Li-Fraumeni syndrome: cancer risk assessment and clinical management (Q38197030)

30 August 2017

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title

Li-Fraumeni syndrome: cancer risk assessment and clinical management (English)

1 reference

30 August 2017

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2

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10 June 2020

Rosalind Eeles

6

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10 June 2020

David M Thomas

7

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10 June 2020

author name string

Kate A McBride

1

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10 June 2020

Emma Killick

3

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10 June 2020

Judy Kirk

4

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10 June 2020

Martin H N Tattersall

5

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10 June 2020

Gillian Mitchell

8

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24642672%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

language of work or name

English

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publication date

18 March 2014

1 reference

Nature Reviews Clinical Oncology

30 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24642672%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

volume

11

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10 June 2020

issue

5

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10 June 2020

page(s)

260-271

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24642672%20AND%20SRC:MED&resulttype=core&format=json

Identification and Management of Women With BRCA Mutations or Hereditary Predisposition for Breast and Ovarian Cancer

10 June 2020

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Prevalence of early onset colorectal cancer in 397 patients with classic Li-Fraumeni syndrome

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Gastric cancer in individuals with Li-Fraumeni syndrome

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Relative frequency and morphology of cancers in carriers of germline TP53 mutations

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Multiple primary cancers in families with Li-Fraumeni syndrome

21 January 2018

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Early occurrence of lung adenocarcinoma and breast cancer after radiotherapy of a chest wall sarcoma in a patient with a de novo germline mutation in TP53.

21 January 2018

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Radio-induced malignancies after breast cancer postoperative radiotherapy in patients with Li-Fraumeni syndrome

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Two metachronous tumors in the radiotherapy fields of a patient with Li-Fraumeni syndrome.

21 January 2018

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Rapid development of post-radiotherapy sarcoma and breast cancer in a patient with a novel germline 'de-novo' TP53 mutation.

21 January 2018

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Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis

21 January 2018

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Comprehensive molecular portraits of human breast tumours

21 January 2018

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Comprehensive molecular characterization of human colon and rectal cancer

21 January 2018

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The p53 proto-oncogene can act as a suppressor of transformation

21 January 2018

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A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

21 January 2018

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The single-nucleotide polymorphism 309 in the MDM2 gene contributes to the Li-Fraumeni syndrome and related phenotypes

21 January 2018

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Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age of tumour onset in Li-Fraumeni syndrome

21 January 2018

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Effects of MDM2, MDM4 and TP53 codon 72 polymorphisms on cancer risk in a cohort study of carriers of TP53 germline mutations

21 January 2018

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TP53 PIN3 and MDM2 SNP309 polymorphisms as genetic modifiers in the Li-Fraumeni syndrome: impact on age at first diagnosis.

21 January 2018

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Joint effects of germ-line TP53 mutation, MDM2 SNP309, and gender on cancer risk in family studies of Li-Fraumeni syndrome

21 January 2018

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Is there anticipation in the age at onset of cancer in families with Li-Fraumeni syndrome?

21 January 2018

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Younger age of cancer initiation is associated with shorter telomere length in Li-Fraumeni syndrome.

21 January 2018

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Excessive genomic DNA copy number variation in the Li-Fraumeni cancer predisposition syndrome

21 January 2018

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Massive genomic rearrangement acquired in a single catastrophic event during cancer development

21 January 2018

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Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

21 January 2018

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Do surgical margin and local recurrence influence survival in soft tissue sarcomas?

21 January 2018

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Neurooncology of familial cancer syndromes

21 January 2018

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The assessment of prognostic factors in surgical treatment of low-grade gliomas: a prospective study.

21 January 2018

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Glioblastoma multiforme with long term survival.

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21 January 2018

Choroid plexus tumours

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Clinical and outcome characteristics of children with adrenocortical tumors: a report from the International Pediatric Adrenocortical Tumor Registry

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Biology, clinical characteristics, and management of adrenocortical tumors in children

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Efficacy of a nationwide screening colonoscopy program for colorectal cancer.

21 January 2018

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Gastric tumours in hereditary cancer syndromes: clinical features, molecular biology and strategies for prevention

21 January 2018

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F18-fluorodeoxyglucose-positron emission tomography/computed tomography screening in Li-Fraumeni syndrome.

21 January 2018

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Radiation-sensitive genetically susceptible pediatric sub-populations

21 January 2018

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Germline TP53 mutations and Li-Fraumeni syndrome

21 January 2018

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Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: a prospective observational study

21 January 2018

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Frequent detection of pancreatic lesions in asymptomatic high-risk individuals.

21 January 2018

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Magnetic resonance imaging for lung cancer detection: experience in a population of more than 10,000 healthy individuals

21 January 2018

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Mouse models of p53 functions

21 January 2018

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Regular surveillance for Li-Fraumeni Syndrome: advice, adherence and perceived benefits

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Tamoxifen for the prevention of breast cancer: current status of the National Surgical Adjuvant Breast and Bowel Project P-1 study

21 January 2018

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Update on effects of screening mammography

21 January 2018

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Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality

21 January 2018

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Predictive factors for local recurrence in osteosarcoma: 540 patients with extremity tumors followed for minimum 2.5 years after neoadjuvant chemotherapy.

21 January 2018

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The influence of tumor- and treatment-related factors on the development of local recurrence in osteosarcoma after adequate surgery. An analysis of 1355 patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols

21 January 2018

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Association of the highly prevalent TP53 R337H mutation with pediatric choroid plexus carcinoma and osteosarcoma in southeast Brazil

21 January 2018

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Bladder cancer: natural history, tumor markers, and early detection strategies

21 January 2018

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Bowel cancer chemoprevention - ready for the clinic?

