Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition. (Q38180770)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24450640%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

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8 February 2021

Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24450640%20AND%20SRC:MED&resulttype=core&format=json

ETS transcription factor family

5 March 2020

main subject

1 reference

22 December 2019

1 reference

8 February 2021

1 reference

inferred from abstract

author

Christopher D. Cooper

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24450640%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Joseph A Newman

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24450640%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Opher Gileadi

3

1 reference

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5 March 2020

author name string

Christopher D O Cooper

1

1 reference

30 August 2017

Joseph A Newman

2

1 reference

30 August 2017

Opher Gileadi

3

1 reference

30 August 2017

language of work or name

1 reference

1 February 2014

7 references

3 April 2019

2 August 2019

11 December 2019

18 December 2019

22 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24450640%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

8 February 2021

Biochemical Society Transactions

7 references

3 April 2019

2 August 2019

11 December 2019

18 December 2019

22 December 2019

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5 March 2020

8 February 2021

42

1 reference

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5 March 2020

issue

1

1 reference

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5 March 2020

page(s)

130-138

1 reference

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Creative Commons Attribution 3.0 Unported

5 March 2020

copyright license

6 references

3 April 2019

2 August 2019

11 December 2019

18 December 2019

22 December 2019

on focus list of Wikimedia project

8 February 2021

copyright status

copyrighted

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ScienceSource

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cites work

Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancer

1 reference

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ETS transcription factors in hematopoietic stem cell development

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Structural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibited

6 September 2017

1 reference

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ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss

6 September 2017

1 reference

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Review of Ets1 structure, function, and roles in immunity

6 September 2017

1 reference

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Drugging the undruggable: transcription therapy for cancer

6 September 2017

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Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines

6 September 2017

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ETS variant 1 regulates matrix metalloproteinase-7 transcription in LNCaP prostate cancer cells

6 September 2017

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Autoinhibition of ETV6 (TEL) DNA Binding: Appended Helices Sterically Block the ETS Domain

6 September 2017

1 reference

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Structural Basis of Ets1 Cooperative Binding to Widely Separated Sites on Promoter DNA

6 September 2017

1 reference

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Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

YK-4-279 inhibits ERG and ETV1 mediated prostate cancer cell invasion

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Genomic and biochemical insights into the specificity of ETS transcription factors

6 September 2017

1 reference

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Small-molecule protein-protein interaction inhibitors: therapeutic potential in light of molecular size, chemical space, and ligand binding efficiency considerations.

6 September 2017

1 reference

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Structural basis of Ets1 cooperative binding to palindromic sequences on stromelysin-1 promoter DNA

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

An atlas of combinatorial transcriptional regulation in mouse and man

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

An oncogenic role for ETV1 in melanoma

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

DNA specificity determinants associate with distinct transcription factor functions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Induction of prostatic intraepithelial neoplasia and modulation of androgen receptor by ETS variant 1/ETS-related protein 81.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Regulation of the transcription factor Ets-1 by DNA-mediated homo-dimerization

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Gene therapy using ets-1 transcription factor decoy for peritoneal dissemination of gastric cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

ETS transcription factors and their emerging roles in human cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

EWS-ETS oncoproteins: the linchpins of Ewing tumors

6 September 2017

1 reference

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The structural and dynamic basis of Ets-1 DNA binding autoinhibition.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Upregulation of the Catalytic Telomerase Subunit by the Transcription Factor ER81 and Oncogenic HER2/Neu, Ras, or Raf.

6 September 2017

1 reference

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PEA3 transcription factors are expressed in tissues undergoing branching morphogenesis and promote formation of duct-like structures by mammary epithelial cells in vitro

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Molecular biology of the Ets family of transcription factors

6 September 2017

1 reference

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Transcription factors as targets for cancer therapy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Structural analysis of the autoinhibition of Ets-1 and its role in protein partnerships

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

AP-1 as a regulator of cell life and death

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

When Ets transcription factors meet their partners

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Structural studies of Ets-1/Pax5 complex formation on DNA

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

The Ets family contains transcriptional activators and repressors involved in angiogenesis.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Identification of amino acid residues in the ETS transcription factor Erg that mediate Erg-Jun/Fos-DNA ternary complex formation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Expression and function of Ets transcription factors in mammalian development: a regulatory network

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

The PEA3 Ets transcription factor comprises multiple domains that regulate transactivation and DNA binding

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Structure of the elk-1-DNA complex reveals how DNA-distal residues affect ETS domain recognition of DNA

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

c-Jun is a JNK-independent coactivator of the PU.1 transcription factor.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

A new pattern for helix-turn-helix recognition revealed by the PU.1 ETS-domain-DNA complex

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Molecular dynamics simulations and in silico peptide ligand screening of the Elk-1 ETS domain.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Dimer formation and conformational flexibility ensure cytoplasmic stability and nuclear accumulation of Elk-1

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Emergence of ETS transcription factors as diagnostic tools and therapeutic targets in prostate cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Interaction between the homeodomain protein HOXC13 and ETS family transcription factor PU.1 and its implication in the differentiation of murine erythroleukemia cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

The PNT domain from Drosophila pointed-P2 contains a dynamic N-terminal helix preceded by a disordered phosphoacceptor sequence

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

ETS-1 transcription factor binds cooperatively to the palindromic head to head ETS-binding sites of the stromelysin-1 promoter by counteracting autoinhibition

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

DNA binding specificity studies of four ETS proteins support an indirect read-out mechanism of protein-DNA recognition.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

NF-IL6 (C/EBPbeta ) vigorously activates il1b gene expression via a Spi-1 (PU.1) protein-protein tether.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Molecular characterization of the B-box protein-protein interaction motif of the ETS-domain transcription factor Elk-1.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901394

Crystal structure of PU.1/IRF-4/DNA ternary complex

31 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24450640

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The ETS-domain transcription factor family

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24450640

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A direct physical association between ETS and AP-1 transcription factors in normal human T cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24450640

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1042/BST20130227

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24450640%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24450640%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference