Insulin and IGFs in obesity-related breast cancer (Q38155073)

29 August 2017

Insulin and IGFs in obesity-related breast cancer (English)

1 reference

29 August 2017

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1 reference

4

Derek LeRoith

1 reference

29 August 2017

Valentina Belardi

1

1 reference

PubMed ID

24154546

29 August 2017

Emily J Gallagher

series ordinal

2

1 reference

PubMed ID

24154546

29 August 2017

Ruslan Novosyadlyy

series ordinal

3

1 reference

29 August 2017

24 October 2013

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Journal of Mammary Gland Biology and Neoplasia

29 August 2017

1 reference

29 August 2017

18

1 reference

29 August 2017

3-4

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29 August 2017

277-289

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https://scigraph.springernature.com/pub.10.1007/s10911-013-9303-7

29 August 2017

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Breast cancer and hormone-replacement therapy in the Million Women Study

21 January 2018

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Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies

21 January 2018

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Overweight, obesity, and cancer risk

21 January 2018

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Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis

21 January 2018

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Long-term mortality after gastric bypass surgery

21 January 2018

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Low-fat dietary pattern and risk of invasive breast cancer: the Women's Health Initiative Randomized Controlled Dietary Modification Trial

21 January 2018

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21 January 2018

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Liver involvement in obese children. Ultrasonography and liver enzyme levels at diagnosis and during follow-up in an Italian population

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21 January 2018

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21 January 2018

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21 January 2018

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Insulin- and obesity-related variables in early-stage breast cancer: correlations and time course of prognostic associations.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Divergent effects of insulin-like growth factor-1 receptor expression on prognosis of estrogen receptor positive versus triple negative invasive ductal breast carcinoma.

21 January 2018

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Expression of insulin-like growth factor 1 receptor in primary breast cancer: immunohistochemical analysis

21 January 2018

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Elevated free IGF2 levels in localized, early-stage breast cancer in women.

21 January 2018

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Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis

21 January 2018

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Loss of imprinting of IGF2 and not H19 in breast cancer, adjacent normal tissue and derived fibroblast cultures

21 January 2018

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Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer

21 January 2018

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Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor gene correlates with poor differentiation in early breast carcinomas

21 January 2018

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Insulin receptor phosphorylation by endogenous insulin or the insulin analog AspB10 promotes mammary tumor growth independent of the IGF-I receptor

21 January 2018

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Insulin-stimulated cell growth in insulin receptor substrate-1-deficient ZR-75-1 cells is mediated by a phosphatidylinositol-3-kinase-independent pathway

21 January 2018

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Glargine promotes proliferation of breast adenocarcinoma cell line MCF-7 via AKT activation

21 January 2018

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Caloric restriction reduces growth of mammary tumors and metastases

21 January 2018

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Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes

21 January 2018

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Hyperinsulinemia enhances c-Myc-mediated mammary tumor development and advances metastatic progression to the lung in a mouse model of type 2 diabetes

21 January 2018

1 reference

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Hyperinsulinemia promotes metastasis to the lung in a mouse model of Her2-mediated breast cancer

21 January 2018

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Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression

21 January 2018

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Mammalian target of rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes

21 January 2018

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Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia

21 January 2018

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Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation

21 January 2018

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Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy

21 January 2018

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Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): rationale for cotargeting IGF-1R and IR in cancer

21 January 2018

1 reference

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Insulin receptor (IR) pathway hyperactivity in IGF-IR null cells and suppression of downstream growth signaling using the dual IGF-IR/IR inhibitor, BMS-754807.

21 January 2018

1 reference

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A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer

21 January 2018

1 reference

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Acquired resistance to tamoxifen is associated with loss of the type I insulin-like growth factor receptor: implications for breast cancer treatment

21 January 2018

1 reference

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Insulin receptor overexpression in 184B5 human mammary epithelial cells induces a ligand-dependent transformed phenotype

21 January 2018

1 reference

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The insulin receptor is essential for virus-induced tumorigenesis of Kaposi's sarcoma

21 January 2018

1 reference

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Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans

21 January 2018

1 reference

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Integrated profiling of basal and luminal breast cancers.

21 January 2018

1 reference

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The IGF-I receptor in cancer research

21 January 2018

1 reference

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Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation

21 January 2018

1 reference

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Transgenic IGF-IR overexpression induces mammary tumors with basal-like characteristics, whereas IGF-IR-independent mammary tumors express a claudin-low gene signature

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

The type I insulin-like growth factor receptor regulates cancer metastasis independently of primary tumor growth by promoting invasion and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

Paracrine overexpression of insulin-like growth factor-1 enhances mammary tumorigenesis in vivo

21 January 2018

1 reference

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Igf1r as a therapeutic target in a mouse model of basal-like breast cancer

21 January 2018

1 reference

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High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy

21 January 2018

1 reference

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The expression and significance of insulin-like growth factor-1 receptor and its pathway on breast cancer stem/progenitors

21 January 2018

1 reference

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Stromal EGF and igf-I together modulate plasticity of disseminated triple-negative breast tumors.

