Development of enterovirus 71 vaccines: from the lab bench to Phase III clinical trials (Q38195326)

30 August 2017

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title

Development of enterovirus 71 vaccines: from the lab bench to Phase III clinical trials (English)

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30 August 2017

phase III clinical trial

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author name string

Jing-Xin Li

1

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30 August 2017

Qun-Ying Mao

2

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30 August 2017

Zheng-Lun Liang

3

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30 August 2017

Hong Ji

4

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30 August 2017

Feng-Cai Zhu

5

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30 August 2017

13 March 2014

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Expert Review of Vaccines

30 August 2017

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30 August 2017

13

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30 August 2017

5

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30 August 2017

609-618

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An apparently new enterovirus isolated from patients with disease of the central nervous system

30 August 2017

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

EV71: an emerging infectious disease vaccine target in the Far East?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Neurological manifestations of enterovirus 71 infection in children during an outbreak of hand, foot, and mouth disease in Western Australia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Enterovirus 71 isolated from cases of epidemic poliomyelitis-like disease in Bulgaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Development of enterovirus 71 vaccines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Frequent importation of enterovirus 71 from surrounding countries into the local community of Yamagata, Japan, between 1998 and 2003.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Epidemic of hand, foot and mouth disease in West Bengal, India in August, 2007: a multicentric study

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Enterovirus 71 infection: An experience in Korea, 2009

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Deaths of children during an outbreak of hand, foot, and mouth disease in sarawak, malaysia: clinical and pathological characteristics of the disease. For the Outbreak Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

The persistent circulation of enterovirus 71 in People's Republic of China: causing emerging nationwide epidemics since 2008.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Epidemiologic and virologic investigation of hand, foot, and mouth disease, southern Vietnam, 2005.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Virology, epidemiology, pathogenesis, and control of enterovirus 71.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Genetic evolution of enterovirus 71: epidemiological and pathological implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Enterovirus 71 encephalitis: a new vaccine on the horizon?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Risk Factors of Enterovirus 71 Infection and Associated Hand, Foot, and Mouth Disease/Herpangina in Children During an Epidemic in Taiwan

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Reemerging of enterovirus 71 in Taiwan: the age impact on disease severity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Seroprevalence and molecular epidemiology of enterovirus 71 in Germany

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Retrospective study of the incidence of HFMD and seroepidemiology of antibodies against EV71 and CoxA16 in prenatal women and their infants

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly in central and southern China before large-scale outbreaks from 2008.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Seroepidemiology of human enterovirus 71, Singapore

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Human enterovirus 71 and hand, foot and mouth disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Cross-reactive neutralizing antibody responses to enterovirus 71 infections in young children: implications for vaccine development

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Molecular epidemiology of human enterovirus 71 in the United Kingdom from 1998 to 2006.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Reemergence of enterovirus 71 in 2008 in taiwan: dynamics of genetic and antigenic evolution from 1998 to 2008.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Sentinel surveillance for human enterovirus 71 in Sarawak, Malaysia: lessons from the first 7 years

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Evolution of re-emergent virus and its impact on enterovirus 71 epidemics

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Evolutionary genetics of human enterovirus 71: origin, population dynamics, natural selection, and seasonal periodicity of the VP1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Cross-antigenicity among EV71 strains from different genogroups isolated in Yamagata, Japan, between 1990 and 2007.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

An attenuated strain of enterovirus 71 belonging to genotype a showed a broad spectrum of antigenicity with attenuated neurovirulence in cynomolgus monkeys.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Immunization with virus-like particles of enterovirus 71 elicits potent immune responses and protects mice against lethal challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Immunoprotection elicited by an enterovirus type 71 experimental inactivated vaccine in mice and rhesus monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Optimized development of a candidate strain of inactivated EV71 vaccine and analysis of its immunogenicity in rhesus monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Protection against lethal enterovirus 71 infection in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Protection of neonatal mice from lethal enterovirus 71 infection by maternal immunization with attenuated Salmonella enterica serovar Typhimurium expressing VP1 of enterovirus 71.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Enterovirus 71 virus-like particle vaccine: improved production conditions for enhanced yield

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Passive protection against lethal enterovirus 71 infection in newborn mice by neutralizing antibodies elicited by a synthetic peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

DNA vaccine constructs against enterovirus 71 elicit immune response in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Immunity to avirulent enterovirus 71 and coxsackie A16 virus protects against enterovirus 71 infection in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Formaldehyde-inactivated whole-virus vaccine protects a murine model of enterovirus 71 encephalomyelitis against disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Immunization of N terminus of enterovirus 71 VP4 elicits cross-protective antibody responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Pilot scale production of highly efficacious and stable enterovirus 71 vaccine candidates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Preclinical evaluation of the immunogenicity and safety of an inactivated enterovirus 71 candidate vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Comparative analysis of the immunogenicity and protective effects of inactivated EV71 vaccines in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Enterovirus 71 vaccine: when will it be available?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Study of the integrated immune response induced by an inactivated EV71 vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Combined peptides of human enterovirus 71 protect against virus infection in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Progress on the research and development of inactivated EV71 whole-virus vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Reactogenicity and immunogenicity of an enterovirus 71 vaccine in Chinese healthy children and infants

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Tolerability and immunogenicity of an inactivated enterovirus 71 vaccine in Chinese healthy adults and children: an open label, phase 1 clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

A Phase I, randomized, open-label study to evaluate the safety and immunogenicity of an enterovirus 71 vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Immunogenicity and safety of an enterovirus 71 vaccine in healthy Chinese children and infants: a randomised, double-blind, placebo-controlled phase 2 clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

The consistency approach for the quality control of vaccines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Immunogenicity, safety, and lot consistency of a novel inactivated enterovirus 71 vaccine in Chinese children aged 6 to 59 months

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Formalin-inactivated EV71 vaccine candidate induced cross-neutralizing antibody against subgenotypes B1, B4, B5 and C4A in adult volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

The cross-neutralizing activity of enterovirus 71 subgenotype c4 vaccines in healthy chinese infants and children

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Efficacy, safety, and immunogenicity of an enterovirus 71 vaccine in China

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Challenges to licensure of enterovirus 71 vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

An overview of the evolution of enterovirus 71 and its clinical and public health significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Efficacy, safety, and immunogenicity of a Vero-cell-culture-derived trivalent influenza vaccine: a multicentre, double-blind, randomised, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Analysis of recombination and natural selection in human enterovirus 71.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Emergence of enterovirus 71 "double-recombinant" strains belonging to a novel genotype D originating from southern China: first evidence for combination of intratypic and intertypic recombination events in EV71.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Antigenic analysis of divergent genotypes human Enterovirus 71 viruses by a panel of neutralizing monoclonal antibodies: current genotyping of EV71 does not reflect their antigenicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Comparison of enterovirus 71 and coxsackie-virus A16 clinical illnesses during the Taiwan enterovirus epidemic, 1998.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

Establishing China's national standards of antigen content and neutralizing antibody responses for evaluation of enterovirus 71 (EV71) vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.897617

10.1586/14760584.2014.897617

21 January 2018

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30 August 2017

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