12 December 2020

Inhibition of protein kinase C by cationic amphiphiles.

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12 December 2020

RNAi-mediated gene silencing in non-human primates.

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12 December 2020

Update on the glomerular filtration barrier

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12 December 2020

Hepatocyte-targeted RNAi therapeutics for the treatment of chronic hepatitis B virus infection

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12 December 2020

Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography

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12 December 2020

The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer

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12 December 2020

Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms

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12 December 2020

Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects

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12 December 2020

Transferrin-Containing, Cyclodextrin Polymer-Based Particles for Tumor-Targeted Gene Delivery

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12 December 2020

Stealth Me.PEG-PLA nanoparticles avoid uptake by the mononuclear phagocytes system

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12 December 2020

Atomic structure and chemistry of human serum albumin

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12 December 2020

Ligand-targeted delivery of small interfering RNAs to malignant cells and tissues

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12 December 2020

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

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12 December 2020

Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone

1 reference

12 December 2020

Knocking down barriers: advances in siRNA delivery

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12 December 2020

Self-assembling nucleic acid delivery vehicles via linear, water-soluble, cyclodextrin-containing polymers

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12 December 2020

Factors affecting the clearance and biodistribution of polymeric nanoparticles.

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12 December 2020

Synthesis of cluster galactosides with high affinity for the hepatic asialoglycoprotein receptor.

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12 December 2020

Structural effects of carbohydrate-containing polycations on gene delivery. 3. Cyclodextrin type and functionalization

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12 December 2020

Sheddable coatings for long-circulating nanoparticles

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12 December 2020

First-in-humans trial of an RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement

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12 December 2020

Combinatorial approach to determine functional group effects on lipidoid-mediated siRNA delivery

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12 December 2020

Elimination pathways of systemically delivered siRNA.

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12 December 2020

Tunable pH-sensitive liposomes composed of mixtures of cationic and anionic lipids

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12 December 2020

Silencing of the MYCN gene by siRNA delivered by folate receptor-targeted liposomes in LA-N-5 cells

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12 December 2020

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

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12 December 2020

Asymmetry in the assembly of the RNAi enzyme complex

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12 December 2020

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

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12 December 2020

siRNA conjugate delivery systems

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12 December 2020

Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles

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12 December 2020

Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo

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12 December 2020

Nonbilayer phase of lipoplex-membrane mixture determines endosomal escape of genetic cargo and transfection efficiency

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12 December 2020

Targeted delivery systems for oligonucleotide therapeutics

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12 December 2020

Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery

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12 December 2020

Rational design of cationic lipids for siRNA delivery

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12 December 2020

Effects of cholesterol on the lamellar and the inverted hexagonal phases of dielaidoylphosphatidylethanolamine

1 reference

12 December 2020

Attacking the genome: emerging siRNA nanocarriers from concept to clinic

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12 December 2020

A review of nanocarriers for the delivery of small interfering RNA.

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12 December 2020

Nucleic acid nanostructures for biomedical applications

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12 December 2020

Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms

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12 December 2020

Thermodynamically stable RNA three-way junction for constructing multifunctional nanoparticles for delivery of therapeutics

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12 December 2020

Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA.

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12 December 2020

Lipid-based vectors for siRNA delivery

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12 December 2020

Comparison of cationic and amphipathic cell penetrating peptides for siRNA delivery and efficacy

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12 December 2020

In vivo delivery of RNAi with lipid-based nanoparticles

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12 December 2020

Folate-targeted therapies for cancer

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12 December 2020

Effect of PEGylation on biodistribution and gene silencing of siRNA/lipid nanoparticle complexes.

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12 December 2020

Design and synthesis of novel N-acetylgalactosamine-terminated glycolipids for targeting of lipoproteins to the hepatic asialoglycoprotein receptor

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12 December 2020

Stimuli-responsive polymers and nanomaterials for gene delivery and imaging applications

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12 December 2020

An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery

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12 December 2020

Strategies in the design of nanoparticles for therapeutic applications

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12 December 2020

Mechanisms and optimization of in vivo delivery of lipophilic siRNAs.

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12 December 2020

Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging

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12 December 2020

On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids

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12 December 2020

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors.

1 reference

12 December 2020

Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes

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12 December 2020

Endosomolysis by masking of a membrane-active agent (EMMA) for cytoplasmic release of macromolecules

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12 December 2020

Membrane activity and transfection ability of amphipathic polycations as a function of alkyl group size

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12 December 2020

Potential efficacy of cell-penetrating peptides for nucleic acid and drug delivery in cancer

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12 December 2020

Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNMAT3765

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NMAT3765

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Dimensions Publication ID

29 August 2017

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