21 January 2018

1 reference

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Cancer stem-like cell marker CD44 promotes bone metastases by enhancing tumorigenicity, cell motility, and hyaluronan production

21 January 2018

1 reference

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The insulin-like growth factor-I receptor gene: a downstream target for oncogene and tumor suppressor action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

IGF1 dependence of dietary energy balance effects on murine Met1 mammary tumor progression, epithelial-to-mesenchymal transition, and chemokine expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

Tumours with PI3K activation are resistant to dietary restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

Co-inhibition of epidermal growth factor receptor and insulin-like growth factor receptor 1 enhances radiosensitivity in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

Insulin/insulin-like growth factor-I and estrogen cooperate to stimulate cyclin E-Cdk2 activation and cell Cycle progression in MCF-7 breast cancer cells through differential regulation of cyclin E and p21(WAF1/Cip1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

Phase II trial of cetuximab in combination with fluorouracil, leucovorin, and oxaliplatin in the first-line treatment of metastatic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

mTORC1 inhibition is required for sensitivity to PI3K p110α inhibitors in PIK3CA-mutant breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

Ganitumab with either exemestane or fulvestrant for postmenopausal women with advanced, hormone-receptor-positive breast cancer: a randomised, controlled, double-blind, phase 2 trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

Randomized trial of tamoxifen versus combined tamoxifen and octreotide LAR Therapy in the adjuvant treatment of early-stage breast cancer in postmenopausal women: NCIC CTG MA.14.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

Investigating new therapeutic strategies targeting hyperinsulinemia's mitogenic effects in a female mouse breast cancer model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

Dual IGF-I/II-neutralizing antibody MEDI-573 potently inhibits IGF signaling and tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

Circulating concentrations of insulin-like growth factor I and risk of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

Relaxation of Imprinting of Human Insulin-like Growth Factor II Gene,IGF2,in Sporadic Breast Carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-013-9303-7

Prognostic value of insulin-like growth factor 1 and insulin-like growth factor binding protein 3 blood levels in breast cancer.

21 January 2018

1 reference

12 December 2020

Case-control study of anthropometric measures and breast cancer risk

1 reference

12 December 2020

Insulin and insulin-like growth factor signaling are defective in the MDA MB-468 human breast cancer cell line

1 reference

12 December 2020

Circulating levels of insulin-like growth factors, their binding proteins, and breast cancer risk

1 reference

12 December 2020

Differential signalling potential of insulin- and IGF-1-receptor cytoplasmic domains

1 reference

12 December 2020

Influence of insulin deprivation on growth of the 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats subjected to alloxan diabetes and food restriction

1 reference

12 December 2020

Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors.

1 reference

12 December 2020

Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor I receptor antisense ribonucleic acid

1 reference

12 December 2020

Waist circumference, waist:hip ratio, and risk of breast cancer in the Nurses' Health Study

1 reference

12 December 2020

Effect of insulin on cell cycle progression in MCF-7 breast cancer cells. Direct and potentiating influence

1 reference

12 December 2020

Effects of insulin-like growth factors (IGFs) and IGF receptor antibodies on the proliferation of human breast cancer cells

1 reference

12 December 2020

IGF-I, IGF-II, and Insulin Stimulate Different Gene Expression Responses through Binding to the IGF-I Receptor

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12 December 2020

Risk of breast cancer by individual insulin use: an international multicenter study.

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12 December 2020

The prognostic value of insulin-like growth factor-I in breast cancer patients. Results of a follow-up study on 126 patients

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12 December 2020

The IGF2 receptor is a USF2-specific target in nontumorigenic mammary epithelial cells but not in breast cancer cells

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12 December 2020

Insulin receptor expression and function in human breast cancer cell lines.

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12 December 2020

Insulin growth factor receptor-1 expression and loss of PTEN protein predict early recurrence in triple-negative breast cancer

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12 December 2020

A recent case of dominant infantile hereditary optic atrophy

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12 December 2020

The potentiation of estrogen on insulin-like growth factor I action in MCF-7 human breast cancer cells includes cell cycle components

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12 December 2020

Diabetes, metabolic syndrome, and breast cancer: a review of the current evidence

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12 December 2020

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

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12 December 2020

Increased incidence of carcinoma of the breast associated with abdominal adiposity in postmenopausal women

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12 December 2020

Functionally distinct insulin receptors generated by tissue-specific alternative splicing

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12 December 2020

The insulin receptor: a new target for cancer therapy

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12 December 2020

HER2-targeted therapies: how far we've come--and where we're headed.

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12 December 2020

A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer.

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12 December 2020

Diet-gene interactions in p53-deficient mice: insulin-like growth factor-1 as a mechanistic target

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12 December 2020

Transgenic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formation

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12 December 2020

10.1007/S10911-013-9303-7

Identifiers

DOI

1 reference

29 August 2017

1 reference

PubMed ID

24154546