When mutants gain new powers: news from the mutant p53 field. (Q37582777)

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5 February 2020

review article

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title

When mutants gain new powers: news from the mutant p53 field (English)

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5 February 2020

1

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5 February 2020

2

Varda Rotter

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19693097%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

language of work or name

English

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publication date

20 August 2009

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5 February 2020

published in

Nature Reviews Cancer

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5 February 2020

volume

9

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5 February 2020

page(s)

701-713

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5 February 2020

issue

10

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https://scigraph.springernature.com/pub.10.1038/nrc2693

5 February 2020

exact match

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Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes

31 March 2020

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p53, a transformation-related cellular-encoded protein, can be used as a biochemical marker for the detection of primary mouse tumor cells

31 March 2020

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Increased expression of mutant forms of p53 oncogene in primary lung cancer

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Assessing TP53 status in human tumours to evaluate clinical outcome

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Growth regulation of a cellular tumour antigen, p53, in nontransformed cells

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mdm2 expression is induced by wild type p53 activity

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Mdm2 promotes the rapid degradation of p53

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p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

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Ubiquitination and degradation of mutant p53.

31 March 2020

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Chaperone-dependent stabilization and degradation of p53 mutants.

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Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

31 March 2020

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Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

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p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

31 March 2020

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The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

31 March 2020

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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31 March 2020

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31 March 2020

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31 March 2020

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PTEN and p53: who will get the upper hand?

31 March 2020

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PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations

31 March 2020

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p16INK4a modulates p53 in primary human mammary epithelial cells.

31 March 2020

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Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines

31 March 2020

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Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

31 March 2020

1 reference

Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell

31 March 2020

1 reference

The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent

31 March 2020

1 reference

Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells.

31 March 2020

1 reference

The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation

31 March 2020

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A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

31 March 2020

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Hsp90: a novel target for cancer therapy

31 March 2020

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P53 transformation-related protein accumulates in the nucleus of transformed fibroblasts in association with the chromatin and is found in the cytoplasm of non-transformed fibroblasts

31 March 2020

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Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis

31 March 2020

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Regulation of p53 nuclear export through sequential changes in conformation and ubiquitination

31 March 2020

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Mutant p53 protein localized in the cytoplasm inhibits autophagy

31 March 2020

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Control of autophagy by oncogenes and tumor suppressor genes

31 March 2020

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Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

31 March 2020

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Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation.

31 March 2020

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Transcriptional activities of mutant p53: when mutations are more than a loss

31 March 2020

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Mutant p53: an oncogenic transcription factor

31 March 2020

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p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.

31 March 2020

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A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

31 March 2020

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p63 and p73 in human cancer: defining the network

31 March 2020

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Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family

31 March 2020

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Are interactions with p63 and p73 involved in mutant p53 gain of oncogenic function?

31 March 2020

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p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis

31 March 2020

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The disruption of the protein complex mutantp53/p73 increases selectively the response of tumor cells to anticancer drugs

31 March 2020

1 reference

Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway.

31 March 2020

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Integrity of the N-terminal transcription domain of p53 is required for mutant p53 interference with drug-induced apoptosis

31 March 2020

1 reference

Mutant p53 proteins bind DNA in a DNA structure-selective mode

31 March 2020

1 reference

Identification of genomic DNA sequences bound by mutant p53 protein (Gly245-->Ser) in vivo.

31 March 2020

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Modulation of gene expression in U251 glioblastoma cells by binding of mutant p53 R273H to intronic and intergenic sequences

31 March 2020

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Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation

31 March 2020

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Recent advances in p53 research: an interdisciplinary perspective.

31 March 2020

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Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer cells

31 March 2020

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Tumor-derived p53 mutants induce NF-kappaB2 gene expression

31 March 2020

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Quantitative analysis of chromosomal CGH in human breast tumors associates copy number abnormalities with p53 status and patient survival

31 March 2020

1 reference

TP53mutations are associated with a particular pattern of genomic imbalances in breast carcinomas

31 March 2020

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Gene-expression signatures in breast cancer

31 March 2020

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Utilization of genomic signatures to direct use of primary chemotherapy

31 March 2020

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Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain

31 March 2020

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Profiling of gene expression changes caused by p53 gain-of-function mutant alleles in prostate cancer cells

31 March 2020

1 reference

Modulation of gene expression by tumor-derived p53 mutants

31 March 2020

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Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

31 March 2020

1 reference

TP53 mutation status and gene expression profiles are powerful prognostic markers of breast cancer

31 March 2020

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Gene expression patterns associated with p53 status in breast cancer.

31 March 2020

1 reference

Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes.

31 March 2020

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Genomic and proteomic profiles reveal the association of gelsolin to TP53 status and bladder cancer progression

31 March 2020

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A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53

31 March 2020

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Common markers of proliferation.

31 March 2020

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A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma.

31 March 2020

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The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation.

31 March 2020

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p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation.

31 March 2020

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Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters.

31 March 2020

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Oncogenomic Approaches in Exploring Gain of Function of Mutant p53.

31 March 2020

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Cancer-derived p53 mutants suppress p53-target gene expression--potential mechanism for gain of function of mutant p53.

31 March 2020

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A comparison between p53 accumulation determined by immunohistochemistry and TP53 mutations as prognostic variables in tumours from breast cancer patients

31 March 2020

1 reference

Mutations in TP53 are a prognostic factor in colorectal hepatic metastases undergoing surgical resection.

31 March 2020

1 reference

The predictive value of p53 and p33(ING1b) in patients with Dukes'C colorectal cancer.

31 March 2020

1 reference

Prognostic significance of p53 gene mutations and protein overexpression in localized gastrointestinal stromal tumours.

31 March 2020

1 reference

Both germ line and somatic genetics of the p53 pathway affect ovarian cancer incidence and survival

31 March 2020

1 reference

TP53 mutations and survival in squamous-cell carcinoma of the head and neck.

31 March 2020

1 reference

Transcriptional functionality of germ line p53 mutants influences cancer phenotype.

31 March 2020

1 reference

Functional analysis of p53 gene and the prognostic impact of dominant-negative p53 mutation in endometrial cancer

31 March 2020

1 reference

Implications of p53 gene mutations on patient survival in transitional cell carcinoma of the bladder: a long-term study

31 March 2020

1 reference

The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer

31 March 2020

1 reference

Mutations in the DNA-binding codons of TP53, which are associated with decreased expression of TRAILreceptor-2, predict for poor survival in diffuse large B-cell lymphoma

31 March 2020

1 reference

Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study.

31 March 2020

1 reference

TP53 mutations and codon 72 genotype--impact on survival among ovarian cancer patients

31 March 2020

1 reference

Age-dependent prognostic effects of genetic alterations in glioblastoma

31 March 2020

1 reference

Relationship between genetic alterations and prognosis in sporadic colorectal cancer.

31 March 2020

1 reference

Worse outcome in primary glioblastoma multiforme with concurrent epidermal growth factor receptor and p53 alteration.

31 March 2020

1 reference

Joint association of polymorphism of the FGFR4 gene and mutation TP53 gene with bladder cancer prognosis

31 March 2020

1 reference

Association of breast cancer outcome with status of p53 and MDM2 SNP309

31 March 2020

1 reference

The combination of p53 mutation and neu/erbB-2 amplification is associated with poor survival in node-negative breast cancer

31 March 2020

1 reference

Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers

31 March 2020

1 reference

Rapid p53 sequence analysis in primary lung cancer using an oligonucleotide probe array

31 March 2020

1 reference

Evaluating the arrayed primer extension resequencing assay of TP53 tumor suppressor gene

31 March 2020

1 reference

Evaluation of arrayed primer extension for TP53 mutation detection in breast and ovarian carcinomas

31 March 2020

1 reference

The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype

31 March 2020

1 reference

Prognostic implications of circulating anti-p53 antibodies in lung cancer--a review

31 March 2020

1 reference

Detection of K-ras and p53 gene mutations in pancreatic juice for the diagnosis of intraductal papillary mucinous tumors

31 March 2020

1 reference

Detecting colorectal cancer in stool with the use of multiple genetic targets

31 March 2020

1 reference

p53 missense mutations in microdissected high-grade ductal carcinoma in situ of the breast

31 March 2020

1 reference

Analysis of p53 mutations in cells taken from paraffin-embedded tissue sections of ductal carcinoma in situ and atypical ductal hyperplasia of the breast.

31 March 2020

1 reference

A low incidence of p53 mutations in pre-malignant lesions of the oral cavity from non-tobacco users

31 March 2020

1 reference

A high prevalence of p53 mutations in pre-malignant oral erythroplakia

31 March 2020

1 reference

Molecular basis of the Li-Fraumeni syndrome: an update from the French LFS families

31 March 2020

1 reference

The C-terminus of mutant p53 is necessary for its ability to interfere with growth arrest or apoptosis

31 March 2020

1 reference

MicroRNAs and cancer: short RNAs go a long way.

31 March 2020

1 reference

Restoration of p53 to limit tumor growth

31 March 2020

1 reference

Structure-function-rescue: the diverse nature of common p53 cancer mutants

31 March 2020

1 reference

Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations

31 March 2020

1 reference

Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas

31 March 2020

1 reference

Breast-Cancer Stromal Cells withTP53Mutations and Nodal Metastases

31 March 2020

1 reference

Breast-cancer stromal cells with TP53 mutations.

31 March 2020

1 reference

Promyelocytic leukemia protein is required for gain of function by mutant p53.

31 March 2020

1 reference

Molecular basis for heterogeneity of the human p53 protein

31 March 2020

1 reference

p53 polymorphisms: cancer implications

31 March 2020

1 reference

Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome?

31 March 2020

1 reference

Germline TP53 mutations and Li-Fraumeni syndrome

31 March 2020

1 reference

Cancer phenotype correlates with constitutional TP53 genotype in families with the Li-Fraumeni syndrome.

31 March 2020

1 reference

Tumor-derived p53 mutant C174Y is a gain-of-function mutant which activates the fos promoter and enhances colony formation

31 March 2020

1 reference

Mutant p53 induces the GEF-H1 oncogene, a guanine nucleotide exchange factor-H1 for RhoA, resulting in accelerated cell proliferation in tumor cells

31 March 2020

1 reference

Suppression of inhibitor of differentiation 2, a target of mutant p53, is required for gain-of-function mutations

31 March 2020

1 reference

Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene

31 March 2020

1 reference

Identification of GRO1 as a critical determinant for mutant p53 gain of function

31 March 2020

1 reference

Transactivation of the EGR1 gene contributes to mutant p53 gain of function

31 March 2020

1 reference

Mutant p53 protects cells from 12-O-tetradecanoylphorbol-13-acetate-induced death by attenuating activating transcription factor 3 induction

31 March 2020

1 reference

Gal-3 is stimulated by gain-of-function p53 mutations and modulates chemoresistance in anaplastic thyroid carcinomas.

31 March 2020

1 reference

Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants

31 March 2020

1 reference

Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53

31 March 2020

1 reference

Activation of the insulin-like growth factor II transcription by aflatoxin B1 induced p53 mutant 249 is caused by activation of transcription complexes; implications for a gain-of-function during the formation of hepatocellular carcinoma

31 March 2020

1 reference

Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants

31 March 2020

1 reference

Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil

31 March 2020

1 reference

Mutant p53 attenuates the SMAD-dependent transforming growth factor beta1 (TGF-beta1) signaling pathway by repressing the expression of TGF-beta receptor type II

31 March 2020

1 reference

Effects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12/15-lipoxygenase gene expression: evidence that 15-lipoxygenase is a mutator gene

31 March 2020

1 reference

Gain of oncogenic function of p53 mutants induces invasive phenotypes in human breast cancer cells by silencing CCN5/WISP-2

31 March 2020

1 reference

p53 hot-spot mutants increase tumor vascularization via ROS-mediated activation of the HIF1/VEGF-A pathway

31 March 2020

1 reference

Genetic alteration of p53, but not overexpression of intratumoral p53 protein, or serum p53 antibody is a prognostic factor in sporadic colorectal adenocarcinoma

31 March 2020

1 reference

12 December 2020

Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome.

1 reference

12 December 2020

Increased concentration of an apparently identical cellular protein in cells transformed by either Abelson murine leukemia virus or other transforming agents

1 reference

12 December 2020

Expression of mitotic spindle checkpoint protein hsMAD1 correlates with cellular proliferation and is activated by a gain-of-function p53 mutant.

1 reference

12 December 2020

Simian virus 40-transformed cells express new species of proteins precipitable by anti-simian virus 40 tumor serum

1 reference

12 December 2020

An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival

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12 December 2020

Family feud in chemosensitvity: p73 and mutant p53.

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12 December 2020

Abelson murine leukemia virus-induced tumors elicit antibodies against a host cell protein, P50

1 reference

12 December 2020

Modulation of cellular and viral promoters by mutant human p53 proteins found in tumor cells

1 reference

12 December 2020

Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies

1 reference

12 December 2020

Prognostic implications of molecular and immunohistochemical profiles of the Rb and p53 cell cycle regulatory pathways in primary non-small cell lung carcinoma

1 reference

12 December 2020

Two critical hydrophobic amino acids in the N-terminal domain of the p53 protein are required for the gain of function phenotypes of human p53 mutants.

1 reference

12 December 2020

TP53 gene mutations as an independent marker for urinary bladder cancer progression

1 reference

12 December 2020

Alterations in tumor development in vivo mediated by expression of wild type or mutant p53 proteins.

1 reference

12 December 2020

Transcriptional control of the proliferation cluster by the tumor suppressor p53.

1 reference

12 December 2020

Mutant p53 protein in serum could be used as a molecular marker in human breast cancer

1 reference

12 December 2020

p53 Antibodies in the sera of patients with various types of cancer: a review

1 reference

12 December 2020

Breast-cancer stromal cells with TP53 mutations

1 reference

12 December 2020

Rhabdomyosarcoma in children: epidemiologic study and identification of a familial cancer syndrome

1 reference

12 December 2020

Elevated expression of ribosomal protein genes L37, RPP-1, and S2 in the presence of mutant p53

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC2693

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19693097%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

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