21 January 2018

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Wilms tumour: prognostic factors, staging, therapy and late effects

21 January 2018

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Hepatoblastoma: 15-year experience and role of surgical treatment

21 January 2018

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Pretreatment prognostic factors for children with hepatoblastoma-- results from the International Society of Paediatric Oncology (SIOP) study SIOPEL 1.

21 January 2018

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Estimating overdiagnosis in low-dose computed tomography screening for lung cancer: a cohort study

21 January 2018

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Malignant transformation of breast fibroadenoma to malignant phyllodes tumor: long-term outcome of 36 malignant phyllodes tumors.

21 January 2018

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Effectiveness and causes for failure of surveillance of CDKN2A-mutated melanoma families.

21 January 2018

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Annual surveillance by CA125 and transvaginal ultrasound for ovarian cancer in both high-risk and population risk women is ineffective.

21 January 2018

1 reference

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Risk-reducing salpingo-oophorectomy for the prevention of BRCA1- and BRCA2-associated breast and gynecologic cancer: a multicenter, prospective study

21 January 2018

1 reference

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Magnetic resonance imaging surveillance detects early-stage pancreatic cancer in carriers of a p16-Leiden mutation.

21 January 2018

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Is early diagnosis of pancreatic cancer fiction? Surveillance of individuals at high risk for pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2014.41

Targeted prostate cancer screening in men with mutations in BRCA1 and BRCA2 detects aggressive prostate cancer: preliminary analysis of the results of the IMPACT study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2014.41

TP53 germline mutation testing in 180 families suspected of Li-Fraumeni syndrome: mutation detection rate and relative frequency of cancers in different familial phenotypes

21 January 2018

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Local recurrence of localized soft tissue sarcoma

21 January 2018

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2009 Version of the Chompret Criteria for Li Fraumeni Syndrome

21 January 2018

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Joint effects of germ-line p53 mutation and sex on cancer risk in Li-Fraumeni syndrome

31 March 2020

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Childhood cancer etiology: recent reports

31 March 2020

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Chest wall leiomyosarcoma after breast-conservative therapy for early-stage breast cancer in a young woman with Li-Fraumeni syndrome

31 March 2020

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p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis

31 March 2020

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Lung cancer risk in germline p53 mutation carriers: association between an inherited cancer predisposition, cigarette smoking, and cancer risk

31 March 2020

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When mutants gain new powers: news from the mutant p53 field.

31 March 2020

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Telomere length in peripheral blood cells of germline TP53 mutation carriers is shorter than that of normal individuals of corresponding age

31 March 2020

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Prognostic factors in soft tissue sarcomas: a study of 395 patients

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2014.41

Long-term survival after complete resection and repeat resection in patients with adrenocortical carcinoma

31 March 2020

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Surveillance for Hereditary Nonpolyposis Colorectal Cancer

31 March 2020

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Impact of screening survey of gastric cancer on clinicopathological features and survival: retrospective study at a single institution

31 March 2020

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Screening for breast cancer with mammography

31 March 2020

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Effect of periodic endoscopy for gastric cancer on early detection and improvement of survival

31 March 2020

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[Sporadic kidney cancer in patients younger than 45]

31 March 2020

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Phyllodes tumors of the breast: the role of pathologic parameters

31 March 2020

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Screening and surveillance of patients at high risk for malignant melanoma result in detection of earlier disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2014.41

The impact of family history on early detection of prostate cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2014.41

Is detection of melanoma metastasis during surveillance in an early phase of development associated with a survival benefit?

31 March 2020

1 reference

12 December 2020

Li-Fraumeni and related syndromes: correlation between tumor type, family structure, and TP53 genotype

1 reference

12 December 2020

Stage I nonsmall cell lung carcinoma: analysis of survival and implications for screening

1 reference

12 December 2020

New concepts in screening.

1 reference

12 December 2020

Beyond Li Fraumeni Syndrome: clinical characteristics of families with p53 germline mutations

1 reference

12 December 2020

Segregation analysis of cancer in families of childhood soft-tissue-sarcoma patients

1 reference

12 December 2020

The incidence of secondary leukemias

1 reference

12 December 2020

Screening with magnetic resonance imaging and mammography of a UK population at high familial risk of breast cancer: a prospective multicentre cohort study (MARIBS).

1 reference

12 December 2020

Second surgery and the prognosis of choroid plexus carcinoma--results of a meta-analysis of individual cases

1 reference

12 December 2020

Follow-up study of twenty-four families with Li-Fraumeni syndrome

1 reference

12 December 2020

Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families.

1 reference

12 December 2020

Germline mutations in the TP53 gene

1 reference

12 December 2020

Serial screening for melanoma: measures and strategies that have consistently achieved early detection and cure

1 reference

12 December 2020

The relationship between the clinical presentation and spread of colon cancer in 315 consecutive patients. A significant trend of earlier cancer detection from 1982 through 1988 at a university hospital

1 reference

12 December 2020

Germ-line mutations of TP53 in Li-Fraumeni families: an extended study of 39 families

1 reference

12 December 2020

Principles and practice of mass screening for disease

1 reference

12 December 2020

Germ-line p53 mutations predispose to a wide spectrum of early-onset cancers.

1 reference

12 December 2020

A cancer family syndrome in twenty-four kindreds

1 reference

12 December 2020

10.1038/NRCLINONC.2014.41

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24642672%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference