Gene therapy for restoring heart rhythm (Q38205308)

31 August 2017

title

Gene therapy for restoring heart rhythm (English)

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31 August 2017

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Gerard J J Boink

1

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31 August 2017

Richard B Robinson

series ordinal

2

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31 August 2017

publication date

17 April 2014

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Journal of Cardiovascular Pharmacology and Therapeutics

31 August 2017

published in

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31 August 2017

volume

19

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31 August 2017

issue

5

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31 August 2017

page(s)

426-438

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Trends in permanent pacemaker implantation in the United States from 1993 to 2009: increasing complexity of patients and procedures

31 August 2017

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Long term complications in single and dual chamber pacing are influenced by surgical experience and patient morbidity

21 January 2018

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Left ventricular septal and apex pacing for optimal pump function in canine hearts.

21 January 2018

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Chronic ventricular pacing in children: toward prevention of pacing-induced heart disease

21 January 2018

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Human mesenchymal stem cells as a gene delivery system to create cardiac pacemakers

21 January 2018

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https://api.crossref.org/works/10.1177%2F1074248414528575

Coupling an HCN2-expressing cell to a myocyte creates a two-cell pacing unit

21 January 2018

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Electromechanical integration of cardiomyocytes derived from human embryonic stem cells.

21 January 2018

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Human embryonic and induced pluripotent stem cell-derived cardiomyocytes exhibit beat rate variability and power-law behavior.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1074248414528575

The road to biological pacing

21 January 2018

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https://api.crossref.org/works/10.1177%2F1074248414528575

Regenerative therapies in electrophysiology and pacing: introducing the next steps

21 January 2018

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Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo.

21 January 2018

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Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors

21 January 2018

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Adeno-associated virus (AAV) vectors achieve prolonged transgene expression in mouse myocardium and arteries in vivo: a comparative study with adenovirus vectors

21 January 2018

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Long-term effects of AAV1/SERCA2a gene transfer in patients with severe heart failure: analysis of recurrent cardiovascular events and mortality.

21 January 2018

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Overcoming preexisting humoral immunity to AAV using capsid decoys

21 January 2018

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Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure

21 January 2018

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https://api.crossref.org/works/10.1177%2F1074248414528575

Expanding AAV packaging capacity with trans-splicing or overlapping vectors: a quantitative comparison

21 January 2018

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Directed evolution of novel adeno-associated viruses for therapeutic gene delivery.

21 January 2018

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In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

21 January 2018

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https://api.crossref.org/works/10.1177%2F1074248414528575

Gene therapy to inhibit the calcium channel beta subunit: physiological consequences and pathophysiological effects in models of cardiac hypertrophy

21 January 2018

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https://api.crossref.org/works/10.1177%2F1074248414528575

Lentiviral vector-mediated SERCA2 gene transfer protects against heart failure and left ventricular remodeling after myocardial infarction in rats

21 January 2018

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Immune responses in liver-directed lentiviral gene therapy.

21 January 2018

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Ex vivo gene transfer and correction for cell-based therapies

21 January 2018

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Gene transfer for ocular neovascularization and macular edema

21 January 2018

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https://api.crossref.org/works/10.1177%2F1074248414528575

Characterization of lentiviral vector production using microwell suspension cultures of HEK293T-derived producer cells

21 January 2018

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Development of inducible EIAV-based lentiviral vector packaging and producer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

What keeps us ticking: a funny current, a calcium clock, or both?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Hyperpolarization-activated cation currents: from molecules to physiological function

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

The role of the funny current in pacemaker activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Ca2+-stimulated adenylyl cyclase isoform AC1 is preferentially expressed in guinea-pig sino-atrial node cells and modulates the I(f) pacemaker current

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Ca(2+) -stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial node

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

The newborn rabbit sino-atrial node expresses a neuronal type I-like Na+ channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

HCN2 overexpression in newborn and adult ventricular myocytes: distinct effects on gating and excitability

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Expression of skeletal but not cardiac Na+ channel isoform preserves normal conduction in a depolarized cardiac syncytium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Engineering physiologically controlled pacemaker cells with lentiviral HCN4 gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Organ explant culture of neonatal rat ventricles: a new model to study gene and cell therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Engineering a biological pacemaker: in vivo, in vitro and in silico models

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Biological pacemaker created by gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Functional role of inward rectifier current in heart probed by Kir2.1 overexpression and dominant-negative suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Developmental change in the voltage-dependence of the pacemaker current, if, in rat ventricle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Wild-type and mutant HCN channels in a tandem biological-electronic cardiac pacemaker.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

In vitro characterization of HCN channel kinetics and frequency dependence in myocytes predicts biological pacemaker functionality

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Mechanistic role of I(f) revealed by induction of ventricular automaticity by somatic gene transfer of gating-engineered pacemaker (HCN) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Dominant-negative suppression of HCN channels markedly reduces the native pacemaker current I(f) and undermines spontaneous beating of neonatal cardiomyocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

HCN212-channel biological pacemakers manifesting ventricular tachyarrhythmias are responsive to treatment with I(f) blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Enhancement of murine cardiac chronotropy by the molecular transfer of the human beta2 adrenergic receptor cDNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Molecular enhancement of porcine cardiac chronotropy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Adenylate-cyclase VI transforms ventricular cardiomyocytes into biological pacemaker cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Ca2+-activated adenylyl cyclase 1 introduces Ca2+-dependence to beta-adrenergic stimulation of HCN2 current

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

I(f)-dependent modulation of pacemaker rate mediated by cAMP in the presence of ryanodine in rabbit sino-atrial node cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Expression and function of a biological pacemaker in canine heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Biological pacemaker implanted in canine left bundle branch provides ventricular escape rhythms that have physiologically acceptable rates

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

HCN2/SkM1 gene transfer into canine left bundle branch induces stable, autonomically responsive biological pacing at physiological heart rates

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Ca(2+)-stimulated adenylyl cyclase AC1 generates efficient biological pacing as single gene therapy and in combination with HCN2

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN Channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome model

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Biological pacemaker created by percutaneous gene delivery via venous catheters in a porcine model of complete heart block

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Pacemaker activity of the human sinoatrial node: role of the hyperpolarization-activated current, I(f).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Adenoviral gene transfer of HCN4 creates a genetic pacemaker in pigs with complete atrioventricular block

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Improving cardiac conduction with a skeletal muscle sodium channel by gene and cell therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

21 January 2018

Cardiac Purkinje cells

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Effect of skeletal muscle Na(+) channel delivered via a cell platform on cardiac conduction and arrhythmia induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Transplantation of mesenchymal stem cells improves atrioventricular conduction in a rat model of complete atrioventricular block

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Human adult bone marrow mesenchymal stem cells repair experimental conduction block in rat cardiomyocyte cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

Resynchronization of separated rat cardiomyocyte fields with genetically modified human ventricular scar fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1074248414528575

21 January 2018

Identifiers

DOI

10.1177/1074248414528575

1 reference

31 August 2017

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